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The map label for this gene is ndoA [H]

Identifier: 28377410

GI number: 28377410

Start: 469802

End: 470194

Strand: Direct

Name: ndoA [H]

Synonym: lp_0524

Alternate gene names: 28377410

Gene position: 469802-470194 (Clockwise)

Preceding gene: 28377409

Following gene: 28377411

Centisome position: 14.2

GC content: 46.06

Gene sequence:

>393_bases
ATGGCCGCAGCTGACATTAAGCGTGGTGACATCTTTTATGCAGATTTATCACCAGTCGTAGGCTCCGAACAAGGAGGCAT
GCGTCCAGTACTAATCGTGCAAAATAATGTCGGTAACCATTACAGTCCCACAGTGATTGTCGCGGCAATCACTGCTAAGG
TTCAAAAAGCGAAGATGCCAACACATGTTAACATCAACGCTGCCCATACGGGGATTGAAAAAAATTCGGTTGTGTTGTTG
GAGCAGATACGAACGATTGATAAGCAACGGCTTAAAGATCGCGTCACTCATTTGGATGATCAGACGATGCGCCGAGTTGA
TAATGCGTTACAGATTAGTATTGGGTTAGCTGATCGAACACGACGTCGGCCACAACGCACGTTTCAATCATAG

Upstream 100 bases:

>100_bases
GGTTGCTAAAAGTGAATGGTTCATGCTATTATGAGTAGCAAGATGGTTATATTGGGGTACTATCAGATACATTGGGTATC
GAATAAAGGGAGATGAGGCG

Downstream 100 bases:

>100_bases
TCAATCGATGGGGATTAATTATTTACATAATTGAACTATTTCGGTGCGATGACCGAGTATGGATAATCAGCGGGTTTCAA
TTCAGTTAATGACTGGATTG

Product: hypothetical protein

Products: NA

Alternate protein names: Endoribonuclease EndoA; Toxin EndoA [H]

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MAAADIKRGDIFYADLSPVVGSEQGGMRPVLIVQNNVGNHYSPTVIVAAITAKVQKAKMPTHVNINAAHTGIEKNSVVLL
EQIRTIDKQRLKDRVTHLDDQTMRRVDNALQISIGLADRTRRRPQRTFQS

Sequences:

>Translated_130_residues
MAAADIKRGDIFYADLSPVVGSEQGGMRPVLIVQNNVGNHYSPTVIVAAITAKVQKAKMPTHVNINAAHTGIEKNSVVLL
EQIRTIDKQRLKDRVTHLDDQTMRRVDNALQISIGLADRTRRRPQRTFQS
>Mature_129_residues
AAADIKRGDIFYADLSPVVGSEQGGMRPVLIVQNNVGNHYSPTVIVAAITAKVQKAKMPTHVNINAAHTGIEKNSVVLLE
QIRTIDKQRLKDRVTHLDDQTMRRVDNALQISIGLADRTRRRPQRTFQS

Specific function: Part of a toxin-antitoxin (TA) module. Has specificity for UAC sequences, yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single

COG id: COG2337

COG function: function code T; Growth inhibitor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemK/MazF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003477
- InterPro:   IPR011067 [H]

Pfam domain/function: PF02452 PemK [H]

EC number: NA

Molecular weight: Translated: 14468; Mature: 14337

Theoretical pI: Translated: 10.92; Mature: 10.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAADIKRGDIFYADLSPVVGSEQGGMRPVLIVQNNVGNHYSPTVIVAAITAKVQKAKMP
CCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHCCCC
THVNINAAHTGIEKNSVVLLEQIRTIDKQRLKDRVTHLDDQTMRRVDNALQISIGLADRT
CEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCHHH
RRRPQRTFQS
HCCCHHHCCC
>Mature Secondary Structure 
AAADIKRGDIFYADLSPVVGSEQGGMRPVLIVQNNVGNHYSPTVIVAAITAKVQKAKMP
CCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHCCCC
THVNINAAHTGIEKNSVVLLEQIRTIDKQRLKDRVTHLDDQTMRRVDNALQISIGLADRT
CEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCHHH
RRRPQRTFQS
HCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]