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The map label for this gene is csd1 [H]

Identifier: 28378187

GI number: 28378187

Start: 1347223

End: 1348461

Strand: Direct

Name: csd1 [H]

Synonym: lp_1470

Alternate gene names: 28378187

Gene position: 1347223-1348461 (Clockwise)

Preceding gene: 28378186

Following gene: 28378188

Centisome position: 40.72

GC content: 49.15

Gene sequence:

>1239_bases
ATGGCATCCAATTTTGAGACGTTACGGTCAGATTTTCCCATTCTAAACCAACAAGTGAATGATGAACGACTTGTCTACCT
AGATAATGCGGCGACTGCGCAGCGCCCCAACCAAGTCGTGGATGCGCTCGTTCACTTTTATCAACACGATAACGCCAATG
TTCATCGTGGTGTCCACACCTTAGCAGAGCGGGCCACTAGTCAATACGAAGCTGCGCGTGCCAAGGTGCAACGGTTCATC
AATGCTCCAAAAACGGATGAAATCGTCTTCACCAAAGGGACGACGGATAGTCTCAATCTGATTGCCAGTACTTATGGCGA
AGCCAATATTCAAGCGGGTGATGAGATCGTCATTTCCGTTATGGAGCATCATAGTAATTTAATTCCGTGGCAACAGTTAG
CATTGCGTAAGCACGCCACCTTGAAATATATTGAGTTAACGGCGACTGGTGAATTGGACATGGCCGATGCTGCCAACAAG
ATTACGGATCGAACAAAAATCGTTTCAGTGACCCATGCTAGTAATGTATTGGGAACGGTCAATCCAATCAAGGCGTTAGC
ACGATTGGCGCATCAACACGGTGCCGTGATGATTGCGGATGGGGCGCAAGCAGCCCCTCATATGCCGGTCGATGTCCAGG
CACTCGATGTTGATTTTTACGCATTTTCGGGGCATAAAATGCTGGGACCAACCGGCATTGGCGTTCTATATGGTCGTGAG
AATTTATTAGCTACGATGCCACCGTATCAATTTGGTGGTGAGATGATTGGCTTTGTTCACCGTGATGACAGTACCTGGGC
GGAACTACCGTGGAAGTTTGAAGCGGGCACTCAGAACATTGCCGGTGCGATCGGCTTGGGCGCGGCGGTTGATTATTTGA
CGCAACTCGGTATGGATCAAGTTCAGCAACACGAACAGCAATTAGTCAATTACTTATTGCCTAAGTTGATTGCAATGCCT
GGTGTCACGGTCTACGGTCCCCAAGATCCCCAATATCATACGGGCGTCATCGCCTTTAATATCGACGGTTTGCACCCGCA
CGACGCGGCTACCGCGTTGGATATGGAAGGTGTCGCCGTTCGCGCGGGTCATCACTGTGCACAACCCCTGATGGCAGCGC
TCGGCTTAGTAGCAACTGCACGGGCTAGTTTTTACATTTACAATACACAAGCGGACGCTGATCAATTATTAACGTCACTC
CAAGCAACAAAGGAGTTTTTCGAACATGGGACTGTCTAA

Upstream 100 bases:

>100_bases
CGGTTGGTTATTCGGGGCTTCTTAAGTACCGTGATTGGTGCGATCCCATCGAAGACTGTCCGGACGCGCTTAACGAACAC
GATTGAAAGGAAGCTTGAAG

Downstream 100 bases:

>100_bases
ATTAAGTGGCTTATATCGCGAAGTGATTTTAGATCATGGTGATCATCCGCATCATAAAAATGCGTTGCCAAACGCAACAC
ATGCCATTACGTTGAAAAAT

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MASNFETLRSDFPILNQQVNDERLVYLDNAATAQRPNQVVDALVHFYQHDNANVHRGVHTLAERATSQYEAARAKVQRFI
NAPKTDEIVFTKGTTDSLNLIASTYGEANIQAGDEIVISVMEHHSNLIPWQQLALRKHATLKYIELTATGELDMADAANK
ITDRTKIVSVTHASNVLGTVNPIKALARLAHQHGAVMIADGAQAAPHMPVDVQALDVDFYAFSGHKMLGPTGIGVLYGRE
NLLATMPPYQFGGEMIGFVHRDDSTWAELPWKFEAGTQNIAGAIGLGAAVDYLTQLGMDQVQQHEQQLVNYLLPKLIAMP
GVTVYGPQDPQYHTGVIAFNIDGLHPHDAATALDMEGVAVRAGHHCAQPLMAALGLVATARASFYIYNTQADADQLLTSL
QATKEFFEHGTV

Sequences:

>Translated_412_residues
MASNFETLRSDFPILNQQVNDERLVYLDNAATAQRPNQVVDALVHFYQHDNANVHRGVHTLAERATSQYEAARAKVQRFI
NAPKTDEIVFTKGTTDSLNLIASTYGEANIQAGDEIVISVMEHHSNLIPWQQLALRKHATLKYIELTATGELDMADAANK
ITDRTKIVSVTHASNVLGTVNPIKALARLAHQHGAVMIADGAQAAPHMPVDVQALDVDFYAFSGHKMLGPTGIGVLYGRE
NLLATMPPYQFGGEMIGFVHRDDSTWAELPWKFEAGTQNIAGAIGLGAAVDYLTQLGMDQVQQHEQQLVNYLLPKLIAMP
GVTVYGPQDPQYHTGVIAFNIDGLHPHDAATALDMEGVAVRAGHHCAQPLMAALGLVATARASFYIYNTQADADQLLTSL
QATKEFFEHGTV
>Mature_411_residues
ASNFETLRSDFPILNQQVNDERLVYLDNAATAQRPNQVVDALVHFYQHDNANVHRGVHTLAERATSQYEAARAKVQRFIN
APKTDEIVFTKGTTDSLNLIASTYGEANIQAGDEIVISVMEHHSNLIPWQQLALRKHATLKYIELTATGELDMADAANKI
TDRTKIVSVTHASNVLGTVNPIKALARLAHQHGAVMIADGAQAAPHMPVDVQALDVDFYAFSGHKMLGPTGIGVLYGREN
LLATMPPYQFGGEMIGFVHRDDSTWAELPWKFEAGTQNIAGAIGLGAAVDYLTQLGMDQVQQHEQQLVNYLLPKLIAMPG
VTVYGPQDPQYHTGVIAFNIDGLHPHDAATALDMEGVAVRAGHHCAQPLMAALGLVATARASFYIYNTQADADQLLTSLQ
ATKEFFEHGTV

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=347, Percent_Identity=25.3602305475504, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI156713448, Length=326, Percent_Identity=27.6073619631902, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787970, Length=402, Percent_Identity=49.5024875621891, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1789175, Length=404, Percent_Identity=43.0693069306931, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI48994898, Length=234, Percent_Identity=31.1965811965812, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=406, Percent_Identity=26.1083743842365, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25143064, Length=295, Percent_Identity=29.1525423728814, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319831, Length=345, Percent_Identity=25.5072463768116, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI20129463, Length=371, Percent_Identity=27.4932614555256, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44924; Mature: 44793

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASNFETLRSDFPILNQQVNDERLVYLDNAATAQRPNQVVDALVHFYQHDNANVHRGVHT
CCCCHHHHHCCCCHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
LAERATSQYEAARAKVQRFINAPKTDEIVFTKGTTDSLNLIASTYGEANIQAGDEIVISV
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHHH
MEHHSNLIPWQQLALRKHATLKYIELTATGELDMADAANKITDRTKIVSVTHASNVLGTV
HHHCCCCCCHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCCCC
NPIKALARLAHQHGAVMIADGAQAAPHMPVDVQALDVDFYAFSGHKMLGPTGIGVLYGRE
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEEEEEECCCEEECCCCCEEEECCC
NLLATMPPYQFGGEMIGFVHRDDSTWAELPWKFEAGTQNIAGAIGLGAAVDYLTQLGMDQ
CCEEECCCHHHCCCEEEEEECCCCCHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHCHHH
VQQHEQQLVNYLLPKLIAMPGVTVYGPQDPQYHTGVIAFNIDGLHPHDAATALDMEGVAV
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCEEE
RAGHHCAQPLMAALGLVATARASFYIYNTQADADQLLTSLQATKEFFEHGTV
ECCCHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASNFETLRSDFPILNQQVNDERLVYLDNAATAQRPNQVVDALVHFYQHDNANVHRGVHT
CCCHHHHHCCCCHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
LAERATSQYEAARAKVQRFINAPKTDEIVFTKGTTDSLNLIASTYGEANIQAGDEIVISV
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHHH
MEHHSNLIPWQQLALRKHATLKYIELTATGELDMADAANKITDRTKIVSVTHASNVLGTV
HHHCCCCCCHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCCCC
NPIKALARLAHQHGAVMIADGAQAAPHMPVDVQALDVDFYAFSGHKMLGPTGIGVLYGRE
HHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEEEEEECCCEEECCCCCEEEECCC
NLLATMPPYQFGGEMIGFVHRDDSTWAELPWKFEAGTQNIAGAIGLGAAVDYLTQLGMDQ
CCEEECCCHHHCCCEEEEEECCCCCHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHCHHH
VQQHEQQLVNYLLPKLIAMPGVTVYGPQDPQYHTGVIAFNIDGLHPHDAATALDMEGVAV
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCEEE
RAGHHCAQPLMAALGLVATARASFYIYNTQADADQLLTSLQATKEFFEHGTV
ECCCHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]