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The map label for this gene is gyrA [H]

Identifier: 28376980

GI number: 28376980

Start: 6676

End: 9237

Strand: Direct

Name: gyrA [H]

Synonym: lp_0007

Alternate gene names: 28376980

Gene position: 6676-9237 (Clockwise)

Preceding gene: 28376979

Following gene: 28376981

Centisome position: 0.2

GC content: 46.29

Gene sequence:

>2562_bases
TTGGCTGATTCAGATTTATCGAACAATCGTATTTCGGATGTGAACCTTTCGAAGACCATGCGAACGTCATTCTTAAGCTA
TGCCATGAGTGTTATCGTGGCACGGGCACTGCCGGACGTACGTGATGGGTTAAAGCCAGTGCACCGGCGGATTCTTTACG
GTATGAGTGAATTAGGTGTGACGCCGGATAAGCCGTATAAGAAGTCGGCCCGGATTGTTGGGGATGTTATGGGGAAGTAT
CATCCCCATGGTGACTCCGCAATTTATGAGTCAATGGTGCGGATGGCCCAAGACTTTAGCTATCGCTACATGTTAGTGGA
TGGTCACGGGAACTTCGGCTCTGTCGATGGTGACGGGGCTGCCGCGATGCGGTATACCGAAGCCCGGATGAGTAAGATTG
CGGTTGAAATGCTCCGCGATATTAACAAGGATACCGTTGATTGGCAACCAAACTATGATGATACAGAACGGGAACCAGCA
GTCTTACCAGCACGTTTCCCGAACTTACTCGTTAACGGTGCCACTGGGATTGCTGTTGGGATGACAACAAACATTCCGCC
ACATAACTTAGCGGAAGTCATTTCAGCAATCCACCTGTTGATGGATAATCCTGATGCAACAGTTGCTGACTTGATGGAAG
TCTTACCTGGACCAGATTTTCCAACTGGCGGGATCGTAATGGGAAAGTCCGGTATTCGTAAGGCTTACCAGACTGGTCGT
GGGAACATTATTGTTCGTGCGAAGGTCGATATTCAAGACCAAAAGAATGGTAAGCAACGAATTATCGTGACTGAATTACC
ATATATGGTCAATAAAGCTAAATTGATCGAACGGATTGCTGGTTTAGCTCGAGACAAGGAAATTGAAGGTATCACTGATA
TCAATGATGAAAGTGACCGTGAAGGGATGCGGATCGTCATTGATGTTCGGCGGGATGCCAGCGCCTCGGTTATCTTGAAT
AACCTTTACAAGATGACATTGATGCAGACTAATTTTGGCTTTAACATGTTAGCCATCGTTAAGGGTGCTCCAAAAGTCTT
AAGCTTAAAGCAAATCTTAATCTATTACCTGGAACACCAAGAAGACGTGATTCGGCGTCGGACTGAGTTTGACTTGAAGA
AAGCCCAAGCACGGGCCCATATTCTTGAAGGCTTACGGATTGCCCTTGATCACATTGATGAAATCATTGCGATTATTCGT
CAATCACAAACGAGTGAAATTGCGAAGAACCAATTGATGGATAATTACGGCTTGTCTGATAAGCAGGCACAAGCCATTCT
TGATATGCGGTTAGTCCGGTTAACTGGTTTGGAACGTGAAAAGATCGAGAGTGAATACCAGGACTTATTGAAAGCCATTG
CTGACTACAAAGAAATCTTAGCTAGCAAGGATCGTATCAACCAAATTATTTACGAAGAATTAATGGAAATTCAACGTAAG
TTTGGTGATAAGCGTCGGACCGAATTGATGGTCGGTGAAGTCCTCAGTATTGAAGATGAAGACTTGATCGAAGAAGAAGA
AGTGGCTGTTACCTTAACTCACAATGGCTACATCAAACGGTTACCAACGACTGAATTTAAGTCGCAACACCGTGGTGGTC
GTGGGATTCAAGGGATGGACGTCCATGATGATGACTTTATCGAACATCTACTGACGACGTCGACCCATGATGTCCTACTC
TTTTTCACTAATGCGGGTAAAGTTTACCGGATGAAGGCTTACGAGATTCCTGAATACGGTCGTACGGCCAAAGGAATCCC
GGTCATCAATTTACTGGGAGTCAATTCTGGTGAAAAAATTCAGGCGGTCGTTAATGTCACGGGCGATGCGAGCGCTTCTG
ATAACTACCTGTTCTTTACAACCGTTAAAGGGGTTGTCAAACGGACACCAGTTCAAGAATTTGCCAATATCCGTAGCAAT
GGTTTGAAGGCCATTACGCTTAAGGATGATGATGAATTAATCGGGGTTACAATCACGGATGGTCACCAAAATGTAATCAT
CGGGACGCACGACGGTTATGCCGTCAGTTTCGACGAAACCACAGTGCGGTCCATGGGCCGGACGGCTTCTGGGGTTCGCG
GGATTCGCTTACGCGATGATGACTTTGTGATTGGCTTTGACGTTTTGAAGCCCGACAGCAACGTCTTCATCATCACGGAA
AAGGGTTATGGGAAACAAACGCCAGCTGCCGATTACCCAATTAAGGGGCGTGGTGGCAAAGGAATCAAGACCGCTAACGT
GACTGAGAAGAATGGTCATTTAGCTGGTTTGACGACGGTTGATGGTCAAGAAGATATCATGGTAATGACGAACCAAGGAG
TCATGATTCGCTTCAATATCGCAACCGTTTCTCAGACTGGTCGGGCAACCTTAGGTGTTCGTCTCATGCGGTTAGGCGAT
GATGGTCAAGTCGCAACGATGGCCAAGGTTGATCCAGAGCCAGAAGTTGATGAGACTGTCGCAACGGATGCAACGACTGA
GGCACCAGTTGACGATCAAACCGTCAACGCCGATGCCACTACGACAGAACCAACAACTGATTCAAACGATTCAAACGAAT
AA

Upstream 100 bases:

>100_bases
TAATGGCACGACGGTTGTCTTAATGGCGACTTTTACTTGAGACATGTAAAGCTTAATCAAGCTTTAATAGCGGCAAAACG
GATGAAGGAGGACGAATATT

Downstream 100 bases:

>100_bases
ATTGATAAAACAAGCGTGGTCGACAATCTTGTCGACCACGCTTGTTTTTTTATGCGAGTCAAGAATTATTTTGGCAACGG
GTCGTGTGTGATTTACCGGT

Product: DNA gyrase, A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 853; Mature: 852

Protein sequence:

>853_residues
MADSDLSNNRISDVNLSKTMRTSFLSYAMSVIVARALPDVRDGLKPVHRRILYGMSELGVTPDKPYKKSARIVGDVMGKY
HPHGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAAMRYTEARMSKIAVEMLRDINKDTVDWQPNYDDTEREPA
VLPARFPNLLVNGATGIAVGMTTNIPPHNLAEVISAIHLLMDNPDATVADLMEVLPGPDFPTGGIVMGKSGIRKAYQTGR
GNIIVRAKVDIQDQKNGKQRIIVTELPYMVNKAKLIERIAGLARDKEIEGITDINDESDREGMRIVIDVRRDASASVILN
NLYKMTLMQTNFGFNMLAIVKGAPKVLSLKQILIYYLEHQEDVIRRRTEFDLKKAQARAHILEGLRIALDHIDEIIAIIR
QSQTSEIAKNQLMDNYGLSDKQAQAILDMRLVRLTGLEREKIESEYQDLLKAIADYKEILASKDRINQIIYEELMEIQRK
FGDKRRTELMVGEVLSIEDEDLIEEEEVAVTLTHNGYIKRLPTTEFKSQHRGGRGIQGMDVHDDDFIEHLLTTSTHDVLL
FFTNAGKVYRMKAYEIPEYGRTAKGIPVINLLGVNSGEKIQAVVNVTGDASASDNYLFFTTVKGVVKRTPVQEFANIRSN
GLKAITLKDDDELIGVTITDGHQNVIIGTHDGYAVSFDETTVRSMGRTASGVRGIRLRDDDFVIGFDVLKPDSNVFIITE
KGYGKQTPAADYPIKGRGGKGIKTANVTEKNGHLAGLTTVDGQEDIMVMTNQGVMIRFNIATVSQTGRATLGVRLMRLGD
DGQVATMAKVDPEPEVDETVATDATTEAPVDDQTVNADATTTEPTTDSNDSNE

Sequences:

>Translated_853_residues
MADSDLSNNRISDVNLSKTMRTSFLSYAMSVIVARALPDVRDGLKPVHRRILYGMSELGVTPDKPYKKSARIVGDVMGKY
HPHGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAAMRYTEARMSKIAVEMLRDINKDTVDWQPNYDDTEREPA
VLPARFPNLLVNGATGIAVGMTTNIPPHNLAEVISAIHLLMDNPDATVADLMEVLPGPDFPTGGIVMGKSGIRKAYQTGR
GNIIVRAKVDIQDQKNGKQRIIVTELPYMVNKAKLIERIAGLARDKEIEGITDINDESDREGMRIVIDVRRDASASVILN
NLYKMTLMQTNFGFNMLAIVKGAPKVLSLKQILIYYLEHQEDVIRRRTEFDLKKAQARAHILEGLRIALDHIDEIIAIIR
QSQTSEIAKNQLMDNYGLSDKQAQAILDMRLVRLTGLEREKIESEYQDLLKAIADYKEILASKDRINQIIYEELMEIQRK
FGDKRRTELMVGEVLSIEDEDLIEEEEVAVTLTHNGYIKRLPTTEFKSQHRGGRGIQGMDVHDDDFIEHLLTTSTHDVLL
FFTNAGKVYRMKAYEIPEYGRTAKGIPVINLLGVNSGEKIQAVVNVTGDASASDNYLFFTTVKGVVKRTPVQEFANIRSN
GLKAITLKDDDELIGVTITDGHQNVIIGTHDGYAVSFDETTVRSMGRTASGVRGIRLRDDDFVIGFDVLKPDSNVFIITE
KGYGKQTPAADYPIKGRGGKGIKTANVTEKNGHLAGLTTVDGQEDIMVMTNQGVMIRFNIATVSQTGRATLGVRLMRLGD
DGQVATMAKVDPEPEVDETVATDATTEAPVDDQTVNADATTTEPTTDSNDSNE
>Mature_852_residues
ADSDLSNNRISDVNLSKTMRTSFLSYAMSVIVARALPDVRDGLKPVHRRILYGMSELGVTPDKPYKKSARIVGDVMGKYH
PHGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGAAAMRYTEARMSKIAVEMLRDINKDTVDWQPNYDDTEREPAV
LPARFPNLLVNGATGIAVGMTTNIPPHNLAEVISAIHLLMDNPDATVADLMEVLPGPDFPTGGIVMGKSGIRKAYQTGRG
NIIVRAKVDIQDQKNGKQRIIVTELPYMVNKAKLIERIAGLARDKEIEGITDINDESDREGMRIVIDVRRDASASVILNN
LYKMTLMQTNFGFNMLAIVKGAPKVLSLKQILIYYLEHQEDVIRRRTEFDLKKAQARAHILEGLRIALDHIDEIIAIIRQ
SQTSEIAKNQLMDNYGLSDKQAQAILDMRLVRLTGLEREKIESEYQDLLKAIADYKEILASKDRINQIIYEELMEIQRKF
GDKRRTELMVGEVLSIEDEDLIEEEEVAVTLTHNGYIKRLPTTEFKSQHRGGRGIQGMDVHDDDFIEHLLTTSTHDVLLF
FTNAGKVYRMKAYEIPEYGRTAKGIPVINLLGVNSGEKIQAVVNVTGDASASDNYLFFTTVKGVVKRTPVQEFANIRSNG
LKAITLKDDDELIGVTITDGHQNVIIGTHDGYAVSFDETTVRSMGRTASGVRGIRLRDDDFVIGFDVLKPDSNVFIITEK
GYGKQTPAADYPIKGRGGKGIKTANVTEKNGHLAGLTTVDGQEDIMVMTNQGVMIRFNIATVSQTGRATLGVRLMRLGDD
GQVATMAKVDPEPEVDETVATDATTEAPVDDQTVNADATTTEPTTDSNDSNE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=317, Percent_Identity=24.9211356466877, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI19913406, Length=175, Percent_Identity=32, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=885, Percent_Identity=47.5706214689266, Blast_Score=815, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=748, Percent_Identity=35.427807486631, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17535065, Length=191, Percent_Identity=29.3193717277487, Blast_Score=73, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=486, Percent_Identity=23.0452674897119, Blast_Score=70, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=179, Percent_Identity=33.5195530726257, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136538, Length=181, Percent_Identity=29.2817679558011, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94525; Mature: 94394

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSDLSNNRISDVNLSKTMRTSFLSYAMSVIVARALPDVRDGLKPVHRRILYGMSELGV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
TPDKPYKKSARIVGDVMGKYHPHGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGA
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
AAMRYTEARMSKIAVEMLRDINKDTVDWQPNYDDTEREPAVLPARFPNLLVNGATGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEE
MTTNIPPHNLAEVISAIHLLMDNPDATVADLMEVLPGPDFPTGGIVMGKSGIRKAYQTGR
EECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCC
GNIIVRAKVDIQDQKNGKQRIIVTELPYMVNKAKLIERIAGLARDKEIEGITDINDESDR
CCEEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
EGMRIVIDVRRDASASVILNNLYKMTLMQTNFGFNMLAIVKGAPKVLSLKQILIYYLEHQ
CCCEEEEEECCCCCHHHHHHHHHEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHH
EDVIRRRTEFDLKKAQARAHILEGLRIALDHIDEIIAIIRQSQTSEIAKNQLMDNYGLSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCH
KQAQAILDMRLVRLTGLEREKIESEYQDLLKAIADYKEILASKDRINQIIYEELMEIQRK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGDKRRTELMVGEVLSIEDEDLIEEEEVAVTLTHNGYIKRLPTTEFKSQHRGGRGIQGMD
HCCHHHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCEEEECCCHHHHHHCCCCCCCCCCC
VHDDDFIEHLLTTSTHDVLLFFTNAGKVYRMKAYEIPEYGRTAKGIPVINLLGVNSGEKI
CCCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCEE
QAVVNVTGDASASDNYLFFTTVKGVVKRTPVQEFANIRSNGLKAITLKDDDELIGVTITD
EEEEEECCCCCCCCCEEEEEEHHHHHHCCCHHHHHHHHCCCEEEEEEECCCCEEEEEEEC
GHQNVIIGTHDGYAVSFDETTVRSMGRTASGVRGIRLRDDDFVIGFDVLKPDSNVFIITE
CCCEEEEECCCCEEEEECHHHHHHCCCCCCCCCEEEEECCCEEEEEEEECCCCCEEEEEE
KGYGKQTPAADYPIKGRGGKGIKTANVTEKNGHLAGLTTVDGQEDIMVMTNQGVMIRFNI
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEEE
ATVSQTGRATLGVRLMRLGDDGQVATMAKVDPEPEVDETVATDATTEAPVDDQTVNADAT
EEECCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCEECCCCC
TTEPTTDSNDSNE
CCCCCCCCCCCCC
>Mature Secondary Structure 
ADSDLSNNRISDVNLSKTMRTSFLSYAMSVIVARALPDVRDGLKPVHRRILYGMSELGV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
TPDKPYKKSARIVGDVMGKYHPHGDSAIYESMVRMAQDFSYRYMLVDGHGNFGSVDGDGA
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCC
AAMRYTEARMSKIAVEMLRDINKDTVDWQPNYDDTEREPAVLPARFPNLLVNGATGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEE
MTTNIPPHNLAEVISAIHLLMDNPDATVADLMEVLPGPDFPTGGIVMGKSGIRKAYQTGR
EECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHCCC
GNIIVRAKVDIQDQKNGKQRIIVTELPYMVNKAKLIERIAGLARDKEIEGITDINDESDR
CCEEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
EGMRIVIDVRRDASASVILNNLYKMTLMQTNFGFNMLAIVKGAPKVLSLKQILIYYLEHQ
CCCEEEEEECCCCCHHHHHHHHHEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHH
EDVIRRRTEFDLKKAQARAHILEGLRIALDHIDEIIAIIRQSQTSEIAKNQLMDNYGLSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCH
KQAQAILDMRLVRLTGLEREKIESEYQDLLKAIADYKEILASKDRINQIIYEELMEIQRK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGDKRRTELMVGEVLSIEDEDLIEEEEVAVTLTHNGYIKRLPTTEFKSQHRGGRGIQGMD
HCCHHHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCEEEECCCHHHHHHCCCCCCCCCCC
VHDDDFIEHLLTTSTHDVLLFFTNAGKVYRMKAYEIPEYGRTAKGIPVINLLGVNSGEKI
CCCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCEE
QAVVNVTGDASASDNYLFFTTVKGVVKRTPVQEFANIRSNGLKAITLKDDDELIGVTITD
EEEEEECCCCCCCCCEEEEEEHHHHHHCCCHHHHHHHHCCCEEEEEEECCCCEEEEEEEC
GHQNVIIGTHDGYAVSFDETTVRSMGRTASGVRGIRLRDDDFVIGFDVLKPDSNVFIITE
CCCEEEEECCCCEEEEECHHHHHHCCCCCCCCCEEEEECCCEEEEEEEECCCCCEEEEEE
KGYGKQTPAADYPIKGRGGKGIKTANVTEKNGHLAGLTTVDGQEDIMVMTNQGVMIRFNI
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCEEEEEECCCCCCEEEEECCCEEEEEEE
ATVSQTGRATLGVRLMRLGDDGQVATMAKVDPEPEVDETVATDATTEAPVDDQTVNADAT
EEECCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCEECCCCC
TTEPTTDSNDSNE
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]