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The map label for this gene is dfp [H]

Identifier: 28378314

GI number: 28378314

Start: 1466575

End: 1467801

Strand: Direct

Name: dfp [H]

Synonym: lp_1614

Alternate gene names: 28378314

Gene position: 1466575-1467801 (Clockwise)

Preceding gene: 28378313

Following gene: 28378315

Centisome position: 44.33

GC content: 48.66

Gene sequence:

>1227_bases
GTGAGTATATGGACAAAACGCCATGTAACGGTAGTCGTTAGTGGTGGGATTGCGAGTTATAAAGCGTTAGTATTGATTCG
TAGTTTGATGAAACAGGGCGCCGTCGTGCGAGTTGCGATGACAACCCATGCGGCAAAGTTTATCACGCCATTGACCTTTC
AAACTTTAACGCAGCAGCCAGTGGTCATTGATGAATTCACAACGACTGACCCGCATCACGTCGTCCACGTCGCGTTAGCT
GACTGGACTGAAGTGATGATTCTCGTTCCGGCTACCGCCAACTTGATTGCTAAGGTGGCTAACGGTCTAGCCGATGATGC
CGCAACGACGACAATTTTAGCGACGACCGCACCCAAGTTTGTGGTGCCAGCAATGAATTCACATATGTACGTTAATCCAG
CAACTCAGCGCAATTTGAAGCAACTGACGACGGATGGGTTACACGTCTTAACTCCTGCTACGGGTATGTTGGCGGAAGGC
TACAGTGGTCAAGGACGCTTGCCGGAACCAGCGGTGATTTTGGCCTGGTTGACAGATCAACTGATTCAGTTGACACCTGA
TTTGCCATTAGCAGGACGGCGAGTTGTCGTCACTGCCGGCGGAACCCGAGAAGCCTTAGATCCGGTACGATTTATCACGA
ATCGTTCATCGGGGAAGATGGGCTACGCAGTTGCTCAAGTCGCACGGGAGTTAGGTGCAACTGTGACACTGATCAGCGCC
ACGACTCATTTAGCAGCGCCTAGTGGTGTTAAGGTCGTGACGGTTGATTCGGCTCAATCCTTATTGACGGCAGTCAGTGA
TATTTTTGATGATACGGATATCTTGGTCATGGCGGCGGCCGTATCTGATTATCGGCCGGCTGAATTAGCTGATCAGAAGA
TTAAAAAGCCAGCTGACCATGCTGACTTAACGTTACGATTGACAGAAACACCGGATATTTTAAAAACGTTAGCGGCCCGG
AAGCACCAACAGTATGTGATTGGCTTTGCAGCTGAAACTCAATCATTGCTGGCCAATGCCAATCGTAAGTTAACTAGTAA
AAAATTAGATTTAATTGTTGCTAACGATGTTTCCAAACCGGGAGTTGGGTTCAATGGTGATACCAATCAGGTCACACTGT
TGCGGCCTGAGCAACAACCAGTTACGACGGAATTGACAACGAAAACTGCAATTGCCAAACAGATCTTGATGACGGCAATT
GCGGATGGTGCAGGAACACAGGCATGA

Upstream 100 bases:

>100_bases
GTTCAGCTTCACGTTACTGTCGATTCTTGATACAATTGTTCTATTAAAGTGTAAAAATCTCGCTGGCACGGTTGCGAGAT
TTTTCAAAGGACGTGAAGAA

Downstream 100 bases:

>100_bases
TTAAGTAGAGAGGAAGAGTTGTGTGGCACAAATTGCCCAAGTATTAGTCGATGTGCCCACTATGCAGACAAATCGACCTT
ATAGTTATCGAATTCCAACC

Product: pantothenate metabolism flavoprotein Dfp

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSIWTKRHVTVVVSGGIASYKALVLIRSLMKQGAVVRVAMTTHAAKFITPLTFQTLTQQPVVIDEFTTTDPHHVVHVALA
DWTEVMILVPATANLIAKVANGLADDAATTTILATTAPKFVVPAMNSHMYVNPATQRNLKQLTTDGLHVLTPATGMLAEG
YSGQGRLPEPAVILAWLTDQLIQLTPDLPLAGRRVVVTAGGTREALDPVRFITNRSSGKMGYAVAQVARELGATVTLISA
TTHLAAPSGVKVVTVDSAQSLLTAVSDIFDDTDILVMAAAVSDYRPAELADQKIKKPADHADLTLRLTETPDILKTLAAR
KHQQYVIGFAAETQSLLANANRKLTSKKLDLIVANDVSKPGVGFNGDTNQVTLLRPEQQPVTTELTTKTAIAKQILMTAI
ADGAGTQA

Sequences:

>Translated_408_residues
MSIWTKRHVTVVVSGGIASYKALVLIRSLMKQGAVVRVAMTTHAAKFITPLTFQTLTQQPVVIDEFTTTDPHHVVHVALA
DWTEVMILVPATANLIAKVANGLADDAATTTILATTAPKFVVPAMNSHMYVNPATQRNLKQLTTDGLHVLTPATGMLAEG
YSGQGRLPEPAVILAWLTDQLIQLTPDLPLAGRRVVVTAGGTREALDPVRFITNRSSGKMGYAVAQVARELGATVTLISA
TTHLAAPSGVKVVTVDSAQSLLTAVSDIFDDTDILVMAAAVSDYRPAELADQKIKKPADHADLTLRLTETPDILKTLAAR
KHQQYVIGFAAETQSLLANANRKLTSKKLDLIVANDVSKPGVGFNGDTNQVTLLRPEQQPVTTELTTKTAIAKQILMTAI
ADGAGTQA
>Mature_407_residues
SIWTKRHVTVVVSGGIASYKALVLIRSLMKQGAVVRVAMTTHAAKFITPLTFQTLTQQPVVIDEFTTTDPHHVVHVALAD
WTEVMILVPATANLIAKVANGLADDAATTTILATTAPKFVVPAMNSHMYVNPATQRNLKQLTTDGLHVLTPATGMLAEGY
SGQGRLPEPAVILAWLTDQLIQLTPDLPLAGRRVVVTAGGTREALDPVRFITNRSSGKMGYAVAQVARELGATVTLISAT
THLAAPSGVKVVTVDSAQSLLTAVSDIFDDTDILVMAAAVSDYRPAELADQKIKKPADHADLTLRLTETPDILKTLAARK
HQQYVIGFAAETQSLLANANRKLTSKKLDLIVANDVSKPGVGFNGDTNQVTLLRPEQQPVTTELTTKTAIAKQILMTAIA
DGAGTQA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI87082301, Length=376, Percent_Identity=44.6808510638298, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17560194, Length=171, Percent_Identity=29.8245614035088, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322762, Length=181, Percent_Identity=27.0718232044199, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=28.6486486486486, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43427; Mature: 43295

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIWTKRHVTVVVSGGIASYKALVLIRSLMKQGAVVRVAMTTHAAKFITPLTFQTLTQQP
CCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCHHHHHHCCCC
VVIDEFTTTDPHHVVHVALADWTEVMILVPATANLIAKVANGLADDAATTTILATTAPKF
EEEEECCCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCHHEEEEEECCCCE
VVPAMNSHMYVNPATQRNLKQLTTDGLHVLTPATGMLAEGYSGQGRLPEPAVILAWLTDQ
EEECCCCEEEECCHHHHHHHHHHCCCEEEECCCCCHHCCCCCCCCCCCCCCEEHHHHHHH
LIQLTPDLPLAGRRVVVTAGGTREALDPVRFITNRSSGKMGYAVAQVARELGATVTLISA
HHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEEE
TTHLAAPSGVKVVTVDSAQSLLTAVSDIFDDTDILVMAAAVSDYRPAELADQKIKKPADH
HHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEEHHCCCCCHHHHHHHHCCCCCC
ADLTLRLTETPDILKTLAARKHQQYVIGFAAETQSLLANANRKLTSKKLDLIVANDVSKP
CCEEEEECCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCHHCCCCEEEEEECCCCCC
GVGFNGDTNQVTLLRPEQQPVTTELTTKTAIAKQILMTAIADGAGTQA
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIWTKRHVTVVVSGGIASYKALVLIRSLMKQGAVVRVAMTTHAAKFITPLTFQTLTQQP
CCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHCCHHHHHHCCCC
VVIDEFTTTDPHHVVHVALADWTEVMILVPATANLIAKVANGLADDAATTTILATTAPKF
EEEEECCCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCHHEEEEEECCCCE
VVPAMNSHMYVNPATQRNLKQLTTDGLHVLTPATGMLAEGYSGQGRLPEPAVILAWLTDQ
EEECCCCEEEECCHHHHHHHHHHCCCEEEECCCCCHHCCCCCCCCCCCCCCEEHHHHHHH
LIQLTPDLPLAGRRVVVTAGGTREALDPVRFITNRSSGKMGYAVAQVARELGATVTLISA
HHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEEE
TTHLAAPSGVKVVTVDSAQSLLTAVSDIFDDTDILVMAAAVSDYRPAELADQKIKKPADH
HHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEEEHHCCCCCHHHHHHHHCCCCCC
ADLTLRLTETPDILKTLAARKHQQYVIGFAAETQSLLANANRKLTSKKLDLIVANDVSKP
CCEEEEECCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCHHCCCCEEEEEECCCCCC
GVGFNGDTNQVTLLRPEQQPVTTELTTKTAIAKQILMTAIADGAGTQA
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]