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The map label for this gene is murC

Identifier: 28378181

GI number: 28378181

Start: 1339444

End: 1340754

Strand: Direct

Name: murC

Synonym: lp_1462

Alternate gene names: 28378181

Gene position: 1339444-1340754 (Clockwise)

Preceding gene: 28378180

Following gene: 28378185

Centisome position: 40.49

GC content: 44.32

Gene sequence:

>1311_bases
ATGGATAAAGCAACGGTTTATTATTTTGTTGGGATCAAGGGCTCTGGGATGAGCTCACTAGCCTTGATTTTACATGACAA
GGGTTACCAAGTTGAAGGCTCAGATATTGAACAATATACGTTTACGCAAAAAGGTCTAGCTGCAGCTGGCATTAAGATGC
TACCGTTTTCCGAAGATAACATTCGCGAAGGCCTCACAGTGATTGCGGGGAACTCATTTACTGATGACCATCCTGAAATC
AAAAAGGCGCGTGAAATGGGGTTGCCCGTTTATCGTTATCATGAATTTCTTGGAAAATTAATGGAAGGCTTCACGAGTAT
TGGTGTGGCCGGGACTCACGGGAAGACGTCGACAACTGGTTTGTTGTCCCACGTTTTGAGTCATATCGCTCCCACCAGTT
ACTTGATTGGTGATGGGACCGGTAAAGGCACCCCTGACGCGCGTTTCTTCGTTTTTGAAGCGGATGAATATCGGCGGCAC
TTCGTTGCTTACCATCCCGATTATGCCATCATGACGAACGTTGACTTTGACCATCCTGATTACTACAAGGATTTAGCTGA
CGTTCAATCCGCTTTCCAACAATTTGGCAATCAAGTGAAGAAGGGCATCTTTGCTTGGGGTGACGATGAAAGTTTACGAC
ACCTCGATGTTGATACCCCAATTTACTATTACGGGACGAATGACCGTGACGACTTTCAAGCGGTTAATATCAAACGAACG
ACTAAGGGGTCTTCATTTGAAGTGAAGTATCACGATGAATCGTTAGGGAAATTTGAAATCCCATTGTTTGGTGAACACAA
TGTCTTAAACAGCACGGCTGTCATTGCGGTTTCTTACTTTGAAAAGGTGAACTTGGACGAAATTCGGCGGGAACTCCTCG
ACTTTAGTGGGGTTAAACGACGTTTCTCAGAACATCAAGTTGGCGATATGGTCATGATCGACGACTACGCACATCATCCA
TCAGAAATTAAAGCAACATTGGATGCTGCACGCCAAAAGTATCCGGATAAGGAAATCTTGGCCGTATTCCAACCACATAC
GTTCTCACGGACGAAAGCATTGATGGATGGCTTTGCAGCCAGCTTAAGCAAGGCAGATCACGTCTTTTTGACCAATATCT
TCAGTTCTGCCCGTGAAAAATCTGGTGATGTTTCCTCCAAAGACTTAGCTGCTAAGTTACCCAATGGTGGTGAAATTATC
ACGACCGATGACATGTCTGCTTTAACGGCTTACCACAATGCCGTCGCTGTCTTTATGGGTGCTGGTGACATTCAAAAGTA
CGAAAAAATTTATGAAGACCAAATGAAATAA

Upstream 100 bases:

>100_bases
CGGCGGCAGATTTAACTAAATTACAAGCCAATTCATAATTAAAAATAAAGCGATTCACCTCATGATTGATGAATTGTGAA
TATGGGAGATTATTATCATA

Downstream 100 bases:

>100_bases
TTTTTAAAAGGGTCTCTGTCAACCGGTGTTGATGAAGTTATATTTAGAATCCAATTCATTTACGAATTGGGCTCTTTTTT
TCGATTTTGATTTTGAACTC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MDKATVYYFVGIKGSGMSSLALILHDKGYQVEGSDIEQYTFTQKGLAAAGIKMLPFSEDNIREGLTVIAGNSFTDDHPEI
KKAREMGLPVYRYHEFLGKLMEGFTSIGVAGTHGKTSTTGLLSHVLSHIAPTSYLIGDGTGKGTPDARFFVFEADEYRRH
FVAYHPDYAIMTNVDFDHPDYYKDLADVQSAFQQFGNQVKKGIFAWGDDESLRHLDVDTPIYYYGTNDRDDFQAVNIKRT
TKGSSFEVKYHDESLGKFEIPLFGEHNVLNSTAVIAVSYFEKVNLDEIRRELLDFSGVKRRFSEHQVGDMVMIDDYAHHP
SEIKATLDAARQKYPDKEILAVFQPHTFSRTKALMDGFAASLSKADHVFLTNIFSSAREKSGDVSSKDLAAKLPNGGEII
TTDDMSALTAYHNAVAVFMGAGDIQKYEKIYEDQMK

Sequences:

>Translated_436_residues
MDKATVYYFVGIKGSGMSSLALILHDKGYQVEGSDIEQYTFTQKGLAAAGIKMLPFSEDNIREGLTVIAGNSFTDDHPEI
KKAREMGLPVYRYHEFLGKLMEGFTSIGVAGTHGKTSTTGLLSHVLSHIAPTSYLIGDGTGKGTPDARFFVFEADEYRRH
FVAYHPDYAIMTNVDFDHPDYYKDLADVQSAFQQFGNQVKKGIFAWGDDESLRHLDVDTPIYYYGTNDRDDFQAVNIKRT
TKGSSFEVKYHDESLGKFEIPLFGEHNVLNSTAVIAVSYFEKVNLDEIRRELLDFSGVKRRFSEHQVGDMVMIDDYAHHP
SEIKATLDAARQKYPDKEILAVFQPHTFSRTKALMDGFAASLSKADHVFLTNIFSSAREKSGDVSSKDLAAKLPNGGEII
TTDDMSALTAYHNAVAVFMGAGDIQKYEKIYEDQMK
>Mature_436_residues
MDKATVYYFVGIKGSGMSSLALILHDKGYQVEGSDIEQYTFTQKGLAAAGIKMLPFSEDNIREGLTVIAGNSFTDDHPEI
KKAREMGLPVYRYHEFLGKLMEGFTSIGVAGTHGKTSTTGLLSHVLSHIAPTSYLIGDGTGKGTPDARFFVFEADEYRRH
FVAYHPDYAIMTNVDFDHPDYYKDLADVQSAFQQFGNQVKKGIFAWGDDESLRHLDVDTPIYYYGTNDRDDFQAVNIKRT
TKGSSFEVKYHDESLGKFEIPLFGEHNVLNSTAVIAVSYFEKVNLDEIRRELLDFSGVKRRFSEHQVGDMVMIDDYAHHP
SEIKATLDAARQKYPDKEILAVFQPHTFSRTKALMDGFAASLSKADHVFLTNIFSSAREKSGDVSSKDLAAKLPNGGEII
TTDDMSALTAYHNAVAVFMGAGDIQKYEKIYEDQMK

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=437, Percent_Identity=28.604118993135, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790680, Length=385, Percent_Identity=30.6493506493506, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_LACPL (Q88WZ5)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785073.1
- ProteinModelPortal:   Q88WZ5
- SMR:   Q88WZ5
- GeneID:   1062363
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1462
- NMPDR:   fig|220668.1.peg.1207
- HOGENOM:   HBG476594
- OMA:   YHEFLGD
- ProtClustDB:   PRK00421
- BioCyc:   LPLA220668:LP_1462-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 48751; Mature: 48751

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKATVYYFVGIKGSGMSSLALILHDKGYQVEGSDIEQYTFTQKGLAAAGIKMLPFSEDN
CCCEEEEEEEEECCCCCCEEEEEEECCCCEECCCCCHHHHHHHCCHHHCCEEEECCCCCH
IREGLTVIAGNSFTDDHPEIKKAREMGLPVYRYHEFLGKLMEGFTSIGVAGTHGKTSTTG
HHCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LLSHVLSHIAPTSYLIGDGTGKGTPDARFFVFEADEYRRHFVAYHPDYAIMTNVDFDHPD
HHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECHHHCCEEEEECCCEEEEEECCCCCCH
YYKDLADVQSAFQQFGNQVKKGIFAWGDDESLRHLDVDTPIYYYGTNDRDDFQAVNIKRT
HHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCEEEECCCCEEEECCCCCCCCEEEEEEEE
TKGSSFEVKYHDESLGKFEIPLFGEHNVLNSTAVIAVSYFEKVNLDEIRRELLDFSGVKR
CCCCEEEEEECCCCCCEEECEECCCCCCCCCHHEEEEEHHHHCCHHHHHHHHHHHHHHHH
RFSEHQVGDMVMIDDYAHHPSEIKATLDAARQKYPDKEILAVFQPHTFSRTKALMDGFAA
HHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHHHHH
SLSKADHVFLTNIFSSAREKSGDVSSKDLAAKLPNGGEIITTDDMSALTAYHNAVAVFMG
HHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEEECCHHHHHHHHCEEEEEEC
AGDIQKYEKIYEDQMK
CCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDKATVYYFVGIKGSGMSSLALILHDKGYQVEGSDIEQYTFTQKGLAAAGIKMLPFSEDN
CCCEEEEEEEEECCCCCCEEEEEEECCCCEECCCCCHHHHHHHCCHHHCCEEEECCCCCH
IREGLTVIAGNSFTDDHPEIKKAREMGLPVYRYHEFLGKLMEGFTSIGVAGTHGKTSTTG
HHCCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LLSHVLSHIAPTSYLIGDGTGKGTPDARFFVFEADEYRRHFVAYHPDYAIMTNVDFDHPD
HHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECHHHCCEEEEECCCEEEEEECCCCCCH
YYKDLADVQSAFQQFGNQVKKGIFAWGDDESLRHLDVDTPIYYYGTNDRDDFQAVNIKRT
HHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCEEEECCCCEEEECCCCCCCCEEEEEEEE
TKGSSFEVKYHDESLGKFEIPLFGEHNVLNSTAVIAVSYFEKVNLDEIRRELLDFSGVKR
CCCCEEEEEECCCCCCEEECEECCCCCCCCCHHEEEEEHHHHCCHHHHHHHHHHHHHHHH
RFSEHQVGDMVMIDDYAHHPSEIKATLDAARQKYPDKEILAVFQPHTFSRTKALMDGFAA
HHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHHHHH
SLSKADHVFLTNIFSSAREKSGDVSSKDLAAKLPNGGEIITTDDMSALTAYHNAVAVFMG
HHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEEECCHHHHHHHHCEEEEEEC
AGDIQKYEKIYEDQMK
CCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566