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The map label for this gene is recQ1 [H]

Identifier: 28377783

GI number: 28377783

Start: 893921

End: 895729

Strand: Direct

Name: recQ1 [H]

Synonym: lp_0962

Alternate gene names: 28377783

Gene position: 893921-895729 (Clockwise)

Preceding gene: 28377782

Following gene: 28377784

Centisome position: 27.02

GC content: 50.08

Gene sequence:

>1809_bases
ATGATTGACTTAGCGGCGGCACAGCAAGTATTGAAGACCACGTTCGGATATGATGAATTCCGACCGGGGCAAAAGGCAGT
GATTGAACAAGTGTTGGCCGGTGAAAACACCCTAGCGATTATGCCAACTGGGGGTGGTAAGTCATTATGTTACCAAATCC
CAGCGTTACTTTTTCAGGGGCTGACCGTCGTTGTCTCACCATTGATTTCTTTAATGAAAGATCAGGTAGACGCGTTAAAT
GATAATGGTATCGCGGCGACTTTTATTAACAGTTCACTGGATTTCCAAGAGATCAACGAACGGCTCCAAGAACTACGGGC
GGGGGATTATACCTTACTTTACGTGGCACCCGAGCGGTTAGATTCGGATTACTTTATTCAAGCGCTGGGCCGGTTGCCCA
TCCAACTGTTAGCAATTGATGAGGCCCACTGTATTTCACAGTGGGGGCACGATTTTCGCCCCAGTTATTTAGCGCTCAGC
ACGGCGATTGAACAATTGCCGACCCATCCGCAAGTCCTAGCTTTAACGGCGACGGCAACTGAGCAAGTTGCTGCGGATAT
TTGCGGCCGCTTAGCGATCAATCCACAACATGAAGTGAATACTGGTTTTGCCCGCGATAACTTGGATTTGACGGTGGTCA
AGGACCAAGACACGGACCGTTACATTTTAGATTATTTGAAAGTTAATCATGGTGAAGCCGGGATTATTTACGCCAGCACC
CGTAAAGAAGTGATGCGTCTGACGAGTTTGTTGCAAAAGCATGATATTAAGGCCACGCCGTACCACGCTGGGCTAGATGA
TGCGGTTCGGCGGCAAAACCAAGAGGATTTCTTGTACGACCGTGTTGACGTCATGGTGGCAACCAACGCGTTTGGAATGG
GTATTGATAAGAGTAACGTGCGTTTTGTGATTCACGCCCAGGTCCCCGGAACTTTGGAAGCTTATTATCAGGAAGCCGGT
CGGGCTGGCCGGGATGGGTTACCTAGTGAAGCGATTTTGATTTTTCGACCGGTTGATATTCAACTTCAGCACTTCTTTAT
TGATGAGTCGGAGATGGATACGGAGCACCGACACCTGGCGTATCAGAAGCTACAGGTGATGACACGGTATGCGAACACCC
AGGGCTGTTTACAACAGTTTATCTTGAAATACTTTGGTGAAAAATCCGCGCCGTGTGGTCGGTGTAGTAATTGTACTGAT
CAGCGGGAATCACAGGATATCACCACGGCAGCCCAACAAGTCTTATCGTGCGTCGTTAGGCTTCATTCACGGTTCGGTAA
AGGGGTCGTGGCCCAGGTATTGACGGGCGCTAATAATCAACGGGTCCGCGAATCGAACCTCAATACATTGTCGACGTACG
GGTTGATGTCCGGGCAGCGACAGAAGAGTGTCGTGGAACTGATCGATTTTTTGACTGCGAGCGGTTATTTGCAGTCGGTG
GGTGGTCAGTATCCAACGCTGACAGTCTCAGCGAGTGGAGTGGCCGTGCTTAAAGGAACGACCACGGTACACCGAAAGAC
GGCCCAAAAGGTGCAGCAGACGGTGCCAGAGAACAGTGCCCTCTTCGAACAGTTGCGGACACTTCGGCGCCAATTGGCGG
AAGAACAGGGCGTACCACCATTTGTGATTTTTTCTGACCGGACGCTTCATTCGATGTGTGACCTTATGCCAGAAGACGAC
GCAGCTTTCTTAACGGTCAAAGGGGTCGGGGCCAGCAAACTTGAAAAGTATGGTGAAACCTTTATGGCGACGATTCGAGC
GGCAGCTCATGCGGAATCAGCAACTAGCACCGATGAGGAAACCGATTAG

Upstream 100 bases:

>100_bases
GCGACTTAACGTACCTAGTGATTACCGTGGCGCGTTCTTGTCATGGGCCGGTATTCTCGGTAGAATGAGAGTATTAATTC
AAAGAGGGAGTTTACGTGTG

Downstream 100 bases:

>100_bases
ATGGCTGATTGGTAAACTACGAGATGAAATGGAGTAACACGTATGGAATTTACTTGGCAACACCAGGGGCAACCAATGGC
AATGAAACGATTCTTGACGA

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MIDLAAAQQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGLTVVVSPLISLMKDQVDALN
DNGIAATFINSSLDFQEINERLQELRAGDYTLLYVAPERLDSDYFIQALGRLPIQLLAIDEAHCISQWGHDFRPSYLALS
TAIEQLPTHPQVLALTATATEQVAADICGRLAINPQHEVNTGFARDNLDLTVVKDQDTDRYILDYLKVNHGEAGIIYAST
RKEVMRLTSLLQKHDIKATPYHAGLDDAVRRQNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAG
RAGRDGLPSEAILIFRPVDIQLQHFFIDESEMDTEHRHLAYQKLQVMTRYANTQGCLQQFILKYFGEKSAPCGRCSNCTD
QRESQDITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRVRESNLNTLSTYGLMSGQRQKSVVELIDFLTASGYLQSV
GGQYPTLTVSASGVAVLKGTTTVHRKTAQKVQQTVPENSALFEQLRTLRRQLAEEQGVPPFVIFSDRTLHSMCDLMPEDD
AAFLTVKGVGASKLEKYGETFMATIRAAAHAESATSTDEETD

Sequences:

>Translated_602_residues
MIDLAAAQQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGLTVVVSPLISLMKDQVDALN
DNGIAATFINSSLDFQEINERLQELRAGDYTLLYVAPERLDSDYFIQALGRLPIQLLAIDEAHCISQWGHDFRPSYLALS
TAIEQLPTHPQVLALTATATEQVAADICGRLAINPQHEVNTGFARDNLDLTVVKDQDTDRYILDYLKVNHGEAGIIYAST
RKEVMRLTSLLQKHDIKATPYHAGLDDAVRRQNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAG
RAGRDGLPSEAILIFRPVDIQLQHFFIDESEMDTEHRHLAYQKLQVMTRYANTQGCLQQFILKYFGEKSAPCGRCSNCTD
QRESQDITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRVRESNLNTLSTYGLMSGQRQKSVVELIDFLTASGYLQSV
GGQYPTLTVSASGVAVLKGTTTVHRKTAQKVQQTVPENSALFEQLRTLRRQLAEEQGVPPFVIFSDRTLHSMCDLMPEDD
AAFLTVKGVGASKLEKYGETFMATIRAAAHAESATSTDEETD
>Mature_602_residues
MIDLAAAQQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQGLTVVVSPLISLMKDQVDALN
DNGIAATFINSSLDFQEINERLQELRAGDYTLLYVAPERLDSDYFIQALGRLPIQLLAIDEAHCISQWGHDFRPSYLALS
TAIEQLPTHPQVLALTATATEQVAADICGRLAINPQHEVNTGFARDNLDLTVVKDQDTDRYILDYLKVNHGEAGIIYAST
RKEVMRLTSLLQKHDIKATPYHAGLDDAVRRQNQEDFLYDRVDVMVATNAFGMGIDKSNVRFVIHAQVPGTLEAYYQEAG
RAGRDGLPSEAILIFRPVDIQLQHFFIDESEMDTEHRHLAYQKLQVMTRYANTQGCLQQFILKYFGEKSAPCGRCSNCTD
QRESQDITTAAQQVLSCVVRLHSRFGKGVVAQVLTGANNQRVRESNLNTLSTYGLMSGQRQKSVVELIDFLTASGYLQSV
GGQYPTLTVSASGVAVLKGTTTVHRKTAQKVQQTVPENSALFEQLRTLRRQLAEEQGVPPFVIFSDRTLHSMCDLMPEDD
AAFLTVKGVGASKLEKYGETFMATIRAAAHAESATSTDEETD

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=629, Percent_Identity=32.4324324324324, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI169218196, Length=467, Percent_Identity=35.9743040685225, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI110735439, Length=466, Percent_Identity=36.0515021459227, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI14591902, Length=420, Percent_Identity=37.1428571428571, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI14591904, Length=420, Percent_Identity=37.1428571428571, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI148612816, Length=421, Percent_Identity=39.1923990498812, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI51242947, Length=360, Percent_Identity=42.2222222222222, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI51242943, Length=360, Percent_Identity=42.2222222222222, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI284005309, Length=347, Percent_Identity=38.328530259366, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI262118318, Length=343, Percent_Identity=25.0728862973761, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI216548263, Length=343, Percent_Identity=25.0728862973761, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI262231852, Length=343, Percent_Identity=25.0728862973761, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI13518015, Length=343, Percent_Identity=25.0728862973761, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI224593278, Length=344, Percent_Identity=21.8023255813953, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI48994977, Length=596, Percent_Identity=43.9597315436242, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI87082221, Length=333, Percent_Identity=22.8228228228228, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787016, Length=340, Percent_Identity=24.7058823529412, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25145561, Length=640, Percent_Identity=32.8125, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71987997, Length=499, Percent_Identity=36.2725450901804, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI71987993, Length=499, Percent_Identity=36.2725450901804, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI32564293, Length=673, Percent_Identity=29.2719167904903, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17552866, Length=401, Percent_Identity=33.6658354114713, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71987143, Length=353, Percent_Identity=23.2294617563739, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508543, Length=354, Percent_Identity=23.1638418079096, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=481, Percent_Identity=36.5904365904366, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6320224, Length=361, Percent_Identity=21.0526315789474, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324217, Length=330, Percent_Identity=24.5454545454545, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24646066, Length=626, Percent_Identity=31.629392971246, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI24664226, Length=444, Percent_Identity=34.009009009009, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI62472181, Length=444, Percent_Identity=34.009009009009, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24664230, Length=444, Percent_Identity=34.009009009009, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21358123, Length=354, Percent_Identity=36.4406779661017, Blast_Score=204, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 66555; Mature: 66555

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLAAAQQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQG
CCCHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH
LTVVVSPLISLMKDQVDALNDNGIAATFINSSLDFQEINERLQELRAGDYTLLYVAPERL
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEHHHC
DSDYFIQALGRLPIQLLAIDEAHCISQWGHDFRPSYLALSTAIEQLPTHPQVLALTATAT
CHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEHHH
EQVAADICGRLAINPQHEVNTGFARDNLDLTVVKDQDTDRYILDYLKVNHGEAGIIYAST
HHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEEEHH
RKEVMRLTSLLQKHDIKATPYHAGLDDAVRRQNQEDFLYDRVDVMVATNAFGMGIDKSNV
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHEEEEECCCCCCCCCCCC
RFVIHAQVPGTLEAYYQEAGRAGRDGLPSEAILIFRPVDIQLQHFFIDESEMDTEHRHLA
EEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEEEECCHHCCHHHHHHH
YQKLQVMTRYANTQGCLQQFILKYFGEKSAPCGRCSNCTDQRESQDITTAAQQVLSCVVR
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LHSRFGKGVVAQVLTGANNQRVRESNLNTLSTYGLMSGQRQKSVVELIDFLTASGYLQSV
HHHHHCCHHHHHHHHCCCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
GGQYPTLTVSASGVAVLKGTTTVHRKTAQKVQQTVPENSALFEQLRTLRRQLAEEQGVPP
CCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
FVIFSDRTLHSMCDLMPEDDAAFLTVKGVGASKLEKYGETFMATIRAAAHAESATSTDEE
EEEECCCHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TD
CC
>Mature Secondary Structure
MIDLAAAQQVLKTTFGYDEFRPGQKAVIEQVLAGENTLAIMPTGGGKSLCYQIPALLFQG
CCCHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH
LTVVVSPLISLMKDQVDALNDNGIAATFINSSLDFQEINERLQELRAGDYTLLYVAPERL
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEHHHC
DSDYFIQALGRLPIQLLAIDEAHCISQWGHDFRPSYLALSTAIEQLPTHPQVLALTATAT
CHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEHHH
EQVAADICGRLAINPQHEVNTGFARDNLDLTVVKDQDTDRYILDYLKVNHGEAGIIYAST
HHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEEEHH
RKEVMRLTSLLQKHDIKATPYHAGLDDAVRRQNQEDFLYDRVDVMVATNAFGMGIDKSNV
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHEEEEECCCCCCCCCCCC
RFVIHAQVPGTLEAYYQEAGRAGRDGLPSEAILIFRPVDIQLQHFFIDESEMDTEHRHLA
EEEEEECCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEEEEEEECCHHCCHHHHHHH
YQKLQVMTRYANTQGCLQQFILKYFGEKSAPCGRCSNCTDQRESQDITTAAQQVLSCVVR
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LHSRFGKGVVAQVLTGANNQRVRESNLNTLSTYGLMSGQRQKSVVELIDFLTASGYLQSV
HHHHHCCHHHHHHHHCCCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
GGQYPTLTVSASGVAVLKGTTTVHRKTAQKVQQTVPENSALFEQLRTLRRQLAEEQGVPP
CCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
FVIFSDRTLHSMCDLMPEDDAAFLTVKGVGASKLEKYGETFMATIRAAAHAESATSTDEE
EEEECCCHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]