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The map label for this gene is pepR2 [H]

Identifier: 28379370

GI number: 28379370

Start: 2597066

End: 2597962

Strand: Direct

Name: pepR2 [H]

Synonym: lp_2919

Alternate gene names: 28379370

Gene position: 2597066-2597962 (Clockwise)

Preceding gene: 28379369

Following gene: 28379371

Centisome position: 78.5

GC content: 45.71

Gene sequence:

>897_bases
ATGAAAAACGTGACACGAATTTTAACGCTTAGTAATGGGTATCATCTTTGGAGCCACACTAGTAACTTAGGCGGTCGCAC
AAAATTGCTCTGCCTTCACGGTGGCCCTGGAGATACTCATGAAGTTTTTGAACGTTTTGGTCCTGAATTAGCCGACCTCG
ACATTGAGGTGACGATGTATGACCAACTCGGTTCGTGGTACTCCGACACCCCTAACTGGGACGACGATGCTATCCGACAA
CAGTATCTCACCGAAGATTATTACCTGAGCGAGGTTGATGAGGTTCGCCAACAATTAGGGTATAAACACTGCTATCTCGC
AGGTCACTCCTGGGGTGGCATGCTCGCAATGACATACGCAGCAGATCATCAAGACCAACTTGACGGGCTAATCATCATTA
GCATGATCGACAATATTGCCGATTACTTAAAGCGGATGCACGCAATTCGCACCGCGGAGTTTTCACCAGCTGAAAATGCC
TTTATGCTCGCAATTGAAAAACGTCAACAATGGAATAACCCCCACTATCGCCAATTAATAACACACCTCTACCACCAATA
TATCAATCGTTGTCACCCCAGTATGATGCAACATCAACTCGATATTCAAGCCAAGCCCGTTTACAACCATTTTCAAGGCG
ACAACGAGTTTGTCGTTTATGGGGTACTTGATGACTGGGACTTCTCGGATACACTTGCAACAATCCAAGTACCGACACTG
TTAATGTTTGCTGATCACGAAACCATGCCACTAGCAACGGCTGAACGAATGCAACAGCGCATGCCGAACGCAAAGTTAGT
CGTAACACCGGACAGTGGGCATAATCATATGGTCGATAATCCAGCCGTATTCTTTACTTATCTACGAAACTATTTTTCTG
ATCAATTGGGCCGCTAA

Upstream 100 bases:

>100_bases
TTGATACTGGTGAGCAGGCGTCTTCATTAAAATTAGATTTGAAAATAATTAGTTTTTGGCGTATCGTCTATGTCAACCAA
ATAATTAAGGAGGCGTTTTA

Downstream 100 bases:

>100_bases
CAAAGCACCGTTGTCAGTTGCGACAAACGACGCCTCACTAATTGTCAACGCCAGCAACCACAGTGCCACTTTATGGAAAC
ATCTACGCTCACTCGTTTAC

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP; Tricorn protease-interacting factor F1 [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKNVTRILTLSNGYHLWSHTSNLGGRTKLLCLHGGPGDTHEVFERFGPELADLDIEVTMYDQLGSWYSDTPNWDDDAIRQ
QYLTEDYYLSEVDEVRQQLGYKHCYLAGHSWGGMLAMTYAADHQDQLDGLIIISMIDNIADYLKRMHAIRTAEFSPAENA
FMLAIEKRQQWNNPHYRQLITHLYHQYINRCHPSMMQHQLDIQAKPVYNHFQGDNEFVVYGVLDDWDFSDTLATIQVPTL
LMFADHETMPLATAERMQQRMPNAKLVVTPDSGHNHMVDNPAVFFTYLRNYFSDQLGR

Sequences:

>Translated_298_residues
MKNVTRILTLSNGYHLWSHTSNLGGRTKLLCLHGGPGDTHEVFERFGPELADLDIEVTMYDQLGSWYSDTPNWDDDAIRQ
QYLTEDYYLSEVDEVRQQLGYKHCYLAGHSWGGMLAMTYAADHQDQLDGLIIISMIDNIADYLKRMHAIRTAEFSPAENA
FMLAIEKRQQWNNPHYRQLITHLYHQYINRCHPSMMQHQLDIQAKPVYNHFQGDNEFVVYGVLDDWDFSDTLATIQVPTL
LMFADHETMPLATAERMQQRMPNAKLVVTPDSGHNHMVDNPAVFFTYLRNYFSDQLGR
>Mature_298_residues
MKNVTRILTLSNGYHLWSHTSNLGGRTKLLCLHGGPGDTHEVFERFGPELADLDIEVTMYDQLGSWYSDTPNWDDDAIRQ
QYLTEDYYLSEVDEVRQQLGYKHCYLAGHSWGGMLAMTYAADHQDQLDGLIIISMIDNIADYLKRMHAIRTAEFSPAENA
FMLAIEKRQQWNNPHYRQLITHLYHQYINRCHPSMMQHQLDIQAKPVYNHFQGDNEFVVYGVLDDWDFSDTLATIQVPTL
LMFADHETMPLATAERMQQRMPNAKLVVTPDSGHNHMVDNPAVFFTYLRNYFSDQLGR

Specific function: Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus. In conjunction with the three factors F1, F2 and F3, Tricorn degrades oligopeptides in a sequential manner, yielding

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 34596; Mature: 34596

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVTRILTLSNGYHLWSHTSNLGGRTKLLCLHGGPGDTHEVFERFGPELADLDIEVTMY
CCCCEEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCHHCCEEEEEEH
DQLGSWYSDTPNWDDDAIRQQYLTEDYYLSEVDEVRQQLGYKHCYLAGHSWGGMLAMTYA
HHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEE
ADHQDQLDGLIIISMIDNIADYLKRMHAIRTAEFSPAENAFMLAIEKRQQWNNPHYRQLI
CCCCHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHCCCCHHHHHH
THLYHQYINRCHPSMMQHQLDIQAKPVYNHFQGDNEFVVYGVLDDWDFSDTLATIQVPTL
HHHHHHHHHHHCHHHHHHHCCCCCCCCHHHCCCCCCEEEEEEECCCCCCCCEEEEECCEE
LMFADHETMPLATAERMQQRMPNAKLVVTPDSGHNHMVDNPAVFFTYLRNYFSDQLGR
EEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNVTRILTLSNGYHLWSHTSNLGGRTKLLCLHGGPGDTHEVFERFGPELADLDIEVTMY
CCCCEEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCHHCCEEEEEEH
DQLGSWYSDTPNWDDDAIRQQYLTEDYYLSEVDEVRQQLGYKHCYLAGHSWGGMLAMTYA
HHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEE
ADHQDQLDGLIIISMIDNIADYLKRMHAIRTAEFSPAENAFMLAIEKRQQWNNPHYRQLI
CCCCHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHCCCCHHHHHH
THLYHQYINRCHPSMMQHQLDIQAKPVYNHFQGDNEFVVYGVLDDWDFSDTLATIQVPTL
HHHHHHHHHHHCHHHHHHHCCCCCCCCHHHCCCCCCEEEEEEECCCCCCCCEEEEECCEE
LMFADHETMPLATAERMQQRMPNAKLVVTPDSGHNHMVDNPAVFFTYLRNYFSDQLGR
EEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11121031 [H]