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The map label for this gene is dinB [H]

Identifier: 28210190

GI number: 28210190

Start: 434468

End: 435526

Strand: Direct

Name: dinB [H]

Synonym: CTC00437

Alternate gene names: 28210190

Gene position: 434468-435526 (Clockwise)

Preceding gene: 28210187

Following gene: 28210192

Centisome position: 15.52

GC content: 27.57

Gene sequence:

>1059_bases
TTGGATAGAATTATTATGCATATAGATTTAGATGCTTTTTTTGCATCAGTTGAACAAAGGGATAACCCTAAATTAAGAGG
AAAACCAGTTATAGTTGGTGGAACCAGTGGTAGAGGAGTTGTAGCAACGGCTTCCTATGAAGCTAGAAAATATGGTGTTC
ATTCTGCTATGCCTGTTTTTATGGCTAGAGAAAAATGTCCTAATGGTATATATGTACCTTCAAGACATGACAGATATAGA
GAGGTATCTAAGAATATATTTAAAATATTTTATGAAATAACTCCAATTGTAGAACCTGTATCCATAGATGAAGCTTATTT
AGATATAACAAATTGCGGTAGGGAACCTTTAGAGATAGTAAAATATATAAAAAAAGAAATATGGAAAAGAGAAGGATTAA
CTGCATCTATGGGGATTTCCTATAACAAATTTTTAGCTAAATTAGCTTCTGATTGGAATAAACCAAATGGAGTTAAGATA
ATAAAAAAAGATATGATTCCAAATATATTATTGCCTTTACCAATAAATAAAGTGCATGGAATGGGAAAAAAATCAGTAGA
AAAAATGAACAATATAGGTATCTTTAAAATTGAAGATATGTATAAGCTACCTTTAGATCTTTTTATAGAGTATTTTGGTA
AATTTGGATTAGAAATATATGAAAGAATAAGGGGATTTGATAACAGGGAAGTTCAAGTTGGAAGAGAAAGAAAATCCATA
GGAAATGAAACAACCCTAAGAAAAGATACTAAAGATACAGAAGAAATTAAAAAATATTTATATACTTTTTCCAAAAGCAT
ATCAGAAGGGTTAAAGAAAAATCATATGTGGGGAAAAACAGTAACAGTAAAAATAAAAAATTATAAGTTTGAAACCACAA
CTAAAAGTAAAACTTTGAAAGATTATATTAATGAAGAAGAAAAAATATATATTGAAGCATGTAAAATACTTGATAGCATA
AATATAAAAGAACCTTTAAGACTTATAGGTCTTACATTGTCTAATCTCTCAGAGAGTAAAATTGAACAATTAACAATAGA
TCAATTTATATCAATTTAA

Upstream 100 bases:

>100_bases
ATTATATTAAGAATTTCTTAAATTTAGGAGAAACATTTTAGAATATATGATAAAATATATAAGAACATAAGTTTGGTTAA
AATGTAAAGGAGTATGTAAA

Downstream 100 bases:

>100_bases
TTAAAGGGTTTTACATACCCTTTAATTAAAAATTTTCTTGCTGAGAGTAAATTTGTTTAAAATATTCATTTTGTACCTCA
TTATCTATTAATTGAAGATT

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MDRIIMHIDLDAFFASVEQRDNPKLRGKPVIVGGTSGRGVVATASYEARKYGVHSAMPVFMAREKCPNGIYVPSRHDRYR
EVSKNIFKIFYEITPIVEPVSIDEAYLDITNCGREPLEIVKYIKKEIWKREGLTASMGISYNKFLAKLASDWNKPNGVKI
IKKDMIPNILLPLPINKVHGMGKKSVEKMNNIGIFKIEDMYKLPLDLFIEYFGKFGLEIYERIRGFDNREVQVGRERKSI
GNETTLRKDTKDTEEIKKYLYTFSKSISEGLKKNHMWGKTVTVKIKNYKFETTTKSKTLKDYINEEEKIYIEACKILDSI
NIKEPLRLIGLTLSNLSESKIEQLTIDQFISI

Sequences:

>Translated_352_residues
MDRIIMHIDLDAFFASVEQRDNPKLRGKPVIVGGTSGRGVVATASYEARKYGVHSAMPVFMAREKCPNGIYVPSRHDRYR
EVSKNIFKIFYEITPIVEPVSIDEAYLDITNCGREPLEIVKYIKKEIWKREGLTASMGISYNKFLAKLASDWNKPNGVKI
IKKDMIPNILLPLPINKVHGMGKKSVEKMNNIGIFKIEDMYKLPLDLFIEYFGKFGLEIYERIRGFDNREVQVGRERKSI
GNETTLRKDTKDTEEIKKYLYTFSKSISEGLKKNHMWGKTVTVKIKNYKFETTTKSKTLKDYINEEEKIYIEACKILDSI
NIKEPLRLIGLTLSNLSESKIEQLTIDQFISI
>Mature_352_residues
MDRIIMHIDLDAFFASVEQRDNPKLRGKPVIVGGTSGRGVVATASYEARKYGVHSAMPVFMAREKCPNGIYVPSRHDRYR
EVSKNIFKIFYEITPIVEPVSIDEAYLDITNCGREPLEIVKYIKKEIWKREGLTASMGISYNKFLAKLASDWNKPNGVKI
IKKDMIPNILLPLPINKVHGMGKKSVEKMNNIGIFKIEDMYKLPLDLFIEYFGKFGLEIYERIRGFDNREVQVGRERKSI
GNETTLRKDTKDTEEIKKYLYTFSKSISEGLKKNHMWGKTVTVKIKNYKFETTTKSKTLKDYINEEEKIYIEACKILDSI
NIKEPLRLIGLTLSNLSESKIEQLTIDQFISI

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=338, Percent_Identity=28.1065088757396, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI7706681, Length=339, Percent_Identity=28.023598820059, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI154350220, Length=335, Percent_Identity=26.865671641791, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI5729982, Length=352, Percent_Identity=26.4204545454545, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI7705344, Length=110, Percent_Identity=47.2727272727273, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786425, Length=351, Percent_Identity=39.031339031339, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1787432, Length=296, Percent_Identity=25, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17537959, Length=366, Percent_Identity=26.775956284153, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI193205700, Length=111, Percent_Identity=39.6396396396396, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115534089, Length=147, Percent_Identity=38.7755102040816, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193205702, Length=228, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324921, Length=250, Percent_Identity=26.8, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19923006, Length=339, Percent_Identity=24.188790560472, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21355641, Length=285, Percent_Identity=27.719298245614, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24644984, Length=285, Percent_Identity=27.719298245614, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24668444, Length=119, Percent_Identity=33.6134453781513, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 40615; Mature: 40615

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIIMHIDLDAFFASVEQRDNPKLRGKPVIVGGTSGRGVVATASYEARKYGVHSAMPVF
CCEEEEEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEECCCHHHHHCCCHHHHHH
MAREKCPNGIYVPSRHDRYREVSKNIFKIFYEITPIVEPVSIDEAYLDITNCGREPLEIV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHH
KYIKKEIWKREGLTASMGISYNKFLAKLASDWNKPNGVKIIKKDMIPNILLPLPINKVHG
HHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCEEEEHHCCCCEEECCCCHHHHC
MGKKSVEKMNNIGIFKIEDMYKLPLDLFIEYFGKFGLEIYERIRGFDNREVQVGRERKSI
CCHHHHHHHHCCCEEEECHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHC
GNETTLRKDTKDTEEIKKYLYTFSKSISEGLKKNHMWGKTVTVKIKNYKFETTTKSKTLK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCHHHHHH
DYINEEEKIYIEACKILDSINIKEPLRLIGLTLSNLSESKIEQLTIDQFISI
HHHCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDRIIMHIDLDAFFASVEQRDNPKLRGKPVIVGGTSGRGVVATASYEARKYGVHSAMPVF
CCEEEEEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEECCCHHHHHCCCHHHHHH
MAREKCPNGIYVPSRHDRYREVSKNIFKIFYEITPIVEPVSIDEAYLDITNCGREPLEIV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHH
KYIKKEIWKREGLTASMGISYNKFLAKLASDWNKPNGVKIIKKDMIPNILLPLPINKVHG
HHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCEEEEHHCCCCEEECCCCHHHHC
MGKKSVEKMNNIGIFKIEDMYKLPLDLFIEYFGKFGLEIYERIRGFDNREVQVGRERKSI
CCHHHHHHHHCCCEEEECHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHC
GNETTLRKDTKDTEEIKKYLYTFSKSISEGLKKNHMWGKTVTVKIKNYKFETTTKSKTLK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCHHHHHH
DYINEEEKIYIEACKILDSINIKEPLRLIGLTLSNLSESKIEQLTIDQFISI
HHHCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]