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The map label for this gene is lysP [H]

Identifier: 28377818

GI number: 28377818

Start: 929241

End: 930692

Strand: Direct

Name: lysP [H]

Synonym: lp_1008

Alternate gene names: 28377818

Gene position: 929241-930692 (Clockwise)

Preceding gene: 28377817

Following gene: 28377819

Centisome position: 28.09

GC content: 47.31

Gene sequence:

>1452_bases
ATGGCAGAAAAACAACATCAGGAAGTGCATCGTTCCTTACAGACGCGGCATTTATCCATGATTGCATTAGGTGGTAGTAT
CGGGACCGGGCTGTTTGTCGCGTCCGGTTCGGCAATTTCAACGGCTGGGCCAGGGGGAGCATTACTGGCCTACGTTGGTA
TTGGAGTGATGGTTTACTTTTTAATGACTAGTCTGGGCGAAATGGCAACTTATTTGCCCGTTTCAGGTTCGTTTTCCACG
TATGCCACGAAGTTTGTTGACCCGGCACTTGGGTTTGCGATGGGCTGGAATTACTGGTTCAACTGGGCAATCACGTTAGC
GGTCGATATTAGTACGGCGGCGATTGTCATGCAGTTCTGGTTGCCATCCGTGCCGGGGTGGGTTTTTAGTCTGATTGCGC
TCGTTTTGATTTTTACGATCAACGCGCTGTCAGTCCGGTCGTTTGGAGAAACTGAGTACTGGCTTTCGCTAATTAAAGTG
GTGACCGTGCTCGTATTCTTGGTTATCGGTGTCTTGACGATCGTGGGAATCATGGGCGGTCATGCCACTGGCCTCAGTAA
CTTTACCTATAAAAAGGCACCATTTGTCGGTGGAATTCCAACGATTTTGAGTGTCTTCGTGGTCGCTGGTTTTTCGTTTC
AAGGAACCGAATTAATTGGGATCACGGCCGGGGAGTCAGCAACACCGGAGAAAAGTATTCCGGCGGCTATTAAACAAGTT
TTCTGGCGTATTTTGTTATTTTACATTTTAGCCATTTTCGTGATTGCGGCGATTATTCCTTATACGTCGAAAGATCTTCT
AGGGTCATCAGCGAGCGATATTGCCATCAGTCCGTTCACGTTAGTCTTTAAACGGGCTGGGTTGGCGGCTGCGGCCAGTG
TGATGAACGCAGTGATCTTGACGTCCGTATTGTCAGCTGCTAATTCGGGGATGTACGCCTCGACACGGATGTTATATTCT
TTGTCATTACAGGGTTATGCCCCCAAGACATTTGGTCGGGTCAATCGTCGTGGGATTCCAATCATGGCATTATTAGGAAC
GACGGTGATTGGATTACTCACGTTCTTGTCGAGTCTATTCGGTGAACGGATTTATATTTTCCTCGTTTCGGCCAGTGGGT
TAACGGGTTTTATCGCTTGGCTAGGAATCGCTATTTCGCATCTGCGTTTCCGTCGCGCGTTTGTTAAGCAGGGGCATCAA
TTGAGTGAATTGCGGTACCATGCCAAGTGGTTCCCATTTGGCCCGTGGTTCGCCTTTATCTTGTGTGTCGTGGTCATTAT
TGGTCAAGACTTACATTCATTTGCAACGCTTGATTGGCAGGCTATTGGGGTGACCTATATGAGCATCCCGTTATTCATCA
TCTTGTATGTCTATTATAAGATTCGCTATCATACTAAGATGATTCCGCTAGACAAGGTTGATTTGACACGCAAACGACAC
CATCAAGATTAA

Upstream 100 bases:

>100_bases
CGCACGTTATCGTGAGGCAAAGAGGCTTTTTATTTTGATTGTGCTAACCTGAATCGGTGTGAACACTTTTAGATATAAAT
CGATTTTTGGAGGTTCTGCA

Downstream 100 bases:

>100_bases
GCACGCACTTTGATAGTTTGATTAAATGCGGTTGACACTGGGTCAATCGCATTTTTTGACGGCGAGAGTTGGACCTGTCA
ACTCAAGGCGCGGTCGTATT

Product: lysine transport protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MAEKQHQEVHRSLQTRHLSMIALGGSIGTGLFVASGSAISTAGPGGALLAYVGIGVMVYFLMTSLGEMATYLPVSGSFST
YATKFVDPALGFAMGWNYWFNWAITLAVDISTAAIVMQFWLPSVPGWVFSLIALVLIFTINALSVRSFGETEYWLSLIKV
VTVLVFLVIGVLTIVGIMGGHATGLSNFTYKKAPFVGGIPTILSVFVVAGFSFQGTELIGITAGESATPEKSIPAAIKQV
FWRILLFYILAIFVIAAIIPYTSKDLLGSSASDIAISPFTLVFKRAGLAAAASVMNAVILTSVLSAANSGMYASTRMLYS
LSLQGYAPKTFGRVNRRGIPIMALLGTTVIGLLTFLSSLFGERIYIFLVSASGLTGFIAWLGIAISHLRFRRAFVKQGHQ
LSELRYHAKWFPFGPWFAFILCVVVIIGQDLHSFATLDWQAIGVTYMSIPLFIILYVYYKIRYHTKMIPLDKVDLTRKRH
HQD

Sequences:

>Translated_483_residues
MAEKQHQEVHRSLQTRHLSMIALGGSIGTGLFVASGSAISTAGPGGALLAYVGIGVMVYFLMTSLGEMATYLPVSGSFST
YATKFVDPALGFAMGWNYWFNWAITLAVDISTAAIVMQFWLPSVPGWVFSLIALVLIFTINALSVRSFGETEYWLSLIKV
VTVLVFLVIGVLTIVGIMGGHATGLSNFTYKKAPFVGGIPTILSVFVVAGFSFQGTELIGITAGESATPEKSIPAAIKQV
FWRILLFYILAIFVIAAIIPYTSKDLLGSSASDIAISPFTLVFKRAGLAAAASVMNAVILTSVLSAANSGMYASTRMLYS
LSLQGYAPKTFGRVNRRGIPIMALLGTTVIGLLTFLSSLFGERIYIFLVSASGLTGFIAWLGIAISHLRFRRAFVKQGHQ
LSELRYHAKWFPFGPWFAFILCVVVIIGQDLHSFATLDWQAIGVTYMSIPLFIILYVYYKIRYHTKMIPLDKVDLTRKRH
HQD
>Mature_482_residues
AEKQHQEVHRSLQTRHLSMIALGGSIGTGLFVASGSAISTAGPGGALLAYVGIGVMVYFLMTSLGEMATYLPVSGSFSTY
ATKFVDPALGFAMGWNYWFNWAITLAVDISTAAIVMQFWLPSVPGWVFSLIALVLIFTINALSVRSFGETEYWLSLIKVV
TVLVFLVIGVLTIVGIMGGHATGLSNFTYKKAPFVGGIPTILSVFVVAGFSFQGTELIGITAGESATPEKSIPAAIKQVF
WRILLFYILAIFVIAAIIPYTSKDLLGSSASDIAISPFTLVFKRAGLAAAASVMNAVILTSVLSAANSGMYASTRMLYSL
SLQGYAPKTFGRVNRRGIPIMALLGTTVIGLLTFLSSLFGERIYIFLVSASGLTGFIAWLGIAISHLRFRRAFVKQGHQL
SELRYHAKWFPFGPWFAFILCVVVIIGQDLHSFATLDWQAIGVTYMSIPLFIILYVYYKIRYHTKMIPLDKVDLTRKRHH
QD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=488, Percent_Identity=55.9426229508197, Blast_Score=560, Evalue=1e-160,
Organism=Escherichia coli, GI87081708, Length=430, Percent_Identity=42.093023255814, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1786789, Length=438, Percent_Identity=39.041095890411, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI48994972, Length=432, Percent_Identity=39.1203703703704, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1786302, Length=429, Percent_Identity=36.1305361305361, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789017, Length=442, Percent_Identity=35.972850678733, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1790653, Length=417, Percent_Identity=36.4508393285372, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87081915, Length=419, Percent_Identity=33.890214797136, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1786602, Length=392, Percent_Identity=38.0102040816327, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87082023, Length=414, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081869, Length=245, Percent_Identity=26.1224489795918, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=495, Percent_Identity=38.1818181818182, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6320772, Length=495, Percent_Identity=37.7777777777778, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6322892, Length=485, Percent_Identity=37.5257731958763, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324059, Length=497, Percent_Identity=36.2173038229376, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6320717, Length=493, Percent_Identity=33.0628803245436, Blast_Score=296, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6319824, Length=495, Percent_Identity=34.3434343434343, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6324990, Length=493, Percent_Identity=34.4827586206897, Blast_Score=289, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6321629, Length=493, Percent_Identity=33.0628803245436, Blast_Score=286, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6324553, Length=491, Percent_Identity=35.234215885947, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6320251, Length=497, Percent_Identity=32.7967806841046, Blast_Score=273, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6319543, Length=491, Percent_Identity=31.7718940936864, Blast_Score=266, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6319542, Length=493, Percent_Identity=31.8458417849899, Blast_Score=264, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6324924, Length=500, Percent_Identity=30.6, Blast_Score=259, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6321053, Length=480, Percent_Identity=33.125, Blast_Score=250, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6322967, Length=489, Percent_Identity=31.6973415132924, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6324981, Length=489, Percent_Identity=32.1063394683027, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6319608, Length=476, Percent_Identity=28.781512605042, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320364, Length=555, Percent_Identity=26.3063063063063, Blast_Score=169, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52705; Mature: 52574

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKQHQEVHRSLQTRHLSMIALGGSIGTGLFVASGSAISTAGPGGALLAYVGIGVMVYF
CCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHHH
LMTSLGEMATYLPVSGSFSTYATKFVDPALGFAMGWNYWFNWAITLAVDISTAAIVMQFW
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHEEEEEEEEEEHHHHHHHHHHH
LPSVPGWVFSLIALVLIFTINALSVRSFGETEYWLSLIKVVTVLVFLVIGVLTIVGIMGG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HATGLSNFTYKKAPFVGGIPTILSVFVVAGFSFQGTELIGITAGESATPEKSIPAAIKQV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHH
FWRILLFYILAIFVIAAIIPYTSKDLLGSSASDIAISPFTLVFKRAGLAAAASVMNAVIL
HHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHH
TSVLSAANSGMYASTRMLYSLSLQGYAPKTFGRVNRRGIPIMALLGTTVIGLLTFLSSLF
HHHHHHHCCCCHHHHHHHHEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GERIYIFLVSASGLTGFIAWLGIAISHLRFRRAFVKQGHQLSELRYHAKWFPFGPWFAFI
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHH
LCVVVIIGQDLHSFATLDWQAIGVTYMSIPLFIILYVYYKIRYHTKMIPLDKVDLTRKRH
HHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCHHHHHHHHC
HQD
CCC
>Mature Secondary Structure 
AEKQHQEVHRSLQTRHLSMIALGGSIGTGLFVASGSAISTAGPGGALLAYVGIGVMVYF
CCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHHH
LMTSLGEMATYLPVSGSFSTYATKFVDPALGFAMGWNYWFNWAITLAVDISTAAIVMQFW
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHEEEEEEEEEEHHHHHHHHHHH
LPSVPGWVFSLIALVLIFTINALSVRSFGETEYWLSLIKVVTVLVFLVIGVLTIVGIMGG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HATGLSNFTYKKAPFVGGIPTILSVFVVAGFSFQGTELIGITAGESATPEKSIPAAIKQV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHH
FWRILLFYILAIFVIAAIIPYTSKDLLGSSASDIAISPFTLVFKRAGLAAAASVMNAVIL
HHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHH
TSVLSAANSGMYASTRMLYSLSLQGYAPKTFGRVNRRGIPIMALLGTTVIGLLTFLSSLF
HHHHHHHCCCCHHHHHHHHEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GERIYIFLVSASGLTGFIAWLGIAISHLRFRRAFVKQGHQLSELRYHAKWFPFGPWFAFI
CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHH
LCVVVIIGQDLHSFATLDWQAIGVTYMSIPLFIILYVYYKIRYHTKMIPLDKVDLTRKRH
HHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCHHHHHHHHC
HQD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]