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The map label for this gene is trxA1 [H]

Identifier: 28377165

GI number: 28377165

Start: 215474

End: 215806

Strand: Direct

Name: trxA1 [H]

Synonym: lp_0236

Alternate gene names: 28377165

Gene position: 215474-215806 (Clockwise)

Preceding gene: 28377163

Following gene: 28377167

Centisome position: 6.51

GC content: 46.55

Gene sequence:

>333_bases
ATGATCGAACCAGTCGATAAGACGACTTTTGCGACGGTGGCTGATGGTACCGCGTTAACTGTGGTTGATTTTTGGGCGGA
TTGGTGTGGCCCTTGCAAGATGCAGGAACCAGTGCTTGAAGCGTTAGATGAACTGTACGATGGGCAAGTGAAATTTGCTT
CGCTCGACGTTGATCAACATCAGGAAATTGCGCAACAATTTGAGATTATGAGTATTCCGGCGTTAGTGATATTCAAGAAT
GGCCAGCCCGCTGAAAAGGTGGTTGGTTTTCATCCCCAAGCAGCATTGAAGAAATATCTGGATCAAAAACTAGCCGAAGT
GAAGCCTGCCTAA

Upstream 100 bases:

>100_bases
GATTTTGTGACCTATGTACGTGATTCAGACCCGGAAGTCATAATTTTGTGGGAAAACATGCTATGATAGAACGGAAATCA
ATTGGAAATGAGGATTAGAT

Downstream 100 bases:

>100_bases
CGAGCGTTATTTAACGGTAGCTGTTGAAGCAATCAATAAGTCCCCCAGAAACGGTTACCGCATCTGGGGGACTTATTTTT
CTTGGTGAGTAATTTACGTG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
MIEPVDKTTFATVADGTALTVVDFWADWCGPCKMQEPVLEALDELYDGQVKFASLDVDQHQEIAQQFEIMSIPALVIFKN
GQPAEKVVGFHPQAALKKYLDQKLAEVKPA

Sequences:

>Translated_110_residues
MIEPVDKTTFATVADGTALTVVDFWADWCGPCKMQEPVLEALDELYDGQVKFASLDVDQHQEIAQQFEIMSIPALVIFKN
GQPAEKVVGFHPQAALKKYLDQKLAEVKPA
>Mature_110_residues
MIEPVDKTTFATVADGTALTVVDFWADWCGPCKMQEPVLEALDELYDGQVKFASLDVDQHQEIAQQFEIMSIPALVIFKN
GQPAEKVVGFHPQAALKKYLDQKLAEVKPA

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=90, Percent_Identity=35.5555555555556, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI50592994, Length=85, Percent_Identity=42.3529411764706, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082331, Length=92, Percent_Identity=45.6521739130435, Blast_Score=89, Evalue=9e-20,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=38.0952380952381, Blast_Score=80, Evalue=3e-17,
Organism=Escherichia coli, GI87081747, Length=81, Percent_Identity=39.5061728395062, Blast_Score=67, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=85, Percent_Identity=34.1176470588235, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=94, Percent_Identity=36.1702127659575, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=76, Percent_Identity=50, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=44.047619047619, Blast_Score=81, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=87, Percent_Identity=39.0804597701149, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321022, Length=91, Percent_Identity=35.1648351648352, Blast_Score=60, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28573567, Length=89, Percent_Identity=37.0786516853933, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639826, Length=71, Percent_Identity=39.4366197183099, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17648013, Length=75, Percent_Identity=40, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583090, Length=75, Percent_Identity=40, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24664269, Length=83, Percent_Identity=37.3493975903614, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12207; Mature: 12207

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEPVDKTTFATVADGTALTVVDFWADWCGPCKMQEPVLEALDELYDGQVKFASLDVDQH
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEECCCHHH
QEIAQQFEIMSIPALVIFKNGQPAEKVVGFHPQAALKKYLDQKLAEVKPA
HHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIEPVDKTTFATVADGTALTVVDFWADWCGPCKMQEPVLEALDELYDGQVKFASLDVDQH
CCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEECCCHHH
QEIAQQFEIMSIPALVIFKNGQPAEKVVGFHPQAALKKYLDQKLAEVKPA
HHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA