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The map label for this gene is helD [H]

Identifier: 28377740

GI number: 28377740

Start: 838126

End: 840432

Strand: Direct

Name: helD [H]

Synonym: lp_0910

Alternate gene names: 28377740

Gene position: 838126-840432 (Clockwise)

Preceding gene: 28377738

Following gene: 28377741

Centisome position: 25.33

GC content: 45.25

Gene sequence:

>2307_bases
ATGGCTAAGTCAATTAAAGCTGCAGAACAGGAACACTTAGATCATGTGGTTGCGAAAATTAAGGTGGCTGAAGAGCAACA
AAGCCAAACCATTACGCGCTCGGAAAAAGATCAGGCCGATATTAAACGTGACTTGCTGAATAACATCAATATTAAAACGG
ATAGTTACGAAGGCATGATGGAGACCGGATTATCCGTGCGGCAGCAACAGCAGATGATGGATGAGCGGCAGAATAGTTGG
AAGCACGCGACTAAGCAATTATCGACGTTAAAAAAGTTGGAAAAGAATGCTTATTTTGCGCGGATCGATTTTCATGAGAC
TGGTGAGCCTAAGCCTGAGACGATTTATATCGGACTCAGTTCATTTTCTGACACGCCGGATCACTTTTTGATCTACGACT
GGCGAGCGCCTATTTCCAGTATTTATTATGACGGTGGGTTAGGGCACGTGACGTACCAGACTCCGGATGGTGAACAGACC
GTTAATGTGAAGTTGAAGCGGCAGTTGATGGTTGAGAATGGCCAGATCGTGACAGTCTACGATACTGATGAAGCCGTTGG
TGACTCGATGTTACTAGAAGTGTTGGATGAAAAGTCCGATGTGAAGATGAAGAGTATCGTGACGACGATTCAAAAGGAAC
AAAATACCATTATTCGGGATACGAGTTCTGACCTCCTGTTTGTGCAGGGGGCGGCCGGTTCCGGGAAGACCTCGTCCGTT
TTACAACGGGTCGCATACTTGTTGTATCGTTACCGGGGTAATTTGACGGCCGGACAAGTCATCTTGTTCTCACCAAATCA
ACTCTTTAATGATTATATTAACCAAGTATTGCCCGAACTGGGTGAACAAAACATGGTTCAGATGACTTATTTCCAATACG
CATCGTACCGGTTACCACACATGCAAGTTGAAACTTTACAGCAGCGGTTTGAAACTGAAAATACACCGCAGATGGCAAAG
ATTACGAAGTTGGAAGGTAGCCTCGCATTTTTCAACGCGGTTACAACGTATGGCCGACATTTGGAACAAGCGGACATGCG
TTTCCGTAACATTACGTTGAACGATGAAGTGATTATTTCCCGGGAAAAGATTAAATCGATTTACTACTCTTTCAACGAAA
ACTACCACTTAGCGAACCGGTTATCAGCAACTAAGGAAGAATTAATCAAGATTTTGAATCGCAAGGTTGAATCGGAGATG
CGTTCCAAGTGGGTCGAAGAAGCGGTTCAAGACTTATCACGCGAAGAGATCAATCAATTATATGGCAATCAGCCGCGGGA
ATTTAAGAATGGCGATAAAGAGTTTAAATTCTTAGCACGTAAAATTGTGATGCAACGCTTAGGAAAAGCCCGGACGCAAA
TCGTGCGTAACCGTTTCTTGAGCATCAACATGCAGTACGCGCATTTCTTACGCGAAGTACCGAAGATCATCAAGTTGGCT
GATCACGGTATCTCAGCTGCTGACTGGGATGCTACGGTTGAACGGAAACTAGCCGAGATTAAGGAACGTCATATCTCGTT
AACAACGGTCTCAGCTTACATGTACCTGCATGACTTAATGACCGGAAAGCACGGGCAGCGTGACATCCGGTTTGTCTTCT
TGGATGAAATTCAAGATTACAATGCCTTTCAGCTAGCGTTCCTGAAGTTTAGCTTCCCTCAAGCCCGTTTCACAATGCTT
GGTGACTTGAACCAGGCGATTTTTACCAAGGAAAACAGCCATTCGCTGATCAATGAATTGGCCACGTTATTTGACCCTGA
AAAGACGCGGGTCGTGCAATTGACTAAATCGTACCGGTCAACACAACAGATTACTGATTTCACCAAGGAAATTTTAGTCA
ATGGTGAAGCCGTCACGGCTTTTGATCGTCAGGGCGACTTGCCAAATGTCGTTGTGACGCCTAACTTTGAAGCGGGGGTT
GATCAAGTCGTTGATCAGCTAGCGATGAACGATTCTGAACGTGATACGACGGCAATTATCGGGAAATCCTTAGCAGAATG
CGAGGCGCTCACGAAGGCCCTGAAAGCTCGTGGTGAGCAGGTCACGTTGATTCAAACTGAAAATCAACGCTTGGCTCCCG
GTGTCATTGTAGTCCCGTCTTTCTTAGCAAAAGGGTTGGAGTTTGACGCGGTCATCGTGTGGAACGCTAATCAGGAAAAT
TACCAACGTGAAGATGAACGGCAACTATTATATACAATCTGTTCACGAGCCATGCACGAGTTAACGTTAGTCGCAGTGGG
TAGCTTGTCACCGTTACTAGCGCGGGTGAACCACGCCTTGTATACATTAAATGAAGCAAAAGTTTAA

Upstream 100 bases:

>100_bases
TAAAAAATCAAAAACTGGCAGCTGCCATGGGTTATTAATTGAGTCGGGCCGCCGATAGTGATAAAATTATTGTTCGATAT
TTAGGAATGGAGGGCGTTCA

Downstream 100 bases:

>100_bases
GTCAGTTTAAGACAGTGAGAGGCTGTGACATAAGTCTCTAGAAACAAAGCAGGTCTGGAAAAATCTTCGGATTTTTCCAG
ACCTGCTTTTGATATAATAG

Product: DNA helicase (putative)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 768; Mature: 767

Protein sequence:

>768_residues
MAKSIKAAEQEHLDHVVAKIKVAEEQQSQTITRSEKDQADIKRDLLNNINIKTDSYEGMMETGLSVRQQQQMMDERQNSW
KHATKQLSTLKKLEKNAYFARIDFHETGEPKPETIYIGLSSFSDTPDHFLIYDWRAPISSIYYDGGLGHVTYQTPDGEQT
VNVKLKRQLMVENGQIVTVYDTDEAVGDSMLLEVLDEKSDVKMKSIVTTIQKEQNTIIRDTSSDLLFVQGAAGSGKTSSV
LQRVAYLLYRYRGNLTAGQVILFSPNQLFNDYINQVLPELGEQNMVQMTYFQYASYRLPHMQVETLQQRFETENTPQMAK
ITKLEGSLAFFNAVTTYGRHLEQADMRFRNITLNDEVIISREKIKSIYYSFNENYHLANRLSATKEELIKILNRKVESEM
RSKWVEEAVQDLSREEINQLYGNQPREFKNGDKEFKFLARKIVMQRLGKARTQIVRNRFLSINMQYAHFLREVPKIIKLA
DHGISAADWDATVERKLAEIKERHISLTTVSAYMYLHDLMTGKHGQRDIRFVFLDEIQDYNAFQLAFLKFSFPQARFTML
GDLNQAIFTKENSHSLINELATLFDPEKTRVVQLTKSYRSTQQITDFTKEILVNGEAVTAFDRQGDLPNVVVTPNFEAGV
DQVVDQLAMNDSERDTTAIIGKSLAECEALTKALKARGEQVTLIQTENQRLAPGVIVVPSFLAKGLEFDAVIVWNANQEN
YQREDERQLLYTICSRAMHELTLVAVGSLSPLLARVNHALYTLNEAKV

Sequences:

>Translated_768_residues
MAKSIKAAEQEHLDHVVAKIKVAEEQQSQTITRSEKDQADIKRDLLNNINIKTDSYEGMMETGLSVRQQQQMMDERQNSW
KHATKQLSTLKKLEKNAYFARIDFHETGEPKPETIYIGLSSFSDTPDHFLIYDWRAPISSIYYDGGLGHVTYQTPDGEQT
VNVKLKRQLMVENGQIVTVYDTDEAVGDSMLLEVLDEKSDVKMKSIVTTIQKEQNTIIRDTSSDLLFVQGAAGSGKTSSV
LQRVAYLLYRYRGNLTAGQVILFSPNQLFNDYINQVLPELGEQNMVQMTYFQYASYRLPHMQVETLQQRFETENTPQMAK
ITKLEGSLAFFNAVTTYGRHLEQADMRFRNITLNDEVIISREKIKSIYYSFNENYHLANRLSATKEELIKILNRKVESEM
RSKWVEEAVQDLSREEINQLYGNQPREFKNGDKEFKFLARKIVMQRLGKARTQIVRNRFLSINMQYAHFLREVPKIIKLA
DHGISAADWDATVERKLAEIKERHISLTTVSAYMYLHDLMTGKHGQRDIRFVFLDEIQDYNAFQLAFLKFSFPQARFTML
GDLNQAIFTKENSHSLINELATLFDPEKTRVVQLTKSYRSTQQITDFTKEILVNGEAVTAFDRQGDLPNVVVTPNFEAGV
DQVVDQLAMNDSERDTTAIIGKSLAECEALTKALKARGEQVTLIQTENQRLAPGVIVVPSFLAKGLEFDAVIVWNANQEN
YQREDERQLLYTICSRAMHELTLVAVGSLSPLLARVNHALYTLNEAKV
>Mature_767_residues
AKSIKAAEQEHLDHVVAKIKVAEEQQSQTITRSEKDQADIKRDLLNNINIKTDSYEGMMETGLSVRQQQQMMDERQNSWK
HATKQLSTLKKLEKNAYFARIDFHETGEPKPETIYIGLSSFSDTPDHFLIYDWRAPISSIYYDGGLGHVTYQTPDGEQTV
NVKLKRQLMVENGQIVTVYDTDEAVGDSMLLEVLDEKSDVKMKSIVTTIQKEQNTIIRDTSSDLLFVQGAAGSGKTSSVL
QRVAYLLYRYRGNLTAGQVILFSPNQLFNDYINQVLPELGEQNMVQMTYFQYASYRLPHMQVETLQQRFETENTPQMAKI
TKLEGSLAFFNAVTTYGRHLEQADMRFRNITLNDEVIISREKIKSIYYSFNENYHLANRLSATKEELIKILNRKVESEMR
SKWVEEAVQDLSREEINQLYGNQPREFKNGDKEFKFLARKIVMQRLGKARTQIVRNRFLSINMQYAHFLREVPKIIKLAD
HGISAADWDATVERKLAEIKERHISLTTVSAYMYLHDLMTGKHGQRDIRFVFLDEIQDYNAFQLAFLKFSFPQARFTMLG
DLNQAIFTKENSHSLINELATLFDPEKTRVVQLTKSYRSTQQITDFTKEILVNGEAVTAFDRQGDLPNVVVTPNFEAGVD
QVVDQLAMNDSERDTTAIIGKSLAECEALTKALKARGEQVTLIQTENQRLAPGVIVVPSFLAKGLEFDAVIVWNANQENY
QREDERQLLYTICSRAMHELTLVAVGSLSPLLARVNHALYTLNEAKV

Specific function: Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP [H]

COG id: COG3973

COG function: function code R; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 88002; Mature: 87871

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSIKAAEQEHLDHVVAKIKVAEEQQSQTITRSEKDQADIKRDLLNNINIKTDSYEGMM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHH
ETGLSVRQQQQMMDERQNSWKHATKQLSTLKKLEKNAYFARIDFHETGEPKPETIYIGLS
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEC
SFSDTPDHFLIYDWRAPISSIYYDGGLGHVTYQTPDGEQTVNVKLKRQLMVENGQIVTVY
CCCCCCCCEEEEECCCCHHHHEECCCCCEEEEECCCCCCEEEHEEEEHHEECCCCEEEEE
DTDEAVGDSMLLEVLDEKSDVKMKSIVTTIQKEQNTIIRDTSSDLLFVQGAAGSGKTSSV
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCHHHH
LQRVAYLLYRYRGNLTAGQVILFSPNQLFNDYINQVLPELGEQNMVQMTYFQYASYRLPH
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCC
MQVETLQQRFETENTPQMAKITKLEGSLAFFNAVTTYGRHLEQADMRFRNITLNDEVIIS
HHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEE
REKIKSIYYSFNENYHLANRLSATKEELIKILNRKVESEMRSKWVEEAVQDLSREEINQL
HHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGNQPREFKNGDKEFKFLARKIVMQRLGKARTQIVRNRFLSINMQYAHFLREVPKIIKLA
HCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHH
DHGISAADWDATVERKLAEIKERHISLTTVSAYMYLHDLMTGKHGQRDIRFVFLDEIQDY
CCCCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
NAFQLAFLKFSFPQARFTMLGDLNQAIFTKENSHSLINELATLFDPEKTRVVQLTKSYRS
CHHEEEEEEECCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TQQITDFTKEILVNGEAVTAFDRQGDLPNVVVTPNFEAGVDQVVDQLAMNDSERDTTAII
HHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHH
GKSLAECEALTKALKARGEQVTLIQTENQRLAPGVIVVPSFLAKGLEFDAVIVWNANQEN
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEHHHHHCCCCCCEEEEECCCCHH
YQREDERQLLYTICSRAMHELTLVAVGSLSPLLARVNHALYTLNEAKV
HCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHEECCCCCC
>Mature Secondary Structure 
AKSIKAAEQEHLDHVVAKIKVAEEQQSQTITRSEKDQADIKRDLLNNINIKTDSYEGMM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHH
ETGLSVRQQQQMMDERQNSWKHATKQLSTLKKLEKNAYFARIDFHETGEPKPETIYIGLS
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEC
SFSDTPDHFLIYDWRAPISSIYYDGGLGHVTYQTPDGEQTVNVKLKRQLMVENGQIVTVY
CCCCCCCCEEEEECCCCHHHHEECCCCCEEEEECCCCCCEEEHEEEEHHEECCCCEEEEE
DTDEAVGDSMLLEVLDEKSDVKMKSIVTTIQKEQNTIIRDTSSDLLFVQGAAGSGKTSSV
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCHHHH
LQRVAYLLYRYRGNLTAGQVILFSPNQLFNDYINQVLPELGEQNMVQMTYFQYASYRLPH
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCC
MQVETLQQRFETENTPQMAKITKLEGSLAFFNAVTTYGRHLEQADMRFRNITLNDEVIIS
HHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEE
REKIKSIYYSFNENYHLANRLSATKEELIKILNRKVESEMRSKWVEEAVQDLSREEINQL
HHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGNQPREFKNGDKEFKFLARKIVMQRLGKARTQIVRNRFLSINMQYAHFLREVPKIIKLA
HCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHH
DHGISAADWDATVERKLAEIKERHISLTTVSAYMYLHDLMTGKHGQRDIRFVFLDEIQDY
CCCCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCC
NAFQLAFLKFSFPQARFTMLGDLNQAIFTKENSHSLINELATLFDPEKTRVVQLTKSYRS
CHHEEEEEEECCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TQQITDFTKEILVNGEAVTAFDRQGDLPNVVVTPNFEAGVDQVVDQLAMNDSERDTTAII
HHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHH
GKSLAECEALTKALKARGEQVTLIQTENQRLAPGVIVVPSFLAKGLEFDAVIVWNANQEN
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEHHHHHCCCCCCEEEEECCCCHH
YQREDERQLLYTICSRAMHELTLVAVGSLSPLLARVNHALYTLNEAKV
HCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]