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The map label for this gene is serS2

Identifier: 28377821

GI number: 28377821

Start: 933125

End: 934402

Strand: Direct

Name: serS2

Synonym: lp_1012

Alternate gene names: 28377821

Gene position: 933125-934402 (Clockwise)

Preceding gene: 28377820

Following gene: 28377822

Centisome position: 28.21

GC content: 44.52

Gene sequence:

>1278_bases
ATGTTAGATGTTAAAATGATTCGTCAAAATCCAGATTTTGTAAAAGAACAGCTTGGTCATCGGGGTGTTGCTGCGAGTGA
CATCGATGATTTATTGGCCGCTGATGAAAAGCGTCGTGAATTGATCGCCAAGAGCGAACAATTGAAGTCGACACGTAACC
AAGTTTCAGGCGAAATTTCACAGAAGAAGCGGAACAAGGAAGACGCTAGTGCCGAAATTGCAGAAATGCAAAAAGTTAGC
GCCGATGTGAAGACGTTGGATGAAGAACGGCGGACAGTTGATGCCCAAGTTCAGGATATGGCTGCACATTTACCAAACAT
GCCCCATCCCGACGTACCAGTTAGCTTGAAAGAAGAAGATGCCGTTGAATTACGTCGAATCGGGACACCACGGCATTTTG
ACTTTACGCCGAAAGCACATTGGGATATCGGTGAAGATTTAGGCATCTTAGACTTTGAGCGCGGTGCTAAGGTTTCTGGT
AGTCGTTTCTTATACTACGTGGGCGATGGTGCTAAACTGGAACGCGCCGTTTACAACTTTTTCTTAGACCAGCACGAAGC
TGAAGGGTATACGGAAGTTTTGCCGCCATACATGGTCACTGATGAATCTATGTACGGTACCGGCCAATTTCCTAAGTTCA
AGGAAGACGCTTTCCGGATTACGACGCAAGATTTGACGTTGATTCCAACGGCCGAGGTGCCATTAGTCAACTATTATCGT
GATGAAGTTATTCCCGCTGAAAAATTACCAGTTTACTTTACGGCCTTATCACCAGCCTTCCGTGAAGAAGCTGGTAGTGC
TGGTCGTGATACGAAAGGCTTGATTCGCTTACACCAATTCAATAAGGTTGAAATGGTTAAGTTCACGAAACCAGAAGATT
CATGGGATGAATTAGAGAAGTTGACCAACAATGCCGAATCATTGCTAAAGAAACTTGGGTTACCATATCACGTTATTACG
TTAACGACTGGTGACATGAGCTTCACAGCTGCCATGACACATGACTTGGAAGTTTGGTTCCCAGAACAAGACAAGTACCG
GGAAATCTCGAGTTGTTCAAATTGTACTGATTTCCAAGCTCGGCGGGCGCACATTCAATATCGCGATGACGATGGCAAAT
TGCAATTCGTTCATACTTTGAACGGGAGTGGCTTAGCTGTCGGTCGGACCGTTGCAGCTATTTTGGAAAACTATCAAAAT
GAAGATGGGACGGTTACGATTCCAGATGTATTAGTTCCATATATGCACGGTAAGACGAAGATTGAAAAACAAGGTTAA

Upstream 100 bases:

>100_bases
ATCCTGAACTTGGGTGGTACCGCGAATCGCAGTCTCTTCGTCCCAATTGGGAGGAGAGACTGTTTTTATTTACGATTAAA
AGTGAAAAGGAGACGTCGTT

Downstream 100 bases:

>100_bases
TTGAGATGAAGTTAGCGAACTCGCAGTGATGCGAGTTCGCTTTTTTTGCATAATTAATGAGTATTAAAGGGAACTGTCGA
TTTTAAAATGTGAGTGGAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase 2; SerRS 2; Seryl-tRNA(Ser/Sec) synthetase 2

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDVKMIRQNPDFVKEQLGHRGVAASDIDDLLAADEKRRELIAKSEQLKSTRNQVSGEISQKKRNKEDASAEIAEMQKVS
ADVKTLDEERRTVDAQVQDMAAHLPNMPHPDVPVSLKEEDAVELRRIGTPRHFDFTPKAHWDIGEDLGILDFERGAKVSG
SRFLYYVGDGAKLERAVYNFFLDQHEAEGYTEVLPPYMVTDESMYGTGQFPKFKEDAFRITTQDLTLIPTAEVPLVNYYR
DEVIPAEKLPVYFTALSPAFREEAGSAGRDTKGLIRLHQFNKVEMVKFTKPEDSWDELEKLTNNAESLLKKLGLPYHVIT
LTTGDMSFTAAMTHDLEVWFPEQDKYREISSCSNCTDFQARRAHIQYRDDDGKLQFVHTLNGSGLAVGRTVAAILENYQN
EDGTVTIPDVLVPYMHGKTKIEKQG

Sequences:

>Translated_425_residues
MLDVKMIRQNPDFVKEQLGHRGVAASDIDDLLAADEKRRELIAKSEQLKSTRNQVSGEISQKKRNKEDASAEIAEMQKVS
ADVKTLDEERRTVDAQVQDMAAHLPNMPHPDVPVSLKEEDAVELRRIGTPRHFDFTPKAHWDIGEDLGILDFERGAKVSG
SRFLYYVGDGAKLERAVYNFFLDQHEAEGYTEVLPPYMVTDESMYGTGQFPKFKEDAFRITTQDLTLIPTAEVPLVNYYR
DEVIPAEKLPVYFTALSPAFREEAGSAGRDTKGLIRLHQFNKVEMVKFTKPEDSWDELEKLTNNAESLLKKLGLPYHVIT
LTTGDMSFTAAMTHDLEVWFPEQDKYREISSCSNCTDFQARRAHIQYRDDDGKLQFVHTLNGSGLAVGRTVAAILENYQN
EDGTVTIPDVLVPYMHGKTKIEKQG
>Mature_425_residues
MLDVKMIRQNPDFVKEQLGHRGVAASDIDDLLAADEKRRELIAKSEQLKSTRNQVSGEISQKKRNKEDASAEIAEMQKVS
ADVKTLDEERRTVDAQVQDMAAHLPNMPHPDVPVSLKEEDAVELRRIGTPRHFDFTPKAHWDIGEDLGILDFERGAKVSG
SRFLYYVGDGAKLERAVYNFFLDQHEAEGYTEVLPPYMVTDESMYGTGQFPKFKEDAFRITTQDLTLIPTAEVPLVNYYR
DEVIPAEKLPVYFTALSPAFREEAGSAGRDTKGLIRLHQFNKVEMVKFTKPEDSWDELEKLTNNAESLLKKLGLPYHVIT
LTTGDMSFTAAMTHDLEVWFPEQDKYREISSCSNCTDFQARRAHIQYRDDDGKLQFVHTLNGSGLAVGRTVAAILENYQN
EDGTVTIPDVLVPYMHGKTKIEKQG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=464, Percent_Identity=31.0344827586207, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI225579074, Length=371, Percent_Identity=34.7708894878706, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI8923421, Length=371, Percent_Identity=34.5013477088949, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=48.5915492957746, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17539260, Length=465, Percent_Identity=30.9677419354839, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17542084, Length=258, Percent_Identity=31.0077519379845, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=440, Percent_Identity=33.4090909090909, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6321799, Length=414, Percent_Identity=30.6763285024155, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24581334, Length=475, Percent_Identity=29.8947368421053, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI17737985, Length=338, Percent_Identity=31.0650887573964, Blast_Score=161, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS2_LACPL (Q88XZ7)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784713.1
- ProteinModelPortal:   Q88XZ7
- SMR:   Q88XZ7
- GeneID:   1063430
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1012
- NMPDR:   fig|220668.1.peg.847
- HOGENOM:   HBG629391
- OMA:   NLRYRDP
- ProtClustDB:   PRK05431
- BioCyc:   LPLA220668:LP_1012-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48137; Mature: 48137

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVKMIRQNPDFVKEQLGHRGVAASDIDDLLAADEKRRELIAKSEQLKSTRNQVSGEIS
CCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHH
QKKRNKEDASAEIAEMQKVSADVKTLDEERRTVDAQVQDMAAHLPNMPHPDVPVSLKEED
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
AVELRRIGTPRHFDFTPKAHWDIGEDLGILDFERGAKVSGSRFLYYVGDGAKLERAVYNF
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCHHHHHHHHHH
FLDQHEAEGYTEVLPPYMVTDESMYGTGQFPKFKEDAFRITTQDLTLIPTAEVPLVNYYR
HHHHHCCCCCHHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCCHHHHHH
DEVIPAEKLPVYFTALSPAFREEAGSAGRDTKGLIRLHQFNKVEMVKFTKPEDSWDELEK
HHCCCCCCCCEEEEECCHHHHHHCCCCCCCCHHHHEEECCCCEEEEEECCCCCCHHHHHH
LTNNAESLLKKLGLPYHVITLTTGDMSFTAAMTHDLEVWFPEQDKYREISSCSNCTDFQA
HHCHHHHHHHHCCCCEEEEEEEECCCEEEEEEEECEEEECCCCHHHHHHHHCCCCCCHHH
RRAHIQYRDDDGKLQFVHTLNGSGLAVGRTVAAILENYQNEDGTVTIPDVLVPYMHGKTK
HHCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHHHHCCCCE
IEKQG
ECCCC
>Mature Secondary Structure
MLDVKMIRQNPDFVKEQLGHRGVAASDIDDLLAADEKRRELIAKSEQLKSTRNQVSGEIS
CCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHH
QKKRNKEDASAEIAEMQKVSADVKTLDEERRTVDAQVQDMAAHLPNMPHPDVPVSLKEED
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
AVELRRIGTPRHFDFTPKAHWDIGEDLGILDFERGAKVSGSRFLYYVGDGAKLERAVYNF
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEEEECCCHHHHHHHHHH
FLDQHEAEGYTEVLPPYMVTDESMYGTGQFPKFKEDAFRITTQDLTLIPTAEVPLVNYYR
HHHHHCCCCCHHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCCHHHHHH
DEVIPAEKLPVYFTALSPAFREEAGSAGRDTKGLIRLHQFNKVEMVKFTKPEDSWDELEK
HHCCCCCCCCEEEEECCHHHHHHCCCCCCCCHHHHEEECCCCEEEEEECCCCCCHHHHHH
LTNNAESLLKKLGLPYHVITLTTGDMSFTAAMTHDLEVWFPEQDKYREISSCSNCTDFQA
HHCHHHHHHHHCCCCEEEEEEEECCCEEEEEEEECEEEECCCCHHHHHHHHCCCCCCHHH
RRAHIQYRDDDGKLQFVHTLNGSGLAVGRTVAAILENYQNEDGTVTIPDVLVPYMHGKTK
HHCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHHHHCCCCE
IEKQG
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566