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The map label for this gene is ifcA [H]

Identifier: 28377901

GI number: 28377901

Start: 1010911

End: 1012299

Strand: Direct

Name: ifcA [H]

Synonym: lp_1113

Alternate gene names: 28377901

Gene position: 1010911-1012299 (Clockwise)

Preceding gene: 28377900

Following gene: 28377902

Centisome position: 30.56

GC content: 50.54

Gene sequence:

>1389_bases
ATGGCTGAAAAGTTTACATTTACACCAACCGCCTTAGCGGATCTAAAACCGAACTATGACGTAGTGATTATTGGATCGGG
GGGCGCGGGTTTGACTGCGGCAATCCAGGCACATGAATTGGGCCTGAACCCGGTTATTTTAGAAAAAATGCCGAAAATCG
GTGGTAACACCACCCGGGCTTCATCCGGTATGAATGCGGCGGAGACGAACGTCCAATTGCATCACCATATTGTTGATAGT
TTTGGCGATTTCTACGGCGAAACCCTTAAAGGTGGTGGCGGTATGAATAACCAAGCACTGTTGAAATTCTTCACGGAACA
CAGTGCGCTCGCAATTGACTGGTTAGCAGACCACGGCATTAAGTTGGATGATTTGACGATTACTGGTGGGATGAGTGTGA
TGCGGACTCATCGGCCAAGTTCCATGGCTCCCATTGGTGGTTTCTTAGTCACTGAGTTGTTGAAACAAGTGGCGGCTGAC
CAGTTACCACTCTTCACAGATGTCAAAGTCGATGAACTACTCGTCGAAGCCGGCAAAATTAGTGGCGTCAAGGCAACAAC
CCCAGATGGAGCTGTCACGATTACGGCTGGAGCCGTCTTGTTAGCAACCGGTGGCTTCGGTGCGAATAAGACCTTGTTAG
GCCAGTATCGTGATGATCTTAAAAACTATCAGACGACCAATCAGCCGGGCGCGACTGGAGATGGGATTCTGTTGGCACAA
GCTATTGGGGCTAAGTTGGTTGATATGGACCAAGTCCAAGTTCATCCGACGGTCCAACAAGATACAGATCATGCTTATTT
AATCGGTGAAGCGGTTCGGGGCGAAGGTGCGATTTTGGTCGATAACCAGGGGGCTCGTTTCGTCAATGAACTCGACACGC
GTAAGAACGTGACGGCCGCTATCGACCAACTGGGTGGTACTGGTGCCTACTTGATCTTTGACCGCGGTATTCGTGACCGG
GTCAAAGCGGTTGAATTCTATGATCACATTGGCCTGGTAAAGACTGGGACTGACTTGGAAGCACTGGCGACTGCGACCGG
CTTAGACGCTGCGACGCTTAAACAGACGGTGGCTGACTGGAATCAGGCAGTCGCTAACCATAATGATGCGGCCTTTAACC
GGACGACTGGGATGGATCGCGATATTGCGGCGGGACCGTTCTACTCAATTCACATTGCGCCAGCTGTTCACTACACGATG
GGTGGGATTGCCATTAATCCAGCAACCCAAGTGTTGAATCAGGACGAACGACCAATTGCCGGCCTGTTTGCAGCCGGTGA
AGTGGTCGGCGGTCTCCACGGCAATAACCGGATTGGTGGTAACTCAATCGCTGAAACGGTGATCTTTGGCCGTCAAGCCG
GACAACAAATGTTCAAATATTTACAATAA

Upstream 100 bases:

>100_bases
TGGAATGGTGGCCCGTGTCCAGTTAACGACAATAATAAATGAGATTTTGGTTCCATCCTGGGGAATACCCCGGACGAATT
GAGAGGAGAAGTGGCAATCA

Downstream 100 bases:

>100_bases
GTTATTTTGACTAACCCAAATCAATAGTCCATGCGCTTGAGTAATCGGTGCGTGGGCTATTTTTGATTTGGGCTGTAGTT
AGAGACCAAAGAAATTAGTT

Product: fumarate reductase, flavoprotein subunit precursor, N-terminally truncated

Products: NA

Alternate protein names: Fe(3+)-induced flavocytochrome C3; Ifc3; Iron(III)-induced flavocytochrome C3 [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAEKFTFTPTALADLKPNYDVVIIGSGGAGLTAAIQAHELGLNPVILEKMPKIGGNTTRASSGMNAAETNVQLHHHIVDS
FGDFYGETLKGGGGMNNQALLKFFTEHSALAIDWLADHGIKLDDLTITGGMSVMRTHRPSSMAPIGGFLVTELLKQVAAD
QLPLFTDVKVDELLVEAGKISGVKATTPDGAVTITAGAVLLATGGFGANKTLLGQYRDDLKNYQTTNQPGATGDGILLAQ
AIGAKLVDMDQVQVHPTVQQDTDHAYLIGEAVRGEGAILVDNQGARFVNELDTRKNVTAAIDQLGGTGAYLIFDRGIRDR
VKAVEFYDHIGLVKTGTDLEALATATGLDAATLKQTVADWNQAVANHNDAAFNRTTGMDRDIAAGPFYSIHIAPAVHYTM
GGIAINPATQVLNQDERPIAGLFAAGEVVGGLHGNNRIGGNSIAETVIFGRQAGQQMFKYLQ

Sequences:

>Translated_462_residues
MAEKFTFTPTALADLKPNYDVVIIGSGGAGLTAAIQAHELGLNPVILEKMPKIGGNTTRASSGMNAAETNVQLHHHIVDS
FGDFYGETLKGGGGMNNQALLKFFTEHSALAIDWLADHGIKLDDLTITGGMSVMRTHRPSSMAPIGGFLVTELLKQVAAD
QLPLFTDVKVDELLVEAGKISGVKATTPDGAVTITAGAVLLATGGFGANKTLLGQYRDDLKNYQTTNQPGATGDGILLAQ
AIGAKLVDMDQVQVHPTVQQDTDHAYLIGEAVRGEGAILVDNQGARFVNELDTRKNVTAAIDQLGGTGAYLIFDRGIRDR
VKAVEFYDHIGLVKTGTDLEALATATGLDAATLKQTVADWNQAVANHNDAAFNRTTGMDRDIAAGPFYSIHIAPAVHYTM
GGIAINPATQVLNQDERPIAGLFAAGEVVGGLHGNNRIGGNSIAETVIFGRQAGQQMFKYLQ
>Mature_461_residues
AEKFTFTPTALADLKPNYDVVIIGSGGAGLTAAIQAHELGLNPVILEKMPKIGGNTTRASSGMNAAETNVQLHHHIVDSF
GDFYGETLKGGGGMNNQALLKFFTEHSALAIDWLADHGIKLDDLTITGGMSVMRTHRPSSMAPIGGFLVTELLKQVAADQ
LPLFTDVKVDELLVEAGKISGVKATTPDGAVTITAGAVLLATGGFGANKTLLGQYRDDLKNYQTTNQPGATGDGILLAQA
IGAKLVDMDQVQVHPTVQQDTDHAYLIGEAVRGEGAILVDNQGARFVNELDTRKNVTAAIDQLGGTGAYLIFDRGIRDRV
KAVEFYDHIGLVKTGTDLEALATATGLDAATLKQTVADWNQAVANHNDAAFNRTTGMDRDIAAGPFYSIHIAPAVHYTMG
GIAINPATQVLNQDERPIAGLFAAGEVVGGLHGNNRIGGNSIAETVIFGRQAGQQMFKYLQ

Specific function: Catalyzes unidirectional fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=440, Percent_Identity=27.0454545454545, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1790597, Length=391, Percent_Identity=29.156010230179, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71986328, Length=448, Percent_Identity=34.8214285714286, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17505833, Length=439, Percent_Identity=27.3348519362187, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17550100, Length=466, Percent_Identity=28.3261802575107, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320788, Length=466, Percent_Identity=37.9828326180258, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6322511, Length=472, Percent_Identity=34.9576271186441, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322416, Length=469, Percent_Identity=26.865671641791, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322701, Length=466, Percent_Identity=26.3948497854077, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24663005, Length=466, Percent_Identity=24.6781115879828, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR010960
- InterPro:   IPR011031 [H]

Pfam domain/function: PF00890 FAD_binding_2 [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 48771; Mature: 48640

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKFTFTPTALADLKPNYDVVIIGSGGAGLTAAIQAHELGLNPVILEKMPKIGGNTTRA
CCCCEECCCHHHHCCCCCCCEEEEECCCCCCEEEEEHHHCCCCHHHHHHCCCCCCCCCCC
SSGMNAAETNVQLHHHIVDSFGDFYGETLKGGGGMNNQALLKFFTEHSALAIDWLADHGI
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEHHHCCC
KLDDLTITGGMSVMRTHRPSSMAPIGGFLVTELLKQVAADQLPLFTDVKVDELLVEAGKI
EEEEEEEECCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHCCC
SGVKATTPDGAVTITAGAVLLATGGFGANKTLLGQYRDDLKNYQTTNQPGATGDGILLAQ
CCCEECCCCCCEEEEECEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
AIGAKLVDMDQVQVHPTVQQDTDHAYLIGEAVRGEGAILVDNQGARFVNELDTRKNVTAA
HHCCHHCCCCCEEECCCCCCCCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHCHHHHH
IDQLGGTGAYLIFDRGIRDRVKAVEFYDHIGLVKTGTDLEALATATGLDAATLKQTVADW
HHHCCCCEEEEEEECCHHHHHHHHHHHHHCCEEECCCCHHHHHHHCCCCHHHHHHHHHHH
NQAVANHNDAAFNRTTGMDRDIAAGPFYSIHIAPAVHYTMGGIAINPATQVLNQDERPIA
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEECCEEECHHHHHHCCCCCCHH
GLFAAGEVVGGLHGNNRIGGNSIAETVIFGRQAGQQMFKYLQ
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEKFTFTPTALADLKPNYDVVIIGSGGAGLTAAIQAHELGLNPVILEKMPKIGGNTTRA
CCCEECCCHHHHCCCCCCCEEEEECCCCCCEEEEEHHHCCCCHHHHHHCCCCCCCCCCC
SSGMNAAETNVQLHHHIVDSFGDFYGETLKGGGGMNNQALLKFFTEHSALAIDWLADHGI
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEHHHCCC
KLDDLTITGGMSVMRTHRPSSMAPIGGFLVTELLKQVAADQLPLFTDVKVDELLVEAGKI
EEEEEEEECCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHCCC
SGVKATTPDGAVTITAGAVLLATGGFGANKTLLGQYRDDLKNYQTTNQPGATGDGILLAQ
CCCEECCCCCCEEEEECEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
AIGAKLVDMDQVQVHPTVQQDTDHAYLIGEAVRGEGAILVDNQGARFVNELDTRKNVTAA
HHCCHHCCCCCEEECCCCCCCCCCEEEEEEEECCCCEEEECCCCCHHHHHHHHHCHHHHH
IDQLGGTGAYLIFDRGIRDRVKAVEFYDHIGLVKTGTDLEALATATGLDAATLKQTVADW
HHHCCCCEEEEEEECCHHHHHHHHHHHHHCCEEECCCCHHHHHHHCCCCHHHHHHHHHHH
NQAVANHNDAAFNRTTGMDRDIAAGPFYSIHIAPAVHYTMGGIAINPATQVLNQDERPIA
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEECCEEECHHHHHHCCCCCCHH
GLFAAGEVVGGLHGNNRIGGNSIAETVIFGRQAGQQMFKYLQ
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10455032; 10581549 [H]