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The map label for this gene is fumC [H]

Identifier: 28377900

GI number: 28377900

Start: 1009356

End: 1010738

Strand: Direct

Name: fumC [H]

Synonym: lp_1112

Alternate gene names: 28377900

Gene position: 1009356-1010738 (Clockwise)

Preceding gene: 28377898

Following gene: 28377901

Centisome position: 30.51

GC content: 46.42

Gene sequence:

>1383_bases
ATGACAGAATATCGAGTTGAATCAGATACTTTAGGCGAAGTTAAAATTCCTGCGAACGCCTTATGGGGTGCTCAGACAGA
ACGGAGTCGCCATAACTTTCCGACTGGTACGAAGATGCCGTTGGAAATGATTCGGGCATTACTTCAAATTAAGCGGGCCG
CAGCGATTGCGAATAAAGAAGTTGAAGCAATGACTGCTGAAAAAGCTGATTTAATCGTGGCTGCCATTGATAAGTTATTA
GCGCTCGACGATGAAGATTTGCGTAAGGACTTTCCGCTGGTTGTTTACCAAACTGGTTCGGGGACGCAAACGAATATGAA
CGTTAATGAAGTGGTCGCACACATGGCTGGTAAGATCAATCCTGATATTGAAATCTTGCCGAACGACGATGTTAACCATG
GTCAAAGCTCTAACGATATCTTCCCAACGGCGATGAACATTACGGCCGCAGTTGCCGTGGATAAGCTGATTGCCGCAGCG
GAACACTTATTAGCGGAATTGAAGATCAAACAAAAGAAGTACTGGCGGGTAGTAAAGATTGGCCGGACCCATCTTCAAGA
TGCAACGCCATTAACTTTTGGCCAAGAAGTGAGTGGTTGGGCCAGTGCGATTGAACATGATATTGCCTACTTAAAACAGT
TGAATCCAACGTTAGGCGAGCTTGCAATGGGTGGGACCGCCGTTGGGACTGGTCTAAATGCTGCCCCTCATTTTGCTGAA
AATATTGCGGCGGCGATGAGCAAATTGTATGGGATTGAATTTACGGCTGATTCCAATAAGTTCTATGGTTTGGCCCATCA
TTCTGGTTTAAACGTGGTTCACGGGGCCATCAAGACCCTAGCAGCCGATTTGATGAAGATTGCCAATGATGTGCGGTTCT
TGGCAAGCGGTCCACGGGCCGGTTATGACGAATTAAACATTCCGGCTAACGAACCCGGCTCATCAATCATGCCTGGGAAA
GTTAACCCAACCCAAGCTGAAGCCATCACTATGGCAGCGGTACGAGTTATGGGGAATGACGTGGTCGTCGATTTAGCTTC
TAGCCAAGGTAATTTTGAAATGAACGTTTACAAGACCGTTTTGATTGATGCTTTCCTTGAATCTGCTGAATTGTTAGCTG
GAACGATTACCGGCTTCACTGACCGAATGATTGCTGGTTTGACGGTCAACCAAGACCGGATGGCAGAGTTAGTCGACAGT
TCCTTGATGACGGTTACGGCATTGTCACCACATATTGGCTATCATGATAGTGCGATGATTGCTCAAGCAGCTGAAAAAGC
GGGGACGACATTGCGTGAAGCAGCTATCAAGTCTGGCAAAGTAACCGCGGAACAATTCGATGAATGGATGGTTCCACTGG
ATATGACGAATATTGATGATTAA

Upstream 100 bases:

>100_bases
ATAGCTATATGGGGGCGCTAAACTAGGTTTATAAACTAAATGTTATTTTTTTCACACACTTAGTAAGCGCTTACCAACAC
ATTAATTGGAGGTTATCAAC

Downstream 100 bases:

>100_bases
GCTAAAATAAGTATTGATCGGCGTTGAACCGTTAACGTGGATCAAGGTGGCACGGGTCATTGTTCCTAGACTTGGAATGG
TGGCCCGTGTCCAGTTAACG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTEYRVESDTLGEVKIPANALWGAQTERSRHNFPTGTKMPLEMIRALLQIKRAAAIANKEVEAMTAEKADLIVAAIDKLL
ALDDEDLRKDFPLVVYQTGSGTQTNMNVNEVVAHMAGKINPDIEILPNDDVNHGQSSNDIFPTAMNITAAVAVDKLIAAA
EHLLAELKIKQKKYWRVVKIGRTHLQDATPLTFGQEVSGWASAIEHDIAYLKQLNPTLGELAMGGTAVGTGLNAAPHFAE
NIAAAMSKLYGIEFTADSNKFYGLAHHSGLNVVHGAIKTLAADLMKIANDVRFLASGPRAGYDELNIPANEPGSSIMPGK
VNPTQAEAITMAAVRVMGNDVVVDLASSQGNFEMNVYKTVLIDAFLESAELLAGTITGFTDRMIAGLTVNQDRMAELVDS
SLMTVTALSPHIGYHDSAMIAQAAEKAGTTLREAAIKSGKVTAEQFDEWMVPLDMTNIDD

Sequences:

>Translated_460_residues
MTEYRVESDTLGEVKIPANALWGAQTERSRHNFPTGTKMPLEMIRALLQIKRAAAIANKEVEAMTAEKADLIVAAIDKLL
ALDDEDLRKDFPLVVYQTGSGTQTNMNVNEVVAHMAGKINPDIEILPNDDVNHGQSSNDIFPTAMNITAAVAVDKLIAAA
EHLLAELKIKQKKYWRVVKIGRTHLQDATPLTFGQEVSGWASAIEHDIAYLKQLNPTLGELAMGGTAVGTGLNAAPHFAE
NIAAAMSKLYGIEFTADSNKFYGLAHHSGLNVVHGAIKTLAADLMKIANDVRFLASGPRAGYDELNIPANEPGSSIMPGK
VNPTQAEAITMAAVRVMGNDVVVDLASSQGNFEMNVYKTVLIDAFLESAELLAGTITGFTDRMIAGLTVNQDRMAELVDS
SLMTVTALSPHIGYHDSAMIAQAAEKAGTTLREAAIKSGKVTAEQFDEWMVPLDMTNIDD
>Mature_459_residues
TEYRVESDTLGEVKIPANALWGAQTERSRHNFPTGTKMPLEMIRALLQIKRAAAIANKEVEAMTAEKADLIVAAIDKLLA
LDDEDLRKDFPLVVYQTGSGTQTNMNVNEVVAHMAGKINPDIEILPNDDVNHGQSSNDIFPTAMNITAAVAVDKLIAAAE
HLLAELKIKQKKYWRVVKIGRTHLQDATPLTFGQEVSGWASAIEHDIAYLKQLNPTLGELAMGGTAVGTGLNAAPHFAEN
IAAAMSKLYGIEFTADSNKFYGLAHHSGLNVVHGAIKTLAADLMKIANDVRFLASGPRAGYDELNIPANEPGSSIMPGKV
NPTQAEAITMAAVRVMGNDVVVDLASSQGNFEMNVYKTVLIDAFLESAELLAGTITGFTDRMIAGLTVNQDRMAELVDSS
LMTVTALSPHIGYHDSAMIAQAAEKAGTTLREAAIKSGKVTAEQFDEWMVPLDMTNIDD

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=49.6746203904555, Blast_Score=422, Evalue=1e-118,
Organism=Escherichia coli, GI1787896, Length=462, Percent_Identity=48.4848484848485, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI87082375, Length=453, Percent_Identity=33.9955849889625, Blast_Score=276, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=48.4913793103448, Blast_Score=430, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI32565146, Length=322, Percent_Identity=51.2422360248447, Blast_Score=331, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6324993, Length=465, Percent_Identity=46.6666666666667, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=46.6522678185745, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24640179, Length=465, Percent_Identity=46.6666666666667, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24640177, Length=465, Percent_Identity=46.6666666666667, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=45.0431034482759, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=40.9090909090909, Blast_Score=342, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49498; Mature: 49367

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEYRVESDTLGEVKIPANALWGAQTERSRHNFPTGTKMPLEMIRALLQIKRAAAIANKE
CCCEECCCCCCCCEECCCHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
VEAMTAEKADLIVAAIDKLLALDDEDLRKDFPLVVYQTGSGTQTNMNVNEVVAHMAGKIN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCC
PDIEILPNDDVNHGQSSNDIFPTAMNITAAVAVDKLIAAAEHLLAELKIKQKKYWRVVKI
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRTHLQDATPLTFGQEVSGWASAIEHDIAYLKQLNPTLGELAMGGTAVGTGLNAAPHFAE
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHCCCCCCCHHHHH
NIAAAMSKLYGIEFTADSNKFYGLAHHSGLNVVHGAIKTLAADLMKIANDVRFLASGPRA
HHHHHHHHHHCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GYDELNIPANEPGSSIMPGKVNPTQAEAITMAAVRVMGNDVVVDLASSQGNFEMNVYKTV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHH
LIDAFLESAELLAGTITGFTDRMIAGLTVNQDRMAELVDSSLMTVTALSPHIGYHDSAMI
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHCHHEEEEECCCCCCCCCHHHH
AQAAEKAGTTLREAAIKSGKVTAEQFDEWMVPLDMTNIDD
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TEYRVESDTLGEVKIPANALWGAQTERSRHNFPTGTKMPLEMIRALLQIKRAAAIANKE
CCEECCCCCCCCEECCCHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
VEAMTAEKADLIVAAIDKLLALDDEDLRKDFPLVVYQTGSGTQTNMNVNEVVAHMAGKIN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCC
PDIEILPNDDVNHGQSSNDIFPTAMNITAAVAVDKLIAAAEHLLAELKIKQKKYWRVVKI
CCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRTHLQDATPLTFGQEVSGWASAIEHDIAYLKQLNPTLGELAMGGTAVGTGLNAAPHFAE
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHCCCCCCCHHHHH
NIAAAMSKLYGIEFTADSNKFYGLAHHSGLNVVHGAIKTLAADLMKIANDVRFLASGPRA
HHHHHHHHHHCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GYDELNIPANEPGSSIMPGKVNPTQAEAITMAAVRVMGNDVVVDLASSQGNFEMNVYKTV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHH
LIDAFLESAELLAGTITGFTDRMIAGLTVNQDRMAELVDSSLMTVTALSPHIGYHDSAMI
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHCHHEEEEECCCCCCCCCHHHH
AQAAEKAGTTLREAAIKSGKVTAEQFDEWMVPLDMTNIDD
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]