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The map label for this gene is gabT [H]

Identifier: 28378405

GI number: 28378405

Start: 1558116

End: 1559465

Strand: Direct

Name: gabT [H]

Synonym: lp_1721

Alternate gene names: 28378405

Gene position: 1558116-1559465 (Clockwise)

Preceding gene: 28378404

Following gene: 28378406

Centisome position: 47.1

GC content: 49.56

Gene sequence:

>1350_bases
ATGATTAGTCAAAACCATCGTTTGGATCAGCAACTTATTGAACGTGAAGACCATTATATGGCGACGGCGGCACGAATCAA
TTACTATGATTTAGTTATTGACCATGCTCACGGGGCCCTGCTTACCGATGTTGATGGCAACCAATACATCGATTTGTTAG
CCAGTGCTTCGGCCATTAACGTGGGCCATACGCACCCTCGCGTTGTTAAGGCCATTCAGGAACAGGCAGCCAAGTTGATT
CATTACACGCCAGCATATTTTCATCATCAACCGGAACAACGATTGGCTGAGCGACTGGCAAAATCAGCTCCCGGCACTGA
TAATGAGGTGGTTTTTGGTAACTCTGGTTCGGATGCCAATGATGCCATTATTAAATTTGCACGGGCCTATACTAACCGAC
AATACATAGTCGCCTATACGGATGCCTATCATGGTTCAACGTATGGCTCAATGTCACTCTCAGGAGTTAGCCTGAATATG
GTCCGTAAGATGGGACCGTTACTACCTGGGATCGTGCACGTCCCGTATCCTGATTGTTATCGTACGTTGCCGCATGAGAC
GGAACATGAACTTGCATTACGCTATTTTGAAGCGTTCAAGGCACCATTTGACTCATACTTACCAGCGGAGGAAACCGCGT
GCGTCATTATTGAACCGATTCAAGGTGATGGCGGTATCCGCAAGGCACCAGCAGAGTATGTCCAATTAGTCTATGACTTT
TGTCACCAGCACGGTATCTTATTTGCCGTCGACGAGGTCAATCAAGGGATGGGACGAACCGGGAAGATGTGGAGCATTCA
AAACTTCCCGGGAATCCGCCCGGACTTAATGTCCGTTGGCAAATCACTGGCTTCGGGATTACCACTTAGTGCAGTGATCG
GTCGCCGTGAAGTGATGGAGAGTCTAGCAGCGCCGGCGCACACCTTTACGACGGCGGCCAATCCGGTTTGTTGTGCGGCG
GCGCTGGCGACAATCGACGTTCTAGCAGATGAACAGTTGGTTGCCCGTTCCGCCAATTATGGCCGCTATGCCAAGGAACA
GTTTTTAGCGCTTCAACAACGCCATCCTAAAATTGGGCAGGTACGGATGTACGGGCTGAACGGGGGCATTGAATTGGTGA
CAGACCGGCAGAGTCAGCAACCTGATCCTGATTTTGCCAGTGACGTCATTTATGCCGCTTTTGAACGGGGTGTCGTCATG
ATAACGCTCAAAGGAAATATTTTGCGGTTCCAACCACCACTAGTCATCACGAAGACGCAATTAGATACTGCGTTAACCGT
ATTAGATGAGGCAATGGCTGCTGCTGAACAGGGCCTGGTTAAACGGCCCCAAGGCAAGATTGGTTGGTAA

Upstream 100 bases:

>100_bases
TAAAGACGGGTATTTGTAAACAAAAATATGGGCGCAAGGGCTTGCATAGAAATTAAAATATGATTAAAATAAGTCTTATT
AAATTAATGGAGGCTTGCGA

Downstream 100 bases:

>100_bases
AATAAGGAGGATTTTGATGCAACGGTTATTAAAACGGTTAACTTTAAAGGAAGATCCAAGCATATATGAAGACAAAGATT
CTCACCTAGCTCGAGTATTG

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MISQNHRLDQQLIEREDHYMATAARINYYDLVIDHAHGALLTDVDGNQYIDLLASASAINVGHTHPRVVKAIQEQAAKLI
HYTPAYFHHQPEQRLAERLAKSAPGTDNEVVFGNSGSDANDAIIKFARAYTNRQYIVAYTDAYHGSTYGSMSLSGVSLNM
VRKMGPLLPGIVHVPYPDCYRTLPHETEHELALRYFEAFKAPFDSYLPAEETACVIIEPIQGDGGIRKAPAEYVQLVYDF
CHQHGILFAVDEVNQGMGRTGKMWSIQNFPGIRPDLMSVGKSLASGLPLSAVIGRREVMESLAAPAHTFTTAANPVCCAA
ALATIDVLADEQLVARSANYGRYAKEQFLALQQRHPKIGQVRMYGLNGGIELVTDRQSQQPDPDFASDVIYAAFERGVVM
ITLKGNILRFQPPLVITKTQLDTALTVLDEAMAAAEQGLVKRPQGKIGW

Sequences:

>Translated_449_residues
MISQNHRLDQQLIEREDHYMATAARINYYDLVIDHAHGALLTDVDGNQYIDLLASASAINVGHTHPRVVKAIQEQAAKLI
HYTPAYFHHQPEQRLAERLAKSAPGTDNEVVFGNSGSDANDAIIKFARAYTNRQYIVAYTDAYHGSTYGSMSLSGVSLNM
VRKMGPLLPGIVHVPYPDCYRTLPHETEHELALRYFEAFKAPFDSYLPAEETACVIIEPIQGDGGIRKAPAEYVQLVYDF
CHQHGILFAVDEVNQGMGRTGKMWSIQNFPGIRPDLMSVGKSLASGLPLSAVIGRREVMESLAAPAHTFTTAANPVCCAA
ALATIDVLADEQLVARSANYGRYAKEQFLALQQRHPKIGQVRMYGLNGGIELVTDRQSQQPDPDFASDVIYAAFERGVVM
ITLKGNILRFQPPLVITKTQLDTALTVLDEAMAAAEQGLVKRPQGKIGW
>Mature_449_residues
MISQNHRLDQQLIEREDHYMATAARINYYDLVIDHAHGALLTDVDGNQYIDLLASASAINVGHTHPRVVKAIQEQAAKLI
HYTPAYFHHQPEQRLAERLAKSAPGTDNEVVFGNSGSDANDAIIKFARAYTNRQYIVAYTDAYHGSTYGSMSLSGVSLNM
VRKMGPLLPGIVHVPYPDCYRTLPHETEHELALRYFEAFKAPFDSYLPAEETACVIIEPIQGDGGIRKAPAEYVQLVYDF
CHQHGILFAVDEVNQGMGRTGKMWSIQNFPGIRPDLMSVGKSLASGLPLSAVIGRREVMESLAAPAHTFTTAANPVCCAA
ALATIDVLADEQLVARSANYGRYAKEQFLALQQRHPKIGQVRMYGLNGGIELVTDRQSQQPDPDFASDVIYAAFERGVVM
ITLKGNILRFQPPLVITKTQLDTALTVLDEAMAAAEQGLVKRPQGKIGW

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=32.6923076923077, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=32.8282828282828, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI13994255, Length=424, Percent_Identity=28.5377358490566, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI226442705, Length=416, Percent_Identity=32.2115384615385, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=29.8329355608592, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4557809, Length=435, Percent_Identity=28.0459770114943, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI284507298, Length=328, Percent_Identity=26.219512195122, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI188536080, Length=438, Percent_Identity=25.1141552511416, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI38679950, Length=438, Percent_Identity=25.1141552511416, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI38679946, Length=438, Percent_Identity=25.1141552511416, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1789016, Length=408, Percent_Identity=32.3529411764706, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1787560, Length=401, Percent_Identity=33.1670822942643, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI145693181, Length=404, Percent_Identity=32.6732673267327, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=29.3827160493827, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1788044, Length=411, Percent_Identity=28.7104622871046, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786349, Length=303, Percent_Identity=29.7029702970297, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1786991, Length=444, Percent_Identity=27.9279279279279, Blast_Score=121, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=450, Percent_Identity=31.1111111111111, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=29.6803652968037, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25144271, Length=434, Percent_Identity=29.0322580645161, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=424, Percent_Identity=27.122641509434, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71981843, Length=215, Percent_Identity=28.3720930232558, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17541228, Length=435, Percent_Identity=22.0689655172414, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=436, Percent_Identity=29.3577981651376, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6324432, Length=417, Percent_Identity=28.7769784172662, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324386, Length=461, Percent_Identity=25.5965292841649, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI161085790, Length=445, Percent_Identity=33.2584269662921, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI28574759, Length=449, Percent_Identity=33.630289532294, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21356575, Length=439, Percent_Identity=30.2961275626424, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21357415, Length=431, Percent_Identity=27.8422273781903, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 49492; Mature: 49492

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISQNHRLDQQLIEREDHYMATAARINYYDLVIDHAHGALLTDVDGNQYIDLLASASAIN
CCCCCCCHHHHHHHCCCCCEEHHHCCEEEEEEEECCCCCEEEECCCCHHHHHHHCCCEEE
VGHTHPRVVKAIQEQAAKLIHYTPAYFHHQPEQRLAERLAKSAPGTDNEVVFGNSGSDAN
CCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCHH
DAIIKFARAYTNRQYIVAYTDAYHGSTYGSMSLSGVSLNMVRKMGPLLPGIVHVPYPDCY
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCHHHHHHHHCCCCCCEEECCCCHHH
RTLPHETEHELALRYFEAFKAPFDSYLPAEETACVIIEPIQGDGGIRKAPAEYVQLVYDF
HCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHH
CHQHGILFAVDEVNQGMGRTGKMWSIQNFPGIRPDLMSVGKSLASGLPLSAVIGRREVME
HHHCCCEEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
SLAAPAHTFTTAANPVCCAAALATIDVLADEQLVARSANYGRYAKEQFLALQQRHPKIGQ
HHCCCCHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
VRMYGLNGGIELVTDRQSQQPDPDFASDVIYAAFERGVVMITLKGNILRFQPPLVITKTQ
EEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCEEEECCCEEEEECH
LDTALTVLDEAMAAAEQGLVKRPQGKIGW
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MISQNHRLDQQLIEREDHYMATAARINYYDLVIDHAHGALLTDVDGNQYIDLLASASAIN
CCCCCCCHHHHHHHCCCCCEEHHHCCEEEEEEEECCCCCEEEECCCCHHHHHHHCCCEEE
VGHTHPRVVKAIQEQAAKLIHYTPAYFHHQPEQRLAERLAKSAPGTDNEVVFGNSGSDAN
CCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCHH
DAIIKFARAYTNRQYIVAYTDAYHGSTYGSMSLSGVSLNMVRKMGPLLPGIVHVPYPDCY
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCHHHHHHHHCCCCCCEEECCCCHHH
RTLPHETEHELALRYFEAFKAPFDSYLPAEETACVIIEPIQGDGGIRKAPAEYVQLVYDF
HCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHH
CHQHGILFAVDEVNQGMGRTGKMWSIQNFPGIRPDLMSVGKSLASGLPLSAVIGRREVME
HHHCCCEEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
SLAAPAHTFTTAANPVCCAAALATIDVLADEQLVARSANYGRYAKEQFLALQQRHPKIGQ
HHCCCCHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
VRMYGLNGGIELVTDRQSQQPDPDFASDVIYAAFERGVVMITLKGNILRFQPPLVITKTQ
EEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCEEEECCCEEEEECH
LDTALTVLDEAMAAAEQGLVKRPQGKIGW
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]