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The map label for this gene is fabF [H]

Identifier: 28378365

GI number: 28378365

Start: 1526214

End: 1527446

Strand: Direct

Name: fabF [H]

Synonym: lp_1675

Alternate gene names: 28378365

Gene position: 1526214-1527446 (Clockwise)

Preceding gene: 28378364

Following gene: 28378366

Centisome position: 46.13

GC content: 48.74

Gene sequence:

>1233_bases
ATGACAGAACGAGTAGTTGTGACTGGAATGGGTGCGGTGACGCCCCTCGGTAATAGTGTTGATGAATTTTTAACGGGGTT
ATTCGCGGGACAAGTTGGGATTAAGCCCATCACGAAGTTTGACGCGACGCCCACTGGGATTACAGTTGCCGGTGAGGTTA
AGGATTTTCAGCCAGAAGAACGAATTGAAAAGAAATTAGCGAAAAGATTGGATTTATTTTCCGTTTATGGTCTATACAGT
GCAAGTGAAGCGATGGCGCAAGCCGGACTAAATGAAGCAAATATTGACCCAGAACGATTAGGCGTTATTTATGGTTCGGG
TATCGGTGGTTTAACGACGATTGAAGCGCAAGTGATCAAGATGCACGACAAGAGTCCCAAACGAGTTTCACCGTTATTCG
TCCCTAATTCAATCATTAACATGGTTGTTGGTAATATCGCGATGCAATTTAACGCACAGAATACCAGTCAAGCGATTGTG
ACCGCGTGTGCGTCGGCGACGAATGCCATCGGCGATGCGTTTGAATATTTGCGTCAAGGAAAGGCAGATGTGATCATCAC
GGGTGGTTCAGAAGCTTCCGTCAACGAAATCGGTATTGCAGGGTTTGCGTCCCTGACTGCGTTGTCGAAAGCCACTGACC
CAACGTTGGCTTCGTTACCGTTTGATCGTCAACGCAATGGGTTTGTGATGGGTGAAGGGGGTGCGACGTTAGTCTTAGAA
ACGTTGGCCCATGCCCAAGCCCGAGGCGCCCAGATTCTTGGTGAAGTCGTGGGTTACGGAACGACTAGCGATGCTTATCA
TATGACAGCCCCCCGACCGGATGGTGCTGGTGCCAAACGTGCAATGCAACAAGCCGTTGCGGAAGCCGGCATTCAACCGC
GTGATGTGGATTACATCAATGCTCATGGAACAGCCACACATGCGAATGATAGTGCCGAAGCTCAAGCAATTAGCGCGTTG
TTTGGTCAAGATGTACAAGTCAGCAGTACTAAAGGAATGACGGGGCACTTATTAGGCGCTGCGGGTGCAATTGAAGCTGT
TGCAACGATTGGTGCTCTGCAAGCGGGTCAGTTACCTGCGAATATTGGTTGTACGGACCAAGATCCTGAGTGTCCAGTCA
ATTTAGTAACGCCAGCAACTCAACATCAAGCCGCAACCTATGCTTTGAGTAATTCATTTGGTTTTGGGGGCCATAATGCC
GTGGTTGCCTTTAAGAAGTGGGTGAATGTATGA

Upstream 100 bases:

>100_bases
TGCCCAAGCAATTGACTTTTTATTGCACCAACCGTACTTAACGGGACAAGTGCTAACAGTTGACGGTGGCATGACGATAT
AAGATATGGGAGGTTATCCA

Downstream 100 bases:

>100_bases
GTATGACGGATACGGAAGCGATGACCGCCCTGATCAATCAGTTTAATCAATCCAGCGCTCAAGTCATGGACGTCAAGACG
ACAACCTTTGAACTGCATTT

Product: 3-oxoacyl-[acyl-carrier protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTERVVVTGMGAVTPLGNSVDEFLTGLFAGQVGIKPITKFDATPTGITVAGEVKDFQPEERIEKKLAKRLDLFSVYGLYS
ASEAMAQAGLNEANIDPERLGVIYGSGIGGLTTIEAQVIKMHDKSPKRVSPLFVPNSIINMVVGNIAMQFNAQNTSQAIV
TACASATNAIGDAFEYLRQGKADVIITGGSEASVNEIGIAGFASLTALSKATDPTLASLPFDRQRNGFVMGEGGATLVLE
TLAHAQARGAQILGEVVGYGTTSDAYHMTAPRPDGAGAKRAMQQAVAEAGIQPRDVDYINAHGTATHANDSAEAQAISAL
FGQDVQVSSTKGMTGHLLGAAGAIEAVATIGALQAGQLPANIGCTDQDPECPVNLVTPATQHQAATYALSNSFGFGGHNA
VVAFKKWVNV

Sequences:

>Translated_410_residues
MTERVVVTGMGAVTPLGNSVDEFLTGLFAGQVGIKPITKFDATPTGITVAGEVKDFQPEERIEKKLAKRLDLFSVYGLYS
ASEAMAQAGLNEANIDPERLGVIYGSGIGGLTTIEAQVIKMHDKSPKRVSPLFVPNSIINMVVGNIAMQFNAQNTSQAIV
TACASATNAIGDAFEYLRQGKADVIITGGSEASVNEIGIAGFASLTALSKATDPTLASLPFDRQRNGFVMGEGGATLVLE
TLAHAQARGAQILGEVVGYGTTSDAYHMTAPRPDGAGAKRAMQQAVAEAGIQPRDVDYINAHGTATHANDSAEAQAISAL
FGQDVQVSSTKGMTGHLLGAAGAIEAVATIGALQAGQLPANIGCTDQDPECPVNLVTPATQHQAATYALSNSFGFGGHNA
VVAFKKWVNV
>Mature_409_residues
TERVVVTGMGAVTPLGNSVDEFLTGLFAGQVGIKPITKFDATPTGITVAGEVKDFQPEERIEKKLAKRLDLFSVYGLYSA
SEAMAQAGLNEANIDPERLGVIYGSGIGGLTTIEAQVIKMHDKSPKRVSPLFVPNSIINMVVGNIAMQFNAQNTSQAIVT
ACASATNAIGDAFEYLRQGKADVIITGGSEASVNEIGIAGFASLTALSKATDPTLASLPFDRQRNGFVMGEGGATLVLET
LAHAQARGAQILGEVVGYGTTSDAYHMTAPRPDGAGAKRAMQQAVAEAGIQPRDVDYINAHGTATHANDSAEAQAISALF
GQDVQVSSTKGMTGHLLGAAGAIEAVATIGALQAGQLPANIGCTDQDPECPVNLVTPATQHQAATYALSNSFGFGGHNAV
VAFKKWVNV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=37.9807692307692, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI223972627, Length=161, Percent_Identity=44.0993788819876, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI41872631, Length=425, Percent_Identity=24, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=44.4987775061125, Blast_Score=307, Evalue=8e-85,
Organism=Escherichia coli, GI1788663, Length=411, Percent_Identity=36.7396593673966, Blast_Score=211, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=37.7403846153846, Blast_Score=267, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=257, Percent_Identity=42.0233463035019, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=339, Percent_Identity=25.6637168141593, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=273, Percent_Identity=29.6703296703297, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=38.5135135135135, Blast_Score=298, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=40.4306220095694, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI19920632, Length=425, Percent_Identity=25.6470588235294, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221330659, Length=425, Percent_Identity=25.6470588235294, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24581345, Length=422, Percent_Identity=24.4075829383886, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42448; Mature: 42317

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERVVVTGMGAVTPLGNSVDEFLTGLFAGQVGIKPITKFDATPTGITVAGEVKDFQPEE
CCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCHHH
RIEKKLAKRLDLFSVYGLYSASEAMAQAGLNEANIDPERLGVIYGSGIGGLTTIEAQVIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEECCCCCCEEHHEEEEE
MHDKSPKRVSPLFVPNSIINMVVGNIAMQFNAQNTSQAIVTACASATNAIGDAFEYLRQG
ECCCCCCCCCCEECCHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KADVIITGGSEASVNEIGIAGFASLTALSKATDPTLASLPFDRQRNGFVMGEGGATLVLE
CCCEEEECCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHH
TLAHAQARGAQILGEVVGYGTTSDAYHMTAPRPDGAGAKRAMQQAVAEAGIQPRDVDYIN
HHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEE
AHGTATHANDSAEAQAISALFGQDVQVSSTKGMTGHLLGAAGAIEAVATIGALQAGQLPA
CCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
NIGCTDQDPECPVNLVTPATQHQAATYALSNSFGFGGHNAVVAFKKWVNV
CCCCCCCCCCCCEEEECCCCHHHHHEEEECCCCCCCCCHHEEEEHHHHCC
>Mature Secondary Structure 
TERVVVTGMGAVTPLGNSVDEFLTGLFAGQVGIKPITKFDATPTGITVAGEVKDFQPEE
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCHHH
RIEKKLAKRLDLFSVYGLYSASEAMAQAGLNEANIDPERLGVIYGSGIGGLTTIEAQVIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEECCCCCCEEHHEEEEE
MHDKSPKRVSPLFVPNSIINMVVGNIAMQFNAQNTSQAIVTACASATNAIGDAFEYLRQG
ECCCCCCCCCCEECCHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KADVIITGGSEASVNEIGIAGFASLTALSKATDPTLASLPFDRQRNGFVMGEGGATLVLE
CCCEEEECCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHH
TLAHAQARGAQILGEVVGYGTTSDAYHMTAPRPDGAGAKRAMQQAVAEAGIQPRDVDYIN
HHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEE
AHGTATHANDSAEAQAISALFGQDVQVSSTKGMTGHLLGAAGAIEAVATIGALQAGQLPA
CCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
NIGCTDQDPECPVNLVTPATQHQAATYALSNSFGFGGHNAVVAFKKWVNV
CCCCCCCCCCCCEEEECCCCHHHHHEEEECCCCCCCCCHHEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]