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The map label for this gene is uppS

Identifier: 28210951

GI number: 28210951

Start: 1354391

End: 1355158

Strand: Direct

Name: uppS

Synonym: CTC01265

Alternate gene names: 28210951

Gene position: 1354391-1355158 (Clockwise)

Preceding gene: 28210950

Following gene: 28210952

Centisome position: 48.38

GC content: 27.73

Gene sequence:

>768_bases
ATGTGGAATATATTTAAAAATAAAAGTGGACAAAGCCATAAAGTGAAGGACAAATTCCAATTAGATTTAGATAATATACC
AAAACATATAGCCATTATAATGGATGGAAATGGTAGATGGGCTAAAGAAAGAAAACTACCTCGTAGTTTAGGACATAAAG
CAGGGGTAGAAACTATAAGGGATATAGTTAAAGAATGTAACAATATAGGTGTTAGATATCTTACTCTATATGCTTTTTCC
ACAGAAAATTGGAAAAGACCAAAGGAAGAAATTAATGCTCTTATGGAATTATTAGTAAATTATCTAAGAAAAGAAGTAGC
TGAATTACATCAAAATAATGTAGTTGTAAATACTATAGGAGACGTATCTAAATTACCTAAAGCTTGTGAAGATGAACTTA
TGAAAGCATACAATAAAACTAAAAATAATACAGGACTTGTATTAAATTTAGCTCTTAATTATGGTGGAAGAGATGAAATT
ATTAGAGCTATAAAACTAATGTATAAGGATATAGAGAAAAAAGGACTAGACATAGAAAATGTAAATGAAGATTTATTAAA
AAACTATTTATATACTAAAGGTATGCCAGACCCTGATTTAATTATAAGGCCTAGCGGAGAACAAAGAATAAGTAATTTTC
TTTTATGGCAATGTGCTTATTCAGAATTTTGGTATTCTAATATAAAATGGCCAGATTTTAAAAAACATCATTTACATAAG
GCTATAAAGGATTATCAAAATAGAAATAGAAGATTTGGTGGAGTATAA

Upstream 100 bases:

>100_bases
ATGATAGATATAAAAGAAAAAGAAATTATGTCTATTTAATAAAGAGTAAAGCCTGCGTTACCGCAGGTTTTATTAATAAG
TTTTAGGGATGGAGATTTAA

Downstream 100 bases:

>100_bases
AAAACTGTGCAACAGTTTTTTAATGAATAATTAATAATGAACAATTAAGGAGGATTTTCTTTCGTTTTACTACAAAAAAT
CTTTAATTTTATTAAAGGCA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MWNIFKNKSGQSHKVKDKFQLDLDNIPKHIAIIMDGNGRWAKERKLPRSLGHKAGVETIRDIVKECNNIGVRYLTLYAFS
TENWKRPKEEINALMELLVNYLRKEVAELHQNNVVVNTIGDVSKLPKACEDELMKAYNKTKNNTGLVLNLALNYGGRDEI
IRAIKLMYKDIEKKGLDIENVNEDLLKNYLYTKGMPDPDLIIRPSGEQRISNFLLWQCAYSEFWYSNIKWPDFKKHHLHK
AIKDYQNRNRRFGGV

Sequences:

>Translated_255_residues
MWNIFKNKSGQSHKVKDKFQLDLDNIPKHIAIIMDGNGRWAKERKLPRSLGHKAGVETIRDIVKECNNIGVRYLTLYAFS
TENWKRPKEEINALMELLVNYLRKEVAELHQNNVVVNTIGDVSKLPKACEDELMKAYNKTKNNTGLVLNLALNYGGRDEI
IRAIKLMYKDIEKKGLDIENVNEDLLKNYLYTKGMPDPDLIIRPSGEQRISNFLLWQCAYSEFWYSNIKWPDFKKHHLHK
AIKDYQNRNRRFGGV
>Mature_255_residues
MWNIFKNKSGQSHKVKDKFQLDLDNIPKHIAIIMDGNGRWAKERKLPRSLGHKAGVETIRDIVKECNNIGVRYLTLYAFS
TENWKRPKEEINALMELLVNYLRKEVAELHQNNVVVNTIGDVSKLPKACEDELMKAYNKTKNNTGLVLNLALNYGGRDEI
IRAIKLMYKDIEKKGLDIENVNEDLLKNYLYTKGMPDPDLIIRPSGEQRISNFLLWQCAYSEFWYSNIKWPDFKKHHLHK
AIKDYQNRNRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=37.9464285714286, Blast_Score=167, Evalue=8e-42,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=37.9464285714286, Blast_Score=167, Evalue=9e-42,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=44.2982456140351, Blast_Score=223, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=34.5132743362832, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=37.5586854460094, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=233, Percent_Identity=31.3304721030043, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=36.6071428571429, Blast_Score=165, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_CLOTE (Q895K8)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781895.1
- ProteinModelPortal:   Q895K8
- SMR:   Q895K8
- GeneID:   1059802
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC01265
- NMPDR:   fig|212717.1.peg.1117
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   Q895K8
- ProtClustDB:   PRK14830
- BioCyc:   CTET212717:CTC_01265-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29821; Mature: 29821

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 35-35

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWNIFKNKSGQSHKVKDKFQLDLDNIPKHIAIIMDGNGRWAKERKLPRSLGHKAGVETIR
CCCCCCCCCCCCCCCCHHHEECCCCCCCEEEEEECCCCCCHHHHCCHHHHCHHCCHHHHH
DIVKECNNIGVRYLTLYAFSTENWKRPKEEINALMELLVNYLRKEVAELHQNNVVVNTIG
HHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
DVSKLPKACEDELMKAYNKTKNNTGLVLNLALNYGGRDEIIRAIKLMYKDIEKKGLDIEN
CHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCC
VNEDLLKNYLYTKGMPDPDLIIRPSGEQRISNFLLWQCAYSEFWYSNIKWPDFKKHHLHK
CCHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AIKDYQNRNRRFGGV
HHHHHHHCCCCCCCC
>Mature Secondary Structure
MWNIFKNKSGQSHKVKDKFQLDLDNIPKHIAIIMDGNGRWAKERKLPRSLGHKAGVETIR
CCCCCCCCCCCCCCCCHHHEECCCCCCCEEEEEECCCCCCHHHHCCHHHHCHHCCHHHHH
DIVKECNNIGVRYLTLYAFSTENWKRPKEEINALMELLVNYLRKEVAELHQNNVVVNTIG
HHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
DVSKLPKACEDELMKAYNKTKNNTGLVLNLALNYGGRDEIIRAIKLMYKDIEKKGLDIEN
CHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCC
VNEDLLKNYLYTKGMPDPDLIIRPSGEQRISNFLLWQCAYSEFWYSNIKWPDFKKHHLHK
CCHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AIKDYQNRNRRFGGV
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129