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The map label for this gene is mtlD

Identifier: 28377163

GI number: 28377163

Start: 213329

End: 214486

Strand: Direct

Name: mtlD

Synonym: lp_0233

Alternate gene names: 28377163

Gene position: 213329-214486 (Clockwise)

Preceding gene: 28377162

Following gene: 28377165

Centisome position: 6.45

GC content: 41.71

Gene sequence:

>1158_bases
ATGTTAGACGTACATTTTGGCGCAGGGAATATTGGTCGGGGCTTCATTGGCGAAACCTTGGCTGACAACGGGTTTAAGAT
TACTTTCGTTGATGTTAACGATACTTTGATTGACGAATTAAACAAACGGAATGGTTATACCATTGAATTGGCTGCAGAAG
GTCAAAAACATATTGAAGTTCACGATGTTAAGGGTATTAACAACGGTAAGGATCCTAAGGCGGTTGCTGAAGAAATTGCC
CAAGCCGATATGGTTACGACTGCGATTGGACCTAAGATCTTGAAGTTCATCGCGCCATTAATTGCTGACGGGTTAAAGTT
ACGGCAAGCTAACAACAATACGACACCAATTGATATCATTGCTTGTGAAAACATGATTGGCGGGAGTCAGTCATTAAAGA
AATCCGTTTATGAATCATTAAATGAAGACGAACAAGCTTGGGCTGACCAAAATGCAGGCTTCCCCAATGCCGCTGTTGAC
CGGATCGTACCGCTTCAAAAGCATGATGATCCATTGTTCGTTTCAGTTGAACCATTCAAGGAATGGGTTATCGACAAGTC
CCAGATGAAGAACCCTAAGATTCAATTAAAGGGTGTTGATTATGCTGACGACTTGGAACCATACATTGAACGGAAACTCT
TCTCCGTTAATACTGGTCATGCCACCGTAGCCTATACTGGTAACATGAAAGGCTACAAGACGATTGGCGAAGCGGTCAAG
GATGACAGTGTCGTTGACCAAGCTAAGCACGTTTTAGGTGAAACCGGCGACTTGTTGATTCAAAAGTGGGGCTTTGATCC
TGAAGTACACCATGCTTATCAAAAGAAGATTTTGAGTCGGTTTGAAAACCCATATATCTCTGATGATATTGAACGGGTCG
GCCGGACACCAATTCGGAAATTAGGTTTCAATGAACGTTTTATTCGCCCAATTCGGGAATTGAAGGAACGTGGTCGTGAT
TACAGTGCCTTAGTTGATACAGTTGGTGAAATGTTCTTCTTCAACTATCCTAATGATAGTGAAAGTGTTAAGTTACAACA
ATTATTGAAGGATGAACCAATCGAACAAGTCATTCGCGAAACAACTGACTTGAAAGATGAAGATTTAGTTAATGAAATCA
AAGCTGCGTACGAAAAGCACTTAGCTGCAGCAAAGTAG

Upstream 100 bases:

>100_bases
CAGATTGCCATATACTGCAGCGACGTTGCCAACGTTGCTAAGTTAGCGGACGCTCAATCTGAAGATGAAATCATAAATCT
ATTAAAGGAAGTTGATTAGC

Downstream 100 bases:

>100_bases
TTCGATAAAAAAACTAATTACTAACCGCCATGGTAATTAGCTGCAAAAGGCGCCCAGAAATTTAATTCTGGGCGCCTTTT
GCGTCTTGCCTGACAAAGAG

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MLDVHFGAGNIGRGFIGETLADNGFKITFVDVNDTLIDELNKRNGYTIELAAEGQKHIEVHDVKGINNGKDPKAVAEEIA
QADMVTTAIGPKILKFIAPLIADGLKLRQANNNTTPIDIIACENMIGGSQSLKKSVYESLNEDEQAWADQNAGFPNAAVD
RIVPLQKHDDPLFVSVEPFKEWVIDKSQMKNPKIQLKGVDYADDLEPYIERKLFSVNTGHATVAYTGNMKGYKTIGEAVK
DDSVVDQAKHVLGETGDLLIQKWGFDPEVHHAYQKKILSRFENPYISDDIERVGRTPIRKLGFNERFIRPIRELKERGRD
YSALVDTVGEMFFFNYPNDSESVKLQQLLKDEPIEQVIRETTDLKDEDLVNEIKAAYEKHLAAAK

Sequences:

>Translated_385_residues
MLDVHFGAGNIGRGFIGETLADNGFKITFVDVNDTLIDELNKRNGYTIELAAEGQKHIEVHDVKGINNGKDPKAVAEEIA
QADMVTTAIGPKILKFIAPLIADGLKLRQANNNTTPIDIIACENMIGGSQSLKKSVYESLNEDEQAWADQNAGFPNAAVD
RIVPLQKHDDPLFVSVEPFKEWVIDKSQMKNPKIQLKGVDYADDLEPYIERKLFSVNTGHATVAYTGNMKGYKTIGEAVK
DDSVVDQAKHVLGETGDLLIQKWGFDPEVHHAYQKKILSRFENPYISDDIERVGRTPIRKLGFNERFIRPIRELKERGRD
YSALVDTVGEMFFFNYPNDSESVKLQQLLKDEPIEQVIRETTDLKDEDLVNEIKAAYEKHLAAAK
>Mature_385_residues
MLDVHFGAGNIGRGFIGETLADNGFKITFVDVNDTLIDELNKRNGYTIELAAEGQKHIEVHDVKGINNGKDPKAVAEEIA
QADMVTTAIGPKILKFIAPLIADGLKLRQANNNTTPIDIIACENMIGGSQSLKKSVYESLNEDEQAWADQNAGFPNAAVD
RIVPLQKHDDPLFVSVEPFKEWVIDKSQMKNPKIQLKGVDYADDLEPYIERKLFSVNTGHATVAYTGNMKGYKTIGEAVK
DDSVVDQAKHVLGETGDLLIQKWGFDPEVHHAYQKKILSRFENPYISDDIERVGRTPIRKLGFNERFIRPIRELKERGRD
YSALVDTVGEMFFFNYPNDSESVKLQQLLKDEPIEQVIRETTDLKDEDLVNEIKAAYEKHLAAAK

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=381, Percent_Identity=41.7322834645669, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI1788497, Length=293, Percent_Identity=24.5733788395904, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787823, Length=229, Percent_Identity=24.8908296943231, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790779, Length=241, Percent_Identity=25.3112033195021, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324401, Length=248, Percent_Identity=27.0161290322581, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320765, Length=248, Percent_Identity=27.0161290322581, Blast_Score=83, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_LACPL (Q88ZS1)

Other databases:

- EMBL:   AL935252
- RefSeq:   NP_784055.1
- ProteinModelPortal:   Q88ZS1
- GeneID:   1061392
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0233
- NMPDR:   fig|220668.1.peg.189
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- BioCyc:   LPLA220668:LP_0233-MONOMER
- BRENDA:   1.1.1.17
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 43200; Mature: 43200

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVHFGAGNIGRGFIGETLADNGFKITFVDVNDTLIDELNKRNGYTIELAAEGQKHIEV
CEEEEECCCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECCCCCCEEE
HDVKGINNGKDPKAVAEEIAQADMVTTAIGPKILKFIAPLIADGLKLRQANNNTTPIDII
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCEEEE
ACENMIGGSQSLKKSVYESLNEDEQAWADQNAGFPNAAVDRIVPLQKHDDPLFVSVEPFK
EECCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEEECHHH
EWVIDKSQMKNPKIQLKGVDYADDLEPYIERKLFSVNTGHATVAYTGNMKGYKTIGEAVK
HHHCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHC
DDSVVDQAKHVLGETGDLLIQKWGFDPEVHHAYQKKILSRFENPYISDDIERVGRTPIRK
CHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHH
LGFNERFIRPIRELKERGRDYSALVDTVGEMFFFNYPNDSESVKLQQLLKDEPIEQVIRE
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCHHHHHHHH
TTDLKDEDLVNEIKAAYEKHLAAAK
HCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDVHFGAGNIGRGFIGETLADNGFKITFVDVNDTLIDELNKRNGYTIELAAEGQKHIEV
CEEEEECCCCCCCCHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECCCCCCEEE
HDVKGINNGKDPKAVAEEIAQADMVTTAIGPKILKFIAPLIADGLKLRQANNNTTPIDII
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCEEEE
ACENMIGGSQSLKKSVYESLNEDEQAWADQNAGFPNAAVDRIVPLQKHDDPLFVSVEPFK
EECCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCEEEEECHHH
EWVIDKSQMKNPKIQLKGVDYADDLEPYIERKLFSVNTGHATVAYTGNMKGYKTIGEAVK
HHHCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHC
DDSVVDQAKHVLGETGDLLIQKWGFDPEVHHAYQKKILSRFENPYISDDIERVGRTPIRK
CHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHH
LGFNERFIRPIRELKERGRDYSALVDTVGEMFFFNYPNDSESVKLQQLLKDEPIEQVIRE
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCHHHHHHHH
TTDLKDEDLVNEIKAAYEKHLAAAK
HCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566