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The map label for this gene is lysA [H]

Identifier: 28378400

GI number: 28378400

Start: 1553351

End: 1554676

Strand: Direct

Name: lysA [H]

Synonym: lp_1713

Alternate gene names: 28378400

Gene position: 1553351-1554676 (Clockwise)

Preceding gene: 28378399

Following gene: 28378401

Centisome position: 46.95

GC content: 48.11

Gene sequence:

>1326_bases
GTGAACGAACAAATTAAGACGGATGCATTAAATTCGGCGCACCATTTAATGGTCGGGGGCGTCGATACATTGACCCTTGC
AAAAAAATATCAAACACCGCTGTATGTCTATGATACCGGTGCAATTCGTGCCGAAATCGCAGCATTCAAGCAAGTTTTTG
AAGAAAACCACGTGGACTATCAAATCAGTTATGCTAGTAAGGCGTTTGCAACGGTCGCGATGTATCAATTGATCGCCCAA
GAACACATTCATTGTGATGTGGTTTCTGGTGGTGAATTGTATACCGCCCAACAAGCAGATTTCCCAATGGCCGCCGTCTC
GTTTCACGGTAATAACAAGTCACTGGCCGAGCTAACCATGGCCTTAGATGCCGGTGTTGGTACCATCGTGGTCGATAATT
TCGGTGAACTACGACAACTGACGACGTTGACGACGCAACGGCAACAGCCGACCACGATTATGTTGCGGATTGCCCCAGGG
ATCTCAGCGCATACGCATGATTACATTTCAACTGGTCAGGCCGATTCTAAGTTTGGATTTGATTTGGACAGTGGGCAAGC
AGACCAGGCTATCAAAGCCGCGCAAGCCGCACCATATTTGAAACTGGTTGGGATTCATTGTCACATTGGGTCACAGATTT
TTGAAGTGAATGGTTTTGAGATGATTGTTGATAAGCTCGTTAGTGAGTTTGCTCGCTGGCAACGCGAACTTGATTTTTAC
CCACAGATCATGAATGTGGGGGGTGGCTTTGGCGTGAAGTACACTGCCGAAGATCATCCGCTGCAGCCAACCGATTTTGT
CGATGCAATTATTAAGGAAACGCGCGCGCAAACTGCAGCCCAACAAGTTCCAATGTTAGAAATCTGGATCGAGCCTGGAC
GCTCGTTAGTCGCTACCGCTGGGATGACCCTGTATACGATTGGCGATGAGAAGGATATTCCGGGCATTCGGAAGTATTTG
TCTGTTGACGGAGGTATGGGTGATAATATTCGGCCAGCTTTATATCAGGCCAAGTATGAAGCGGTATTAGCCAAGAATCC
GGCCTTACCAGCTGAACAGGTAGCCTCGATTGCTGGTAAATACTGTGAGTCAGGTGATATGTTGATCTGGAATCAGCAAT
TACCGGCCACTGCACCAGGCGACGTGTTAGCGGTCCTAGATACCGGTGCATACGGTTATTCGATGGCTAGCAACTACAAT
CGGAATCCACGACCTGCCGTTGTTTTTTGTGAACAGGGACATAGTCAACTTGTTGTGCAGCGTGAAAGCTATGCTGACTT
AACACGGCTGGACCTCCCACTCTCAGTGCCGGAGAAAACCAAGTAG

Upstream 100 bases:

>100_bases
CTTAAAGAGCGACGAAGAAGCAGAATAGGTTGTTCATTGCCGGACCGGTCGAATATGACGTGGCCGGCTTTTTTTAAAAG
TTTAGAAGGTAGGTTAAACT

Downstream 100 bases:

>100_bases
ATTAGTCACCAAAAAGCATTTCAAGAGTTGGGCTCTTGAAATGCTTTTTTAGGTCTGTTGCTGTCGTCGAAGGGCTTGTG
GCAACGTTTGACTAGGATCA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNEQIKTDALNSAHHLMVGGVDTLTLAKKYQTPLYVYDTGAIRAEIAAFKQVFEENHVDYQISYASKAFATVAMYQLIAQ
EHIHCDVVSGGELYTAQQADFPMAAVSFHGNNKSLAELTMALDAGVGTIVVDNFGELRQLTTLTTQRQQPTTIMLRIAPG
ISAHTHDYISTGQADSKFGFDLDSGQADQAIKAAQAAPYLKLVGIHCHIGSQIFEVNGFEMIVDKLVSEFARWQRELDFY
PQIMNVGGGFGVKYTAEDHPLQPTDFVDAIIKETRAQTAAQQVPMLEIWIEPGRSLVATAGMTLYTIGDEKDIPGIRKYL
SVDGGMGDNIRPALYQAKYEAVLAKNPALPAEQVASIAGKYCESGDMLIWNQQLPATAPGDVLAVLDTGAYGYSMASNYN
RNPRPAVVFCEQGHSQLVVQRESYADLTRLDLPLSVPEKTK

Sequences:

>Translated_441_residues
MNEQIKTDALNSAHHLMVGGVDTLTLAKKYQTPLYVYDTGAIRAEIAAFKQVFEENHVDYQISYASKAFATVAMYQLIAQ
EHIHCDVVSGGELYTAQQADFPMAAVSFHGNNKSLAELTMALDAGVGTIVVDNFGELRQLTTLTTQRQQPTTIMLRIAPG
ISAHTHDYISTGQADSKFGFDLDSGQADQAIKAAQAAPYLKLVGIHCHIGSQIFEVNGFEMIVDKLVSEFARWQRELDFY
PQIMNVGGGFGVKYTAEDHPLQPTDFVDAIIKETRAQTAAQQVPMLEIWIEPGRSLVATAGMTLYTIGDEKDIPGIRKYL
SVDGGMGDNIRPALYQAKYEAVLAKNPALPAEQVASIAGKYCESGDMLIWNQQLPATAPGDVLAVLDTGAYGYSMASNYN
RNPRPAVVFCEQGHSQLVVQRESYADLTRLDLPLSVPEKTK
>Mature_441_residues
MNEQIKTDALNSAHHLMVGGVDTLTLAKKYQTPLYVYDTGAIRAEIAAFKQVFEENHVDYQISYASKAFATVAMYQLIAQ
EHIHCDVVSGGELYTAQQADFPMAAVSFHGNNKSLAELTMALDAGVGTIVVDNFGELRQLTTLTTQRQQPTTIMLRIAPG
ISAHTHDYISTGQADSKFGFDLDSGQADQAIKAAQAAPYLKLVGIHCHIGSQIFEVNGFEMIVDKLVSEFARWQRELDFY
PQIMNVGGGFGVKYTAEDHPLQPTDFVDAIIKETRAQTAAQQVPMLEIWIEPGRSLVATAGMTLYTIGDEKDIPGIRKYL
SVDGGMGDNIRPALYQAKYEAVLAKNPALPAEQVASIAGKYCESGDMLIWNQQLPATAPGDVLAVLDTGAYGYSMASNYN
RNPRPAVVFCEQGHSQLVVQRESYADLTRLDLPLSVPEKTK

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=426, Percent_Identity=28.8732394366197, Blast_Score=139, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48264; Mature: 48264

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQIKTDALNSAHHLMVGGVDTLTLAKKYQTPLYVYDTGAIRAEIAAFKQVFEENHVDY
CCCCCCCHHCCCCCEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCE
QISYASKAFATVAMYQLIAQEHIHCDVVSGGELYTAQQADFPMAAVSFHGNNKSLAELTM
EEECHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCCEEEEEEECCCCHHHHHHH
ALDAGVGTIVVDNFGELRQLTTLTTQRQQPTTIMLRIAPGISAHTHDYISTGQADSKFGF
HHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCC
DLDSGQADQAIKAAQAAPYLKLVGIHCHIGSQIFEVNGFEMIVDKLVSEFARWQRELDFY
CCCCCCHHHHHHHHHCCCCEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHCCC
PQIMNVGGGFGVKYTAEDHPLQPTDFVDAIIKETRAQTAAQQVPMLEIWIEPGRSLVATA
HHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEC
GMTLYTIGDEKDIPGIRKYLSVDGGMGDNIRPALYQAKYEAVLAKNPALPAEQVASIAGK
CEEEEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHH
YCESGDMLIWNQQLPATAPGDVLAVLDTGAYGYSMASNYNRNPRPAVVFCEQGHSQLVVQ
HCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEECCCCEEEEE
RESYADLTRLDLPLSVPEKTK
ECCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNEQIKTDALNSAHHLMVGGVDTLTLAKKYQTPLYVYDTGAIRAEIAAFKQVFEENHVDY
CCCCCCCHHCCCCCEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCE
QISYASKAFATVAMYQLIAQEHIHCDVVSGGELYTAQQADFPMAAVSFHGNNKSLAELTM
EEECHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCCEEEEEEECCCCHHHHHHH
ALDAGVGTIVVDNFGELRQLTTLTTQRQQPTTIMLRIAPGISAHTHDYISTGQADSKFGF
HHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCC
DLDSGQADQAIKAAQAAPYLKLVGIHCHIGSQIFEVNGFEMIVDKLVSEFARWQRELDFY
CCCCCCHHHHHHHHHCCCCEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHCCC
PQIMNVGGGFGVKYTAEDHPLQPTDFVDAIIKETRAQTAAQQVPMLEIWIEPGRSLVATA
HHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEC
GMTLYTIGDEKDIPGIRKYLSVDGGMGDNIRPALYQAKYEAVLAKNPALPAEQVASIAGK
CEEEEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHH
YCESGDMLIWNQQLPATAPGDVLAVLDTGAYGYSMASNYNRNPRPAVVFCEQGHSQLVVQ
HCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEECCCCEEEEE
RESYADLTRLDLPLSVPEKTK
ECCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8215365 [H]