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The map label for this gene is hexA [H]

Identifier: 28209998

GI number: 28209998

Start: 198823

End: 200634

Strand: Direct

Name: hexA [H]

Synonym: CTC00231

Alternate gene names: 28209998

Gene position: 198823-200634 (Clockwise)

Preceding gene: 28209997

Following gene: 28209999

Centisome position: 7.1

GC content: 25.55

Gene sequence:

>1812_bases
TTGGATTATATAAGGAACAAATATGTAAAAAGAAAAACTAAATATGATAAATTAAGAGAAAAACAAATACAAACTATAAA
TTTTATAAGTGTTTTGAGAATGATAATCTTTATTTTGGGTGTTTTATTTACTGCTATAATATATTATAAGTTTAAAAATT
ACTATATGAGTATATTAATTGCAGTAATATTTACTGGAGCTTTTATATATTTAGCTGTAAAACATCAAGATGTTATAAAT
AATAAGGAAATTATAGATAAAATATGTTATTTAAATGATAAATCTATAAAACGCTTAGATGGAAAATGGAGAGATTTTGA
AGATACAGGAAAAGAATTTATAAAAGAAGATCATAATTATTCAAAGGATTTGGATATATTCGGAAGAGCATCTCTTTTTC
AGTATCTAAACGCAACAAATACATACATGGGTCGTAGGCAATTAAAATCATCTTTAGAAAATCCTAATTATAATATAAAA
GAAATATACGAAAGACAGGAAGCAACAAAAGAGTTATCTAAATATCTTGGATGGAGACAAAGGTTTCAGGCAGAAGGATT
GCACACATCTAGCAATAAAAGTGTAGATGAATTAATTGAATGGGGAGAGCAAAGAGATGATTTTTATACTAATTCTATAG
TTATTTTATTATCTTTAGTAGTACCTATAGCTACTGTAGCTACTATAATAATGTATTTTATGAAGTACATAAGTTATTCT
ATACCTATTTTTTTTATGATTATACAAGGAATTATGTTAAAAATAAAAAAAGAAAATAGGGATAATACATTAAAATTAGT
GTATAAGTATAAAAAAATAATAAATAGTTATTATAACATGCTAGAACTTATAGGTAAAAAAGAATTTAAAAGCAAGTATT
TAAAAGATTTGAAATTAAATATTATGTCCAAAGAAGAAAATAAAGCATTAAATGGAATAGATGGTTTAATCAAAATATCT
AGTTTCGTTTCTGATAGAAATAATATGCTTTATTTATTAGTTAATGTAATATTACTTTGGGATTATCAGTGTATGATTTT
ATTAGAAAAATGGAATAAAGAATATGGAAGTGAACTTGAAAAATGGTTAGATACCATAGGCAAAGTAGAAGAAATCTCTA
GTTTATCGATTATAACGCATGATAATCCAGATTGGGTAATGCCCAAATTTAATAAAGATTACCTAATTATAAAAGGTAAA
AACTTAGGTCATCCTCTTCTAGGTAAGGAAAGAATTTGTAATGATTTTCAATTGGGAGAAAGGGAGAAAGTTTTACTAAT
TACTGGTTCTAACATGTCTGGTAAGAGTACTCTTTTAAGAACGGTAGGAGTAAATTTAGTTTTAGCATATGCTGGAGGGG
TTGTTTGTGCTGAAGAGTTCTATTGTACACCTATGTATATATATACATGTATGAGAATAAGTGATAATTTAGAAAAGAAT
ATATCGTCCTTTTATGGAGAAATTTTAAGAATTAAGAAGCTAATAGAAGGAGTAAAAACAGGTAAACCGATATTCTTTTT
GTTAGATGAGATATTTAAAGGTACAAATTCTCTTGATAGACATACTGGAGCAGAAATATTAATAAATAAACTAAGTAAAG
AAAATGTATTAGGAATTGTATCTACCCATGATTTAGAATTAGGAGATTTGGAAAAGCAGAATAGTAATGTTAGAAATTAT
CACTTCAGAGAATATTACAAAGATAATAGGATATATTTCGATTATAAATTAAGATTAGGAATTTCTACTACAAGAAACGC
ATTGTACCTCATGAAAATGGCGGGTATAGAGGTAGATGAAAATAATATTTAA

Upstream 100 bases:

>100_bases
TGTTCTGGCACATATTTGTGCCTTTTTTATTTTGGTACAATATTTTGTATAATACTTGTATAATAGAATATATAAACTTA
AAATAGGTAGGTGAAAAAGT

Downstream 100 bases:

>100_bases
GATTATTAAGTTGGGAGGAAGTCCATGAGAGTAGGAATAGGATATGATGTACATAAACTGGTAGATGGAAGAGATTTAAT
AATAGGGGGAGAAAAAATAC

Product: DNA mismatch repair protein hexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MDYIRNKYVKRKTKYDKLREKQIQTINFISVLRMIIFILGVLFTAIIYYKFKNYYMSILIAVIFTGAFIYLAVKHQDVIN
NKEIIDKICYLNDKSIKRLDGKWRDFEDTGKEFIKEDHNYSKDLDIFGRASLFQYLNATNTYMGRRQLKSSLENPNYNIK
EIYERQEATKELSKYLGWRQRFQAEGLHTSSNKSVDELIEWGEQRDDFYTNSIVILLSLVVPIATVATIIMYFMKYISYS
IPIFFMIIQGIMLKIKKENRDNTLKLVYKYKKIINSYYNMLELIGKKEFKSKYLKDLKLNIMSKEENKALNGIDGLIKIS
SFVSDRNNMLYLLVNVILLWDYQCMILLEKWNKEYGSELEKWLDTIGKVEEISSLSIITHDNPDWVMPKFNKDYLIIKGK
NLGHPLLGKERICNDFQLGEREKVLLITGSNMSGKSTLLRTVGVNLVLAYAGGVVCAEEFYCTPMYIYTCMRISDNLEKN
ISSFYGEILRIKKLIEGVKTGKPIFFLLDEIFKGTNSLDRHTGAEILINKLSKENVLGIVSTHDLELGDLEKQNSNVRNY
HFREYYKDNRIYFDYKLRLGISTTRNALYLMKMAGIEVDENNI

Sequences:

>Translated_603_residues
MDYIRNKYVKRKTKYDKLREKQIQTINFISVLRMIIFILGVLFTAIIYYKFKNYYMSILIAVIFTGAFIYLAVKHQDVIN
NKEIIDKICYLNDKSIKRLDGKWRDFEDTGKEFIKEDHNYSKDLDIFGRASLFQYLNATNTYMGRRQLKSSLENPNYNIK
EIYERQEATKELSKYLGWRQRFQAEGLHTSSNKSVDELIEWGEQRDDFYTNSIVILLSLVVPIATVATIIMYFMKYISYS
IPIFFMIIQGIMLKIKKENRDNTLKLVYKYKKIINSYYNMLELIGKKEFKSKYLKDLKLNIMSKEENKALNGIDGLIKIS
SFVSDRNNMLYLLVNVILLWDYQCMILLEKWNKEYGSELEKWLDTIGKVEEISSLSIITHDNPDWVMPKFNKDYLIIKGK
NLGHPLLGKERICNDFQLGEREKVLLITGSNMSGKSTLLRTVGVNLVLAYAGGVVCAEEFYCTPMYIYTCMRISDNLEKN
ISSFYGEILRIKKLIEGVKTGKPIFFLLDEIFKGTNSLDRHTGAEILINKLSKENVLGIVSTHDLELGDLEKQNSNVRNY
HFREYYKDNRIYFDYKLRLGISTTRNALYLMKMAGIEVDENNI
>Mature_603_residues
MDYIRNKYVKRKTKYDKLREKQIQTINFISVLRMIIFILGVLFTAIIYYKFKNYYMSILIAVIFTGAFIYLAVKHQDVIN
NKEIIDKICYLNDKSIKRLDGKWRDFEDTGKEFIKEDHNYSKDLDIFGRASLFQYLNATNTYMGRRQLKSSLENPNYNIK
EIYERQEATKELSKYLGWRQRFQAEGLHTSSNKSVDELIEWGEQRDDFYTNSIVILLSLVVPIATVATIIMYFMKYISYS
IPIFFMIIQGIMLKIKKENRDNTLKLVYKYKKIINSYYNMLELIGKKEFKSKYLKDLKLNIMSKEENKALNGIDGLIKIS
SFVSDRNNMLYLLVNVILLWDYQCMILLEKWNKEYGSELEKWLDTIGKVEEISSLSIITHDNPDWVMPKFNKDYLIIKGK
NLGHPLLGKERICNDFQLGEREKVLLITGSNMSGKSTLLRTVGVNLVLAYAGGVVCAEEFYCTPMYIYTCMRISDNLEKN
ISSFYGEILRIKKLIEGVKTGKPIFFLLDEIFKGTNSLDRHTGAEILINKLSKENVLGIVSTHDLELGDLEKQNSNVRNY
HFREYYKDNRIYFDYKLRLGISTTRNALYLMKMAGIEVDENNI

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=224, Percent_Identity=29.4642857142857, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI284813531, Length=289, Percent_Identity=27.681660899654, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1789089, Length=202, Percent_Identity=28.2178217821782, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508447, Length=275, Percent_Identity=28.7272727272727, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508445, Length=210, Percent_Identity=30.4761904761905, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320302, Length=274, Percent_Identity=27.3722627737226, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319935, Length=267, Percent_Identity=28.4644194756554, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=248, Percent_Identity=27.8225806451613, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 70717; Mature: 70717

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA