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The map label for this gene is proA

Identifier: 28376989

GI number: 28376989

Start: 17454

End: 18692

Strand: Direct

Name: proA

Synonym: lp_0017

Alternate gene names: 28376989

Gene position: 17454-18692 (Clockwise)

Preceding gene: 28376988

Following gene: 28376990

Centisome position: 0.53

GC content: 48.91

Gene sequence:

>1239_bases
ATGGTAGATTTAGAACAGTTGGGTCAGCAGGCTCAACAAGCTAGCTATACGCTGGGGTTACTTTCAACGGCGCAAAAAAA
TCAAGTGTTGACCGCAATGGCAACGGCGTTAACGAGCCATCAAGATGAGATATTGGCAGCTAATGCGCAGGATTTAGAGA
ACCCGCAAGTACCAGTTAAGTTTGTTGACCGGCTCCGGCTAACAGCAGACCGCATCCAGGATATGGCGATCGGGCTCAAA
CAGGTCGTGAGTTTGCCAGATCCAATTGGAAATGTGGACCGCGCGTGGCGCAACGAGGCCGGGTTGATGATTGCCAAGGA
ACGGGTACCATTAGGTGTTATCGGCATGATTTTTGAAGCGCGCCCCAATGTGACGGTGGATGCATCAGCACTGTGTTTTA
AAACCGGAAACGCTGTAATCTTACGCGGTGGTAAGGAAGCCCTTCACTCTAATCAAGCACTTGTCCAAGTCTTACGTGGT
GCATTACGGGCCGAAGCGGTCGATGAGAATGCGATTCAACTGATTACGGATACGTCGCATGCGACTGCGGCTAAGTTCAT
GCAGCTCACTGATTACGTGGACGTCTTAATTCCACGCGGGAGCGCCCGTTTGATTCAAACGGTGTTGGCTAAAGCAACGG
TACCCGTTATTGAAACGGGAGCCGGTAATTGTCACGTATACGTGGACAAAGACGCGCAATTGCAAATGGCAACCGATATC
GTGATCAATGGGAAAGTTCAGCGGCCATCAGTTTGCAACGCCACTGAAAAGCTTCTAATTCATCGTGAGGTTGCGGCCGA
TTATTTACCTAGCATGATTCAGGCACTTCGTGAACAAGGCGTAGAAGTACGCGGGGATGCCGCAACTCAAGCCATTGTTC
CTGATGTGGTTCCAGCAACGGATGCGGACTGGGGAACGGAATATAATGATTTAATTATTGCAGTGAAAGTTGTTGATTCA
GAAGCAGCGGCCATTACGCACATCAATCGTTACAATACCCAACATTCCGAAGCTATTGTGACGGATAATTATCAAGCTGG
GAAGCTCTTCCAGCAACGGGTCAACGCAGCGTGTGTTTATATCAATGCTTCCACCCGGTTTACGGATGGCTTTGAATTTG
GGTTTGGCGCTGAAATCGGGATCTCAACGCAGAAGTTACATGCTCGCGGTCCGATGGGATTAGCGGAATTAACATCTTAT
AAATACGTCATTGATGGCAATGGTCAGATTCGCCATTGA

Upstream 100 bases:

>100_bases
AATGATTTTAGCCAATGGTGCGGATCCCACAATTATTTTTCAAATTTTAGCAGGCGAACCAGTCGGAACGCTATTCGGTT
AAGTTGGGGAGGTTATCAAA

Downstream 100 bases:

>100_bases
TGAGCAAGTATCGTTATTAGTCAGTATATCGGCTAATAGCGATTTTTTTATTGCCGATTGGGGGGACAAGTGTTTATCCG
ATTTTTGACTTCTTGATTTG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MVDLEQLGQQAQQASYTLGLLSTAQKNQVLTAMATALTSHQDEILAANAQDLENPQVPVKFVDRLRLTADRIQDMAIGLK
QVVSLPDPIGNVDRAWRNEAGLMIAKERVPLGVIGMIFEARPNVTVDASALCFKTGNAVILRGGKEALHSNQALVQVLRG
ALRAEAVDENAIQLITDTSHATAAKFMQLTDYVDVLIPRGSARLIQTVLAKATVPVIETGAGNCHVYVDKDAQLQMATDI
VINGKVQRPSVCNATEKLLIHREVAADYLPSMIQALREQGVEVRGDAATQAIVPDVVPATDADWGTEYNDLIIAVKVVDS
EAAAITHINRYNTQHSEAIVTDNYQAGKLFQQRVNAACVYINASTRFTDGFEFGFGAEIGISTQKLHARGPMGLAELTSY
KYVIDGNGQIRH

Sequences:

>Translated_412_residues
MVDLEQLGQQAQQASYTLGLLSTAQKNQVLTAMATALTSHQDEILAANAQDLENPQVPVKFVDRLRLTADRIQDMAIGLK
QVVSLPDPIGNVDRAWRNEAGLMIAKERVPLGVIGMIFEARPNVTVDASALCFKTGNAVILRGGKEALHSNQALVQVLRG
ALRAEAVDENAIQLITDTSHATAAKFMQLTDYVDVLIPRGSARLIQTVLAKATVPVIETGAGNCHVYVDKDAQLQMATDI
VINGKVQRPSVCNATEKLLIHREVAADYLPSMIQALREQGVEVRGDAATQAIVPDVVPATDADWGTEYNDLIIAVKVVDS
EAAAITHINRYNTQHSEAIVTDNYQAGKLFQQRVNAACVYINASTRFTDGFEFGFGAEIGISTQKLHARGPMGLAELTSY
KYVIDGNGQIRH
>Mature_412_residues
MVDLEQLGQQAQQASYTLGLLSTAQKNQVLTAMATALTSHQDEILAANAQDLENPQVPVKFVDRLRLTADRIQDMAIGLK
QVVSLPDPIGNVDRAWRNEAGLMIAKERVPLGVIGMIFEARPNVTVDASALCFKTGNAVILRGGKEALHSNQALVQVLRG
ALRAEAVDENAIQLITDTSHATAAKFMQLTDYVDVLIPRGSARLIQTVLAKATVPVIETGAGNCHVYVDKDAQLQMATDI
VINGKVQRPSVCNATEKLLIHREVAADYLPSMIQALREQGVEVRGDAATQAIVPDVVPATDADWGTEYNDLIIAVKVVDS
EAAAITHINRYNTQHSEAIVTDNYQAGKLFQQRVNAACVYINASTRFTDGFEFGFGAEIGISTQKLHARGPMGLAELTSY
KYVIDGNGQIRH

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=36.6504854368932, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=36.6504854368932, Blast_Score=272, Evalue=4e-73,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=44.3373493975904, Blast_Score=344, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI17569969, Length=414, Percent_Identity=34.2995169082126, Blast_Score=260, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17569967, Length=414, Percent_Identity=34.2995169082126, Blast_Score=260, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=33.6405529953917, Blast_Score=239, Evalue=4e-64,
Organism=Drosophila melanogaster, GI21357643, Length=412, Percent_Identity=34.7087378640777, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_LACPL (Q890J4)

Other databases:

- EMBL:   AL935252
- RefSeq:   NP_783881.1
- ProteinModelPortal:   Q890J4
- SMR:   Q890J4
- GeneID:   1061286
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0017
- NMPDR:   fig|220668.1.peg.15
- HOGENOM:   HBG318080
- OMA:   ITHINRY
- ProtClustDB:   PRK00197
- BioCyc:   LPLA220668:LP_0017-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44621; Mature: 44621

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLEQLGQQAQQASYTLGLLSTAQKNQVLTAMATALTSHQDEILAANAQDLENPQVPVK
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCHHCCCCCCCHH
FVDRLRLTADRIQDMAIGLKQVVSLPDPIGNVDRAWRNEAGLMIAKERVPLGVIGMIFEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCEEEEEHEEEC
RPNVTVDASALCFKTGNAVILRGGKEALHSNQALVQVLRGALRAEAVDENAIQLITDTSH
CCCCEEECCEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCH
ATAAKFMQLTDYVDVLIPRGSARLIQTVLAKATVPVIETGAGNCHVYVDKDAQLQMATDI
HHHHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCEEEEEEE
VINGKVQRPSVCNATEKLLIHREVAADYLPSMIQALREQGVEVRGDAATQAIVPDVVPAT
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCCCCC
DADWGTEYNDLIIAVKVVDSEAAAITHINRYNTQHSEAIVTDNYQAGKLFQQRVNAACVY
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCEEEEE
INASTRFTDGFEFGFGAEIGISTQKLHARGPMGLAELTSYKYVIDGNGQIRH
EECCCCCCCCCCCCCCCEECCCHHHECCCCCCCHHHHCCEEEEECCCCCCCC
>Mature Secondary Structure
MVDLEQLGQQAQQASYTLGLLSTAQKNQVLTAMATALTSHQDEILAANAQDLENPQVPVK
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEECCCHHCCCCCCCHH
FVDRLRLTADRIQDMAIGLKQVVSLPDPIGNVDRAWRNEAGLMIAKERVPLGVIGMIFEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCEEEEEHEEEC
RPNVTVDASALCFKTGNAVILRGGKEALHSNQALVQVLRGALRAEAVDENAIQLITDTSH
CCCCEEECCEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCH
ATAAKFMQLTDYVDVLIPRGSARLIQTVLAKATVPVIETGAGNCHVYVDKDAQLQMATDI
HHHHHHHHHHHHHHHEECCCHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCEEEEEEE
VINGKVQRPSVCNATEKLLIHREVAADYLPSMIQALREQGVEVRGDAATQAIVPDVVPAT
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHCCCCCCCC
DADWGTEYNDLIIAVKVVDSEAAAITHINRYNTQHSEAIVTDNYQAGKLFQQRVNAACVY
CCCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCEEEEE
INASTRFTDGFEFGFGAEIGISTQKLHARGPMGLAELTSYKYVIDGNGQIRH
EECCCCCCCCCCCCCCCEECCCHHHECCCCCCCHHHHCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566