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The map label for this gene is tcyB [H]

Identifier: 28379592

GI number: 28379592

Start: 2861016

End: 2861723

Strand: Direct

Name: tcyB [H]

Synonym: lp_3210

Alternate gene names: 28379592

Gene position: 2861016-2861723 (Clockwise)

Preceding gene: 28379591

Following gene: 28379593

Centisome position: 86.48

GC content: 46.19

Gene sequence:

>708_bases
ATGGATTCAATCTGGCACATCATTGTCACATCAACGCCGCAAATTGCTGCAGCGGGTTTAAAATATACCATTCCGATTGC
CATTATTTCGTTTATTCTCGGTTTGATACTTGCGATTTTCACGGCCCTCGTCAAGATTTCGACTCGTCGTGGTTGGTTTT
TAATTCTAAAAGCCATCGCTAACTTCTACGTCTGGCTCTTTCGGAGTACCCCACTGCTAGTACAACTCTTTATCGTCTAT
TTCGGGCTTCCCTACCTTAAAATCAAAGGGCTCTTTCCAAATGGGGTCCAGCTCGACCCCTGGACTGCTGGGATTGCCAC
TTTTTCACTGAACACCGGGGCTTACTGTGCGGAAACGATTCGAGCAGCCATTCTCTCCATTCCTCAAGGTCAGTGGGAAG
CGGCCTACTCGATTGGCATGACCAAGTCACAAGTACTCAAACGAATTATTTTGCCGCAAGCTGCGCGAGTCTCACTACCG
CCACTATCCAATAGTTTTATTAGCTTAGTCAAGGACACCTCCTTGGCCGCTTCAATCACGATTATTGAAATGTTCGAAGT
CAGCCAACAAATTGCTGCTCAAAATTATCAACCACTTGTGATGTACTCCCTGGTTGCTGCCCTATACGCAATTCTATGTA
CGATTCTCAGCTGGCTACAAGGCTACTTGGAAAAACGGACGTCACGTTACTTACGGCCACTTAATTAG

Upstream 100 bases:

>100_bases
AGTATTTTGGTGGTAACGTTACTGATAAGTAACGTACCATTGCCCGCTATTATGGCGGGATACATAGCACCAAATTCTAA
TTTGTTACAGGAGGCTCCCT

Downstream 100 bases:

>100_bases
GAGGTTGTCGAATGATCAAATTAGAACACTTAAATAAGACGTTTGGCAATCACCAGGCGTTAACCGATATCAATACTGAA
TTTAAAGAACACCAGACGAC

Product: amino acid ABC transporter, permease protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MDSIWHIIVTSTPQIAAAGLKYTIPIAIISFILGLILAIFTALVKISTRRGWFLILKAIANFYVWLFRSTPLLVQLFIVY
FGLPYLKIKGLFPNGVQLDPWTAGIATFSLNTGAYCAETIRAAILSIPQGQWEAAYSIGMTKSQVLKRIILPQAARVSLP
PLSNSFISLVKDTSLAASITIIEMFEVSQQIAAQNYQPLVMYSLVAALYAILCTILSWLQGYLEKRTSRYLRPLN

Sequences:

>Translated_235_residues
MDSIWHIIVTSTPQIAAAGLKYTIPIAIISFILGLILAIFTALVKISTRRGWFLILKAIANFYVWLFRSTPLLVQLFIVY
FGLPYLKIKGLFPNGVQLDPWTAGIATFSLNTGAYCAETIRAAILSIPQGQWEAAYSIGMTKSQVLKRIILPQAARVSLP
PLSNSFISLVKDTSLAASITIIEMFEVSQQIAAQNYQPLVMYSLVAALYAILCTILSWLQGYLEKRTSRYLRPLN
>Mature_235_residues
MDSIWHIIVTSTPQIAAAGLKYTIPIAIISFILGLILAIFTALVKISTRRGWFLILKAIANFYVWLFRSTPLLVQLFIVY
FGLPYLKIKGLFPNGVQLDPWTAGIATFSLNTGAYCAETIRAAILSIPQGQWEAAYSIGMTKSQVLKRIILPQAARVSLP
PLSNSFISLVKDTSLAASITIIEMFEVSQQIAAQNYQPLVMYSLVAALYAILCTILSWLQGYLEKRTSRYLRPLN

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788226, Length=214, Percent_Identity=47.196261682243, Blast_Score=184, Evalue=4e-48,
Organism=Escherichia coli, GI1787030, Length=208, Percent_Identity=35.5769230769231, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1788645, Length=221, Percent_Identity=33.4841628959276, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787086, Length=223, Percent_Identity=31.390134529148, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787087, Length=238, Percent_Identity=28.1512605042017, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788646, Length=209, Percent_Identity=28.7081339712919, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1786873, Length=229, Percent_Identity=32.7510917030568, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786874, Length=174, Percent_Identity=32.7586206896552, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87082239, Length=213, Percent_Identity=31.4553990610329, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI48994930, Length=216, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26136; Mature: 26136

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSIWHIIVTSTPQIAAAGLKYTIPIAIISFILGLILAIFTALVKISTRRGWFLILKAIA
CCCEEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NFYVWLFRSTPLLVQLFIVYFGLPYLKIKGLFPNGVQLDPWTAGIATFSLNTGAYCAETI
HHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCEECCCCCCEEEEECCCCHHHHHHH
RAAILSIPQGQWEAAYSIGMTKSQVLKRIILPQAARVSLPPLSNSFISLVKDTSLAASIT
HHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHH
IIEMFEVSQQIAAQNYQPLVMYSLVAALYAILCTILSWLQGYLEKRTSRYLRPLN
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDSIWHIIVTSTPQIAAAGLKYTIPIAIISFILGLILAIFTALVKISTRRGWFLILKAIA
CCCEEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NFYVWLFRSTPLLVQLFIVYFGLPYLKIKGLFPNGVQLDPWTAGIATFSLNTGAYCAETI
HHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCEECCCCCCEEEEECCCCHHHHHHH
RAAILSIPQGQWEAAYSIGMTKSQVLKRIILPQAARVSLPPLSNSFISLVKDTSLAASIT
HHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHH
IIEMFEVSQQIAAQNYQPLVMYSLVAALYAILCTILSWLQGYLEKRTSRYLRPLN
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]