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The map label for this gene is natC2 [H]

Identifier: 28379258

GI number: 28379258

Start: 2462812

End: 2464245

Strand: Direct

Name: natC2 [H]

Synonym: lp_2771

Alternate gene names: 28379258

Gene position: 2462812-2464245 (Clockwise)

Preceding gene: 28379256

Following gene: 28379267

Centisome position: 74.44

GC content: 50.07

Gene sequence:

>1434_bases
ATGCGCAATTTATCTTTATTAACCGACTTATACGAACTCTCAATGGCAAATGGATTTCATCACGACTTACCTCAGACCAA
CGCCACCTTCGACCTTTTTTATCGCCGGGTTCCTGACAATGGTAGCTTTGTCATTGCGGCCGGCCTCCAGCAAGTTGTCG
AAGCTTTACAAGATTTTCATTTTACCAACAGTGACCTCGACTACTTCCGTCAACTTAACCTATGGGATGAATCCTTCTTA
GCCATGCTGGCAAATTTTAAGTTAACTTGTCAAATTAAGGCACTACCAGAAGGAACCCCGGTCTTTCCTCGTGAACCACT
ATTGACAATCACTGGGCCACTTGAGCAAGCGCAATTACTTGAAACACTCGCCTTAAATATCGTCAATCACCAATCACTGA
TTGCCACTAAAGCTCGTCGACTGAGTTATGCTGCGGCAGGACGTCCAATTATGGAATTCGGTGCGCGCCGTGCGCAAGGC
CCGGACAGCGCGCTTTACGGCACCCGGGCAGCCATTATTGGTGGCGCCAATAGTACTTCAAACGTTCTCGCTGCGAAGCT
GTTTGATATTCCCGTTGCTGGTACCATGGCCCACAGTTGGATTGAGGCCTTCCCGGATGAACTAACGGCGTTTCGCAAGT
GGGCCGAACAATATCCTGACAATAGTGCGCTACTAGTCGATACTTATGATGTGCTTAACTCTGGGATTCCTAACGCGGTG
ACGGTCTTTAAGGAGCTACGAGCAGCTGGGCATGAACCCGTCGGTATTCGAATCGATTCGGGGGACGTCACGACTTTATC
ACAAGCTGCCCGGACACAATTGGACGCGGCTGGCTTTCCCAATGCCAAAATCACTATTTCTAACGCATTGGATGAACACA
TCATTACTTCGCTGTTGCACGAAGGCGCACCGATCGATAATTTTGGTATCGGTGAAAAGCTCATCACTAGCGCGTCCGCA
CCGGTTCTAAGTGGCGTCTACAAGCTTGCGGCAACTGAGAGCAATGGTCAGAGCACCCCCAAGATCAAGGTCAGTGCCAG
TCGCGAAAAACTAACGATTCCTGGTGATAAGCAAGTCTATCGTCTGTACGAACCAGGAACTCAGCGGGCCTTTGCTGACT
TGATTGCACTAGCTACCGAGACGATCGTCGATGCGACCAGCCTAACCGTCGTCAACAGTGACCCACTCAGTGTCGACCGC
CAACAGCGACTCACCCGTTTTGAAGCCCGGCCCTTACTCGCGCCGGTAGATTTGTCCAACACCACGTCAATTCCGGTTAC
AACCATTCAGGCAACGACCCAGGCTAAACTTGCCGAGCTCCCACGAACAACCCAGCGGCTCGTCAACCCAGATCTTTACC
CGGTCTACATGACAACCACACTCAGCCAGTTACAAACTAGTTTGTTGAATAAAATGACGATACTAGCAGATTAA

Upstream 100 bases:

>100_bases
CCAGTAGAATAGCTTTCATCAAATACTAAATTATGATAAACTAAGTTCATTTATCATAGGTGTCAAGACATCTAAATCTT
AATAACGGGATTGATTAGCA

Downstream 100 bases:

>100_bases
CAAACGAACACGCGTAGCAACGACCAAAGCCACTTCTGTACTTAGCGTTCAAATGACCGCTAAGTACAGAAGTGGCTTTA
GTTTATAACAAGTAACAGTT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MRNLSLLTDLYELSMANGFHHDLPQTNATFDLFYRRVPDNGSFVIAAGLQQVVEALQDFHFTNSDLDYFRQLNLWDESFL
AMLANFKLTCQIKALPEGTPVFPREPLLTITGPLEQAQLLETLALNIVNHQSLIATKARRLSYAAAGRPIMEFGARRAQG
PDSALYGTRAAIIGGANSTSNVLAAKLFDIPVAGTMAHSWIEAFPDELTAFRKWAEQYPDNSALLVDTYDVLNSGIPNAV
TVFKELRAAGHEPVGIRIDSGDVTTLSQAARTQLDAAGFPNAKITISNALDEHIITSLLHEGAPIDNFGIGEKLITSASA
PVLSGVYKLAATESNGQSTPKIKVSASREKLTIPGDKQVYRLYEPGTQRAFADLIALATETIVDATSLTVVNSDPLSVDR
QQRLTRFEARPLLAPVDLSNTTSIPVTTIQATTQAKLAELPRTTQRLVNPDLYPVYMTTTLSQLQTSLLNKMTILAD

Sequences:

>Translated_477_residues
MRNLSLLTDLYELSMANGFHHDLPQTNATFDLFYRRVPDNGSFVIAAGLQQVVEALQDFHFTNSDLDYFRQLNLWDESFL
AMLANFKLTCQIKALPEGTPVFPREPLLTITGPLEQAQLLETLALNIVNHQSLIATKARRLSYAAAGRPIMEFGARRAQG
PDSALYGTRAAIIGGANSTSNVLAAKLFDIPVAGTMAHSWIEAFPDELTAFRKWAEQYPDNSALLVDTYDVLNSGIPNAV
TVFKELRAAGHEPVGIRIDSGDVTTLSQAARTQLDAAGFPNAKITISNALDEHIITSLLHEGAPIDNFGIGEKLITSASA
PVLSGVYKLAATESNGQSTPKIKVSASREKLTIPGDKQVYRLYEPGTQRAFADLIALATETIVDATSLTVVNSDPLSVDR
QQRLTRFEARPLLAPVDLSNTTSIPVTTIQATTQAKLAELPRTTQRLVNPDLYPVYMTTTLSQLQTSLLNKMTILAD
>Mature_477_residues
MRNLSLLTDLYELSMANGFHHDLPQTNATFDLFYRRVPDNGSFVIAAGLQQVVEALQDFHFTNSDLDYFRQLNLWDESFL
AMLANFKLTCQIKALPEGTPVFPREPLLTITGPLEQAQLLETLALNIVNHQSLIATKARRLSYAAAGRPIMEFGARRAQG
PDSALYGTRAAIIGGANSTSNVLAAKLFDIPVAGTMAHSWIEAFPDELTAFRKWAEQYPDNSALLVDTYDVLNSGIPNAV
TVFKELRAAGHEPVGIRIDSGDVTTLSQAARTQLDAAGFPNAKITISNALDEHIITSLLHEGAPIDNFGIGEKLITSASA
PVLSGVYKLAATESNGQSTPKIKVSASREKLTIPGDKQVYRLYEPGTQRAFADLIALATETIVDATSLTVVNSDPLSVDR
QQRLTRFEARPLLAPVDLSNTTSIPVTTIQATTQAKLAELPRTTQRLVNPDLYPVYMTTTLSQLQTSLLNKMTILAD

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=530, Percent_Identity=32.8301886792453, Blast_Score=231, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI71997947, Length=533, Percent_Identity=33.3958724202627, Blast_Score=254, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI71997952, Length=533, Percent_Identity=33.3958724202627, Blast_Score=254, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI71997955, Length=231, Percent_Identity=41.991341991342, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24581587, Length=518, Percent_Identity=35.3281853281853, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI161076680, Length=278, Percent_Identity=37.7697841726619, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24581595, Length=278, Percent_Identity=37.7697841726619, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI28574709, Length=278, Percent_Identity=37.7697841726619, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24581593, Length=278, Percent_Identity=37.7697841726619, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24581591, Length=278, Percent_Identity=37.7697841726619, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 51998; Mature: 51998

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNLSLLTDLYELSMANGFHHDLPQTNATFDLFYRRVPDNGSFVIAAGLQQVVEALQDFH
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHEEECCCCCCEEEHHHHHHHHHHHHHCC
FTNSDLDYFRQLNLWDESFLAMLANFKLTCQIKALPEGTPVFPREPLLTITGPLEQAQLL
CCCCCHHHHHHCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCEEEECCHHHHHHH
ETLALNIVNHQSLIATKARRLSYAAAGRPIMEFGARRAQGPDSALYGTRAAIIGGANSTS
HHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHCCCEEEEECCCCCC
NVLAAKLFDIPVAGTMAHSWIEAFPDELTAFRKWAEQYPDNSALLVDTYDVLNSGIPNAV
HHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCHHH
TVFKELRAAGHEPVGIRIDSGDVTTLSQAARTQLDAAGFPNAKITISNALDEHIITSLLH
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHH
EGAPIDNFGIGEKLITSASAPVLSGVYKLAATESNGQSTPKIKVSASREKLTIPGDKQVY
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHEECCCCCCCCEEEEECCCCEEECCCCCCEE
RLYEPGTQRAFADLIALATETIVDATSLTVVNSDPLSVDRQQRLTRFEARPLLAPVDLSN
EEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEECCCCC
TTSIPVTTIQATTQAKLAELPRTTQRLVNPDLYPVYMTTTLSQLQTSLLNKMTILAD
CCCCCEEEEEHHHHHHHHHCCHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MRNLSLLTDLYELSMANGFHHDLPQTNATFDLFYRRVPDNGSFVIAAGLQQVVEALQDFH
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHEEECCCCCCEEEHHHHHHHHHHHHHCC
FTNSDLDYFRQLNLWDESFLAMLANFKLTCQIKALPEGTPVFPREPLLTITGPLEQAQLL
CCCCCHHHHHHCCCCHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCEEEECCHHHHHHH
ETLALNIVNHQSLIATKARRLSYAAAGRPIMEFGARRAQGPDSALYGTRAAIIGGANSTS
HHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHCCCEEEEECCCCCC
NVLAAKLFDIPVAGTMAHSWIEAFPDELTAFRKWAEQYPDNSALLVDTYDVLNSGIPNAV
HHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCHHH
TVFKELRAAGHEPVGIRIDSGDVTTLSQAARTQLDAAGFPNAKITISNALDEHIITSLLH
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHH
EGAPIDNFGIGEKLITSASAPVLSGVYKLAATESNGQSTPKIKVSASREKLTIPGDKQVY
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHEECCCCCCCCEEEEECCCCEEECCCCCCEE
RLYEPGTQRAFADLIALATETIVDATSLTVVNSDPLSVDRQQRLTRFEARPLLAPVDLSN
EEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEECCCCC
TTSIPVTTIQATTQAKLAELPRTTQRLVNPDLYPVYMTTTLSQLQTSLLNKMTILAD
CCCCCEEEEEHHHHHHHHHCCHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]