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The map label for this gene is lrgB [H]

Identifier: 28211469

GI number: 28211469

Start: 1938941

End: 1939630

Strand: Direct

Name: lrgB [H]

Synonym: CTC01826

Alternate gene names: 28211469

Gene position: 1938941-1939630 (Clockwise)

Preceding gene: 28211468

Following gene: 28211482

Centisome position: 69.27

GC content: 28.7

Gene sequence:

>690_bases
ATGAGAGATCTTACAAATTCTCCAATGATGAGTATAATCATATCAATAATCTGTTTTGAAATTGGATTATATATAAACAA
GAAAACTAAAATTTCACTTTTAAATCCACTTTTAATATGTGTTCCATTGATTATATTCATAATGTTTTTTCTAAATATAA
ATCTTAAAGATTTTAATAAAGGCGGTGAGCTGATATCCTTCTTTTTAGCACCTGCTACGGTAGTGTTAGCTGTTCCTTTA
TATAATAAAATAGATTTAGTTAAAAAATACTTTATACCTATTTTACTGGGGGTAACAGTAGGATGTATTACATCTATAGT
AAGTGTTTACTATCTTTGCAGATTATTTGGTCTTACAGAAGGATTAACTTACTCTTTTCTTCCAAAATCTATAACCACTC
CTATAGGCATAGAAGTTTCAAAATTAATTGGTGGAATCCCTTCAATTACAGTTTCTGCTATTATAATAACAGGAATAATT
GGAGCTATTATATCTCCTATAGTCTGTAAAATCTTTAATATAAAAGATGAAGTAGCTGTTGGAATATCTATTGGAACGGC
TTCCCACGCTATAGGTACTACAAAAGCTATAGAAATGGGTGAAACTGAAGGGGCAATGAGTGGACTTGCTATAGGTATTT
CAGGTCTTATAACTTCATTTTTAATACCAATTATAATTAAATTTTTATAA

Upstream 100 bases:

>100_bases
AATGGCTAGCTTTTTTAGTAATATGTATTATATCTACTATAATTGTAATAGGAGTAACTGGCTGGACGATACAAGCCTAT
ATAAGAAAGGTTGATAGAAA

Downstream 100 bases:

>100_bases
TTTATATTAATAAAAATCTAAACTAGATATTAATATGGAGTTAACTAAGATATTATATCTTAGTTAACTCCATATTAATA
TTTCTACTGCTTATCTACAT

Product: murein hydrolase export regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MRDLTNSPMMSIIISIICFEIGLYINKKTKISLLNPLLICVPLIIFIMFFLNINLKDFNKGGELISFFLAPATVVLAVPL
YNKIDLVKKYFIPILLGVTVGCITSIVSVYYLCRLFGLTEGLTYSFLPKSITTPIGIEVSKLIGGIPSITVSAIIITGII
GAIISPIVCKIFNIKDEVAVGISIGTASHAIGTTKAIEMGETEGAMSGLAIGISGLITSFLIPIIIKFL

Sequences:

>Translated_229_residues
MRDLTNSPMMSIIISIICFEIGLYINKKTKISLLNPLLICVPLIIFIMFFLNINLKDFNKGGELISFFLAPATVVLAVPL
YNKIDLVKKYFIPILLGVTVGCITSIVSVYYLCRLFGLTEGLTYSFLPKSITTPIGIEVSKLIGGIPSITVSAIIITGII
GAIISPIVCKIFNIKDEVAVGISIGTASHAIGTTKAIEMGETEGAMSGLAIGISGLITSFLIPIIIKFL
>Mature_229_residues
MRDLTNSPMMSIIISIICFEIGLYINKKTKISLLNPLLICVPLIIFIMFFLNINLKDFNKGGELISFFLAPATVVLAVPL
YNKIDLVKKYFIPILLGVTVGCITSIVSVYYLCRLFGLTEGLTYSFLPKSITTPIGIEVSKLIGGIPSITVSAIIITGII
GAIISPIVCKIFNIKDEVAVGISIGTASHAIGTTKAIEMGETEGAMSGLAIGISGLITSFLIPIIIKFL

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell

COG id: COG1346

COG function: function code M; Putative effector of murein hydrolase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidB/LrgB family. LrgB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788464, Length=225, Percent_Identity=34.6666666666667, Blast_Score=134, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007300 [H]

Pfam domain/function: PF04172 LrgB [H]

EC number: NA

Molecular weight: Translated: 24575; Mature: 24575

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLTNSPMMSIIISIICFEIGLYINKKTKISLLNPLLICVPLIIFIMFFLNINLKDFNK
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
GGELISFFLAPATVVLAVPLYNKIDLVKKYFIPILLGVTVGCITSIVSVYYLCRLFGLTE
CHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLTYSFLPKSITTPIGIEVSKLIGGIPSITVSAIIITGIIGAIISPIVCKIFNIKDEVAV
CCCHHHCCHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEE
GISIGTASHAIGTTKAIEMGETEGAMSGLAIGISGLITSFLIPIIIKFL
EEEECCCHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MRDLTNSPMMSIIISIICFEIGLYINKKTKISLLNPLLICVPLIIFIMFFLNINLKDFNK
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
GGELISFFLAPATVVLAVPLYNKIDLVKKYFIPILLGVTVGCITSIVSVYYLCRLFGLTE
CHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLTYSFLPKSITTPIGIEVSKLIGGIPSITVSAIIITGIIGAIISPIVCKIFNIKDEVAV
CCCHHHCCHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEE
GISIGTASHAIGTTKAIEMGETEGAMSGLAIGISGLITSFLIPIIIKFL
EEEECCCHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA