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The map label for this gene is cadA [H]

Identifier: 28379763

GI number: 28379763

Start: 3047003

End: 3048907

Strand: Direct

Name: cadA [H]

Synonym: lp_3435

Alternate gene names: 28379763

Gene position: 3047003-3048907 (Clockwise)

Preceding gene: 28379761

Following gene: 28379765

Centisome position: 92.1

GC content: 46.46

Gene sequence:

>1905_bases
ATGAAATTCCAATTATTTCTCACTAAACATACGAATCACATTACATTAGTTACGGGGATTCTGATTGTCCTTGGGATGCT
CAGTAAATATCTCTTACAATTTACGCTCGGTTACCAAGTCATTTTAGCAGTTGCTTCAATTATTGCCGTCATTCCGATTG
CGGTTCGTGCTTGGAGCGCACTTCGGAACAAAGTTTTCAGTATTGAACTGTTAGTTAGTATCGCAGTGATTGGGGCATTC
ATTATTGGTGAATTCAACGAATCCGCAATCGTTACTTTCCTCTTCTTGTTTGGCTCCTATCTCGAAAGCAAGACCTTGCA
GAAGACGCGGACCGCAATCAAAGGCTTGACTGACATGTCACCAACTACCGCAACTTTAGTTACTGATGATGGCACCGAAG
AAGTCGACGTTGATGATGTGGACGAAGGTGACGTTGTCCTAGTTAAAACTGGGAGTCAGGTTCCCGTTGACGGGATTGTT
GTTGAAGGTAACGGCTACCTTAACGAAGCCTCAATTACGGGTGAAGCACGCCAAATCAACAAGCAACTCAAGGACTCGGT
TTACTCCGGAACAATGGTTGAAAATGGCTATCTGAAGATCAAAGCGACTCAGGTTGGCGACGACACGACTTTTGCCAAAA
TTATTGAATTGGTTGAAGAAGCTCAAGATACCAAGTCCAAAGCTGAAAAGTTCATCGACCGCTTTGCTCAATATTATACG
CCTGCCGTCCTCGTTTTAGCAGTCTTAGTCTTCGCCTTCTCCCGTGACTTCCGCTTAGCAATCACGGTACTGGTTCTCGG
TTGCCCAGGTGCCTTAGTTATCGGTGCCCCAGTGTCAAACGTTGCCGGAATCGGGAATGGTGCCAAGCGTGGTATCCTGA
TCAAGGGTGGTGAAGTCGTCGATACTTTTGCCAAAGTCGATACCCTGGTCTTCGATAAGACCGGTACTTTAACGGAAGGT
AACACTGCCGTTACAACCATGCACACTTACACAAACAATGCGGATAATCAACTAGCTCTCGCTGCCGCTATTGAGGGCGT
TTCCGACCATCCGTTAGGCCAAGCAATCGTCAGTTATGCCGACCAGCAGTCAGCGGGGGTCGCTCCCGTCCTAGATGACA
CTGAAACCGTTAAGGGCCAAGGAATCTGTGCACAAGTCGGTAAGCAAGAAGTTGTCATTGGTAATCAAAAAATGTTGACG
GCTCATAATATCAAACTAAATCCTACCCAACTCAAAGATCTCAATGGTTTACAAGCTGGTGGTCAATCAACCGTTATCAT
GGCAGTCGACGGACAAGTTCAACTCATCTTCGGGATTGCCGATACGATTCGTCCAGGCGTGAAGGATTCCCTCGCCGCAT
TAAAAGCCCAAGGAATCAAGAAACTCGTTATGTTAACTGGAGACAATGAACTCACCGCTCAAGCCGTTGCCAACGAATTG
AACCTAGATGAAGTTCACGCCAACCTCTTGCCAGAAGAAAAAGTCGAATACGTTAAGAAACTAAAAGCAGCCGGTAATAC
GGTCGCCTTTATTGGAGATGGCATCAACGACAGTCCTTCAATCGCTAACGCCGATATCGGAATCGCAATGGGTAGTGGGA
CTGACGTTGCCATCGACACATCCGATGTCGTCTTGATGCAATCAAGCTTCCCCGCATTAGTACACGCCCACGGTCTCGCC
AAGAAAACTGTCTTGAACACTCGTGAAAACATCTTCATCGCCATTGCCACCGTGGCCTTCCTACTGATTGGGCTAATCTT
CGGTTATATCTACATGGCCAGTGGGATGTTTGTCCATGAAGCTAGTATCTTAGTCGTTATCTTCAACGCTATGCGGTTAA
TCAATTTCCAAACCAAGTTCGACAAGCACCAACCAACTAAAACCATTCAAGCAGCCACAGCTTAA

Upstream 100 bases:

>100_bases
AATTAATACTGTTATTTTTCAAAACTTGACGCCTATCAAGTTGCCATCAAGCTGAACTCACTATACTAGGGTCATCAAAT
CAAATAAGGAGTTGCAAATT

Downstream 100 bases:

>100_bases
TCAAGTCTCCCCAACTTGGTTACAGGCCTAGCAAAAAATAACGGTCCGCCGACTAGTCTTCCCCAGCTAGTCGGCGGACC
GTTTTATCATATTGCAATCA

Product: cadmium transporting P-type ATPase

Products: NA

Alternate protein names: Cadmium efflux ATPase [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MKFQLFLTKHTNHITLVTGILIVLGMLSKYLLQFTLGYQVILAVASIIAVIPIAVRAWSALRNKVFSIELLVSIAVIGAF
IIGEFNESAIVTFLFLFGSYLESKTLQKTRTAIKGLTDMSPTTATLVTDDGTEEVDVDDVDEGDVVLVKTGSQVPVDGIV
VEGNGYLNEASITGEARQINKQLKDSVYSGTMVENGYLKIKATQVGDDTTFAKIIELVEEAQDTKSKAEKFIDRFAQYYT
PAVLVLAVLVFAFSRDFRLAITVLVLGCPGALVIGAPVSNVAGIGNGAKRGILIKGGEVVDTFAKVDTLVFDKTGTLTEG
NTAVTTMHTYTNNADNQLALAAAIEGVSDHPLGQAIVSYADQQSAGVAPVLDDTETVKGQGICAQVGKQEVVIGNQKMLT
AHNIKLNPTQLKDLNGLQAGGQSTVIMAVDGQVQLIFGIADTIRPGVKDSLAALKAQGIKKLVMLTGDNELTAQAVANEL
NLDEVHANLLPEEKVEYVKKLKAAGNTVAFIGDGINDSPSIANADIGIAMGSGTDVAIDTSDVVLMQSSFPALVHAHGLA
KKTVLNTRENIFIAIATVAFLLIGLIFGYIYMASGMFVHEASILVVIFNAMRLINFQTKFDKHQPTKTIQAATA

Sequences:

>Translated_634_residues
MKFQLFLTKHTNHITLVTGILIVLGMLSKYLLQFTLGYQVILAVASIIAVIPIAVRAWSALRNKVFSIELLVSIAVIGAF
IIGEFNESAIVTFLFLFGSYLESKTLQKTRTAIKGLTDMSPTTATLVTDDGTEEVDVDDVDEGDVVLVKTGSQVPVDGIV
VEGNGYLNEASITGEARQINKQLKDSVYSGTMVENGYLKIKATQVGDDTTFAKIIELVEEAQDTKSKAEKFIDRFAQYYT
PAVLVLAVLVFAFSRDFRLAITVLVLGCPGALVIGAPVSNVAGIGNGAKRGILIKGGEVVDTFAKVDTLVFDKTGTLTEG
NTAVTTMHTYTNNADNQLALAAAIEGVSDHPLGQAIVSYADQQSAGVAPVLDDTETVKGQGICAQVGKQEVVIGNQKMLT
AHNIKLNPTQLKDLNGLQAGGQSTVIMAVDGQVQLIFGIADTIRPGVKDSLAALKAQGIKKLVMLTGDNELTAQAVANEL
NLDEVHANLLPEEKVEYVKKLKAAGNTVAFIGDGINDSPSIANADIGIAMGSGTDVAIDTSDVVLMQSSFPALVHAHGLA
KKTVLNTRENIFIAIATVAFLLIGLIFGYIYMASGMFVHEASILVVIFNAMRLINFQTKFDKHQPTKTIQAATA
>Mature_634_residues
MKFQLFLTKHTNHITLVTGILIVLGMLSKYLLQFTLGYQVILAVASIIAVIPIAVRAWSALRNKVFSIELLVSIAVIGAF
IIGEFNESAIVTFLFLFGSYLESKTLQKTRTAIKGLTDMSPTTATLVTDDGTEEVDVDDVDEGDVVLVKTGSQVPVDGIV
VEGNGYLNEASITGEARQINKQLKDSVYSGTMVENGYLKIKATQVGDDTTFAKIIELVEEAQDTKSKAEKFIDRFAQYYT
PAVLVLAVLVFAFSRDFRLAITVLVLGCPGALVIGAPVSNVAGIGNGAKRGILIKGGEVVDTFAKVDTLVFDKTGTLTEG
NTAVTTMHTYTNNADNQLALAAAIEGVSDHPLGQAIVSYADQQSAGVAPVLDDTETVKGQGICAQVGKQEVVIGNQKMLT
AHNIKLNPTQLKDLNGLQAGGQSTVIMAVDGQVQLIFGIADTIRPGVKDSLAALKAQGIKKLVMLTGDNELTAQAVANEL
NLDEVHANLLPEEKVEYVKKLKAAGNTVAFIGDGINDSPSIANADIGIAMGSGTDVAIDTSDVVLMQSSFPALVHAHGLA
KKTVLNTRENIFIAIATVAFLLIGLIFGYIYMASGMFVHEASILVVIFNAMRLINFQTKFDKHQPTKTIQAATA

Specific function: This electroneutral antiporter ejects one cadmium ion while accumulating two protons by an energy-dependent efflux mechanism [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=653, Percent_Identity=32.6186830015314, Blast_Score=294, Evalue=2e-79,
Organism=Homo sapiens, GI55743071, Length=636, Percent_Identity=31.1320754716981, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI55743073, Length=535, Percent_Identity=33.0841121495327, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI48762687, Length=624, Percent_Identity=21.9551282051282, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI48762685, Length=624, Percent_Identity=21.9551282051282, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI48762689, Length=624, Percent_Identity=21.9551282051282, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI48762691, Length=624, Percent_Identity=21.9551282051282, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI118498343, Length=595, Percent_Identity=22.8571428571429, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI51944966, Length=324, Percent_Identity=23.1481481481481, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789879, Length=623, Percent_Identity=34.8314606741573, Blast_Score=311, Evalue=1e-85,
Organism=Escherichia coli, GI1786691, Length=604, Percent_Identity=33.112582781457, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1786914, Length=462, Percent_Identity=29.2207792207792, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI2367363, Length=606, Percent_Identity=23.9273927392739, Blast_Score=112, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17556548, Length=624, Percent_Identity=32.2115384615385, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI71988506, Length=201, Percent_Identity=28.3582089552239, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193210130, Length=152, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17554158, Length=152, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71997262, Length=149, Percent_Identity=31.5436241610738, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997269, Length=149, Percent_Identity=31.5436241610738, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997275, Length=149, Percent_Identity=31.5436241610738, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17557486, Length=262, Percent_Identity=22.9007633587786, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=652, Percent_Identity=28.2208588957055, Blast_Score=257, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6319772, Length=665, Percent_Identity=26.1654135338346, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321432, Length=183, Percent_Identity=32.7868852459016, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321271, Length=151, Percent_Identity=34.4370860927152, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325221, Length=234, Percent_Identity=24.3589743589744, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321430, Length=234, Percent_Identity=23.9316239316239, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320243, Length=225, Percent_Identity=28, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320244, Length=225, Percent_Identity=28, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320245, Length=225, Percent_Identity=27.5555555555556, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221329854, Length=411, Percent_Identity=31.6301703163017, Blast_Score=155, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24668704, Length=170, Percent_Identity=32.3529411764706, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281366617, Length=170, Percent_Identity=32.3529411764706, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24668708, Length=170, Percent_Identity=32.3529411764706, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24668696, Length=170, Percent_Identity=32.3529411764706, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI161085803, Length=170, Percent_Identity=32.3529411764706, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281366676, Length=257, Percent_Identity=26.0700389105058, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281362164, Length=280, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45553441, Length=280, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24648580, Length=280, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24648578, Length=280, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45553435, Length=280, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45553439, Length=280, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45553437, Length=280, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24648576, Length=280, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3 [H]

Molecular weight: Translated: 67510; Mature: 67510

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFQLFLTKHTNHITLVTGILIVLGMLSKYLLQFTLGYQVILAVASIIAVIPIAVRAWSA
CEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRNKVFSIELLVSIAVIGAFIIGEFNESAIVTFLFLFGSYLESKTLQKTRTAIKGLTDMS
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PTTATLVTDDGTEEVDVDDVDEGDVVLVKTGSQVPVDGIVVEGNGYLNEASITGEARQIN
CCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCEECCCCCCHHHHHH
KQLKDSVYSGTMVENGYLKIKATQVGDDTTFAKIIELVEEAQDTKSKAEKFIDRFAQYYT
HHHHHHHHCCCEEECCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PAVLVLAVLVFAFSRDFRLAITVLVLGCPGALVIGAPVSNVAGIGNGAKRGILIKGGEVV
HHHHHHHHHHHHHCCCHHEEEEEEEECCCCCEEECCCHHHHCCCCCCCCCCEEEECCHHH
DTFAKVDTLVFDKTGTLTEGNTAVTTMHTYTNNADNQLALAAAIEGVSDHPLGQAIVSYA
HHHHHHHHEEEECCCCCCCCCEEEEEEEEECCCCCCCEEEEHHHCCCCCCCHHHHHHHHC
DQQSAGVAPVLDDTETVKGQGICAQVGKQEVVIGNQKMLTAHNIKLNPTQLKDLNGLQAG
CCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEECCCEEEEEECEEECCHHHCCCCCCCCC
GQSTVIMAVDGQVQLIFGIADTIRPGVKDSLAALKAQGIKKLVMLTGDNELTAQAVANEL
CCEEEEEEECCCEEEEEEEHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHC
NLDEVHANLLPEEKVEYVKKLKAAGNTVAFIGDGINDSPSIANADIGIAMGSGTDVAIDT
CHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEC
SDVVLMQSSFPALVHAHGLAKKTVLNTRENIFIAIATVAFLLIGLIFGYIYMASGMFVHE
CCEEEEECCCCHHHHHHCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEH
ASILVVIFNAMRLINFQTKFDKHQPTKTIQAATA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKFQLFLTKHTNHITLVTGILIVLGMLSKYLLQFTLGYQVILAVASIIAVIPIAVRAWSA
CEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRNKVFSIELLVSIAVIGAFIIGEFNESAIVTFLFLFGSYLESKTLQKTRTAIKGLTDMS
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PTTATLVTDDGTEEVDVDDVDEGDVVLVKTGSQVPVDGIVVEGNGYLNEASITGEARQIN
CCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCEECCCCCCHHHHHH
KQLKDSVYSGTMVENGYLKIKATQVGDDTTFAKIIELVEEAQDTKSKAEKFIDRFAQYYT
HHHHHHHHCCCEEECCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PAVLVLAVLVFAFSRDFRLAITVLVLGCPGALVIGAPVSNVAGIGNGAKRGILIKGGEVV
HHHHHHHHHHHHHCCCHHEEEEEEEECCCCCEEECCCHHHHCCCCCCCCCCEEEECCHHH
DTFAKVDTLVFDKTGTLTEGNTAVTTMHTYTNNADNQLALAAAIEGVSDHPLGQAIVSYA
HHHHHHHHEEEECCCCCCCCCEEEEEEEEECCCCCCCEEEEHHHCCCCCCCHHHHHHHHC
DQQSAGVAPVLDDTETVKGQGICAQVGKQEVVIGNQKMLTAHNIKLNPTQLKDLNGLQAG
CCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEECCCEEEEEECEEECCHHHCCCCCCCCC
GQSTVIMAVDGQVQLIFGIADTIRPGVKDSLAALKAQGIKKLVMLTGDNELTAQAVANEL
CCEEEEEEECCCEEEEEEEHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHC
NLDEVHANLLPEEKVEYVKKLKAAGNTVAFIGDGINDSPSIANADIGIAMGSGTDVAIDT
CHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEC
SDVVLMQSSFPALVHAHGLAKKTVLNTRENIFIAIATVAFLLIGLIFGYIYMASGMFVHE
CCEEEEECCCCHHHHHHCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEH
ASILVVIFNAMRLINFQTKFDKHQPTKTIQAATA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11302791 [H]