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The map label for this gene is treR [H]

Identifier: 28377188

GI number: 28377188

Start: 235306

End: 236025

Strand: Direct

Name: treR [H]

Synonym: lp_0262

Alternate gene names: 28377188

Gene position: 235306-236025 (Clockwise)

Preceding gene: 28377187

Following gene: 28377189

Centisome position: 7.11

GC content: 46.81

Gene sequence:

>720_bases
GTGAATAAAGCGGCCTTAGTTTATCAAGATTTGCTCCAGAAAATTGATGCGGAGGTTTACCCGATCGGGAGTTATTTGCC
GAGTGAACATCAACTTTGTGAGCTATATGGGATTTCACGTGAGACTGGGCGCAAAGCATTAGCGACATTGGCTGAGGATG
GCTATATTCAAAAAATTCGTGGTAAAGGGTCCATTGTGATTGAGCATCGACAGTATGAATTTCCAGTTTCTGGCATTGTG
AGTTATAAAGAGTTAGCCGAAAAGTTACACATTAAGACGCAAAATATTGTTTATGACTATCAACCGGATGCAACGTTACC
GGTTGCTGACTTTACGTCACTTGGTACCGAATTGACGGAAGCGCCAGTGACGGCCATCAAACGAGTCCGAGTGATCGATG
GCGAACCAGCTATTATTGATAAGGATTATATTTTGAAATCGATCGTTCCGAAAGTTCCCAAGCAAGCGGCGGAAGACTCA
CTGTACGCGTATTTTGAAAATCAGCTTGGGTTGACGATCGGTTACGCGACGAAGGAAATTACGATGGCGCCGGCAACTGA
TGAGGACCGCGAACACCTCGCTATTAGTAAGGGCGCCTATGTGGCAGTTGTTCGAAGCGTGACGAGCCTCACGGATGCGC
GAGCGTTCCAGTATACGGAATCACGACACCGGGCGGACCGCTTTAGTTTCCGCGATTTTGCTCGGCGAACTAAGAAATAA

Upstream 100 bases:

>100_bases
TATAATCTACAAATTTAATTGGGTTATTACTTAAATATTGACAACTTGTCTAAACAAGTCTATATTCATAAATGAAAACG
ATAACAAAGGGGTGGTTGCC

Downstream 100 bases:

>100_bases
GATGTGGCATGAGAGGGATAGCGCATGAAATTATCAGAACAAGTGATTTATCAGATTTATCCGAAGTCGTTTTACGACAG
CAATGGCGATGGCGTCGGTG

Product: transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MNKAALVYQDLLQKIDAEVYPIGSYLPSEHQLCELYGISRETGRKALATLAEDGYIQKIRGKGSIVIEHRQYEFPVSGIV
SYKELAEKLHIKTQNIVYDYQPDATLPVADFTSLGTELTEAPVTAIKRVRVIDGEPAIIDKDYILKSIVPKVPKQAAEDS
LYAYFENQLGLTIGYATKEITMAPATDEDREHLAISKGAYVAVVRSVTSLTDARAFQYTESRHRADRFSFRDFARRTKK

Sequences:

>Translated_239_residues
MNKAALVYQDLLQKIDAEVYPIGSYLPSEHQLCELYGISRETGRKALATLAEDGYIQKIRGKGSIVIEHRQYEFPVSGIV
SYKELAEKLHIKTQNIVYDYQPDATLPVADFTSLGTELTEAPVTAIKRVRVIDGEPAIIDKDYILKSIVPKVPKQAAEDS
LYAYFENQLGLTIGYATKEITMAPATDEDREHLAISKGAYVAVVRSVTSLTDARAFQYTESRHRADRFSFRDFARRTKK
>Mature_239_residues
MNKAALVYQDLLQKIDAEVYPIGSYLPSEHQLCELYGISRETGRKALATLAEDGYIQKIRGKGSIVIEHRQYEFPVSGIV
SYKELAEKLHIKTQNIVYDYQPDATLPVADFTSLGTELTEAPVTAIKRVRVIDGEPAIIDKDYILKSIVPKVPKQAAEDS
LYAYFENQLGLTIGYATKEITMAPATDEDREHLAISKGAYVAVVRSVTSLTDARAFQYTESRHRADRFSFRDFARRTKK

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=221, Percent_Identity=27.6018099547511, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790540, Length=231, Percent_Identity=25.1082251082251, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87082252, Length=227, Percent_Identity=24.6696035242291, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26899; Mature: 26899

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAALVYQDLLQKIDAEVYPIGSYLPSEHQLCELYGISRETGRKALATLAEDGYIQKIR
CCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEC
GKGSIVIEHRQYEFPVSGIVSYKELAEKLHIKTQNIVYDYQPDATLPVADFTSLGTELTE
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCHHHHH
APVTAIKRVRVIDGEPAIIDKDYILKSIVPKVPKQAAEDSLYAYFENQLGLTIGYATKEI
HHHHHHHEEEEECCCCCEECHHHHHHHHHHHCCHHHHHHHHHEEECCCCCEEEEECEEEE
TMAPATDEDREHLAISKGAYVAVVRSVTSLTDARAFQYTESRHRADRFSFRDFARRTKK
EECCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKAALVYQDLLQKIDAEVYPIGSYLPSEHQLCELYGISRETGRKALATLAEDGYIQKIR
CCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEC
GKGSIVIEHRQYEFPVSGIVSYKELAEKLHIKTQNIVYDYQPDATLPVADFTSLGTELTE
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCHHHHH
APVTAIKRVRVIDGEPAIIDKDYILKSIVPKVPKQAAEDSLYAYFENQLGLTIGYATKEI
HHHHHHHEEEEECCCCCEECHHHHHHHHHHHCCHHHHHHHHHEEECCCCCEEEEECEEEE
TMAPATDEDREHLAISKGAYVAVVRSVTSLTDARAFQYTESRHRADRFSFRDFARRTKK
EECCCCCCCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887 [H]