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The map label for this gene is ppx1 [H]

Identifier: 28377348

GI number: 28377348

Start: 400625

End: 401542

Strand: Direct

Name: ppx1 [H]

Synonym: lp_0446

Alternate gene names: 28377348

Gene position: 400625-401542 (Clockwise)

Preceding gene: 28377347

Following gene: 28377349

Centisome position: 12.11

GC content: 46.84

Gene sequence:

>918_bases
ATGAGAAACTTAGCGATTGTGGATTTAGGGTCCAATTCGGCGCGGATGGCGGTCAGTCGGTTGCATGCTAACGGCACTGC
TCAAGAAATCAAGCGTGTTAAGGAAGATACGCGTTTGTCGGAAGGAATGGGAACGGCACACGTACTCCAGCCAGCCGCAA
TTGAGCGAACAATCAAGGCGTTACTCAATTTTCGCCGACTTTATGAAAAAATGCCCAATACGGATGTTATTGGCATCACC
ACAGCCGCAGTTCGGATGGCACAAAACCAGACTGAATTTCTCAATCAAGTCAAGCAAGAAGTGGGGCTCGATTTACGAGT
CTTATCTGGTGACGATGAGGCCTATTACGATTATCTTGGGGTTGCCAATTCATTGGTCATCCATGATTGCCTAATCTTAG
ACACGGGTGGCGCAAGTTGTGAACTGATCTTGGTCAAAAATGGCCGCAAACAGCAACTGATCAGCATTCCATTTGGCGCG
GTGACATTATCGGAACAATTCGGTCTCGACGACTTAGTGCCGTCTGCGAGTCTATTTCGGGCGCAGATGTTCCTACGTAA
CCGACTGGCAGATATTTGGTGGTTATCAGAAGCAGTGCACTTCCCAATCATTCTATTGGGTGGTGCCAACCGAACCTTAG
CCCGCATTAATCGGCGCCGGCAACAAAAGTTAAAAGTTGAAGATATTCACGGGTATCGTCTGAAGACAGAGACGGTGTTC
CACACGTTTTTGGACTTACTGTCACGGTCGAAAAAAGGTCGCCAGGAAATTTCAGGAATGGAATATGATCGTGCGGACAT
TATTGTTGGTGGAATGTTACCGCTAGTGACGTTATTACAGATGTTGGATAGTGATCGGGTGATCTTTTCTGAAAGTGGTG
TTCGTGAGGGAATTATTTCAGAACACCTCAATCAATAG

Upstream 100 bases:

>100_bases
TTTTTGGTGTGCAATCCGGCCCTAGAAGTCACAGTGTTACATCATAAATGTTAGAATAAACCTAACTAATATTTTATAAA
CGAAAAGTGAGCGTGGTGTT

Downstream 100 bases:

>100_bases
GTCGGTTCGGTAGATGATTCGAATGGAGAGAATAGGAATGAGAATATGACAGCTGATTTTCGGCACTTTTATCAAAAAAA
TTGGGCGGAACGCACTGCCA

Product: exopolyphosphatase

Products: NA

Alternate protein names: 3-dehydroquinate synthase; Unknown phosphatase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRNLAIVDLGSNSARMAVSRLHANGTAQEIKRVKEDTRLSEGMGTAHVLQPAAIERTIKALLNFRRLYEKMPNTDVIGIT
TAAVRMAQNQTEFLNQVKQEVGLDLRVLSGDDEAYYDYLGVANSLVIHDCLILDTGGASCELILVKNGRKQQLISIPFGA
VTLSEQFGLDDLVPSASLFRAQMFLRNRLADIWWLSEAVHFPIILLGGANRTLARINRRRQQKLKVEDIHGYRLKTETVF
HTFLDLLSRSKKGRQEISGMEYDRADIIVGGMLPLVTLLQMLDSDRVIFSESGVREGIISEHLNQ

Sequences:

>Translated_305_residues
MRNLAIVDLGSNSARMAVSRLHANGTAQEIKRVKEDTRLSEGMGTAHVLQPAAIERTIKALLNFRRLYEKMPNTDVIGIT
TAAVRMAQNQTEFLNQVKQEVGLDLRVLSGDDEAYYDYLGVANSLVIHDCLILDTGGASCELILVKNGRKQQLISIPFGA
VTLSEQFGLDDLVPSASLFRAQMFLRNRLADIWWLSEAVHFPIILLGGANRTLARINRRRQQKLKVEDIHGYRLKTETVF
HTFLDLLSRSKKGRQEISGMEYDRADIIVGGMLPLVTLLQMLDSDRVIFSESGVREGIISEHLNQ
>Mature_305_residues
MRNLAIVDLGSNSARMAVSRLHANGTAQEIKRVKEDTRLSEGMGTAHVLQPAAIERTIKALLNFRRLYEKMPNTDVIGIT
TAAVRMAQNQTEFLNQVKQEVGLDLRVLSGDDEAYYDYLGVANSLVIHDCLILDTGGASCELILVKNGRKQQLISIPFGA
VTLSEQFGLDDLVPSASLFRAQMFLRNRLADIWWLSEAVHFPIILLGGANRTLARINRRRQQKLKVEDIHGYRLKTETVF
HTFLDLLSRSKKGRQEISGMEYDRADIIVGGMLPLVTLLQMLDSDRVIFSESGVREGIISEHLNQ

Specific function: Conversion Of Pppgpp To Ppgpp. Guanosine Pentaphosphate (Pppgpp) Is A Cytoplasmic Signaling Molecule Which Together With Ppgpp Controls The "Stringent Response", An Adaptive Process That Allows Bacteria To Respond To Amino Acid Starvation, Resulting In T

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=309, Percent_Identity=26.8608414239482, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788848, Length=301, Percent_Identity=23.2558139534884, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002658
- InterPro:   IPR016037
- InterPro:   IPR003695 [H]

Pfam domain/function: PF01761 DHQ_synthase; PF02541 Ppx-GppA [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 34174; Mature: 34174

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNLAIVDLGSNSARMAVSRLHANGTAQEIKRVKEDTRLSEGMGTAHVLQPAAIERTIKA
CCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHH
LLNFRRLYEKMPNTDVIGITTAAVRMAQNQTEFLNQVKQEVGLDLRVLSGDDEAYYDYLG
HHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
VANSLVIHDCLILDTGGASCELILVKNGRKQQLISIPFGAVTLSEQFGLDDLVPSASLFR
HHHHHHHHHEEEEECCCCCEEEEEEECCCCCEEEECCCCCEEEHHHCCCHHHCCCHHHHH
AQMFLRNRLADIWWLSEAVHFPIILLGGANRTLARINRRRQQKLKVEDIHGYRLKTETVF
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHH
HTFLDLLSRSKKGRQEISGMEYDRADIIVGGMLPLVTLLQMLDSDRVIFSESGVREGIIS
HHHHHHHHHCCCHHHHHCCCCCCCHHEEECCHHHHHHHHHHHCCCCEEECCCCCHHHHHH
EHLNQ
HHCCC
>Mature Secondary Structure
MRNLAIVDLGSNSARMAVSRLHANGTAQEIKRVKEDTRLSEGMGTAHVLQPAAIERTIKA
CCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHH
LLNFRRLYEKMPNTDVIGITTAAVRMAQNQTEFLNQVKQEVGLDLRVLSGDDEAYYDYLG
HHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
VANSLVIHDCLILDTGGASCELILVKNGRKQQLISIPFGAVTLSEQFGLDDLVPSASLFR
HHHHHHHHHEEEEECCCCCEEEEEEECCCCCEEEECCCCCEEEHHHCCCHHHCCCHHHHH
AQMFLRNRLADIWWLSEAVHFPIILLGGANRTLARINRRRQQKLKVEDIHGYRLKTETVF
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHH
HTFLDLLSRSKKGRQEISGMEYDRADIIVGGMLPLVTLLQMLDSDRVIFSESGVREGIIS
HHHHHHHHHCCCHHHHHCCCCCCCHHEEECCHHHHHHHHHHHCCCCEEECCCCCHHHHHH
EHLNQ
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]