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The map label for this gene is yesM [H]

Identifier: 28211485

GI number: 28211485

Start: 1961405

End: 1963138

Strand: Direct

Name: yesM [H]

Synonym: CTC01848

Alternate gene names: 28211485

Gene position: 1961405-1963138 (Clockwise)

Preceding gene: 28211482

Following gene: 28211486

Centisome position: 70.07

GC content: 27.45

Gene sequence:

>1734_bases
TTGACAATGAGGTGTAAAACTATGTCTTTACGTTTTAAAATTATCATAACTTTTATGTTATGCATTGTACTAACTTTTTC
TCCTCTATTATATATAATGCAAACTAAGGTAAAGGATTTTAACATGAAACAATTGGAACATGAGACAATACAATTAATTG
ATTCTAAAAGCAATGAAATCGGTGCTTGGCTCAATCATCGTATTGGAGAAATTAAAATTATTCATGAGTATCCTGCCTGT
AAAGAGATGAACTTTTCTCAATTAAAACCCTATTTAACACAATTAAATCATGTATTTGGAAATCAATATGGTACCTTTGC
TCTTGGAGGGTTGGATGGAAAAGGATGGATAGATGATACTTTGGTAATTGATGTGTCTCAACGTGAATATTTTAAGAAAG
CAATGTCAACGAATGTTGAATATGTTATAAGTAAACCCCTTGTCTCAAGATCTGATAATAAACCTATATTTCTTATCTGT
TATCCAATTTTAAATGATAATAAGGATAAAATAGGCTTTATTAATGGCTCTGTAAATTTAGATAAGATATCTAATATTAT
CCATGACATTGATATACATAATGGCTTTGCATGGATTATGAACAAAAATACTGATATTTATTCTACTACTAAAGAAAATT
TAAATAGTAACTATATTTCTTTAGAGGAATTATCTTGTATTGCTAACCAATCAAAAAATAAGAGTTCAGGTACAGTTGCA
TTAAAAAATGTACATAATAAGGATTCTACAGTATTTTTTTCTTCCGTACCCTATACAGAAAATTGGATTTTATGTATCAT
AGTTGAAAATAAGAAAATTCATACACAAATCAACCAAATAATAAACCTAATTCTTTTTGTAGGGTTGATTCTACTACTAG
CCGCTATATTATTATCTATTGTTATTTCAGGTTCTATTGTAAAACCTATACATAGATTAAAAAGCAATATGTTGGAAATA
TCCAAGGGTAACTTTGATTCCTATTATGAGATAAAAAACAATGATGAAATTTCTATATTAGGACAAGTTTTTAATCAGAT
GCTCACTGATATTAAAAGGCTTATAAATAAAGTTTATCAAGTTGAAAAACAGAAACGAAGTGCAGAGTTAAGGGTACTTC
AATCTCAAATAAATCCTCATTTTCTATACAACACATTGGATACAATACAGTGGAAAGCTTTAGAATACAATGCATTTGAG
GTTGTAGATATGATTAATTACTTATCAAATTTTTTTAGAATTTCTTTAAGTGATGGAAAAGAATTTATTACAATTTCCGA
TGAAGTAGCACATGTTAGTAATTACTTAGAAATTCAAAAGATCCGTTATAAAGATAAAATTAGTTATTCTATGGATGTAG
ATAGTTCACTTGATCAATACCTTATTCCAAAACTTATTGTACAACCTTTAGTAGAAAACTCTATATATCATGGACTTAAG
CTTCAAAAACACAAAGGTATAATTAATGTATCTATTTCTTCAAAAGACGGATTTCTTTTTATTAAAGTGATAGATAATGG
TTTAGGTATGGATGTAGAACAGCTTAGAACTCTTCGTAAAAATCTTTGGGAATCCATTGAAACAAATCATTATGGACTAT
ATAACATTAATGAACGTCTAAAACTTGCCTTTGGAAAAAAATATAGTATTGAAATAAAAAGTGAATTAAAAATAGGAACT
CAGGTATTGTTAAGAATACCTTTAATAAGTGAGGGATTTGAATGTTTAGAATAG

Upstream 100 bases:

>100_bases
TTTGTACTTTTAACTACAATATTTGATAAAATATAAGTATTGTATATAATTATTAATGTAATAGTAAATATGAATATTAT
ATTAAAATCAACCATTTTCT

Downstream 100 bases:

>100_bases
TAATTGCCGACGATGAAGATACCATTCGCAATGGTTTAAAAAACTTAATAGAATCCTACGAACTAAATTTATCAGTAATT
GCCACAGCTAAAGATGGTGA

Product: two-component sensor kinase yesM

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MTMRCKTMSLRFKIIITFMLCIVLTFSPLLYIMQTKVKDFNMKQLEHETIQLIDSKSNEIGAWLNHRIGEIKIIHEYPAC
KEMNFSQLKPYLTQLNHVFGNQYGTFALGGLDGKGWIDDTLVIDVSQREYFKKAMSTNVEYVISKPLVSRSDNKPIFLIC
YPILNDNKDKIGFINGSVNLDKISNIIHDIDIHNGFAWIMNKNTDIYSTTKENLNSNYISLEELSCIANQSKNKSSGTVA
LKNVHNKDSTVFFSSVPYTENWILCIIVENKKIHTQINQIINLILFVGLILLLAAILLSIVISGSIVKPIHRLKSNMLEI
SKGNFDSYYEIKNNDEISILGQVFNQMLTDIKRLINKVYQVEKQKRSAELRVLQSQINPHFLYNTLDTIQWKALEYNAFE
VVDMINYLSNFFRISLSDGKEFITISDEVAHVSNYLEIQKIRYKDKISYSMDVDSSLDQYLIPKLIVQPLVENSIYHGLK
LQKHKGIINVSISSKDGFLFIKVIDNGLGMDVEQLRTLRKNLWESIETNHYGLYNINERLKLAFGKKYSIEIKSELKIGT
QVLLRIPLISEGFECLE

Sequences:

>Translated_577_residues
MTMRCKTMSLRFKIIITFMLCIVLTFSPLLYIMQTKVKDFNMKQLEHETIQLIDSKSNEIGAWLNHRIGEIKIIHEYPAC
KEMNFSQLKPYLTQLNHVFGNQYGTFALGGLDGKGWIDDTLVIDVSQREYFKKAMSTNVEYVISKPLVSRSDNKPIFLIC
YPILNDNKDKIGFINGSVNLDKISNIIHDIDIHNGFAWIMNKNTDIYSTTKENLNSNYISLEELSCIANQSKNKSSGTVA
LKNVHNKDSTVFFSSVPYTENWILCIIVENKKIHTQINQIINLILFVGLILLLAAILLSIVISGSIVKPIHRLKSNMLEI
SKGNFDSYYEIKNNDEISILGQVFNQMLTDIKRLINKVYQVEKQKRSAELRVLQSQINPHFLYNTLDTIQWKALEYNAFE
VVDMINYLSNFFRISLSDGKEFITISDEVAHVSNYLEIQKIRYKDKISYSMDVDSSLDQYLIPKLIVQPLVENSIYHGLK
LQKHKGIINVSISSKDGFLFIKVIDNGLGMDVEQLRTLRKNLWESIETNHYGLYNINERLKLAFGKKYSIEIKSELKIGT
QVLLRIPLISEGFECLE
>Mature_576_residues
TMRCKTMSLRFKIIITFMLCIVLTFSPLLYIMQTKVKDFNMKQLEHETIQLIDSKSNEIGAWLNHRIGEIKIIHEYPACK
EMNFSQLKPYLTQLNHVFGNQYGTFALGGLDGKGWIDDTLVIDVSQREYFKKAMSTNVEYVISKPLVSRSDNKPIFLICY
PILNDNKDKIGFINGSVNLDKISNIIHDIDIHNGFAWIMNKNTDIYSTTKENLNSNYISLEELSCIANQSKNKSSGTVAL
KNVHNKDSTVFFSSVPYTENWILCIIVENKKIHTQINQIINLILFVGLILLLAAILLSIVISGSIVKPIHRLKSNMLEIS
KGNFDSYYEIKNNDEISILGQVFNQMLTDIKRLINKVYQVEKQKRSAELRVLQSQINPHFLYNTLDTIQWKALEYNAFEV
VDMINYLSNFFRISLSDGKEFITISDEVAHVSNYLEIQKIRYKDKISYSMDVDSSLDQYLIPKLIVQPLVENSIYHGLKL
QKHKGIINVSISSKDGFLFIKVIDNGLGMDVEQLRTLRKNLWESIETNHYGLYNINERLKLAFGKKYSIEIKSELKIGTQ
VLLRIPLISEGFECLE

Specific function: Member of the two-component regulatory system yesM/yesN. Probably activates yesN by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=244, Percent_Identity=31.1475409836066, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788723, Length=215, Percent_Identity=33.953488372093, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR010559
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66453; Mature: 66322

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS50885 HAMP ; PS01109 RIBOSOMAL_L10

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMRCKTMSLRFKIIITFMLCIVLTFSPLLYIMQTKVKDFNMKQLEHETIQLIDSKSNEI
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCH
GAWLNHRIGEIKIIHEYPACKEMNFSQLKPYLTQLNHVFGNQYGTFALGGLDGKGWIDDT
HHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCE
LVIDVSQREYFKKAMSTNVEYVISKPLVSRSDNKPIFLICYPILNDNKDKIGFINGSVNL
EEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCH
DKISNIIHDIDIHNGFAWIMNKNTDIYSTTKENLNSNYISLEELSCIANQSKNKSSGTVA
HHHHHHHHHCCCCCCEEEEEECCCCEEECCHHCCCCCCEEHHHHHHHHCCCCCCCCCEEE
LKNVHNKDSTVFFSSVPYTENWILCIIVENKKIHTQINQIINLILFVGLILLLAAILLSI
EEECCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VISGSIVKPIHRLKSNMLEISKGNFDSYYEIKNNDEISILGQVFNQMLTDIKRLINKVYQ
HHCCHHHHHHHHHHHHHEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VEKQKRSAELRVLQSQINPHFLYNTLDTIQWKALEYNAFEVVDMINYLSNFFRISLSDGK
HHHHHHHHHHHHHHHHCCCEEEEECHHHEEEEEEECCHHHHHHHHHHHHHHEEEEECCCC
EFITISDEVAHVSNYLEIQKIRYKDKISYSMDVDSSLDQYLIPKLIVQPLVENSIYHGLK
EEEEECHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEE
LQKHKGIINVSISSKDGFLFIKVIDNGLGMDVEQLRTLRKNLWESIETNHYGLYNINERL
EECCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCE
KLAFGKKYSIEIKSELKIGTQVLLRIPLISEGFECLE
EEEECCEEEEEEHHHHHHCCCCEEECCCHHCCHHHCC
>Mature Secondary Structure 
TMRCKTMSLRFKIIITFMLCIVLTFSPLLYIMQTKVKDFNMKQLEHETIQLIDSKSNEI
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCH
GAWLNHRIGEIKIIHEYPACKEMNFSQLKPYLTQLNHVFGNQYGTFALGGLDGKGWIDDT
HHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCE
LVIDVSQREYFKKAMSTNVEYVISKPLVSRSDNKPIFLICYPILNDNKDKIGFINGSVNL
EEEEEHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCH
DKISNIIHDIDIHNGFAWIMNKNTDIYSTTKENLNSNYISLEELSCIANQSKNKSSGTVA
HHHHHHHHHCCCCCCEEEEEECCCCEEECCHHCCCCCCEEHHHHHHHHCCCCCCCCCEEE
LKNVHNKDSTVFFSSVPYTENWILCIIVENKKIHTQINQIINLILFVGLILLLAAILLSI
EEECCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VISGSIVKPIHRLKSNMLEISKGNFDSYYEIKNNDEISILGQVFNQMLTDIKRLINKVYQ
HHCCHHHHHHHHHHHHHEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VEKQKRSAELRVLQSQINPHFLYNTLDTIQWKALEYNAFEVVDMINYLSNFFRISLSDGK
HHHHHHHHHHHHHHHHCCCEEEEECHHHEEEEEEECCHHHHHHHHHHHHHHEEEEECCCC
EFITISDEVAHVSNYLEIQKIRYKDKISYSMDVDSSLDQYLIPKLIVQPLVENSIYHGLK
EEEEECHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEE
LQKHKGIINVSISSKDGFLFIKVIDNGLGMDVEQLRTLRKNLWESIETNHYGLYNINERL
EECCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCE
KLAFGKKYSIEIKSELKIGTQVLLRIPLISEGFECLE
EEEECCEEEEEEHHHHHHCCCCEEECCCHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]