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The map label for this gene is trkA [H]

Identifier: 28211299

GI number: 28211299

Start: 1754783

End: 1756219

Strand: Direct

Name: trkA [H]

Synonym: CTC01637

Alternate gene names: 28211299

Gene position: 1754783-1756219 (Clockwise)

Preceding gene: 28211272

Following gene: 28211305

Centisome position: 62.69

GC content: 26.72

Gene sequence:

>1437_bases
ATGGAACAAGCTATAAGTTTTCAATCCATCCTTATAATTTCTCTTTTAGCTTTTGTAACTCCAATAATAGTCAGCAGCTT
TAAAAGGGTAAAAATTCCCTATGTAGTAGGGGAGATTCTGGTTGGAATTGTAGTAGGAAAAAGTCTTTTTAATATAGTTC
AAGATGATATTTGGATAATATTTTTATCCAATTTAGGTTTAGCCTATCTAATGTTTTTAAGTGGTTTAGAGGTAGAAGTG
GAGGATCTAAAAATAAGTGATGGAAATAATAAAGGTTTTAAAAATTTAATACTATGTTTTTCTATGTTTTTAATTTCTTT
AGTTATTTCTTTTTTAATTTCTAAATTTTTAGTATCTATAAATTTAATAAGAAATGTAACTTTCTTTACTTTCCTATTTG
CATCCTCTGCACCAGGATTTATTGTTCCTTTCCTAAAGGAACGAGATCTATTAAATACAGAATACGGTCAAATAATATTA
ATTTTTAACCTTATAGCAGAATTTATATGTTTAATAGGAATTACTATAATATCTTCCACTGCAACTCGAGGTTTTAGCTA
TAAGAATTTCCTATTTATAATAGTAATATTAGTTTCTTTTTTACTTTATATAATAACTAGAAAACTATTTAAACATTTTG
ATTTTTCTATAGCTGCTTTTAGAAATTTACACATAGAAGTAAGAGCTGCTTTTGCCTTGATATTACTTCTTGTTACTTTA
TCTCAAGTAGTACATTCTGAAATAGTTTTAGGTTCGTTTTTGGCAGGCCTTATATTCTCTTTTCTTTTCCAAAGAGAAAG
AGAGGACTTAAAATATAAATTAGATATAATAGGATATGGATTTTTAATACCTATATTTTTTATTGGAGTAGGCGTAAATT
TAGATATATCCTCTATGTTTCAAAATCCTAAAACATTATTTATGATACCAGTTTTACTTTTGATATTTTACTTAGTAAAA
CTTATCCCCTCTTTATTATTAAGTAAGTATTTTGGAATAAAAAAAGCCATATCTTCTTCTTTTATATTATCTACACAGTT
AAGCCTTATTATAGTTGGTTCTCAAATAGCCTATAGTCTGGATTTAATAGATTCATCTACCTATTCTCTATTTATAATAA
CCACTATAATATCTTGCTTATTGTTCCCAGTAATCTTTGATAGAAGCTTTAACTATGATGATATAGAAAGAAAGAAAAAA
CCTTTGATAGATAAAGTATGTATAAGAGAAACTGTGGTAACAAATGAAGAAGTATTTAATAAGCCTTTAAAAGAAATACC
CTTTCCAAAGAATTGTATAGTGTTTTTGCTAATTAGGGATGAATTAGAAATAGTTCCAAGCGGCAATACTATTTTACTAG
AAGGAGATATATTAATTCTTGCAGGTATGCACGAACATGAAGAAGAAATGCTTAGAGTAGTAAACATTTACTCCTAG

Upstream 100 bases:

>100_bases
AAATCTTTTATACAGTTACAACTATTCATTGATTTATACATGAAACTTATAATATAATCACTTTATTGACATAATAAAAA
AATACAAGGGAGTGTGATAA

Downstream 100 bases:

>100_bases
AAAGCCTTTTAATTAACTAAAAAATTCTCAAATAAAAATGTGGTTCGAAAAGTTCGAACCACATTTTTTACTATTTCTTA
TAAAACTCTTTTATTTTTTC

Product: trk system potassium uptake protein trkA

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MEQAISFQSILIISLLAFVTPIIVSSFKRVKIPYVVGEILVGIVVGKSLFNIVQDDIWIIFLSNLGLAYLMFLSGLEVEV
EDLKISDGNNKGFKNLILCFSMFLISLVISFLISKFLVSINLIRNVTFFTFLFASSAPGFIVPFLKERDLLNTEYGQIIL
IFNLIAEFICLIGITIISSTATRGFSYKNFLFIIVILVSFLLYIITRKLFKHFDFSIAAFRNLHIEVRAAFALILLLVTL
SQVVHSEIVLGSFLAGLIFSFLFQREREDLKYKLDIIGYGFLIPIFFIGVGVNLDISSMFQNPKTLFMIPVLLLIFYLVK
LIPSLLLSKYFGIKKAISSSFILSTQLSLIIVGSQIAYSLDLIDSSTYSLFIITTIISCLLFPVIFDRSFNYDDIERKKK
PLIDKVCIRETVVTNEEVFNKPLKEIPFPKNCIVFLLIRDELEIVPSGNTILLEGDILILAGMHEHEEEMLRVVNIYS

Sequences:

>Translated_478_residues
MEQAISFQSILIISLLAFVTPIIVSSFKRVKIPYVVGEILVGIVVGKSLFNIVQDDIWIIFLSNLGLAYLMFLSGLEVEV
EDLKISDGNNKGFKNLILCFSMFLISLVISFLISKFLVSINLIRNVTFFTFLFASSAPGFIVPFLKERDLLNTEYGQIIL
IFNLIAEFICLIGITIISSTATRGFSYKNFLFIIVILVSFLLYIITRKLFKHFDFSIAAFRNLHIEVRAAFALILLLVTL
SQVVHSEIVLGSFLAGLIFSFLFQREREDLKYKLDIIGYGFLIPIFFIGVGVNLDISSMFQNPKTLFMIPVLLLIFYLVK
LIPSLLLSKYFGIKKAISSSFILSTQLSLIIVGSQIAYSLDLIDSSTYSLFIITTIISCLLFPVIFDRSFNYDDIERKKK
PLIDKVCIRETVVTNEEVFNKPLKEIPFPKNCIVFLLIRDELEIVPSGNTILLEGDILILAGMHEHEEEMLRVVNIYS
>Mature_478_residues
MEQAISFQSILIISLLAFVTPIIVSSFKRVKIPYVVGEILVGIVVGKSLFNIVQDDIWIIFLSNLGLAYLMFLSGLEVEV
EDLKISDGNNKGFKNLILCFSMFLISLVISFLISKFLVSINLIRNVTFFTFLFASSAPGFIVPFLKERDLLNTEYGQIIL
IFNLIAEFICLIGITIISSTATRGFSYKNFLFIIVILVSFLLYIITRKLFKHFDFSIAAFRNLHIEVRAAFALILLLVTL
SQVVHSEIVLGSFLAGLIFSFLFQREREDLKYKLDIIGYGFLIPIFFIGVGVNLDISSMFQNPKTLFMIPVLLLIFYLVK
LIPSLLLSKYFGIKKAISSSFILSTQLSLIIVGSQIAYSLDLIDSSTYSLFIITTIISCLLFPVIFDRSFNYDDIERKKK
PLIDKVCIRETVVTNEEVFNKPLKEIPFPKNCIVFLLIRDELEIVPSGNTILLEGDILILAGMHEHEEEMLRVVNIYS

Specific function: Probable Na(+)/H(+) antiporter [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=425, Percent_Identity=21.8823529411765, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016040
- InterPro:   IPR006037
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02080 TrkA_C; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 54210; Mature: 54210

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQAISFQSILIISLLAFVTPIIVSSFKRVKIPYVVGEILVGIVVGKSLFNIVQDDIWII
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHEE
FLSNLGLAYLMFLSGLEVEVEDLKISDGNNKGFKNLILCFSMFLISLVISFLISKFLVSI
EHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLIRNVTFFTFLFASSAPGFIVPFLKERDLLNTEYGQIILIFNLIAEFICLIGITIISST
HHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ATRGFSYKNFLFIIVILVSFLLYIITRKLFKHFDFSIAAFRNLHIEVRAAFALILLLVTL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SQVVHSEIVLGSFLAGLIFSFLFQREREDLKYKLDIIGYGFLIPIFFIGVGVNLDISSMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHH
QNPKTLFMIPVLLLIFYLVKLIPSLLLSKYFGIKKAISSSFILSTQLSLIIVGSQIAYSL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEEEEECCHHHEEE
DLIDSSTYSLFIITTIISCLLFPVIFDRSFNYDDIERKKKPLIDKVCIRETVVTNEEVFN
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHC
KPLKEIPFPKNCIVFLLIRDELEIVPSGNTILLEGDILILAGMHEHEEEMLRVVNIYS
CCHHHCCCCCCCEEEEEEECCEEEEECCCEEEEECCEEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEQAISFQSILIISLLAFVTPIIVSSFKRVKIPYVVGEILVGIVVGKSLFNIVQDDIWII
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHEE
FLSNLGLAYLMFLSGLEVEVEDLKISDGNNKGFKNLILCFSMFLISLVISFLISKFLVSI
EHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLIRNVTFFTFLFASSAPGFIVPFLKERDLLNTEYGQIILIFNLIAEFICLIGITIISST
HHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ATRGFSYKNFLFIIVILVSFLLYIITRKLFKHFDFSIAAFRNLHIEVRAAFALILLLVTL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SQVVHSEIVLGSFLAGLIFSFLFQREREDLKYKLDIIGYGFLIPIFFIGVGVNLDISSMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCHHHHH
QNPKTLFMIPVLLLIFYLVKLIPSLLLSKYFGIKKAISSSFILSTQLSLIIVGSQIAYSL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEEEEECCHHHEEE
DLIDSSTYSLFIITTIISCLLFPVIFDRSFNYDDIERKKKPLIDKVCIRETVVTNEEVFN
EEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHC
KPLKEIPFPKNCIVFLLIRDELEIVPSGNTILLEGDILILAGMHEHEEEMLRVVNIYS
CCHHHCCCCCCCEEEEEEECCEEEEECCCEEEEECCEEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]