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The map label for this gene is ymxG [H]

Identifier: 28210967

GI number: 28210967

Start: 1375165

End: 1376475

Strand: Direct

Name: ymxG [H]

Synonym: CTC01281

Alternate gene names: 28210967

Gene position: 1375165-1376475 (Clockwise)

Preceding gene: 28210966

Following gene: 28210968

Centisome position: 49.13

GC content: 28.45

Gene sequence:

>1311_bases
ATGGAGGAATTTATGTATAAACTATATAGCCTCAATAACGGATTAAGAGTAGCTTTAGAGAAAATAGATTATGTGCAATC
TGTAAGTATAGGTCTATGGGTAAAAAATGGATCTAGAAATGAAAATGAACATAATAATGGTATTTCTCATTTTATAGAAC
ATATGATGTTCAAGGGAACCAATAATAGAAATGCAAAAGAAATTGTAAAAACTATAGAAGATTTAGGTGGTCACATAAAT
GCCTTTACAGGAAAAGAAGCAACTTGCTACTATATAAAACTTTTATATACACATTTAGATGTTGCTTTAGATATATTATC
AGATATGATTTTTAATAGTAAATTTAATGAAGAAGATATAGAACTAGAAAAGGGCGTTATACTTGAAGAAATAAGCATGA
ATGAAGATTCACCAGAGGATGTGCTTGTAGAACTTCATAGTAAGGCAGCTTGGGGAGATGACCCTATATCACTTCCAATA
CTGGGATCAGCAAAAGGGGTTAGATCCTTTACAAGAAATCATATTATAGAATATTTAAAGAGTCACTATACTCCAGAAAA
TTGCGTTATATCTATAGCAGGGAATTTTGATGAAAATATATATAAATTAATAGAGGACTATTTTGGTCATTGGAAAGCTT
CAAATGAAAAACCTTTGCTATATTCTACACCTGATGTTTTGAATAATCATCTTTTTAGAAAAAAGGAAATAGAACAGCTA
CATATGAATTTAGGTATGCAAGGAGTAGAAATCGGAAACGAAGACATGTATACTATATTATTACTAAATAATATATTTGG
GGGCTCCACTTCATCTATATTATTTCAAAAGATAAGAGAAGAAAAAGGAAGATGTTATTCTATATACTCTTATGTAAATA
GTTATAATAATACAGGAATAGTAAATATATATACAGGGTTAAACTCTAAATATTCTATAGAGGTTTTAAAACTCATTGTG
GAGGAAGTACATAAGTTTTCCAAGTATTGCATATGTCAGGAACAAATTATACAGGGAAAAGAAGGATTAAAGGGAAGTTA
TATACTAGGACTTGAAAGTACCAGTAGTAGAATGTTTAGCAACGCAAGATCTGTATTATTTTTAAATAGAATTAATAAAC
CAGAGGATATAATTAAAAAAATAGATAAAATAGACATGGAAAGCATTCATAGAGTGAAAGAGAATACATTTGAAAAAGGT
ATAATAAACTCTGCTTTTGTAGGAGAAAATATAGATATAGAAACAGTTAATAACATGATGGATAAAAGTATAAACCCATT
TAAGAACAATTCCAATAGCACATTTATATAA

Upstream 100 bases:

>100_bases
GCAATAAAGAAAGAAGAAGACGAAAAAACTAAAGAAAATAATCATTAAAATAGAAGGGCTTTGTGCCTTTTTATTTTTTA
AATGGAATATTATAAAATTT

Downstream 100 bases:

>100_bases
TATAGGTATATAAATGTAATATATCCTTGATGTATTTCATAGAGATAAAATAGAAATATATTAGGGAGGTTTTAATATGT
CGGAAGATGTAAAAAAATAT

Product: zinc protease

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MEEFMYKLYSLNNGLRVALEKIDYVQSVSIGLWVKNGSRNENEHNNGISHFIEHMMFKGTNNRNAKEIVKTIEDLGGHIN
AFTGKEATCYYIKLLYTHLDVALDILSDMIFNSKFNEEDIELEKGVILEEISMNEDSPEDVLVELHSKAAWGDDPISLPI
LGSAKGVRSFTRNHIIEYLKSHYTPENCVISIAGNFDENIYKLIEDYFGHWKASNEKPLLYSTPDVLNNHLFRKKEIEQL
HMNLGMQGVEIGNEDMYTILLLNNIFGGSTSSILFQKIREEKGRCYSIYSYVNSYNNTGIVNIYTGLNSKYSIEVLKLIV
EEVHKFSKYCICQEQIIQGKEGLKGSYILGLESTSSRMFSNARSVLFLNRINKPEDIIKKIDKIDMESIHRVKENTFEKG
IINSAFVGENIDIETVNNMMDKSINPFKNNSNSTFI

Sequences:

>Translated_436_residues
MEEFMYKLYSLNNGLRVALEKIDYVQSVSIGLWVKNGSRNENEHNNGISHFIEHMMFKGTNNRNAKEIVKTIEDLGGHIN
AFTGKEATCYYIKLLYTHLDVALDILSDMIFNSKFNEEDIELEKGVILEEISMNEDSPEDVLVELHSKAAWGDDPISLPI
LGSAKGVRSFTRNHIIEYLKSHYTPENCVISIAGNFDENIYKLIEDYFGHWKASNEKPLLYSTPDVLNNHLFRKKEIEQL
HMNLGMQGVEIGNEDMYTILLLNNIFGGSTSSILFQKIREEKGRCYSIYSYVNSYNNTGIVNIYTGLNSKYSIEVLKLIV
EEVHKFSKYCICQEQIIQGKEGLKGSYILGLESTSSRMFSNARSVLFLNRINKPEDIIKKIDKIDMESIHRVKENTFEKG
IINSAFVGENIDIETVNNMMDKSINPFKNNSNSTFI
>Mature_436_residues
MEEFMYKLYSLNNGLRVALEKIDYVQSVSIGLWVKNGSRNENEHNNGISHFIEHMMFKGTNNRNAKEIVKTIEDLGGHIN
AFTGKEATCYYIKLLYTHLDVALDILSDMIFNSKFNEEDIELEKGVILEEISMNEDSPEDVLVELHSKAAWGDDPISLPI
LGSAKGVRSFTRNHIIEYLKSHYTPENCVISIAGNFDENIYKLIEDYFGHWKASNEKPLLYSTPDVLNNHLFRKKEIEQL
HMNLGMQGVEIGNEDMYTILLLNNIFGGSTSSILFQKIREEKGRCYSIYSYVNSYNNTGIVNIYTGLNSKYSIEVLKLIV
EEVHKFSKYCICQEQIIQGKEGLKGSYILGLESTSSRMFSNARSVLFLNRINKPEDIIKKIDKIDMESIHRVKENTFEKG
IINSAFVGENIDIETVNNMMDKSINPFKNNSNSTFI

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=398, Percent_Identity=28.643216080402, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI46593007, Length=399, Percent_Identity=27.0676691729323, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI24308013, Length=444, Percent_Identity=23.8738738738739, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI50592988, Length=394, Percent_Identity=19.5431472081218, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787770, Length=218, Percent_Identity=25.6880733944954, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71999683, Length=416, Percent_Identity=29.3269230769231, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17553678, Length=401, Percent_Identity=24.1895261845387, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323192, Length=397, Percent_Identity=28.463476070529, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321813, Length=424, Percent_Identity=24.2924528301887, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319426, Length=265, Percent_Identity=24.5283018867925, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357875, Length=400, Percent_Identity=28.25, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24646943, Length=400, Percent_Identity=28.25, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI19921772, Length=427, Percent_Identity=23.8875878220141, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 49909; Mature: 49909

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEFMYKLYSLNNGLRVALEKIDYVQSVSIGLWVKNGSRNENEHNNGISHFIEHMMFKGT
CHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCC
NNRNAKEIVKTIEDLGGHINAFTGKEATCYYIKLLYTHLDVALDILSDMIFNSKFNEEDI
CCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ELEKGVILEEISMNEDSPEDVLVELHSKAAWGDDPISLPILGSAKGVRSFTRNHIIEYLK
HHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
SHYTPENCVISIAGNFDENIYKLIEDYFGHWKASNEKPLLYSTPDVLNNHLFRKKEIEQL
HCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHH
HMNLGMQGVEIGNEDMYTILLLNNIFGGSTSSILFQKIREEKGRCYSIYSYVNSYNNTGI
HHHCCCCEEEECCCCEEEEEEEEHHCCCCHHHHHHHHHHHHCCCEEHHHHHHHCCCCCCE
VNIYTGLNSKYSIEVLKLIVEEVHKFSKYCICQEQIIQGKEGLKGSYILGLESTSSRMFS
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
NARSVLFLNRINKPEDIIKKIDKIDMESIHRVKENTFEKGIINSAFVGENIDIETVNNMM
CCHHEEEEHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHH
DKSINPFKNNSNSTFI
HCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEEFMYKLYSLNNGLRVALEKIDYVQSVSIGLWVKNGSRNENEHNNGISHFIEHMMFKGT
CHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCC
NNRNAKEIVKTIEDLGGHINAFTGKEATCYYIKLLYTHLDVALDILSDMIFNSKFNEEDI
CCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ELEKGVILEEISMNEDSPEDVLVELHSKAAWGDDPISLPILGSAKGVRSFTRNHIIEYLK
HHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
SHYTPENCVISIAGNFDENIYKLIEDYFGHWKASNEKPLLYSTPDVLNNHLFRKKEIEQL
HCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHH
HMNLGMQGVEIGNEDMYTILLLNNIFGGSTSSILFQKIREEKGRCYSIYSYVNSYNNTGI
HHHCCCCEEEECCCCEEEEEEEEHHCCCCHHHHHHHHHHHHCCCEEHHHHHHHCCCCCCE
VNIYTGLNSKYSIEVLKLIVEEVHKFSKYCICQEQIIQGKEGLKGSYILGLESTSSRMFS
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
NARSVLFLNRINKPEDIIKKIDKIDMESIHRVKENTFEKGIINSAFVGENIDIETVNNMM
CCHHEEEEHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHH
DKSINPFKNNSNSTFI
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]