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The map label for this gene is ywlC [H]

Identifier: 28210066

GI number: 28210066

Start: 288708

End: 289760

Strand: Direct

Name: ywlC [H]

Synonym: CTC00305

Alternate gene names: 28210066

Gene position: 288708-289760 (Clockwise)

Preceding gene: 28210065

Following gene: 28210067

Centisome position: 10.31

GC content: 31.81

Gene sequence:

>1053_bases
TTGGAAACAAAAGTTATAAAAACACATAAAGATAAATTAGAAAATAAAATATTAAAGGAGTGCGGGGAAGCTCTGAGAAA
TGGCAAATTAGTAGTTTTTCCTACTGAAACTGTGTATGGTTTAGGGGCAAATGCTTTAAAAGAAGATGCAGTAAAAAAGA
TATTTGAAGCTAAAGGAAGACCACAAGATAATCCTCTAATAGTTCATATATCAGAACTAGAAGAAATAGCACCTTTAGTT
GAAGAAGTACCCAAAATAGCTTATAAATTAATGGAAAAGTTTTGGCCAGGACCTATGACTATAATTTTACCTAAAAGTTC
TTTAATTCCAAGTAGAACTAGTGGTGGACTTAATAGTGTAGGTATAAGAATGCCTTCAAATGAGATAGCAAGGAAACTTA
TAAAAGAAGCAAAGGTACCTATAGCGGCTCCGTCAGCTAATATATCAGGAAGACCAAGTCCTACGAATATAGAGACTTGT
ATAGAAGATTTAAAGGGAAAGGTAGATTATATTATAGGTGGAGAAAAATGCGATGTAGGGGTAGAATCCACTGTTATAGA
TTGTACTATATATCCACCCTGCGTGTTAAGACCAGGTGGAATAACTTTAGAAATGCTAAAAAACATAGATAATAAAATAT
ATATAGATCCTGCCATAATGGCTGGAGATAATAAGGATTTGAAACCGAAGGCTCCTGGAATGAAATATAGACATTATGCA
CCTAAAGCAGAATTAAAAATAATTAGAGGTGATCTAAAAAATTCTGTAGATAAAATAAAGAAACTTACAGACGAATATGA
ATCACAAGGAAAAAATGTGGGAATAATGGCAACAGATGAGACTAGAGAGTTTTATGTAAATGGTCAGGTAATATCCTTGG
GAGGTAGAGAAAATTTAGAAACTATTGCAAGAAACTTATTTTCAGTATTAAGAAGTTTTGATAGTAAGAACGTAGATATT
ATATTATCAGAAACCTTTGAAGAGAAGGGTATAGGTATTGCTATAATGAATAGATTAAAAAAATCGGCTGGATTTAATAT
TATAGAGGTTTAA

Upstream 100 bases:

>100_bases
TATGGGAAGGTGTATCTAGTACAATTGGAGTATTATCGGGATTGATTTTTGGACTAATTATAGTATATTTATTGTAGAAG
ATACAAAAGGAGATGTAGTT

Downstream 100 bases:

>100_bases
AATTTTTAAAATAAATAGTTGACATATAAAATAAGGTAGTATAGAATATTTTACTGGTAGTTAGAAAAGTTAATTGGAGG
AGCTAATGGATATATTATTT

Product: SUA5 protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
METKVIKTHKDKLENKILKECGEALRNGKLVVFPTETVYGLGANALKEDAVKKIFEAKGRPQDNPLIVHISELEEIAPLV
EEVPKIAYKLMEKFWPGPMTIILPKSSLIPSRTSGGLNSVGIRMPSNEIARKLIKEAKVPIAAPSANISGRPSPTNIETC
IEDLKGKVDYIIGGEKCDVGVESTVIDCTIYPPCVLRPGGITLEMLKNIDNKIYIDPAIMAGDNKDLKPKAPGMKYRHYA
PKAELKIIRGDLKNSVDKIKKLTDEYESQGKNVGIMATDETREFYVNGQVISLGGRENLETIARNLFSVLRSFDSKNVDI
ILSETFEEKGIGIAIMNRLKKSAGFNIIEV

Sequences:

>Translated_350_residues
METKVIKTHKDKLENKILKECGEALRNGKLVVFPTETVYGLGANALKEDAVKKIFEAKGRPQDNPLIVHISELEEIAPLV
EEVPKIAYKLMEKFWPGPMTIILPKSSLIPSRTSGGLNSVGIRMPSNEIARKLIKEAKVPIAAPSANISGRPSPTNIETC
IEDLKGKVDYIIGGEKCDVGVESTVIDCTIYPPCVLRPGGITLEMLKNIDNKIYIDPAIMAGDNKDLKPKAPGMKYRHYA
PKAELKIIRGDLKNSVDKIKKLTDEYESQGKNVGIMATDETREFYVNGQVISLGGRENLETIARNLFSVLRSFDSKNVDI
ILSETFEEKGIGIAIMNRLKKSAGFNIIEV
>Mature_350_residues
METKVIKTHKDKLENKILKECGEALRNGKLVVFPTETVYGLGANALKEDAVKKIFEAKGRPQDNPLIVHISELEEIAPLV
EEVPKIAYKLMEKFWPGPMTIILPKSSLIPSRTSGGLNSVGIRMPSNEIARKLIKEAKVPIAAPSANISGRPSPTNIETC
IEDLKGKVDYIIGGEKCDVGVESTVIDCTIYPPCVLRPGGITLEMLKNIDNKIYIDPAIMAGDNKDLKPKAPGMKYRHYA
PKAELKIIRGDLKNSVDKIKKLTDEYESQGKNVGIMATDETREFYVNGQVISLGGRENLETIARNLFSVLRSFDSKNVDI
ILSETFEEKGIGIAIMNRLKKSAGFNIIEV

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=201, Percent_Identity=28.8557213930348, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI2367210, Length=144, Percent_Identity=26.3888888888889, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87081864, Length=200, Percent_Identity=27.5, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17537239, Length=189, Percent_Identity=26.984126984127, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321269, Length=379, Percent_Identity=36.1477572559367, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI78707274, Length=149, Percent_Identity=27.5167785234899, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 38635; Mature: 38635

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKVIKTHKDKLENKILKECGEALRNGKLVVFPTETVYGLGANALKEDAVKKIFEAKGR
CCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHECCCCHHHHHHHHHHHHHHCCC
PQDNPLIVHISELEEIAPLVEEVPKIAYKLMEKFWPGPMTIILPKSSLIPSRTSGGLNSV
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
GIRMPSNEIARKLIKEAKVPIAAPSANISGRPSPTNIETCIEDLKGKVDYIIGGEKCDVG
EEECCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCC
VESTVIDCTIYPPCVLRPGGITLEMLKNIDNKIYIDPAIMAGDNKDLKPKAPGMKYRHYA
CCCEEEEEEECCCCEECCCCCHHHHHHCCCCEEEECCEEEECCCCCCCCCCCCCCEECCC
PKAELKIIRGDLKNSVDKIKKLTDEYESQGKNVGIMATDETREFYVNGQVISLGGRENLE
CCHHHEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCEEEEECCCCCHH
TIARNLFSVLRSFDSKNVDIILSETFEEKGIGIAIMNRLKKSAGFNIIEV
HHHHHHHHHHHHCCCCCEEEEEECCHHHCCCHHHHHHHHHHHCCCCEEEC
>Mature Secondary Structure
METKVIKTHKDKLENKILKECGEALRNGKLVVFPTETVYGLGANALKEDAVKKIFEAKGR
CCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHECCCCHHHHHHHHHHHHHHCCC
PQDNPLIVHISELEEIAPLVEEVPKIAYKLMEKFWPGPMTIILPKSSLIPSRTSGGLNSV
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
GIRMPSNEIARKLIKEAKVPIAAPSANISGRPSPTNIETCIEDLKGKVDYIIGGEKCDVG
EEECCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCC
VESTVIDCTIYPPCVLRPGGITLEMLKNIDNKIYIDPAIMAGDNKDLKPKAPGMKYRHYA
CCCEEEEEEECCCCEECCCCCHHHHHHCCCCEEEECCEEEECCCCCCCCCCCCCCEECCC
PKAELKIIRGDLKNSVDKIKKLTDEYESQGKNVGIMATDETREFYVNGQVISLGGRENLE
CCHHHEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCEEEEECCCCCHH
TIARNLFSVLRSFDSKNVDIILSETFEEKGIGIAIMNRLKKSAGFNIIEV
HHHHHHHHHHHHCCCCCEEEEEECCHHHCCCHHHHHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]