Click here to switch to the map view.

The map label for this gene is arsA [H]

Identifier: 28211528

GI number: 28211528

Start: 2013854

End: 2015623

Strand: Direct

Name: arsA [H]

Synonym: CTC01894

Alternate gene names: 28211528

Gene position: 2013854-2015623 (Clockwise)

Preceding gene: 28211523

Following gene: 28211532

Centisome position: 71.94

GC content: 30.96

Gene sequence:

>1770_bases
GTGATGAAATTTATGTTTGAACAATTTAATGCTGATAAATTAGATTTAACAAAATATTTATTTTATACTGGAAAAGGTGG
AGTTGGTAAAACATCTATAGCTTGTGCTACCGCTGTTAGTCTTGCTGATTCTGGTAAAAAGGTTTTATTAATTAGTACAG
ATCCTGCTTCAAATTTGCAAGATGTTTTTCATACAGAATTGAGCAACAAAGAAACTAAAATAAAAGAAACACCCAATTTA
TCTGTAGTTAATTTAAATCCAGAAGAAGCTGCAAGGGAGTACAGAGATTCTATGATTAATCCATATAAAGGAAAGCTTCC
AGAAGCCGTTCTTAAAAATATGGAAGAGCAATTATCTGGTTCTTGTACAGTAGAAATTGCAGCATTTAACGAATTTTCAA
ATTATCTTACAGATAAAAACATTGAAAATGAATATGAATTCATTATATTTGATACTGCTCCCACAGGGCATACACTTAGA
ATGCTACAATTACCATCTGCATGGACTAATTTTATCAGTGAAAGTACACACGGGGCTTCTTGTCTAGGACAACTTTCAGG
ACTTGAAGACAGAAAAGAAATGTATAAAGAAGCAGTTCAAACATTGGCAAATGGTAAACTTACAACACTTATACTAGTTG
CTAGACCTGAGAGTTCAACTCTTTTAGAAGCTGAGAGAGCATCTGATGAGTTAAGTCAATTAGGAATCAATAATCGAATG
TTAATAATAAATGGAGTGATGCAAACAGTAAATAAAGATGATGAAGTTTCTTTAGAATTTTATAATAAACAACAAAGTAC
TTTAAAAAATATTCCAAATGCTATAAAAGATATTAAAACTTATGCTGTTCCTTTACGTTCTTACAATGTATCTGGGATAG
ATAGTATTAGAATGATGTTAAAAGGTGATAGTGAAGTAATAACAACAGAAACGCTTGATAATATTGACTTTCCATCGATA
AATGATTTAATAAATGATTTATATAAATCTAAGAAAAAAGTTATTTTCACCATGGGAAAAGGTGGAGTTGGTAAAACTAC
AGTTGCCTCTACTATTGCACTAGCCCTTTCTCAAAAAGGTGTAAAAGTACATCTTACAACCACAGACCCCTCTAATCACA
TTAAATATATTATGGGCAAACATAAGAATATCACAATAAGTGAAATAAATGAACAAGAAGAATTAAAGAAATATCAAAAT
GAAGTTATTTCTAAAGCATCAGAGACAATGAGTGGTGAAGATCTAGAATATATAAAAGAAGATTTACGTTCACCTTGTAC
ACAGGAAATAGCTGTTTTCAGAGCTTTTGCCGAAATAGTAGAAAAAGCTGATGATGAAGTTGTTGTAATAGATACAGCTC
CTACTGGTCATACACTTTTACTTTTAGATTCAACTCAAAGCTATCACAAAGAAGTTGAAAGAACACAAGGTGATATTCCC
AAATCAGTTAAAAAATTATTGCCAAGACTTAGAGATGAAAATGAAACAGATGTTGTTATAGTTACATTACCCGAAGCCAC
ACCTGTTTACGAAGCAGAGCGATTAAATACTGATTTAAAAAGAGCAGGAATACACTCTAAATGGTGGGTAATAAACTCCA
GCTTGTTATTAACGGGAACAAAATCCACTTTATTACAATCAAAAGCTCAAAGTGAAATAAAGTGGATAAACGAAGTAAAT
AAATATTCTAATGGTAATTATACTGTTGTAAAATGGCTTCCAAAAGAAGTAAATGATACTACATTGCTTGAAATAATTAA
GCTGAAATAA

Upstream 100 bases:

>100_bases
GTTTTTTAAATATACAGGTCTAAAAATTGAATCAAATAAAAGTACAAATAAAGGTTGCTATTGTGGAGGAAATAACGATT
GTTGCTAAATAAAATGAAAG

Downstream 100 bases:

>100_bases
TTAGAGAACAAATATTGGATTTACGTTCAAAAATTCCTGATCTAATTTGACTATATTAATTTATATTTCAAGGAAAGTAA
CTTTTTATTTATATACTAAT

Product: arsenical pump-driving ATPase

Products: NA

Alternate protein names: Arsenical resistance ATPase; Arsenite-translocating ATPase; Arsenite-transporting ATPase [H]

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MMKFMFEQFNADKLDLTKYLFYTGKGGVGKTSIACATAVSLADSGKKVLLISTDPASNLQDVFHTELSNKETKIKETPNL
SVVNLNPEEAAREYRDSMINPYKGKLPEAVLKNMEEQLSGSCTVEIAAFNEFSNYLTDKNIENEYEFIIFDTAPTGHTLR
MLQLPSAWTNFISESTHGASCLGQLSGLEDRKEMYKEAVQTLANGKLTTLILVARPESSTLLEAERASDELSQLGINNRM
LIINGVMQTVNKDDEVSLEFYNKQQSTLKNIPNAIKDIKTYAVPLRSYNVSGIDSIRMMLKGDSEVITTETLDNIDFPSI
NDLINDLYKSKKKVIFTMGKGGVGKTTVASTIALALSQKGVKVHLTTTDPSNHIKYIMGKHKNITISEINEQEELKKYQN
EVISKASETMSGEDLEYIKEDLRSPCTQEIAVFRAFAEIVEKADDEVVVIDTAPTGHTLLLLDSTQSYHKEVERTQGDIP
KSVKKLLPRLRDENETDVVIVTLPEATPVYEAERLNTDLKRAGIHSKWWVINSSLLLTGTKSTLLQSKAQSEIKWINEVN
KYSNGNYTVVKWLPKEVNDTTLLEIIKLK

Sequences:

>Translated_589_residues
MMKFMFEQFNADKLDLTKYLFYTGKGGVGKTSIACATAVSLADSGKKVLLISTDPASNLQDVFHTELSNKETKIKETPNL
SVVNLNPEEAAREYRDSMINPYKGKLPEAVLKNMEEQLSGSCTVEIAAFNEFSNYLTDKNIENEYEFIIFDTAPTGHTLR
MLQLPSAWTNFISESTHGASCLGQLSGLEDRKEMYKEAVQTLANGKLTTLILVARPESSTLLEAERASDELSQLGINNRM
LIINGVMQTVNKDDEVSLEFYNKQQSTLKNIPNAIKDIKTYAVPLRSYNVSGIDSIRMMLKGDSEVITTETLDNIDFPSI
NDLINDLYKSKKKVIFTMGKGGVGKTTVASTIALALSQKGVKVHLTTTDPSNHIKYIMGKHKNITISEINEQEELKKYQN
EVISKASETMSGEDLEYIKEDLRSPCTQEIAVFRAFAEIVEKADDEVVVIDTAPTGHTLLLLDSTQSYHKEVERTQGDIP
KSVKKLLPRLRDENETDVVIVTLPEATPVYEAERLNTDLKRAGIHSKWWVINSSLLLTGTKSTLLQSKAQSEIKWINEVN
KYSNGNYTVVKWLPKEVNDTTLLEIIKLK
>Mature_589_residues
MMKFMFEQFNADKLDLTKYLFYTGKGGVGKTSIACATAVSLADSGKKVLLISTDPASNLQDVFHTELSNKETKIKETPNL
SVVNLNPEEAAREYRDSMINPYKGKLPEAVLKNMEEQLSGSCTVEIAAFNEFSNYLTDKNIENEYEFIIFDTAPTGHTLR
MLQLPSAWTNFISESTHGASCLGQLSGLEDRKEMYKEAVQTLANGKLTTLILVARPESSTLLEAERASDELSQLGINNRM
LIINGVMQTVNKDDEVSLEFYNKQQSTLKNIPNAIKDIKTYAVPLRSYNVSGIDSIRMMLKGDSEVITTETLDNIDFPSI
NDLINDLYKSKKKVIFTMGKGGVGKTTVASTIALALSQKGVKVHLTTTDPSNHIKYIMGKHKNITISEINEQEELKKYQN
EVISKASETMSGEDLEYIKEDLRSPCTQEIAVFRAFAEIVEKADDEVVVIDTAPTGHTLLLLDSTQSYHKEVERTQGDIP
KSVKKLLPRLRDENETDVVIVTLPEATPVYEAERLNTDLKRAGIHSKWWVINSSLLLTGTKSTLLQSKAQSEIKWINEVN
KYSNGNYTVVKWLPKEVNDTTLLEIIKLK

Specific function: Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents [H]

COG id: COG0003

COG function: function code P; Oxyanion-translocating ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arsA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI50428938, Length=304, Percent_Identity=28.9473684210526, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17557003, Length=319, Percent_Identity=28.2131661442006, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320103, Length=309, Percent_Identity=27.1844660194175, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24586297, Length=310, Percent_Identity=28.3870967741935, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016300
- InterPro:   IPR003593
- InterPro:   IPR003348 [H]

Pfam domain/function: NA

EC number: =3.6.3.16 [H]

Molecular weight: Translated: 65894; Mature: 65894

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKFMFEQFNADKLDLTKYLFYTGKGGVGKTSIACATAVSLADSGKKVLLISTDPASNLQ
CCCHHHHHCCCCHHHHEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
DVFHTELSNKETKIKETPNLSVVNLNPEEAAREYRDSMINPYKGKLPEAVLKNMEEQLSG
HHHHHHHCCCCCEEECCCCEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
SCTVEIAAFNEFSNYLTDKNIENEYEFIIFDTAPTGHTLRMLQLPSAWTNFISESTHGAS
CEEEEEEEHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEECCHHHHHHHHCCCCCHH
CLGQLSGLEDRKEMYKEAVQTLANGKLTTLILVARPESSTLLEAERASDELSQLGINNRM
HHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
LIINGVMQTVNKDDEVSLEFYNKQQSTLKNIPNAIKDIKTYAVPLRSYNVSGIDSIRMML
EEEEHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEHHCCCCCCHHHHHHEE
KGDSEVITTETLDNIDFPSINDLINDLYKSKKKVIFTMGKGGVGKTTVASTIALALSQKG
CCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
VKVHLTTTDPSNHIKYIMGKHKNITISEINEQEELKKYQNEVISKASETMSGEDLEYIKE
EEEEEEECCCCCCHHHHCCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DLRSPCTQEIAVFRAFAEIVEKADDEVVVIDTAPTGHTLLLLDSTQSYHKEVERTQGDIP
HHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCCCH
KSVKKLLPRLRDENETDVVIVTLPEATPVYEAERLNTDLKRAGIHSKWWVINSSLLLTGT
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHCCHHHHCCCCCEEEEEECCEEEECC
KSTLLQSKAQSEIKWINEVNKYSNGNYTVVKWLPKEVNDTTLLEIIKLK
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEHEEEECC
>Mature Secondary Structure
MMKFMFEQFNADKLDLTKYLFYTGKGGVGKTSIACATAVSLADSGKKVLLISTDPASNLQ
CCCHHHHHCCCCHHHHEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
DVFHTELSNKETKIKETPNLSVVNLNPEEAAREYRDSMINPYKGKLPEAVLKNMEEQLSG
HHHHHHHCCCCCEEECCCCEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
SCTVEIAAFNEFSNYLTDKNIENEYEFIIFDTAPTGHTLRMLQLPSAWTNFISESTHGAS
CEEEEEEEHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEECCHHHHHHHHCCCCCHH
CLGQLSGLEDRKEMYKEAVQTLANGKLTTLILVARPESSTLLEAERASDELSQLGINNRM
HHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCE
LIINGVMQTVNKDDEVSLEFYNKQQSTLKNIPNAIKDIKTYAVPLRSYNVSGIDSIRMML
EEEEHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEHHCCCCCCHHHHHHEE
KGDSEVITTETLDNIDFPSINDLINDLYKSKKKVIFTMGKGGVGKTTVASTIALALSQKG
CCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCC
VKVHLTTTDPSNHIKYIMGKHKNITISEINEQEELKKYQNEVISKASETMSGEDLEYIKE
EEEEEEECCCCCCHHHHCCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DLRSPCTQEIAVFRAFAEIVEKADDEVVVIDTAPTGHTLLLLDSTQSYHKEVERTQGDIP
HHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCCCH
KSVKKLLPRLRDENETDVVIVTLPEATPVYEAERLNTDLKRAGIHSKWWVINSSLLLTGT
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHCCHHHHCCCCCEEEEEECCEEEECC
KSTLLQSKAQSEIKWINEVNKYSNGNYTVVKWLPKEVNDTTLLEIIKLK
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9464374 [H]