Click here to switch to the map view.

The map label for this gene is fpg

Identifier: 28378223

GI number: 28378223

Start: 1381161

End: 1381985

Strand: Direct

Name: fpg

Synonym: lp_1509

Alternate gene names: 28378223

Gene position: 1381161-1381985 (Clockwise)

Preceding gene: 28378222

Following gene: 28378224

Centisome position: 41.75

GC content: 46.42

Gene sequence:

>825_bases
ATGCCTGAATTACCTGAAGTTGAAACTGTTCGTCGCGGCTTAAATCGTCTGGTTAGCGGGGCAACGATTGCTAGTATCGA
GGTTTTTTGGCCGAAAATTATTAATAATGATGTCGATAGTTTCAAACAGCGTTTAGCCAACCAAACGATCCAGACCATTG
ATCGGCGGGGGAAGTATTTATTGTTTCGCTTTAGCAATGGTCTGACGATGGTGTCGCATTTGCGGATGGAAGGCAAGTAT
AATGTTGTACCGCGTGGTGAAGATCAAGGTAAACACACGCACGTGATCTTCCATCTGACCGATGATCGTGATTTACTGTA
CAACGATACGCGTAAGTTCGGGCGAATGACGCTCGTGCCGACCGGTGAAGAAAACACGGTGGCGGGATTGCGGACAATTG
GCCCGGAACCCGTTGCTGAACAGTTAACACTGGCTTATATGACGGCCACTTTTGGCAAGTCGAAAAAGATGATCAAGCCA
CTATTGTTGGATCAAAGTAAGATTGCGGGCATTGGGAATATTTACGCGGACGAAACGCTATGGATGAGTAAGATTCATCC
AATGCGGCCTGCTAATTCACTAACCACTGATGAGATTGCAACATTGCGCCAAAACATTATTGATGAAATGGCGATGGCAA
TTAAAGGTCACGGCACCACTGTTCATTCATTTTCAACGGCATTTGGTGAGGCCGGTCAGTTTCAAAATCACTTACACGTC
TATGGTCGTGAAGGGGAGCCTTGCGAACGGTGTGGCACAATTATTGAGAAAATCAAAGTGGCACAGCGAGGGACCCATTT
TTGCCCGTTAGAACAACGGTTGTAG

Upstream 100 bases:

>100_bases
TGCCAAGCGTGATGGATTCCGCCGTACAGTTAGCCGTACCGTTAAAGGTTGAGAGCCACTACGGTGATACTTGGTACGAT
GCAAAATAGGGGGAACCACC

Downstream 100 bases:

>100_bases
GTGATCAAGATGACAAAGTTGATTGGATTGACTGGTGGCATTGCCACTGGTAAGTCGACTGTTTCTAAGCTGCTGGCAAC
TAAGTTACCAATCGTTGATG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MPELPEVETVRRGLNRLVSGATIASIEVFWPKIINNDVDSFKQRLANQTIQTIDRRGKYLLFRFSNGLTMVSHLRMEGKY
NVVPRGEDQGKHTHVIFHLTDDRDLLYNDTRKFGRMTLVPTGEENTVAGLRTIGPEPVAEQLTLAYMTATFGKSKKMIKP
LLLDQSKIAGIGNIYADETLWMSKIHPMRPANSLTTDEIATLRQNIIDEMAMAIKGHGTTVHSFSTAFGEAGQFQNHLHV
YGREGEPCERCGTIIEKIKVAQRGTHFCPLEQRL

Sequences:

>Translated_274_residues
MPELPEVETVRRGLNRLVSGATIASIEVFWPKIINNDVDSFKQRLANQTIQTIDRRGKYLLFRFSNGLTMVSHLRMEGKY
NVVPRGEDQGKHTHVIFHLTDDRDLLYNDTRKFGRMTLVPTGEENTVAGLRTIGPEPVAEQLTLAYMTATFGKSKKMIKP
LLLDQSKIAGIGNIYADETLWMSKIHPMRPANSLTTDEIATLRQNIIDEMAMAIKGHGTTVHSFSTAFGEAGQFQNHLHV
YGREGEPCERCGTIIEKIKVAQRGTHFCPLEQRL
>Mature_273_residues
PELPEVETVRRGLNRLVSGATIASIEVFWPKIINNDVDSFKQRLANQTIQTIDRRGKYLLFRFSNGLTMVSHLRMEGKYN
VVPRGEDQGKHTHVIFHLTDDRDLLYNDTRKFGRMTLVPTGEENTVAGLRTIGPEPVAEQLTLAYMTATFGKSKKMIKPL
LLDQSKIAGIGNIYADETLWMSKIHPMRPANSLTTDEIATLRQNIIDEMAMAIKGHGTTVHSFSTAFGEAGQFQNHLHVY
GREGEPCERCGTIIEKIKVAQRGTHFCPLEQRL

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=273, Percent_Identity=38.4615384615385, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI1786932, Length=280, Percent_Identity=26.7857142857143, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_LACPL (Q88WV4)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785115.1
- ProteinModelPortal:   Q88WV4
- SMR:   Q88WV4
- GeneID:   1063357
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1509
- NMPDR:   fig|220668.1.peg.1249
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK01103
- BioCyc:   LPLA220668:LP_1509-MONOMER
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30893; Mature: 30762

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 263-263 BINDING 92-92 BINDING 111-111

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLNRLVSGATIASIEVFWPKIINNDVDSFKQRLANQTIQTIDRRGKYL
CCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEE
LFRFSNGLTMVSHLRMEGKYNVVPRGEDQGKHTHVIFHLTDDRDLLYNDTRKFGRMTLVP
EEEECCCCEEEHHHHCCCCEECCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCEEEEE
TGEENTVAGLRTIGPEPVAEQLTLAYMTATFGKSKKMIKPLLLDQSKIAGIGNIYADETL
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCHHCCCHH
WMSKIHPMRPANSLTTDEIATLRQNIIDEMAMAIKGHGTTVHSFSTAFGEAGQFQNHLHV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCCCEEE
YGREGEPCERCGTIIEKIKVAQRGTHFCPLEQRL
ECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCC
>Mature Secondary Structure 
PELPEVETVRRGLNRLVSGATIASIEVFWPKIINNDVDSFKQRLANQTIQTIDRRGKYL
CCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEE
LFRFSNGLTMVSHLRMEGKYNVVPRGEDQGKHTHVIFHLTDDRDLLYNDTRKFGRMTLVP
EEEECCCCEEEHHHHCCCCEECCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCEEEEE
TGEENTVAGLRTIGPEPVAEQLTLAYMTATFGKSKKMIKPLLLDQSKIAGIGNIYADETL
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCCCCCHHCCCHH
WMSKIHPMRPANSLTTDEIATLRQNIIDEMAMAIKGHGTTVHSFSTAFGEAGQFQNHLHV
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCCCCEEE
YGREGEPCERCGTIIEKIKVAQRGTHFCPLEQRL
ECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566