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The map label for this gene is lytS [H]

Identifier: 28211603

GI number: 28211603

Start: 2103322

End: 2105019

Strand: Direct

Name: lytS [H]

Synonym: CTC01978

Alternate gene names: 28211603

Gene position: 2103322-2105019 (Clockwise)

Preceding gene: 28211598

Following gene: 28211604

Centisome position: 75.14

GC content: 27.97

Gene sequence:

>1698_bases
ATGATATTAATGATATATATACAACTTTTAGGTAGTATGTCTACAATAGCTTTATCCGCCTATATTTTCAATCAGTACTA
CATATCTAAAAAACTTTTTTGCTTAGATAAAGAATTTAATAAACTTGCTTTAATAGTTTTTTTCAGTCTTCTATCCATAT
TGGGTACCTACACTGGAGTTAATATAGATTCTATGGCCCCAGCTAGTTTTAATAAATCTACATTAATTAATTTAAATCCC
CATGCCATAGCTAATACTCGCCCCATAGGAGCTATAACTGCTGGATATTTAGGTGGCCCTCTGGTTGGTATATGTGTAGG
ACTTATTGCAGGTTTACAAAGGTATTATGTAGGGGGCTTTACAGCATTAGCCTGTGCAGTAGCCACAATAATGGGAGGAA
TTTGTGGTGGTTTAGCCAGAAAACACTCTAAATCTAAAACCCTTAATCCAAAACTTGCTTTTATAACCACAATAATTGCA
GAAATATTGGAAATGATTATAATACTTATTTTATCCAAACCCTTTAATCATGCCCTACAATTAGAAAAAATTTTTGCTCT
ACCTATGATAATTATAAATTCTGTAGGAGTTTTCGTTTTTGTATATATTACAAAAGATGCCTTAGAGCAATATAACAGAA
TAGGTGCCACAGAGGCACAAAAAGCTTTAAATATAGCTGAAAAAACTCTAAATTACTTTAAAAAGGGTTTTCACAAAGAT
AATTCTGAAAAAATAGCAAAAATCATTTGGCAAAATACTTCCTTTGAAAGTGTTTTTATTGCAGATACTAAAAAAATGAT
CTCATATTATGGAGAAGATATAAATTCTAATCTTTTAAATGAATCCTTAAAAAATTACTATAAATCTGCTGACTATAAAA
TAATTAAATATAGAGACTCTTCATCTGAAACAGTTGAAAATATATTTTTTTGTATTCCAATATATGATGAAAATAATTTA
GAATTAGTAATTGGCTTAAATATAGTATCCGAAAGTTTTGTAGATAAATATTTTACATTGTTTGTTAAGCAATTAAGCAC
ATTGCTCTCTAATCAATTAAAGCTTTACAAATTAAATAAAATAGCCAATGAAGTTTATGTAGCTGAATTTAAAGCATTAA
AAGCTCAAATACACCCTCATTTTTTATTTAATGCACTAAACACTATTTCCTCTTTTTGCAGAACAAACCCTAATAAAGCA
AGAGAACTTATACTAAATTTATCTAGCTACTTTAGACAGACTTTGAAAAGAGAAGAAGATTTTATTACAATTAAAGAAGA
GTATGATTTTTTAAATTCTTATCTTTCTATAGAAAACGCACGTTTTGGAGAAAGATTAAAAGTGAATATAAATTTCCCTA
AAAATTTATTAAACTATAAAATTCCTGTTTTTTTATTACAACCTCTAGTAGAGAACTCTATAAATCATGGAATTTTACCT
AAACCCTCTGGTGGAACAGTTATTATAGAGGCTTACTCCTCTAATGAAAATTTAAATTTTATTGTAAAAGATAATGGAGT
TGGTATGAAAGAAACTGATCTTAAAAAGATACATTCTTTTTCTACTGGTATAGGACTAAACAATGTAAATGAAAGGCTAA
AACTTCTCTTCGGAGAAGACTATAAAATAAATATAAAAAGCAACCCTAATAAAGGTACTTCTATATCTTTTTCAATACCT
AAGGAGATGAATTTATGA

Upstream 100 bases:

>100_bases
AAATAACAAAACTTAAGGTTCAAATGCATTTTATATAGGTTCAATAACACTTAATTTTGTATTCTTTATTGTATAATAGT
TATGTAACTTTCTTGAAAGG

Downstream 100 bases:

>100_bases
ACAAAATAAATTGTGTAATAATAGAAGATGAAATTCCTTCTGCAGATGAATTAAATTATATGCTTAAAAACTATAACTTT
ATTAATATAGTAGGCATAGC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MILMIYIQLLGSMSTIALSAYIFNQYYISKKLFCLDKEFNKLALIVFFSLLSILGTYTGVNIDSMAPASFNKSTLINLNP
HAIANTRPIGAITAGYLGGPLVGICVGLIAGLQRYYVGGFTALACAVATIMGGICGGLARKHSKSKTLNPKLAFITTIIA
EILEMIIILILSKPFNHALQLEKIFALPMIIINSVGVFVFVYITKDALEQYNRIGATEAQKALNIAEKTLNYFKKGFHKD
NSEKIAKIIWQNTSFESVFIADTKKMISYYGEDINSNLLNESLKNYYKSADYKIIKYRDSSSETVENIFFCIPIYDENNL
ELVIGLNIVSESFVDKYFTLFVKQLSTLLSNQLKLYKLNKIANEVYVAEFKALKAQIHPHFLFNALNTISSFCRTNPNKA
RELILNLSSYFRQTLKREEDFITIKEEYDFLNSYLSIENARFGERLKVNINFPKNLLNYKIPVFLLQPLVENSINHGILP
KPSGGTVIIEAYSSNENLNFIVKDNGVGMKETDLKKIHSFSTGIGLNNVNERLKLLFGEDYKINIKSNPNKGTSISFSIP
KEMNL

Sequences:

>Translated_565_residues
MILMIYIQLLGSMSTIALSAYIFNQYYISKKLFCLDKEFNKLALIVFFSLLSILGTYTGVNIDSMAPASFNKSTLINLNP
HAIANTRPIGAITAGYLGGPLVGICVGLIAGLQRYYVGGFTALACAVATIMGGICGGLARKHSKSKTLNPKLAFITTIIA
EILEMIIILILSKPFNHALQLEKIFALPMIIINSVGVFVFVYITKDALEQYNRIGATEAQKALNIAEKTLNYFKKGFHKD
NSEKIAKIIWQNTSFESVFIADTKKMISYYGEDINSNLLNESLKNYYKSADYKIIKYRDSSSETVENIFFCIPIYDENNL
ELVIGLNIVSESFVDKYFTLFVKQLSTLLSNQLKLYKLNKIANEVYVAEFKALKAQIHPHFLFNALNTISSFCRTNPNKA
RELILNLSSYFRQTLKREEDFITIKEEYDFLNSYLSIENARFGERLKVNINFPKNLLNYKIPVFLLQPLVENSINHGILP
KPSGGTVIIEAYSSNENLNFIVKDNGVGMKETDLKKIHSFSTGIGLNNVNERLKLLFGEDYKINIKSNPNKGTSISFSIP
KEMNL
>Mature_565_residues
MILMIYIQLLGSMSTIALSAYIFNQYYISKKLFCLDKEFNKLALIVFFSLLSILGTYTGVNIDSMAPASFNKSTLINLNP
HAIANTRPIGAITAGYLGGPLVGICVGLIAGLQRYYVGGFTALACAVATIMGGICGGLARKHSKSKTLNPKLAFITTIIA
EILEMIIILILSKPFNHALQLEKIFALPMIIINSVGVFVFVYITKDALEQYNRIGATEAQKALNIAEKTLNYFKKGFHKD
NSEKIAKIIWQNTSFESVFIADTKKMISYYGEDINSNLLNESLKNYYKSADYKIIKYRDSSSETVENIFFCIPIYDENNL
ELVIGLNIVSESFVDKYFTLFVKQLSTLLSNQLKLYKLNKIANEVYVAEFKALKAQIHPHFLFNALNTISSFCRTNPNKA
RELILNLSSYFRQTLKREEDFITIKEEYDFLNSYLSIENARFGERLKVNINFPKNLLNYKIPVFLLQPLVENSINHGILP
KPSGGTVIIEAYSSNENLNFIVKDNGVGMKETDLKKIHSFSTGIGLNNVNERLKLLFGEDYKINIKSNPNKGTSISFSIP
KEMNL

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=541, Percent_Identity=33.456561922366, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1788723, Length=538, Percent_Identity=30.4832713754647, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63601; Mature: 63601

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILMIYIQLLGSMSTIALSAYIFNQYYISKKLFCLDKEFNKLALIVFFSLLSILGTYTGV
CCCEEEHHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
NIDSMAPASFNKSTLINLNPHAIANTRPIGAITAGYLGGPLVGICVGLIAGLQRYYVGGF
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCHH
TALACAVATIMGGICGGLARKHSKSKTLNPKLAFITTIIAEILEMIIILILSKPFNHALQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LEKIFALPMIIINSVGVFVFVYITKDALEQYNRIGATEAQKALNIAEKTLNYFKKGFHKD
HHHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
NSEKIAKIIWQNTSFESVFIADTKKMISYYGEDINSNLLNESLKNYYKSADYKIIKYRDS
CHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECC
SSETVENIFFCIPIYDENNLELVIGLNIVSESFVDKYFTLFVKQLSTLLSNQLKLYKLNK
CCHHHCEEEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEHHH
IANEVYVAEFKALKAQIHPHFLFNALNTISSFCRTNPNKARELILNLSSYFRQTLKREED
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
FITIKEEYDFLNSYLSIENARFGERLKVNINFPKNLLNYKIPVFLLQPLVENSINHGILP
EEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCHHHHHHHHHHCCCCCCCCC
KPSGGTVIIEAYSSNENLNFIVKDNGVGMKETDLKKIHSFSTGIGLNNVNERLKLLFGED
CCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHEECCC
YKINIKSNPNKGTSISFSIPKEMNL
EEEEEECCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MILMIYIQLLGSMSTIALSAYIFNQYYISKKLFCLDKEFNKLALIVFFSLLSILGTYTGV
CCCEEEHHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCC
NIDSMAPASFNKSTLINLNPHAIANTRPIGAITAGYLGGPLVGICVGLIAGLQRYYVGGF
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCHH
TALACAVATIMGGICGGLARKHSKSKTLNPKLAFITTIIAEILEMIIILILSKPFNHALQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LEKIFALPMIIINSVGVFVFVYITKDALEQYNRIGATEAQKALNIAEKTLNYFKKGFHKD
HHHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
NSEKIAKIIWQNTSFESVFIADTKKMISYYGEDINSNLLNESLKNYYKSADYKIIKYRDS
CHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECC
SSETVENIFFCIPIYDENNLELVIGLNIVSESFVDKYFTLFVKQLSTLLSNQLKLYKLNK
CCHHHCEEEEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEHHH
IANEVYVAEFKALKAQIHPHFLFNALNTISSFCRTNPNKARELILNLSSYFRQTLKREED
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
FITIKEEYDFLNSYLSIENARFGERLKVNINFPKNLLNYKIPVFLLQPLVENSINHGILP
EEEEHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCCHHHHHHHHHHCCCCCCCCC
KPSGGTVIIEAYSSNENLNFIVKDNGVGMKETDLKKIHSFSTGIGLNNVNERLKLLFGED
CCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHEECCC
YKINIKSNPNKGTSISFSIPKEMNL
EEEEEECCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]