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The map label for this gene is guaC

Identifier: 28379640

GI number: 28379640

Start: 2911724

End: 2912701

Strand: Direct

Name: guaC

Synonym: lp_3271

Alternate gene names: 28379640

Gene position: 2911724-2912701 (Clockwise)

Preceding gene: 28379639

Following gene: 28379641

Centisome position: 88.01

GC content: 48.47

Gene sequence:

>978_bases
ATGGGCATGGAGATTTTTGATTACGAAGATATTCAACTAATTCCGAACAAGTGTGTCATTAATAGTCGTTCGGAAGCCGA
TACGACCGTAGAATTGGGTGGCCGTCGTTTTAAGATTCCAGTGGTGCCTGCCAATATGGCAACCGTCATCAACGACGAGA
TTGCCAAGTGGCTCGCCACTAACGACTACTTCTACATTATGCACCGCTTCGCCCCCGAGACCCGCCGTGCTTTTATTGAA
ACGATGCATGCCGCGCAACTGTACGCATCTATTTCGGTCGGTGTTAAGTCCAGCGAGTATGACTTTATCGACGACCTGGC
TACTAATCAAATCGTGCCAGAATATATCACGATTGATATCGCACATGGTCATGCTGACAGTGTCATTGCAATGATCAAAC
ACATCAAAGACGTCCTTCCGGATAGTTTTGTAATTGCCGGAAATGTGGCCACACCAGCCGCCGTTCGCGACCTTGAAAAT
GCTGGTGCCGATGCAACTAAGGTTGGCGTTGGCCCGGGTAAGGCCTGCATTACTAAAGTCAAAACGGGCTTTGGTACTGG
CGGCTGGCAATTAGCTGCTGTCCGGTGGTGTGCTAAGGCCGCTCGCAAACCAATCATCGCAGACGGTGGTGTCCGGACCA
ATGGTGACATCGCCAAGTCGATTCGGTTCGGCGCTACGATGGTCATGATTGGCTCAATGTTGGCCGGACACCAAGAATCA
CCCGGCAACATTTTAAAAATCGATGGTAAGACTTATAAGCAATACTACGGTTCCGCCAGTGAAACCCAAAAAGGCGAACA
TAAAAACGTTGAGGGTAAACAAATGCTGGTTCCTTACCGGGGCCGCTTAGTCGACACCTTAAATGAGATGCAAGAAGACT
TACAATCATCCATCTCATATGCCGGTGGCCGGGATTTAAAGGCCATTACTAAGTGCGACTATGTGGTAGTTAAAAATTCG
ATTTACAACGGGGACTAA

Upstream 100 bases:

>100_bases
CTCTGTTGGTCCCGATCGCCAACAAACTAACGTTATCGATCACAACATTTGGGGCTAATTGAACGTGACACCGTGAATTA
ACTTAAAGGAGTTTTGCATC

Downstream 100 bases:

>100_bases
TTAAGTCTCACTAATACCTAAAAAAACTTGTCAGCCAATTCTGGTCTGACAGTTTTTTTAGTATCCAATTCTAATTTTTG
CACCCACCTTACCCTGACAC

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MGMEIFDYEDIQLIPNKCVINSRSEADTTVELGGRRFKIPVVPANMATVINDEIAKWLATNDYFYIMHRFAPETRRAFIE
TMHAAQLYASISVGVKSSEYDFIDDLATNQIVPEYITIDIAHGHADSVIAMIKHIKDVLPDSFVIAGNVATPAAVRDLEN
AGADATKVGVGPGKACITKVKTGFGTGGWQLAAVRWCAKAARKPIIADGGVRTNGDIAKSIRFGATMVMIGSMLAGHQES
PGNILKIDGKTYKQYYGSASETQKGEHKNVEGKQMLVPYRGRLVDTLNEMQEDLQSSISYAGGRDLKAITKCDYVVVKNS
IYNGD

Sequences:

>Translated_325_residues
MGMEIFDYEDIQLIPNKCVINSRSEADTTVELGGRRFKIPVVPANMATVINDEIAKWLATNDYFYIMHRFAPETRRAFIE
TMHAAQLYASISVGVKSSEYDFIDDLATNQIVPEYITIDIAHGHADSVIAMIKHIKDVLPDSFVIAGNVATPAAVRDLEN
AGADATKVGVGPGKACITKVKTGFGTGGWQLAAVRWCAKAARKPIIADGGVRTNGDIAKSIRFGATMVMIGSMLAGHQES
PGNILKIDGKTYKQYYGSASETQKGEHKNVEGKQMLVPYRGRLVDTLNEMQEDLQSSISYAGGRDLKAITKCDYVVVKNS
IYNGD
>Mature_324_residues
GMEIFDYEDIQLIPNKCVINSRSEADTTVELGGRRFKIPVVPANMATVINDEIAKWLATNDYFYIMHRFAPETRRAFIET
MHAAQLYASISVGVKSSEYDFIDDLATNQIVPEYITIDIAHGHADSVIAMIKHIKDVLPDSFVIAGNVATPAAVRDLENA
GADATKVGVGPGKACITKVKTGFGTGGWQLAAVRWCAKAARKPIIADGGVRTNGDIAKSIRFGATMVMIGSMLAGHQESP
GNILKIDGKTYKQYYGSASETQKGEHKNVEGKQMLVPYRGRLVDTLNEMQEDLQSSISYAGGRDLKAITKCDYVVVKNSI
YNGD

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily

Homologues:

Organism=Homo sapiens, GI50541954, Length=322, Percent_Identity=34.1614906832298, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI50541952, Length=322, Percent_Identity=34.1614906832298, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI50541948, Length=322, Percent_Identity=34.1614906832298, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI50541956, Length=322, Percent_Identity=34.1614906832298, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI156104880, Length=323, Percent_Identity=32.5077399380805, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI66933016, Length=191, Percent_Identity=36.1256544502618, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI217035146, Length=178, Percent_Identity=38.2022471910112, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI217035150, Length=178, Percent_Identity=38.2022471910112, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI217035152, Length=178, Percent_Identity=37.6404494382022, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI217035148, Length=178, Percent_Identity=38.2022471910112, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI156616279, Length=178, Percent_Identity=37.6404494382022, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI34328930, Length=178, Percent_Identity=37.6404494382022, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI34328928, Length=178, Percent_Identity=37.6404494382022, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1786293, Length=337, Percent_Identity=32.3442136498516, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1788855, Length=225, Percent_Identity=37.7777777777778, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560440, Length=323, Percent_Identity=32.1981424148607, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71994385, Length=151, Percent_Identity=38.4105960264901, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71994389, Length=151, Percent_Identity=38.4105960264901, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323585, Length=150, Percent_Identity=40, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323464, Length=150, Percent_Identity=40, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322012, Length=184, Percent_Identity=33.695652173913, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24641071, Length=178, Percent_Identity=37.6404494382022, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24641073, Length=178, Percent_Identity=37.6404494382022, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571163, Length=178, Percent_Identity=37.6404494382022, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): GUAC_LACPL (Q88SV5)

Other databases:

- EMBL:   AL935261
- RefSeq:   NP_786532.1
- ProteinModelPortal:   Q88SV5
- SMR:   Q88SV5
- GeneID:   1061982
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_3271
- NMPDR:   fig|220668.1.peg.2666
- HOGENOM:   HBG298985
- OMA:   PDYITID
- ProtClustDB:   PRK05458
- BioCyc:   LPLA220668:LP_3271-MONOMER
- BRENDA:   1.7.1.7
- HAMAP:   MF_01511
- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF036500
- TIGRFAMs:   TIGR01306

Pfam domain/function: PF00478 IMPDH

EC number: =1.7.1.7

Molecular weight: Translated: 35433; Mature: 35302

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: ACT_SITE 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMEIFDYEDIQLIPNKCVINSRSEADTTVELGGRRFKIPVVPANMATVINDEIAKWLAT
CCCCCCCCCCCEECCCEEEECCCCCCCCEEEECCEEEEEEEECCCHHHHHHHHHHHHHHC
NDYFYIMHRFAPETRRAFIETMHAAQLYASISVGVKSSEYDFIDDLATNQIVPEYITIDI
CCEEEEEEHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCEEEEEE
AHGHADSVIAMIKHIKDVLPDSFVIAGNVATPAAVRDLENAGADATKVGVGPGKACITKV
ECCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHH
KTGFGTGGWQLAAVRWCAKAARKPIIADGGVRTNGDIAKSIRFGATMVMIGSMLAGHQES
HCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PGNILKIDGKTYKQYYGSASETQKGEHKNVEGKQMLVPYRGRLVDTLNEMQEDLQSSISY
CCCEEEECCHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
AGGRDLKAITKCDYVVVKNSIYNGD
CCCCCCHHHHHCCEEEEECCCCCCC
>Mature Secondary Structure 
GMEIFDYEDIQLIPNKCVINSRSEADTTVELGGRRFKIPVVPANMATVINDEIAKWLAT
CCCCCCCCCCEECCCEEEECCCCCCCCEEEECCEEEEEEEECCCHHHHHHHHHHHHHHC
NDYFYIMHRFAPETRRAFIETMHAAQLYASISVGVKSSEYDFIDDLATNQIVPEYITIDI
CCEEEEEEHHCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCEEEEEE
AHGHADSVIAMIKHIKDVLPDSFVIAGNVATPAAVRDLENAGADATKVGVGPGKACITKV
ECCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHH
KTGFGTGGWQLAAVRWCAKAARKPIIADGGVRTNGDIAKSIRFGATMVMIGSMLAGHQES
HCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PGNILKIDGKTYKQYYGSASETQKGEHKNVEGKQMLVPYRGRLVDTLNEMQEDLQSSISY
CCCEEEECCHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
AGGRDLKAITKCDYVVVKNSIYNGD
CCCCCCHHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566