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The map label for this gene is mepA [H]

Identifier: 28211042

GI number: 28211042

Start: 1465006

End: 1466385

Strand: Direct

Name: mepA [H]

Synonym: CTC01362

Alternate gene names: 28211042

Gene position: 1465006-1466385 (Clockwise)

Preceding gene: 28211041

Following gene: 28211044

Centisome position: 52.34

GC content: 28.77

Gene sequence:

>1380_bases
ATGGGAGTTAATGACAATATTTTTGAAAGCAATAATATAGGAAAAACTCTTTTCAAACTTGCAGTTCCCTTAGTGTTATC
CTTACTAGTAGCGGAACTTTATAATTTAGTAGATACAATATTTGTAGGACGTTATGTAGGGCCTAATGCAATAGGTGCCT
TAACCATAGCCTTTCCTATACAAAGACTTCTAATTTCTGTTGGAATACTTATAGCAGTTGGTACTTCTACTTTTATTTCA
AGAAGTCTTGGTGAACGAAATTATAATAATGTAAAAAAAGGAATATTAAACTCTATTAGTTTAACCATAGTAGCAATTAT
AGCTATATCAATTTTAATATACATTTTTAGAAAACCTATTATATATAAACTTGGAGCTAGTGATATATTATATCCTCTAG
CAGAAGAATATATATCCATAATACTTTTAGGAGCATTGTTCCAATCTCTAACAGTTGTATTTTCATATATATTAACGTCC
TTAGGCAATACTAAAATAGGATTATATGCAAATATGATAGGTGCTATGATAAATTTAATTATAGACTTTGTCTTGGTAGC
AAATTTTAACATAGGCATAAGAGGAGCTGCAATAGCCACATCTTTATCCCAATTATTAGGTTTTGTTTATGCTTATTATG
CATTTAAAAAGGTACAAAAAAACTTAAACTTTAAATTTTCTTTTACTTTAAATTTAAGCCTCCTTTGGATAATAGTTTCT
GTAGGATTTTCAAGCTTTATAGTAGAATTCTCAGATGCTATAAATGCTGGACTTTTAAATAACTTACTACATGCTTCTGG
CGGAGATGAAGCTGTAATTATAATAGGTGTAGTTACTAAACTATCTATGTTTATGTATATAACAATAATAGGAATAAGCA
TCGCAATGCAACCAATTATAGCTTACAATTATGGTGCAGGAAATTATACAAAAATGAAAAAAGCTTTAAAAGTAGCTATA
ATAGCTGTTATGGGAACATCTATTATTTTCTGGCTTGGTTTTCTTGTATTTGCAACACCTATTATAGGATTTTTCTTAAA
GGAACAAGCCTTATTACCTAGAGCCGTAAAAGCCTTTAGATTGTGTATATCTTTACTTCCATCCGTTGGAATATATTATA
TTACCATATATTATCATCAAGCTCTTGGTGAATCTACAAAATCCTTCTTACTTTCAATTTATAGACAAATAATAGTATTC
ATACCGATAGCTATACTTCTTATTGGAAAATTAGGAGTACTCGGTGCATGGATAGCTTATCCATTATCTGATATAATATC
AGCGGTTACATCTATTTACTTTATTAAAAAAGCACAAAAATTTGATTTTCAAGCCAATGAATCATTGAATAGAAAATACA
ATTCCCTTGTTAATTTTTAA

Upstream 100 bases:

>100_bases
TCTCAGCACTTAAGGGAATGCAATGGCTCATACATATAATCTATAATAGAATATATAGATTTGCTTAATTTAACTGCAAA
AAAATTATGAGGTGATATAA

Downstream 100 bases:

>100_bases
TTAACAAATTAAATACTATTTAAAACTTTTATAACAAAAGAAAGGAGCTAATGCCCTAGCTCCTTTCTTTTTTTGAATTT
ATGGATTACATACCTTACAT

Product: Na+ driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MGVNDNIFESNNIGKTLFKLAVPLVLSLLVAELYNLVDTIFVGRYVGPNAIGALTIAFPIQRLLISVGILIAVGTSTFIS
RSLGERNYNNVKKGILNSISLTIVAIIAISILIYIFRKPIIYKLGASDILYPLAEEYISIILLGALFQSLTVVFSYILTS
LGNTKIGLYANMIGAMINLIIDFVLVANFNIGIRGAAIATSLSQLLGFVYAYYAFKKVQKNLNFKFSFTLNLSLLWIIVS
VGFSSFIVEFSDAINAGLLNNLLHASGGDEAVIIIGVVTKLSMFMYITIIGISIAMQPIIAYNYGAGNYTKMKKALKVAI
IAVMGTSIIFWLGFLVFATPIIGFFLKEQALLPRAVKAFRLCISLLPSVGIYYITIYYHQALGESTKSFLLSIYRQIIVF
IPIAILLIGKLGVLGAWIAYPLSDIISAVTSIYFIKKAQKFDFQANESLNRKYNSLVNF

Sequences:

>Translated_459_residues
MGVNDNIFESNNIGKTLFKLAVPLVLSLLVAELYNLVDTIFVGRYVGPNAIGALTIAFPIQRLLISVGILIAVGTSTFIS
RSLGERNYNNVKKGILNSISLTIVAIIAISILIYIFRKPIIYKLGASDILYPLAEEYISIILLGALFQSLTVVFSYILTS
LGNTKIGLYANMIGAMINLIIDFVLVANFNIGIRGAAIATSLSQLLGFVYAYYAFKKVQKNLNFKFSFTLNLSLLWIIVS
VGFSSFIVEFSDAINAGLLNNLLHASGGDEAVIIIGVVTKLSMFMYITIIGISIAMQPIIAYNYGAGNYTKMKKALKVAI
IAVMGTSIIFWLGFLVFATPIIGFFLKEQALLPRAVKAFRLCISLLPSVGIYYITIYYHQALGESTKSFLLSIYRQIIVF
IPIAILLIGKLGVLGAWIAYPLSDIISAVTSIYFIKKAQKFDFQANESLNRKYNSLVNF
>Mature_458_residues
GVNDNIFESNNIGKTLFKLAVPLVLSLLVAELYNLVDTIFVGRYVGPNAIGALTIAFPIQRLLISVGILIAVGTSTFISR
SLGERNYNNVKKGILNSISLTIVAIIAISILIYIFRKPIIYKLGASDILYPLAEEYISIILLGALFQSLTVVFSYILTSL
GNTKIGLYANMIGAMINLIIDFVLVANFNIGIRGAAIATSLSQLLGFVYAYYAFKKVQKNLNFKFSFTLNLSLLWIIVSV
GFSSFIVEFSDAINAGLLNNLLHASGGDEAVIIIGVVTKLSMFMYITIIGISIAMQPIIAYNYGAGNYTKMKKALKVAII
AVMGTSIIFWLGFLVFATPIIGFFLKEQALLPRAVKAFRLCISLLPSVGIYYITIYYHQALGESTKSFLLSIYRQIIVFI
PIAILLIGKLGVLGAWIAYPLSDIISAVTSIYFIKKAQKFDFQANESLNRKYNSLVNF

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50428; Mature: 50297

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVNDNIFESNNIGKTLFKLAVPLVLSLLVAELYNLVDTIFVGRYVGPNAIGALTIAFPI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QRLLISVGILIAVGTSTFISRSLGERNYNNVKKGILNSISLTIVAIIAISILIYIFRKPI
HHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
IYKLGASDILYPLAEEYISIILLGALFQSLTVVFSYILTSLGNTKIGLYANMIGAMINLI
HEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IDFVLVANFNIGIRGAAIATSLSQLLGFVYAYYAFKKVQKNLNFKFSFTLNLSLLWIIVS
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHH
VGFSSFIVEFSDAINAGLLNNLLHASGGDEAVIIIGVVTKLSMFMYITIIGISIAMQPII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AYNYGAGNYTKMKKALKVAIIAVMGTSIIFWLGFLVFATPIIGFFLKEQALLPRAVKAFR
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCISLLPSVGIYYITIYYHQALGESTKSFLLSIYRQIIVFIPIAILLIGKLGVLGAWIAY
HHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLSDIISAVTSIYFIKKAQKFDFQANESLNRKYNSLVNF
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
GVNDNIFESNNIGKTLFKLAVPLVLSLLVAELYNLVDTIFVGRYVGPNAIGALTIAFPI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QRLLISVGILIAVGTSTFISRSLGERNYNNVKKGILNSISLTIVAIIAISILIYIFRKPI
HHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
IYKLGASDILYPLAEEYISIILLGALFQSLTVVFSYILTSLGNTKIGLYANMIGAMINLI
HEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IDFVLVANFNIGIRGAAIATSLSQLLGFVYAYYAFKKVQKNLNFKFSFTLNLSLLWIIVS
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHH
VGFSSFIVEFSDAINAGLLNNLLHASGGDEAVIIIGVVTKLSMFMYITIIGISIAMQPII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AYNYGAGNYTKMKKALKVAIIAVMGTSIIFWLGFLVFATPIIGFFLKEQALLPRAVKAFR
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LCISLLPSVGIYYITIYYHQALGESTKSFLLSIYRQIIVFIPIAILLIGKLGVLGAWIAY
HHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLSDIISAVTSIYFIKKAQKFDFQANESLNRKYNSLVNF
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA