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The map label for this gene is mvaA [H]

Identifier: 28377349

GI number: 28377349

Start: 401588

End: 402862

Strand: Direct

Name: mvaA [H]

Synonym: lp_0447

Alternate gene names: 28377349

Gene position: 401588-402862 (Clockwise)

Preceding gene: 28377348

Following gene: 28377350

Centisome position: 12.14

GC content: 49.18

Gene sequence:

>1275_bases
ATGACAGCTGATTTTCGGCACTTTTATCAAAAAAATTGGGCGGAACGCACTGCCATCGTAGCGCAACAGGCCCATTTAAC
GCCAGCTGAACAGGCGTTATTTAAACAATATTATTTACCACAACATCATGAAATTATTGAGAATTATTTGACGGATTACC
CATTACCGATGGGGTTGGCTGTCAACTTAGTCGTCGATGGCGTGGATCACATTGTTCCAATGGTTACTGAGGAACCTTCT
GTTATTGCGGCAGCAAGTAATGGCGCTAAAATTGTCAAGCGTGCAGGGGGCTTCACGACCGTCCTTAATCAACGTGAAAT
GATTGGTCAAATCGTTCTGGAGCAGTTGTCTGATCCGGCTGCAACCGCTGCCGTGATTGAAGCCCACGCTGCAGCATTAT
TAAAAGTAGCTGATGCGGCCCATCCCAGTTTAAAAAAACGAGGTGGTGGCGCTCGGCGCCTACGTACGCGTGTTCTCGGA
CAAGGCTATTTATCAATTGACCTATTCGTTGATGTGCAGGCTGCTATGGGGGCCAATATGCTCAATAGTATGTTGGAAGC
CGTGGCAAAGTCCATCGGTGTGATGACGAAGCAGGACGCTTTACTGAGTATTCTATCGAATTATGCAACGGCGAGCTTAG
TCAAGGCCATTTGTGACATTCCGGTCGGATTATTACAGGCTGGGCGGTATGCCGGCAAACTAGTTGCCCAGAAGATTGCG
TCGGCCAGCACGGTCGCTCAGCTTGATCCGTACCGGGCCACGACTCATAATAAAGGTATCATGAACGGTATTGATGCTGT
CGCTATTGCTAGTGGCAACGACTGGCGCGCTTTGGAGAGTGGGGCACACGCCTATGCTGTTAAGGACGGTCAATATCGTG
GCATGAGTACCTGGACCAGTGATGGTCGGATGCTGCATGGTGAACTGGAATTGCCACTACCGGTTGGCATTGTGGGCGGT
TCAATCAAAATTAACGAGTTAGCCCAGTTGAATCAACGAATATTAGGTATTCAAACAGCGGGTGATTTGGAAAGAATTAT
GGTTGCCATCGGGTTAGCCCAAAATCTAGCCGCTTTACGCGCCTTGGTCACGACTGGTATCCAGCAGGGCCATATGCACC
TACAGTTGAAATCGCTCGCGATGGCAGCGGGAGCGACTCCTGAGGAACTCCCCGTTATCTTACAACGACTTGAATTAGCA
TCTCAACAAGACCTCGCAACCACGCAACAACTCATTGCGGAATTGCGGCAAACAAAGGAAGAGACCGATGACTGA

Upstream 100 bases:

>100_bases
CTTTTCTGAAAGTGGTGTTCGTGAGGGAATTATTTCAGAACACCTCAATCAATAGGTCGGTTCGGTAGATGATTCGAATG
GAGAGAATAGGAATGAGAAT

Downstream 100 bases:

>100_bases
AATTAAATTGAACCAAACTGTTACAGATTTATTAAGTACCGCCAATTCGTTATATCCGGGCAATATTAGTGTTCGTTTTG
GTGACACAAAAGCGGGTTAC

Product: hydroxymethylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTADFRHFYQKNWAERTAIVAQQAHLTPAEQALFKQYYLPQHHEIIENYLTDYPLPMGLAVNLVVDGVDHIVPMVTEEPS
VIAAASNGAKIVKRAGGFTTVLNQREMIGQIVLEQLSDPAATAAVIEAHAAALLKVADAAHPSLKKRGGGARRLRTRVLG
QGYLSIDLFVDVQAAMGANMLNSMLEAVAKSIGVMTKQDALLSILSNYATASLVKAICDIPVGLLQAGRYAGKLVAQKIA
SASTVAQLDPYRATTHNKGIMNGIDAVAIASGNDWRALESGAHAYAVKDGQYRGMSTWTSDGRMLHGELELPLPVGIVGG
SIKINELAQLNQRILGIQTAGDLERIMVAIGLAQNLAALRALVTTGIQQGHMHLQLKSLAMAAGATPEELPVILQRLELA
SQQDLATTQQLIAELRQTKEETDD

Sequences:

>Translated_424_residues
MTADFRHFYQKNWAERTAIVAQQAHLTPAEQALFKQYYLPQHHEIIENYLTDYPLPMGLAVNLVVDGVDHIVPMVTEEPS
VIAAASNGAKIVKRAGGFTTVLNQREMIGQIVLEQLSDPAATAAVIEAHAAALLKVADAAHPSLKKRGGGARRLRTRVLG
QGYLSIDLFVDVQAAMGANMLNSMLEAVAKSIGVMTKQDALLSILSNYATASLVKAICDIPVGLLQAGRYAGKLVAQKIA
SASTVAQLDPYRATTHNKGIMNGIDAVAIASGNDWRALESGAHAYAVKDGQYRGMSTWTSDGRMLHGELELPLPVGIVGG
SIKINELAQLNQRILGIQTAGDLERIMVAIGLAQNLAALRALVTTGIQQGHMHLQLKSLAMAAGATPEELPVILQRLELA
SQQDLATTQQLIAELRQTKEETDD
>Mature_423_residues
TADFRHFYQKNWAERTAIVAQQAHLTPAEQALFKQYYLPQHHEIIENYLTDYPLPMGLAVNLVVDGVDHIVPMVTEEPSV
IAAASNGAKIVKRAGGFTTVLNQREMIGQIVLEQLSDPAATAAVIEAHAAALLKVADAAHPSLKKRGGGARRLRTRVLGQ
GYLSIDLFVDVQAAMGANMLNSMLEAVAKSIGVMTKQDALLSILSNYATASLVKAICDIPVGLLQAGRYAGKLVAQKIAS
ASTVAQLDPYRATTHNKGIMNGIDAVAIASGNDWRALESGAHAYAVKDGQYRGMSTWTSDGRMLHGELELPLPVGIVGGS
IKINELAQLNQRILGIQTAGDLERIMVAIGLAQNLAALRALVTTGIQQGHMHLQLKSLAMAAGATPEELPVILQRLELAS
QQDLATTQQLIAELRQTKEETDD

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 45483; Mature: 45352

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADFRHFYQKNWAERTAIVAQQAHLTPAEQALFKQYYLPQHHEIIENYLTDYPLPMGLA
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHH
VNLVVDGVDHIVPMVTEEPSVIAAASNGAKIVKRAGGFTTVLNQREMIGQIVLEQLSDPA
HHHHHHCHHHHHHCCCCCCCEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCH
ATAAVIEAHAAALLKVADAAHPSLKKRGGGARRLRTRVLGQGYLSIDLFVDVQAAMGANM
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCEEEEEEEEEHHHHCHHH
LNSMLEAVAKSIGVMTKQDALLSILSNYATASLVKAICDIPVGLLQAGRYAGKLVAQKIA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHH
SASTVAQLDPYRATTHNKGIMNGIDAVAIASGNDWRALESGAHAYAVKDGQYRGMSTWTS
HHHHHHHCCCCCCCCCCCCHHCCCCEEEEECCCCCHHHHCCCCEEEEECCCCCCCCEECC
DGRMLHGELELPLPVGIVGGSIKINELAQLNQRILGIQTAGDLERIMVAIGLAQNLAALR
CCEEEEEEEECCCCEEEECCCEEHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
ALVTTGIQQGHMHLQLKSLAMAAGATPEELPVILQRLELASQQDLATTQQLIAELRQTKE
HHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
ETDD
CCCC
>Mature Secondary Structure 
TADFRHFYQKNWAERTAIVAQQAHLTPAEQALFKQYYLPQHHEIIENYLTDYPLPMGLA
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHH
VNLVVDGVDHIVPMVTEEPSVIAAASNGAKIVKRAGGFTTVLNQREMIGQIVLEQLSDPA
HHHHHHCHHHHHHCCCCCCCEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCH
ATAAVIEAHAAALLKVADAAHPSLKKRGGGARRLRTRVLGQGYLSIDLFVDVQAAMGANM
HHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCEEEEEEEEEHHHHCHHH
LNSMLEAVAKSIGVMTKQDALLSILSNYATASLVKAICDIPVGLLQAGRYAGKLVAQKIA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHH
SASTVAQLDPYRATTHNKGIMNGIDAVAIASGNDWRALESGAHAYAVKDGQYRGMSTWTS
HHHHHHHCCCCCCCCCCCCHHCCCCEEEEECCCCCHHHHCCCCEEEEECCCCCCCCEECC
DGRMLHGELELPLPVGIVGGSIKINELAQLNQRILGIQTAGDLERIMVAIGLAQNLAALR
CCEEEEEEEECCCCEEEECCCEEHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
ALVTTGIQQGHMHLQLKSLAMAAGATPEELPVILQRLELASQQDLATTQQLIAELRQTKE
HHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
ETDD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]