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The map label for this gene is tlyC [C]

Identifier: 28198446

GI number: 28198446

Start: 658378

End: 659724

Strand: Reverse

Name: tlyC [C]

Synonym: PD0536

Alternate gene names: 28198446

Gene position: 659724-658378 (Counterclockwise)

Preceding gene: 28198447

Following gene: 77747647

Centisome position: 26.18

GC content: 52.64

Gene sequence:

>1347_bases
TTGCCACGTCACCTAAGGAAGAGGCGCGTGTTTGAACTGCTGATTGTCATTGCGCTGATTTTTCTCAACGGCTTCTTTGC
TATGTCAGAGATGTCTCTGATGACCTCACGCAAAAGCCGGCTGAAGCAGATGGCCCACTCCAGCAAACACGCGGCTAAAG
CGCTGACACTCGCCCAAAACCCTGAGAGCTTTCTATCCACAGTACAGATAGGCATCACTCTCATCGGCATCTTGACCGGG
CTGTTTGGCGGCGACGCAATCGGTACGGCAATCGGTCAATGGCTGACCGCATTGACCCCACAGCTAGGCGAATACACAAG
CATCATCGGCAAAACTCTGTCCGTCGCACTCATCACCTTCTTAACACTGATCTTCGGCGAACTGGTACCCAAACGGCTGG
CACTGACACATTCAGAAAAAATCGCCAGCACCATCGCCGTTCCGATGAGCGTGTTAGCGCGCATCGCCGCACCCGGCGTT
TGGGTATTGGCCAAATCCACCCAACTTGTACTGCGTGTCTTTGGATTTGGAAAAATTCCATCCAGTGCAGTCACTGAAGA
GGAAATCCGCCTGCTCGTCGCCGAAAGTCACGAAGCCGGTGTGATTGATGATTACGAACGCAACATGATGAACCGAGTCA
TGCGCCTGGGTGATCGTACTGCCGATAGCCTAATGACACCACGCAATCGGATTGCTTGGCTGGATAACAGCGCCGACCTG
GAACACAACCTTGAAATCATGCGTGAACACCAATTCTCACGCTATCCCGTCTATCGCAGCAGCGACCAGGACATCGTTGG
CATTCTCGAAGTGAAATCTGTCATCACACGCATTGATAGTCAGACCCAGACCACGCTATCCCTGTTCCAAGAACTATGCG
AACCAGTCTTTGTCTCTGAATCCACACATGCGTTGAAACTGCTAGAAATCTTCCGCGAGGAACAACAATCAATGGCGCTG
GTGGTCGACGAATACGGAGAGATCCTTGGCTTAGTGACAATCAGCGACCTCATGGGCGCAGTCATCGGCCGTCTCCAAAA
CGTGGAAAACACCGACGAAGACGCTTTGATGGTCACTCGGGAAGATGGCTCATTCCTGATCGACGGGACCCTGCCCATTG
AGGAACTGCGCGAAGTACTCGGCGCCGAACTGCCAGACGGAGAGGAAAACAACTACCACACCTTAGCCGGGATGTGTATC
TCCTACTTCGGCCGCATCCCACATGTTGGCGAATACTTCGACTGGGCCGGCTGGCGTATCGAAATCGTTGATCTAGACGG
CGCACGCATCGACAAACTCTTACTTCAGCGGCTGAATAAAGAAAAAAACCACGTCCCCCATAAATGA

Upstream 100 bases:

>100_bases
CCCAGTGCCCTCGCGGCACGCCCTATGGACCACGACCTAATCTCCCTCCACTACTCCTCTCCCTCGACGCGCCCAGGCTT
GATTGACCTATGTGCTCTCC

Downstream 100 bases:

>100_bases
AATCCAGCCAACCCCTAGCATTCAAACACCATGATGTAACGTGCGGCTTTTAAAAATCCCGAATCATCATAGCGATGCAT
CGTCGCAAGTATTCATTGCC

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MPRHLRKRRVFELLIVIALIFLNGFFAMSEMSLMTSRKSRLKQMAHSSKHAAKALTLAQNPESFLSTVQIGITLIGILTG
LFGGDAIGTAIGQWLTALTPQLGEYTSIIGKTLSVALITFLTLIFGELVPKRLALTHSEKIASTIAVPMSVLARIAAPGV
WVLAKSTQLVLRVFGFGKIPSSAVTEEEIRLLVAESHEAGVIDDYERNMMNRVMRLGDRTADSLMTPRNRIAWLDNSADL
EHNLEIMREHQFSRYPVYRSSDQDIVGILEVKSVITRIDSQTQTTLSLFQELCEPVFVSESTHALKLLEIFREEQQSMAL
VVDEYGEILGLVTISDLMGAVIGRLQNVENTDEDALMVTREDGSFLIDGTLPIEELREVLGAELPDGEENNYHTLAGMCI
SYFGRIPHVGEYFDWAGWRIEIVDLDGARIDKLLLQRLNKEKNHVPHK

Sequences:

>Translated_448_residues
MPRHLRKRRVFELLIVIALIFLNGFFAMSEMSLMTSRKSRLKQMAHSSKHAAKALTLAQNPESFLSTVQIGITLIGILTG
LFGGDAIGTAIGQWLTALTPQLGEYTSIIGKTLSVALITFLTLIFGELVPKRLALTHSEKIASTIAVPMSVLARIAAPGV
WVLAKSTQLVLRVFGFGKIPSSAVTEEEIRLLVAESHEAGVIDDYERNMMNRVMRLGDRTADSLMTPRNRIAWLDNSADL
EHNLEIMREHQFSRYPVYRSSDQDIVGILEVKSVITRIDSQTQTTLSLFQELCEPVFVSESTHALKLLEIFREEQQSMAL
VVDEYGEILGLVTISDLMGAVIGRLQNVENTDEDALMVTREDGSFLIDGTLPIEELREVLGAELPDGEENNYHTLAGMCI
SYFGRIPHVGEYFDWAGWRIEIVDLDGARIDKLLLQRLNKEKNHVPHK
>Mature_447_residues
PRHLRKRRVFELLIVIALIFLNGFFAMSEMSLMTSRKSRLKQMAHSSKHAAKALTLAQNPESFLSTVQIGITLIGILTGL
FGGDAIGTAIGQWLTALTPQLGEYTSIIGKTLSVALITFLTLIFGELVPKRLALTHSEKIASTIAVPMSVLARIAAPGVW
VLAKSTQLVLRVFGFGKIPSSAVTEEEIRLLVAESHEAGVIDDYERNMMNRVMRLGDRTADSLMTPRNRIAWLDNSADLE
HNLEIMREHQFSRYPVYRSSDQDIVGILEVKSVITRIDSQTQTTLSLFQELCEPVFVSESTHALKLLEIFREEQQSMALV
VDEYGEILGLVTISDLMGAVIGRLQNVENTDEDALMVTREDGSFLIDGTLPIEELREVLGAELPDGEENNYHTLAGMCIS
YFGRIPHVGEYFDWAGWRIEIVDLDGARIDKLLLQRLNKEKNHVPHK

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=372, Percent_Identity=28.2258064516129, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1790664, Length=441, Percent_Identity=29.2517006802721, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI145693175, Length=414, Percent_Identity=27.2946859903382, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI87082033, Length=398, Percent_Identity=27.1356783919598, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786879, Length=244, Percent_Identity=27.8688524590164, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788119, Length=455, Percent_Identity=24.8351648351648, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 50058; Mature: 49926

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRHLRKRRVFELLIVIALIFLNGFFAMSEMSLMTSRKSRLKQMAHSSKHAAKALTLAQN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PESFLSTVQIGITLIGILTGLFGGDAIGTAIGQWLTALTPQLGEYTSIIGKTLSVALITF
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
LTLIFGELVPKRLALTHSEKIASTIAVPMSVLARIAAPGVWVLAKSTQLVLRVFGFGKIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCC
SSAVTEEEIRLLVAESHEAGVIDDYERNMMNRVMRLGDRTADSLMTPRNRIAWLDNSADL
CCCCCHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHEEEECCCCCC
EHNLEIMREHQFSRYPVYRSSDQDIVGILEVKSVITRIDSQTQTTLSLFQELCEPVFVSE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
STHALKLLEIFREEQQSMALVVDEYGEILGLVTISDLMGAVIGRLQNVENTDEDALMVTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
EDGSFLIDGTLPIEELREVLGAELPDGEENNYHTLAGMCISYFGRIPHVGEYFDWAGWRI
CCCCEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
EIVDLDGARIDKLLLQRLNKEKNHVPHK
EEEECCCHHHHHHHHHHHCHHCCCCCCC
>Mature Secondary Structure 
PRHLRKRRVFELLIVIALIFLNGFFAMSEMSLMTSRKSRLKQMAHSSKHAAKALTLAQN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PESFLSTVQIGITLIGILTGLFGGDAIGTAIGQWLTALTPQLGEYTSIIGKTLSVALITF
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
LTLIFGELVPKRLALTHSEKIASTIAVPMSVLARIAAPGVWVLAKSTQLVLRVFGFGKIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCC
SSAVTEEEIRLLVAESHEAGVIDDYERNMMNRVMRLGDRTADSLMTPRNRIAWLDNSADL
CCCCCHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHEEEECCCCCC
EHNLEIMREHQFSRYPVYRSSDQDIVGILEVKSVITRIDSQTQTTLSLFQELCEPVFVSE
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
STHALKLLEIFREEQQSMALVVDEYGEILGLVTISDLMGAVIGRLQNVENTDEDALMVTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
EDGSFLIDGTLPIEELREVLGAELPDGEENNYHTLAGMCISYFGRIPHVGEYFDWAGWRI
CCCCEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
EIVDLDGARIDKLLLQRLNKEKNHVPHK
EEEECCCHHHHHHHHHHHCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]