BacMap

Definition	Lactobacillus plantarum WCFS1, complete genome.
Accession	NC_004567
Length	3,308,274

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The map label for this gene is yvgN [H]

Identifier: 28377084

GI number: 28377084

Start: 119743

End: 120591

Strand: Direct

Name: yvgN [H]

Synonym: lp_0136

Alternate gene names: 28377084

Gene position: 119743-120591 (Clockwise)

Preceding gene: 28377083

Following gene: 28377085

Centisome position: 3.62

GC content: 48.29

Gene sequence:

>849_bases
ATGACAGTGTTAACAACGATGTATCAACTAGCAAATGGTGTCAACATTCCCAAAGTCGCATTCGGAACTTGGCAGATACC
TGGTGGTGAGGCAACGTATCAAGCCGTTCGTGCGGCCTTAGCAGCGGGATACCGGCATATTGATACTGCACTGGCCTATC
AAAATGAAGCAAGCGTTGGCCAGGCGATTCGTGATTCTGGCATTCCGCGTGAGCAAATCTTTGTGACGACTAAATTACCG
GCCGAAACGAAGTCATATCAAGGTGCACTAAATGATTTCGATCGCTCACTGAAAAATTTGGGCTTAGACTACGTGGATCT
CTATTTGGTACACGCACCTTGGCCATGGGGGCAAGTCGGTCGAGTTTACGATGAAGCTAACCTCGATGTTTGGCAGGCAA
TGGAAGCTATTTATCAAAGTGGCCGGGCGAAAGCGATTGGCGTCTCTAACTTTGCTGTTCGGGATTTGAAGAATATTCTT
AACCAGGCGACGATACCACCAATGGTCAATCAAATTCAATATTACTTGGGCTTCACGGAACCTAAGATCACCAAGTTTTC
TGAGGAACATGCCATGCTTGTAGAAGCATACTCGCCGTTAGCGACGGGCGGGGTCCTCGATAATCCGCAAGTACAGGCCT
ATGCCGATAAATACGGCGTCAGTGTGGCGCAGTTAGCGTTACGCTTCGTTTTGCAAAATGGGGTCTTGCCATTGCCCAAG
GCTGTTAATCCAGCCCATATTGAGGCGAATACGCAATTGGACTTCGCAATTAGTGTGGCCGATATGCAAGCCTTAAACGA
CTTGCCAGATGCGGCTGGTTCATACATGCACAACCCAACCCAAGGTTAA

Upstream 100 bases:

>100_bases
CAAATTCTAACGGTCGTCGGCGTGGCGATCATCGGGGCAAGCCTTGTAGGTGATCCTACTCAGCAACGACAGTCAAAACC
AGTAAAGGAGCAAAAATAAG

Downstream 100 bases:

>100_bases
CGAACAAAATGTTTGACCGCACTTGGGTCGATAGGAGTAAACTGAACATAATTAATAAACGATAAGGAGCGATTTGATGA
CAACGATTAATGCAGCTAAC

Product: oxidoreductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTVLTTMYQLANGVNIPKVAFGTWQIPGGEATYQAVRAALAAGYRHIDTALAYQNEASVGQAIRDSGIPREQIFVTTKLP
AETKSYQGALNDFDRSLKNLGLDYVDLYLVHAPWPWGQVGRVYDEANLDVWQAMEAIYQSGRAKAIGVSNFAVRDLKNIL
NQATIPPMVNQIQYYLGFTEPKITKFSEEHAMLVEAYSPLATGGVLDNPQVQAYADKYGVSVAQLALRFVLQNGVLPLPK
AVNPAHIEANTQLDFAISVADMQALNDLPDAAGSYMHNPTQG

Sequences:

>Translated_282_residues
MTVLTTMYQLANGVNIPKVAFGTWQIPGGEATYQAVRAALAAGYRHIDTALAYQNEASVGQAIRDSGIPREQIFVTTKLP
AETKSYQGALNDFDRSLKNLGLDYVDLYLVHAPWPWGQVGRVYDEANLDVWQAMEAIYQSGRAKAIGVSNFAVRDLKNIL
NQATIPPMVNQIQYYLGFTEPKITKFSEEHAMLVEAYSPLATGGVLDNPQVQAYADKYGVSVAQLALRFVLQNGVLPLPK
AVNPAHIEANTQLDFAISVADMQALNDLPDAAGSYMHNPTQG
>Mature_281_residues
TVLTTMYQLANGVNIPKVAFGTWQIPGGEATYQAVRAALAAGYRHIDTALAYQNEASVGQAIRDSGIPREQIFVTTKLPA
ETKSYQGALNDFDRSLKNLGLDYVDLYLVHAPWPWGQVGRVYDEANLDVWQAMEAIYQSGRAKAIGVSNFAVRDLKNILN
QATIPPMVNQIQYYLGFTEPKITKFSEEHAMLVEAYSPLATGGVLDNPQVQAYADKYGVSVAQLALRFVLQNGVLPLPKA
VNPAHIEANTQLDFAISVADMQALNDLPDAAGSYMHNPTQG

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI5174695, Length=292, Percent_Identity=35.6164383561644, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI223468663, Length=290, Percent_Identity=32.7586206896552, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI300116273, Length=275, Percent_Identity=35.6363636363636, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI310109920, Length=292, Percent_Identity=35.6164383561644, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI45446745, Length=292, Percent_Identity=35.6164383561644, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4503285, Length=292, Percent_Identity=35.6164383561644, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI5453543, Length=292, Percent_Identity=35.2739726027397, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI24497577, Length=286, Percent_Identity=33.2167832167832, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI5174391, Length=286, Percent_Identity=33.2167832167832, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI93277124, Length=297, Percent_Identity=34.006734006734, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI24497583, Length=292, Percent_Identity=34.9315068493151, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI24497585, Length=292, Percent_Identity=34.9315068493151, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI310109922, Length=281, Percent_Identity=35.2313167259786, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI4502049, Length=287, Percent_Identity=36.2369337979094, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI291291012, Length=262, Percent_Identity=32.4427480916031, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI300116271, Length=279, Percent_Identity=29.7491039426523, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI310109926, Length=112, Percent_Identity=43.75, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI207028673, Length=112, Percent_Identity=43.75, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310109924, Length=149, Percent_Identity=32.8859060402685, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI87082198, Length=261, Percent_Identity=35.2490421455939, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786400, Length=244, Percent_Identity=31.1475409836066, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1788081, Length=283, Percent_Identity=32.5088339222615, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17564128, Length=291, Percent_Identity=33.6769759450172, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17566692, Length=292, Percent_Identity=33.5616438356164, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71998625, Length=265, Percent_Identity=32.8301886792453, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17537075, Length=285, Percent_Identity=34.7368421052632, Blast_Score=153, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17561298, Length=270, Percent_Identity=33.7037037037037, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17537077, Length=307, Percent_Identity=32.8990228013029, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17552492, Length=264, Percent_Identity=31.4393939393939, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17550248, Length=307, Percent_Identity=31.2703583061889, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17538386, Length=277, Percent_Identity=31.0469314079422, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562292, Length=299, Percent_Identity=28.7625418060201, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17537079, Length=292, Percent_Identity=27.7397260273973, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17561300, Length=253, Percent_Identity=28.8537549407115, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324694, Length=292, Percent_Identity=38.013698630137, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320576, Length=291, Percent_Identity=37.4570446735395, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6320079, Length=291, Percent_Identity=37.1134020618557, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319625, Length=293, Percent_Identity=36.1774744027304, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322556, Length=279, Percent_Identity=33.3333333333333, Blast_Score=146, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6321896, Length=305, Percent_Identity=25.9016393442623, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20129731, Length=289, Percent_Identity=37.0242214532872, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24657054, Length=284, Percent_Identity=36.6197183098592, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21356425, Length=282, Percent_Identity=35.4609929078014, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=33.3333333333333, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24662789, Length=301, Percent_Identity=33.8870431893688, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=30.9375, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24663317, Length=283, Percent_Identity=33.2155477031802, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI45553081, Length=282, Percent_Identity=32.9787234042553, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24662781, Length=276, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24662785, Length=273, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281366140, Length=249, Percent_Identity=34.136546184739, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 30820; Mature: 30689

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLTTMYQLANGVNIPKVAFGTWQIPGGEATYQAVRAALAAGYRHIDTALAYQNEASVG
CHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QAIRDSGIPREQIFVTTKLPAETKSYQGALNDFDRSLKNLGLDYVDLYLVHAPWPWGQVG
HHHHHCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHH
RVYDEANLDVWQAMEAIYQSGRAKAIGVSNFAVRDLKNILNQATIPPMVNQIQYYLGFTE
HHHCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
PKITKFSEEHAMLVEAYSPLATGGVLDNPQVQAYADKYGVSVAQLALRFVLQNGVLPLPK
CHHHHHCHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
AVNPAHIEANTQLDFAISVADMQALNDLPDAAGSYMHNPTQG
CCCCCEEECCCCEEEEEEHHHHHHHHHCCHHHHHHCCCCCCC
>Mature Secondary Structure 
TVLTTMYQLANGVNIPKVAFGTWQIPGGEATYQAVRAALAAGYRHIDTALAYQNEASVG
HHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QAIRDSGIPREQIFVTTKLPAETKSYQGALNDFDRSLKNLGLDYVDLYLVHAPWPWGQVG
HHHHHCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHH
RVYDEANLDVWQAMEAIYQSGRAKAIGVSNFAVRDLKNILNQATIPPMVNQIQYYLGFTE
HHHCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
PKITKFSEEHAMLVEAYSPLATGGVLDNPQVQAYADKYGVSVAQLALRFVLQNGVLPLPK
CHHHHHCHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
AVNPAHIEANTQLDFAISVADMQALNDLPDAAGSYMHNPTQG
CCCCCEEECCCCEEEEEEHHHHHHHHHCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]