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The map label for this gene is menA [H]

Identifier: 28378401

GI number: 28378401

Start: 1555082

End: 1555999

Strand: Direct

Name: menA [H]

Synonym: lp_1715

Alternate gene names: 28378401

Gene position: 1555082-1555999 (Clockwise)

Preceding gene: 28378400

Following gene: 28378402

Centisome position: 47.01

GC content: 45.32

Gene sequence:

>918_bases
ATGTTTAAAAAATGGCTAACTTGGCCAGTATTCTATGAGCTGACAGAAATTTATACGGCACCACTTAATATCATGTGGTT
TGTTCTCGGAAGCGCCATTGCGCAGTATCACTTAGGTACGGTGAATTGGCTTAACGTGACGCTGTGTTTAGTTAGCGTAT
TTATTTTTGATTTAGCCGTCAATGTTTCTGATAATTATTATGATTATCGGCATGCTCGTGATCGGGAAGGCTATGCGCAG
AAGACGAATCCGATTGGTCGCTTGCAGTTACCCGTAGCGGGTGTCGGCCGCTTAGCATTGGGATTGTACCTGATTTCATT
GATTCCCGGAATCTGGCTTGTCATGCGGACTGGGTGGTTAGTGCTCGTCCTTGGATTAGTTGGCTATGTGATTGGTATTT
TTTACACAGCTGGGCCCTATCCAATCAACGCGACCCCGCTGTGTGAGACGGTCGTGGCGTTAGCAATTGCATTTTTAATT
GAATTGACCTGTGTGGTCGTATCGACGTATGGACAGCATCCGTTGACTTGGTCGATCGTTGGAACGACTTTCTTACTATG
TTTACCACTGACCCTGATTTTCTTTTGCCTACAACTGGCTAATAACACAGCGGACCGTGATGAAGATATTTTGAATCATC
GCTACACCTTGGCCTACTACCTTGGTAAACCAGGTTCGGTACGGCTGATTCAAGCGTTTTTAGTTATTGGTGGCATTTGG
CCGCTCGTGAACGTCTTACTGGGACTGGCACCCGTTGTTACGATTTGGGTCGTACTCTTACTACCAATTATGTGGCAAGG
TATGCGCCCGTTCTTTGAGGTGCAAGATAAAAAGAAGACGTTTATTACGACGGTCAAGAGTGCCTCGCTGTTCTTCATTC
TATACCCAGTGCTATTTGTTTTAGGGACTTGGTTGTAA

Upstream 100 bases:

>100_bases
TTGTTAAAATTTGATAGTTAAAGTCTTCGACGGTGACGATGGTCAATAAGGTCCCAATAGATAATTAACGATTTAAATAA
CCGGTGGGGGAGTTGTTAAA

Downstream 100 bases:

>100_bases
CAAATTAGTAAAGCTCACTTAATTTTTCGCACTTATCGTGGTTATTTTTATGAAAGTGGACTATATTATTACCAGTTTAT
AAAATAGGGGTAAGCAGGAT

Product: prenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MFKKWLTWPVFYELTEIYTAPLNIMWFVLGSAIAQYHLGTVNWLNVTLCLVSVFIFDLAVNVSDNYYDYRHARDREGYAQ
KTNPIGRLQLPVAGVGRLALGLYLISLIPGIWLVMRTGWLVLVLGLVGYVIGIFYTAGPYPINATPLCETVVALAIAFLI
ELTCVVVSTYGQHPLTWSIVGTTFLLCLPLTLIFFCLQLANNTADRDEDILNHRYTLAYYLGKPGSVRLIQAFLVIGGIW
PLVNVLLGLAPVVTIWVVLLLPIMWQGMRPFFEVQDKKKTFITTVKSASLFFILYPVLFVLGTWL

Sequences:

>Translated_305_residues
MFKKWLTWPVFYELTEIYTAPLNIMWFVLGSAIAQYHLGTVNWLNVTLCLVSVFIFDLAVNVSDNYYDYRHARDREGYAQ
KTNPIGRLQLPVAGVGRLALGLYLISLIPGIWLVMRTGWLVLVLGLVGYVIGIFYTAGPYPINATPLCETVVALAIAFLI
ELTCVVVSTYGQHPLTWSIVGTTFLLCLPLTLIFFCLQLANNTADRDEDILNHRYTLAYYLGKPGSVRLIQAFLVIGGIW
PLVNVLLGLAPVVTIWVVLLLPIMWQGMRPFFEVQDKKKTFITTVKSASLFFILYPVLFVLGTWL
>Mature_305_residues
MFKKWLTWPVFYELTEIYTAPLNIMWFVLGSAIAQYHLGTVNWLNVTLCLVSVFIFDLAVNVSDNYYDYRHARDREGYAQ
KTNPIGRLQLPVAGVGRLALGLYLISLIPGIWLVMRTGWLVLVLGLVGYVIGIFYTAGPYPINATPLCETVVALAIAFLI
ELTCVVVSTYGQHPLTWSIVGTTFLLCLPLTLIFFCLQLANNTADRDEDILNHRYTLAYYLGKPGSVRLIQAFLVIGGIW
PLVNVLLGLAPVVTIWVVLLLPIMWQGMRPFFEVQDKKKTFITTVKSASLFFILYPVLFVLGTWL

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34392; Mature: 34392

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKWLTWPVFYELTEIYTAPLNIMWFVLGSAIAQYHLGTVNWLNVTLCLVSVFIFDLAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NVSDNYYDYRHARDREGYAQKTNPIGRLQLPVAGVGRLALGLYLISLIPGIWLVMRTGWL
CCCCCCHHHHHCCCCCCCHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVLGLVGYVIGIFYTAGPYPINATPLCETVVALAIAFLIELTCVVVSTYGQHPLTWSIV
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHH
GTTFLLCLPLTLIFFCLQLANNTADRDEDILNHRYTLAYYLGKPGSVRLIQAFLVIGGIW
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHH
PLVNVLLGLAPVVTIWVVLLLPIMWQGMRPFFEVQDKKKTFITTVKSASLFFILYPVLFV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LGTWL
HHCCC
>Mature Secondary Structure
MFKKWLTWPVFYELTEIYTAPLNIMWFVLGSAIAQYHLGTVNWLNVTLCLVSVFIFDLAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NVSDNYYDYRHARDREGYAQKTNPIGRLQLPVAGVGRLALGLYLISLIPGIWLVMRTGWL
CCCCCCHHHHHCCCCCCCHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVLGLVGYVIGIFYTAGPYPINATPLCETVVALAIAFLIELTCVVVSTYGQHPLTWSIV
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHH
GTTFLLCLPLTLIFFCLQLANNTADRDEDILNHRYTLAYYLGKPGSVRLIQAFLVIGGIW
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHH
PLVNVLLGLAPVVTIWVVLLLPIMWQGMRPFFEVQDKKKTFITTVKSASLFFILYPVLFV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LGTWL
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]