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The map label for this gene is alr

Identifier: 28377409

GI number: 28377409

Start: 468266

End: 469393

Strand: Direct

Name: alr

Synonym: lp_0523

Alternate gene names: 28377409

Gene position: 468266-469393 (Clockwise)

Preceding gene: 28377408

Following gene: 28377410

Centisome position: 14.15

GC content: 49.91

Gene sequence:

>1128_bases
ATGGTTGTAATTGGGGAGCACCGCCACACACAAGTCACAGTCGACTTGCAGGCAATTAAGACAAATATTAGTAATGAAAT
GGCGCAAAAGGATGAGTTGACCGAGTTATGGGCAGTCGTTAAAGCGAATGGTTATGGACATGGAATTATCCAAGTTGCTC
AGGCCGCCAAAGAAGCCGGGGCGACCGGCTTTTGTGTTGCAATCCTGGATGAGGCCTTAGCGTTGCGGGCCGCTGGCTTT
GCGGAACCCATCCTAGTACTTGGAATTACGGAACCGGAATACGCCCCACTGGTAGCTGAAAAGGATATTTCACTAGCTGT
TGGAACGCAAGATTGGCTGACTACGGCCGCAGCAATTTTAGCGGCTAATCAAGTGACGACACCACTTCACGTTCATCTTG
CATTAGATACGGGTATGGGACGAATCGGGTTTCAGACGCCCGAAGAATTGGCAACGGCGGTTACGACTTTGCGTCAACCG
CAGTCACCATTTGACTTTGAAGGGATTTTTACGCATTTTGCAACGGCTGACCAGGCAGATGATACGTATTTTACTCATCA
ATTAAATAATTGGAAACACTTGATTGCAGTGGTGGATGAGCTACCACGCTATGTCCACGTGTCCAATTCGGCCACCAGTC
TCTGGCATCAAGCTTGCAATGGCAACATGGTGCGCTTTGGGGTTGCACTCTATGGTCTAAATCCTTCTGGTCGCGAACTC
AGCGCACCATACCCCTTGCAACCCGCGTTGTCGCTAACGGCACGCTTGACGTTTGTTAAACGCTTGGCTCGGGGCAAATC
GGTCAGCTATGGTGCCACGTATACGGCCGCACAGGATGAATGGATTGGCACGGTGCCGATTGGGTATGCGGACGGCTATG
AACGCCGATTACAAGGCTTCCATGTACTTGTTGATGGTGAGTTTTGCGAAATCGTCGGACGGGTCTGCATGGACCAGCTG
ATGGTTCGTCTGCCACATGAAGTACCGGTTGGAGCTAAGGTAACTTTGGTTGGCACGGACGGTGCTCGTACCATTTCGTT
GCAAGATATTGCTGACTATTGTGGGACAATTCATTATGAGATTGCTTGTGGGTTAGCACCACGAGTGCCGAGAGTTTATA
TAGATTAA

Upstream 100 bases:

>100_bases
AAGTTACGCGCCACCCGTTTGATGGTCCAGCGTGGATTTCAATTTCACACACGGATACGTTAGTAATGACACAAGTTATA
TTGGAAAGAGGCAATTTGTG

Downstream 100 bases:

>100_bases
GTTTTATCAGACGATAGGTTTGCGCCGACTGTCTCGTACAGGCTATGGTTACATGGTTGGTTATTGAGATTAAGCCAATA
AAATGAGTGCCGGAGAAATT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MVVIGEHRHTQVTVDLQAIKTNISNEMAQKDELTELWAVVKANGYGHGIIQVAQAAKEAGATGFCVAILDEALALRAAGF
AEPILVLGITEPEYAPLVAEKDISLAVGTQDWLTTAAAILAANQVTTPLHVHLALDTGMGRIGFQTPEELATAVTTLRQP
QSPFDFEGIFTHFATADQADDTYFTHQLNNWKHLIAVVDELPRYVHVSNSATSLWHQACNGNMVRFGVALYGLNPSGREL
SAPYPLQPALSLTARLTFVKRLARGKSVSYGATYTAAQDEWIGTVPIGYADGYERRLQGFHVLVDGEFCEIVGRVCMDQL
MVRLPHEVPVGAKVTLVGTDGARTISLQDIADYCGTIHYEIACGLAPRVPRVYID

Sequences:

>Translated_375_residues
MVVIGEHRHTQVTVDLQAIKTNISNEMAQKDELTELWAVVKANGYGHGIIQVAQAAKEAGATGFCVAILDEALALRAAGF
AEPILVLGITEPEYAPLVAEKDISLAVGTQDWLTTAAAILAANQVTTPLHVHLALDTGMGRIGFQTPEELATAVTTLRQP
QSPFDFEGIFTHFATADQADDTYFTHQLNNWKHLIAVVDELPRYVHVSNSATSLWHQACNGNMVRFGVALYGLNPSGREL
SAPYPLQPALSLTARLTFVKRLARGKSVSYGATYTAAQDEWIGTVPIGYADGYERRLQGFHVLVDGEFCEIVGRVCMDQL
MVRLPHEVPVGAKVTLVGTDGARTISLQDIADYCGTIHYEIACGLAPRVPRVYID
>Mature_375_residues
MVVIGEHRHTQVTVDLQAIKTNISNEMAQKDELTELWAVVKANGYGHGIIQVAQAAKEAGATGFCVAILDEALALRAAGF
AEPILVLGITEPEYAPLVAEKDISLAVGTQDWLTTAAAILAANQVTTPLHVHLALDTGMGRIGFQTPEELATAVTTLRQP
QSPFDFEGIFTHFATADQADDTYFTHQLNNWKHLIAVVDELPRYVHVSNSATSLWHQACNGNMVRFGVALYGLNPSGREL
SAPYPLQPALSLTARLTFVKRLARGKSVSYGATYTAAQDEWIGTVPIGYADGYERRLQGFHVLVDGEFCEIVGRVCMDQL
MVRLPHEVPVGAKVTLVGTDGARTISLQDIADYCGTIHYEIACGLAPRVPRVYID

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=373, Percent_Identity=35.3887399463807, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1790487, Length=369, Percent_Identity=31.9783197831978, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_LACPL (O08445)

Other databases:

- EMBL:   Y08941
- EMBL:   AL935253
- RefSeq:   NP_784301.1
- ProteinModelPortal:   O08445
- SMR:   O08445
- GeneID:   1061815
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0523
- NMPDR:   fig|220668.1.peg.435
- HOGENOM:   HBG712172
- OMA:   GTHADWV
- ProtClustDB:   CLSK821195
- BioCyc:   LPLA220668:LP_0523-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 40711; Mature: 40711

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 41-41 ACT_SITE 270-270

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVIGEHRHTQVTVDLQAIKTNISNEMAQKDELTELWAVVKANGYGHGIIQVAQAAKEAG
CEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
ATGFCVAILDEALALRAAGFAEPILVLGITEPEYAPLVAEKDISLAVGTQDWLTTAAAIL
CCEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCEEEECCHHHHHHHHHHH
AANQVTTPLHVHLALDTGMGRIGFQTPEELATAVTTLRQPQSPFDFEGIFTHFATADQAD
HHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
DTYFTHQLNNWKHLIAVVDELPRYVHVSNSATSLWHQACNGNMVRFGVALYGLNPSGREL
CCEEEECCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCEEEEEEEEEECCCCCCCC
SAPYPLQPALSLTARLTFVKRLARGKSVSYGATYTAAQDEWIGTVPIGYADGYERRLQGF
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCCCCCCHHHHHCCE
HVLVDGEFCEIVGRVCMDQLMVRLPHEVPVGAKVTLVGTDGARTISLQDIADYCGTIHYE
EEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHCEEEEE
IACGLAPRVPRVYID
EEECCCCCCCEEEEC
>Mature Secondary Structure
MVVIGEHRHTQVTVDLQAIKTNISNEMAQKDELTELWAVVKANGYGHGIIQVAQAAKEAG
CEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
ATGFCVAILDEALALRAAGFAEPILVLGITEPEYAPLVAEKDISLAVGTQDWLTTAAAIL
CCEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCEEEECCHHHHHHHHHHH
AANQVTTPLHVHLALDTGMGRIGFQTPEELATAVTTLRQPQSPFDFEGIFTHFATADQAD
HHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
DTYFTHQLNNWKHLIAVVDELPRYVHVSNSATSLWHQACNGNMVRFGVALYGLNPSGREL
CCEEEECCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCEEEEEEEEEECCCCCCCC
SAPYPLQPALSLTARLTFVKRLARGKSVSYGATYTAAQDEWIGTVPIGYADGYERRLQGF
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEECCCCCCCHHHHHCCE
HVLVDGEFCEIVGRVCMDQLMVRLPHEVPVGAKVTLVGTDGARTISLQDIADYCGTIHYE
EEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHCEEEEE
IACGLAPRVPRVYID
EEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171436; 12566566