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The map label for this gene is yfnA [H]

Identifier: 28378406

GI number: 28378406

Start: 1559482

End: 1560981

Strand: Direct

Name: yfnA [H]

Synonym: lp_1722

Alternate gene names: 28378406

Gene position: 1559482-1560981 (Clockwise)

Preceding gene: 28378405

Following gene: 28378408

Centisome position: 47.14

GC content: 48.0

Gene sequence:

>1500_bases
ATGCAACGGTTATTAAAACGGTTAACTTTAAAGGAAGATCCAAGCATATATGAAGACAAAGATTCTCACCTAGCTCGAGT
ATTGACGGTCAAGGACTTCTTGGCTTTAGGGGTGGGGACGATTGTTTCAACGTCAATTTTTACATTACCCGGAGTGGTGG
CTGCGAACCATGCGGGCCCTGCGGTAGTCTTCTCATTCATCGTCGCAGCCGTCGTTGCCGGCCTGGTTGCATTTGCTTAT
GCTGAAATGGCGGCGGCGATGCCGTTTGCCGGTTCTGCTTATTCGTGGATCAACGTAATGTTCGGTGAATTCTTTGGTTG
GATCGCTGGTTGGGCGTTGCTTGCGGAGTACTTTATTGCGTTGGCATTCGTCGGTTCAGGACTGTCCGCCAATCTGCGGG
GGCTCTTGTCACCATTAGGACTAACTCTACCGAAAGCTTTGTCAAATACGTTTGGGACTGATGGTGGTGTGGTCGACCTG
ATTGCCGTCTTGGTGATTGCGCTGGTCTCGTTACTGCTCTCACGTGGAATCAGTAAGGCCTCCCGGGTCGAAAACGTGTT
AGTGGTGTTGAAAGTGTTAGCCGTACTCACGTTTATCGTCGTGGGTGCGACGGCGATCCACGTGCAAAACTACGTCCCGT
TTATCCCCAAGTATCATTTAAACGCTGATGGTAGTGCTTTTGGGGGCTGGCAAGGAATTTATGCCGGGGTATCGATGATT
TTCTTAGCTTATATTGGGTTTGATTCGATTGCCGCTAATTCAGCGGAAGCTAAGAATCCTGGCAAAACAATGCCACGAGG
AATTCTTGGTTCACTCGTCATTGCGGTGGTACTCTTTGTGGCTGTTGCTTTGGTCTTAGTCGGTATGTTCAAATATTCAT
CATATGCTAATAACGCTGAACCAGTCGGCTGGGCATTACGACAAGCTGGCCATCCGATTGTTGCCAGTGTTATTCAGGCC
ATTGCCGTGCTGGGAATGTTTACTGCGCTGATTGGGATGACTTTAGCAGGGTCACGGCTAATTTATTCCTTTGGGCGTGA
TGGTATGTTACCTAAGTGGCTTGGCAAGTTACATCGTAATCAACCTAATAACGCGCTACTTGTGTTAACAATCGTTGCTA
TTATCATTGGGGCGTTTTGCCCGTTTGCTTTTCTGGCCCAATTGATTTCAGCGGGAACCCTGATTGCCTTCATGTTTGTC
TCGCTGGGAATCTATGCTTTGCGGCGTCGTGAAGGTGTTGATATTGCGGTACCAGCCTTTAAGATGCCGTTCTATCCAGT
TTTACCAGCTATTGCCTTTCTAGGCGCACTGTTCGTTTTTATGGGCTTAGATATCCAGGCAAAATTATACGCGGGCGTGT
GGTTCATCGTCGGTTTAGTGATCTACTTTAGCTATGGTATGCGTCACTCATATTTGGCTGAAAAACGTCTGTCTGAGACT
GATACTGCGGCTAAATCAGCTTCGAAGGTGGCTGATTCGACTGTTGAAGAGCGTGACTGA

Upstream 100 bases:

>100_bases
ACTGCGTTAACCGTATTAGATGAGGCAATGGCTGCTGCTGAACAGGGCCTGGTTAAACGGCCCCAAGGCAAGATTGGTTG
GTAAAATAAGGAGGATTTTG

Downstream 100 bases:

>100_bases
GCTTAGCTAACGCAAGCCCTTGATAGTTGAACAACAACTAAAATGGCACTTCCAGAATTGAATTTTATCTGGAAGTGCCA
TTTTTGAGTGGTGATTACGA

Product: amino acid transport protein

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MQRLLKRLTLKEDPSIYEDKDSHLARVLTVKDFLALGVGTIVSTSIFTLPGVVAANHAGPAVVFSFIVAAVVAGLVAFAY
AEMAAAMPFAGSAYSWINVMFGEFFGWIAGWALLAEYFIALAFVGSGLSANLRGLLSPLGLTLPKALSNTFGTDGGVVDL
IAVLVIALVSLLLSRGISKASRVENVLVVLKVLAVLTFIVVGATAIHVQNYVPFIPKYHLNADGSAFGGWQGIYAGVSMI
FLAYIGFDSIAANSAEAKNPGKTMPRGILGSLVIAVVLFVAVALVLVGMFKYSSYANNAEPVGWALRQAGHPIVASVIQA
IAVLGMFTALIGMTLAGSRLIYSFGRDGMLPKWLGKLHRNQPNNALLVLTIVAIIIGAFCPFAFLAQLISAGTLIAFMFV
SLGIYALRRREGVDIAVPAFKMPFYPVLPAIAFLGALFVFMGLDIQAKLYAGVWFIVGLVIYFSYGMRHSYLAEKRLSET
DTAAKSASKVADSTVEERD

Sequences:

>Translated_499_residues
MQRLLKRLTLKEDPSIYEDKDSHLARVLTVKDFLALGVGTIVSTSIFTLPGVVAANHAGPAVVFSFIVAAVVAGLVAFAY
AEMAAAMPFAGSAYSWINVMFGEFFGWIAGWALLAEYFIALAFVGSGLSANLRGLLSPLGLTLPKALSNTFGTDGGVVDL
IAVLVIALVSLLLSRGISKASRVENVLVVLKVLAVLTFIVVGATAIHVQNYVPFIPKYHLNADGSAFGGWQGIYAGVSMI
FLAYIGFDSIAANSAEAKNPGKTMPRGILGSLVIAVVLFVAVALVLVGMFKYSSYANNAEPVGWALRQAGHPIVASVIQA
IAVLGMFTALIGMTLAGSRLIYSFGRDGMLPKWLGKLHRNQPNNALLVLTIVAIIIGAFCPFAFLAQLISAGTLIAFMFV
SLGIYALRRREGVDIAVPAFKMPFYPVLPAIAFLGALFVFMGLDIQAKLYAGVWFIVGLVIYFSYGMRHSYLAEKRLSET
DTAAKSASKVADSTVEERD
>Mature_499_residues
MQRLLKRLTLKEDPSIYEDKDSHLARVLTVKDFLALGVGTIVSTSIFTLPGVVAANHAGPAVVFSFIVAAVVAGLVAFAY
AEMAAAMPFAGSAYSWINVMFGEFFGWIAGWALLAEYFIALAFVGSGLSANLRGLLSPLGLTLPKALSNTFGTDGGVVDL
IAVLVIALVSLLLSRGISKASRVENVLVVLKVLAVLTFIVVGATAIHVQNYVPFIPKYHLNADGSAFGGWQGIYAGVSMI
FLAYIGFDSIAANSAEAKNPGKTMPRGILGSLVIAVVLFVAVALVLVGMFKYSSYANNAEPVGWALRQAGHPIVASVIQA
IAVLGMFTALIGMTLAGSRLIYSFGRDGMLPKWLGKLHRNQPNNALLVLTIVAIIIGAFCPFAFLAQLISAGTLIAFMFV
SLGIYALRRREGVDIAVPAFKMPFYPVLPAIAFLGALFVFMGLDIQAKLYAGVWFIVGLVIYFSYGMRHSYLAEKRLSET
DTAAKSASKVADSTVEERD

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Phenylalanine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=406, Percent_Identity=32.2660098522167, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI258645169, Length=422, Percent_Identity=29.1469194312796, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI258614005, Length=422, Percent_Identity=29.1469194312796, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI258614003, Length=422, Percent_Identity=29.1469194312796, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI4507047, Length=432, Percent_Identity=29.6296296296296, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI114326544, Length=439, Percent_Identity=29.3849658314351, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI114326550, Length=439, Percent_Identity=29.3849658314351, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI110347453, Length=413, Percent_Identity=30.5084745762712, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI33286428, Length=351, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786789, Length=444, Percent_Identity=22.7477477477477, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082250, Length=359, Percent_Identity=26.7409470752089, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790653, Length=486, Percent_Identity=23.4567901234568, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786602, Length=479, Percent_Identity=23.3820459290188, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081869, Length=417, Percent_Identity=23.7410071942446, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788480, Length=458, Percent_Identity=23.5807860262009, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081708, Length=452, Percent_Identity=18.5840707964602, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=21.5859030837004, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081915, Length=405, Percent_Identity=21.9753086419753, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI2367353, Length=367, Percent_Identity=23.7057220708447, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789017, Length=423, Percent_Identity=23.8770685579196, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994972, Length=476, Percent_Identity=20.1680672268908, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786694, Length=396, Percent_Identity=23.2323232323232, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=425, Percent_Identity=29.1764705882353, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17533459, Length=408, Percent_Identity=31.8627450980392, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17532491, Length=460, Percent_Identity=27.6086956521739, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=539, Percent_Identity=20.9647495361781, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321629, Length=453, Percent_Identity=22.7373068432671, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24668806, Length=434, Percent_Identity=31.5668202764977, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI21356285, Length=434, Percent_Identity=31.5668202764977, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24668802, Length=434, Percent_Identity=31.5668202764977, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI221512776, Length=423, Percent_Identity=31.6784869976359, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24666159, Length=423, Percent_Identity=31.6784869976359, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI161077963, Length=423, Percent_Identity=30.2600472813239, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI281366235, Length=422, Percent_Identity=30.0947867298578, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI116007820, Length=422, Percent_Identity=30.0947867298578, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI116007818, Length=415, Percent_Identity=31.0843373493976, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI85725152, Length=415, Percent_Identity=31.0843373493976, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24667468, Length=404, Percent_Identity=31.1881188118812, Blast_Score=141, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53153; Mature: 53153

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]