BacMap

Definition	Lactobacillus plantarum WCFS1, complete genome.
Accession	NC_004567
Length	3,308,274

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The map label for this gene is gmk

Identifier: 28378312

GI number: 28378312

Start: 1465582

End: 1466202

Strand: Direct

Name: gmk

Synonym: lp_1612

Alternate gene names: 28378312

Gene position: 1465582-1466202 (Clockwise)

Preceding gene: 28378310

Following gene: 28378313

Centisome position: 44.3

GC content: 44.61

Gene sequence:

>621_bases
ATGGCGAAACAAGGCATGTTAATCGTCTTATCAGGTCCTTCGGGTGTCGGTAAAGGTACCGTCCGCAAGGAAATCTTTGA
CTCAGATGATAACGATTTTCAATATTCAGTCTCGATGACGACGCGGCAAATGCGTCCGGGCGAAGTAGATGGCAAGGACT
ACTATTTTGTGTCCAAAGAAGAGTTCGAGGATGAAATTAAGAGCGGCGGTATGCTTGAATATGCCAAGTATGTTGACAAT
TACTATGGGACGCCCTTAAAATATATTAAGCAGTCGTTGGCGGCTGGCAAAGACGTTTTCTTAGAAATTGAAGTTAACGG
GGCCATGCAAGTCCGCGAAAAAATGCCTGATGGCGTCTTCATTTTCTTGACGCCGCCGGATTTGATGGAATTGAAGCACC
GCATCATTGGTCGTGGGACTGATGATATGAGTGTGATCAACAAGCGGATGGCAAAAGCGGTTGATGAAATCAAGATGATG
CGTAATTATGATTATGCGGTTATCAATGATGAAGTCCCGCTAGCTGCTGAACGAATCAAGGCTATTATTCGTAGTGAACG
GTTTAGTGTTAAACGGGTCATGCCCGAGTATGAAGAAATGTTAGGAGATGCGGAATCATGA

Upstream 100 bases:

>100_bases
ATGAAAAAAAGCTGTGTAACCTTGATAATACTTGCAATATAGGGTTAAAAAGTGCAAAATAAACTTTAAAACATATTTTA
ATTAAGGGGAATTTGTGATC

Downstream 100 bases:

>100_bases
TCTTATATCCATCAGTTGATGACTTATTGAAGCAAGTTAATTCGCGTTACTCATTGATTATGTTAGCTAGCAAGCGGGCC
CATGAATTGGACGCTGGTGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MAKQGMLIVLSGPSGVGKGTVRKEIFDSDDNDFQYSVSMTTRQMRPGEVDGKDYYFVSKEEFEDEIKSGGMLEYAKYVDN
YYGTPLKYIKQSLAAGKDVFLEIEVNGAMQVREKMPDGVFIFLTPPDLMELKHRIIGRGTDDMSVINKRMAKAVDEIKMM
RNYDYAVINDEVPLAAERIKAIIRSERFSVKRVMPEYEEMLGDAES

Sequences:

>Translated_206_residues
MAKQGMLIVLSGPSGVGKGTVRKEIFDSDDNDFQYSVSMTTRQMRPGEVDGKDYYFVSKEEFEDEIKSGGMLEYAKYVDN
YYGTPLKYIKQSLAAGKDVFLEIEVNGAMQVREKMPDGVFIFLTPPDLMELKHRIIGRGTDDMSVINKRMAKAVDEIKMM
RNYDYAVINDEVPLAAERIKAIIRSERFSVKRVMPEYEEMLGDAES
>Mature_205_residues
AKQGMLIVLSGPSGVGKGTVRKEIFDSDDNDFQYSVSMTTRQMRPGEVDGKDYYFVSKEEFEDEIKSGGMLEYAKYVDNY
YGTPLKYIKQSLAAGKDVFLEIEVNGAMQVREKMPDGVFIFLTPPDLMELKHRIIGRGTDDMSVINKRMAKAVDEIKMMR
NYDYAVINDEVPLAAERIKAIIRSERFSVKRVMPEYEEMLGDAES

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=182, Percent_Identity=32.967032967033, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4504221, Length=182, Percent_Identity=32.967032967033, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI226874831, Length=182, Percent_Identity=32.967032967033, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI14780902, Length=191, Percent_Identity=29.8429319371728, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=25.8426966292135, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI21361598, Length=200, Percent_Identity=29, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI4505237, Length=120, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI262118259, Length=120, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI262118263, Length=120, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI262118255, Length=120, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI111154074, Length=112, Percent_Identity=30.3571428571429, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI52630447, Length=146, Percent_Identity=28.0821917808219, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21536464, Length=119, Percent_Identity=30.2521008403361, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI119943108, Length=131, Percent_Identity=29.7709923664122, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI261862237, Length=131, Percent_Identity=29.7709923664122, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI186972120, Length=167, Percent_Identity=26.3473053892216, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI186700629, Length=167, Percent_Identity=26.3473053892216, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI186700627, Length=167, Percent_Identity=26.3473053892216, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790080, Length=200, Percent_Identity=44, Blast_Score=173, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=35.3591160220994, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=35.3591160220994, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17556244, Length=124, Percent_Identity=35.4838709677419, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988048, Length=125, Percent_Identity=32, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71988041, Length=125, Percent_Identity=32, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17557440, Length=133, Percent_Identity=30.8270676691729, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=135, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982296, Length=95, Percent_Identity=32.6315789473684, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=39.6739130434783, Blast_Score=136, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356141, Length=150, Percent_Identity=36, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161077626, Length=180, Percent_Identity=28.8888888888889, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640542, Length=180, Percent_Identity=28.8888888888889, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=28.8888888888889, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=28.8888888888889, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=28.8888888888889, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=28.8888888888889, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221330162, Length=184, Percent_Identity=29.3478260869565, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221330166, Length=184, Percent_Identity=29.3478260869565, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221330164, Length=184, Percent_Identity=29.3478260869565, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI85816106, Length=129, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI85816281, Length=129, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551002, Length=129, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281362230, Length=174, Percent_Identity=27.0114942528736, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24648808, Length=174, Percent_Identity=27.0114942528736, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI161078487, Length=174, Percent_Identity=27.0114942528736, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281362232, Length=170, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161078485, Length=170, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648810, Length=170, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_LACPL (Q88WL7)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785204.1
- ProteinModelPortal:   Q88WL7
- SMR:   Q88WL7
- GeneID:   1063703
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1612
- NMPDR:   fig|220668.1.peg.1338
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BioCyc:   LPLA220668:LP_1612-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23461; Mature: 23330

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.8 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQGMLIVLSGPSGVGKGTVRKEIFDSDDNDFQYSVSMTTRQMRPGEVDGKDYYFVSKE
CCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECHH
EFEDEIKSGGMLEYAKYVDNYYGTPLKYIKQSLAAGKDVFLEIEVNGAMQVREKMPDGVF
HHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCCEE
IFLTPPDLMELKHRIIGRGTDDMSVINKRMAKAVDEIKMMRNYDYAVINDEVPLAAERIK
EEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
AIIRSERFSVKRVMPEYEEMLGDAES
HHHHHHHHHHHHHCHHHHHHCCCCCC
>Mature Secondary Structure 
AKQGMLIVLSGPSGVGKGTVRKEIFDSDDNDFQYSVSMTTRQMRPGEVDGKDYYFVSKE
CCCCEEEEEECCCCCCCCHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEECHH
EFEDEIKSGGMLEYAKYVDNYYGTPLKYIKQSLAAGKDVFLEIEVNGAMQVREKMPDGVF
HHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCCEE
IFLTPPDLMELKHRIIGRGTDDMSVINKRMAKAVDEIKMMRNYDYAVINDEVPLAAERIK
EEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
AIIRSERFSVKRVMPEYEEMLGDAES
HHHHHHHHHHHHHCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566