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The map label for this gene is tesB [H]

Identifier: 28198232

GI number: 28198232

Start: 390706

End: 391602

Strand: Reverse

Name: tesB [H]

Synonym: PD0311

Alternate gene names: 28198232

Gene position: 391602-390706 (Counterclockwise)

Preceding gene: 28198233

Following gene: 28198231

Centisome position: 15.54

GC content: 52.73

Gene sequence:

>897_bases
TTGCCAACGCATACCACATCTAACGCATCCTCCGAATGGACCAAAATGCTCTCGCTGGAAAGGCTTGAAGATAATCTGTT
CCGTGGTCAAAACCGTGACATTGGAACGAAATATGTGTTTGGTGGGCAAATACTTGCCCAAGCCCTGGCCGCAGCGCAAA
ACACCATTGAAAACAGCCGCATTGCGCACTCCCTACATGCCTACTTTCTACGCACTGGCAACATCCAACAACCGATTATC
TATAACGTAGAACGCACTCGGGACGGCAAAAGCTTCTCATTACGCCGCGTCACCGCAATCCAGCACGGTCAAGTAATCTT
TTTCTGCACGGCATCATTCCAGGAACGCGAAGACGGCGCTGAACACCAAACCAACATGCCTGCAGTCCCTCCCCCTGAAG
ACATCGCACCAACCCCACCGCTGCCTCCGGAAACACTAGCCAGAATGCCACCCCAAATGCAAACCTGGCTCAACCTGAGC
GGACAATTTGAATTTCGCCGCGTGCCGCCCAACAACACACTGGATTTGCAGAAACATTCAGCATTCCAACACTTGTGGCT
ACGCATGAACGCCCCACTTGGTGACCGCATTGAATTGCATCAGATATTGCTAACCTACGCATCCGACTTCCAACTCCTCG
AAACAGCCACCTCACGACATGGAATCAACTACCACACACCACAAGTACAGATGGCCTCACTGGACCATGCACTGTGGTTC
CACCGCCCATTCCGCATTGATGACTGGTTGTTATATACGCTTGAAAGCCCCACCGCACAGGGCGCCCGCGGATTGGCCCG
CGGACAATTTTTCACCCGCAATGGCGTATTGATCGCCAACACCGCCCAGGAAGGACTCATGCGCATGACCAACCATACAA
CGCCCTCCAAGGATTAA

Upstream 100 bases:

>100_bases
AGAGATTCAGAGATTCAGCAATATACATCATTATAATTTTCCAAATAAATCCCATCCGCTATAATGAATTACCCATCACA
ACTATTCAGGCCACATTATC

Downstream 100 bases:

>100_bases
CCGATGCGTGGCATCTTTACCAGCCAGCGTGTGGAAACAGTCGAAGGTGTCGCTGCACTCCTCAACGAAGCCGACATCCA
AGTAAAAATCAGCCATCAAC

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MPTHTTSNASSEWTKMLSLERLEDNLFRGQNRDIGTKYVFGGQILAQALAAAQNTIENSRIAHSLHAYFLRTGNIQQPII
YNVERTRDGKSFSLRRVTAIQHGQVIFFCTASFQEREDGAEHQTNMPAVPPPEDIAPTPPLPPETLARMPPQMQTWLNLS
GQFEFRRVPPNNTLDLQKHSAFQHLWLRMNAPLGDRIELHQILLTYASDFQLLETATSRHGINYHTPQVQMASLDHALWF
HRPFRIDDWLLYTLESPTAQGARGLARGQFFTRNGVLIANTAQEGLMRMTNHTTPSKD

Sequences:

>Translated_298_residues
MPTHTTSNASSEWTKMLSLERLEDNLFRGQNRDIGTKYVFGGQILAQALAAAQNTIENSRIAHSLHAYFLRTGNIQQPII
YNVERTRDGKSFSLRRVTAIQHGQVIFFCTASFQEREDGAEHQTNMPAVPPPEDIAPTPPLPPETLARMPPQMQTWLNLS
GQFEFRRVPPNNTLDLQKHSAFQHLWLRMNAPLGDRIELHQILLTYASDFQLLETATSRHGINYHTPQVQMASLDHALWF
HRPFRIDDWLLYTLESPTAQGARGLARGQFFTRNGVLIANTAQEGLMRMTNHTTPSKD
>Mature_297_residues
PTHTTSNASSEWTKMLSLERLEDNLFRGQNRDIGTKYVFGGQILAQALAAAQNTIENSRIAHSLHAYFLRTGNIQQPIIY
NVERTRDGKSFSLRRVTAIQHGQVIFFCTASFQEREDGAEHQTNMPAVPPPEDIAPTPPLPPETLARMPPQMQTWLNLSG
QFEFRRVPPNNTLDLQKHSAFQHLWLRMNAPLGDRIELHQILLTYASDFQLLETATSRHGINYHTPQVQMASLDHALWFH
RPFRIDDWLLYTLESPTAQGARGLARGQFFTRNGVLIANTAQEGLMRMTNHTTPSKD

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=296, Percent_Identity=39.1891891891892, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI1786657, Length=273, Percent_Identity=46.5201465201465, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71988741, Length=288, Percent_Identity=37.8472222222222, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17558508, Length=303, Percent_Identity=37.2937293729373, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI115532456, Length=279, Percent_Identity=35.4838709677419, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17531889, Length=279, Percent_Identity=35.4838709677419, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17531885, Length=279, Percent_Identity=35.4838709677419, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71982224, Length=311, Percent_Identity=34.7266881028939, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI212645202, Length=294, Percent_Identity=29.9319727891156, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322480, Length=306, Percent_Identity=23.5294117647059, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33895; Mature: 33764

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTHTTSNASSEWTKMLSLERLEDNLFRGQNRDIGTKYVFGGQILAQALAAAQNTIENSR
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHH
IAHSLHAYFLRTGNIQQPIIYNVERTRDGKSFSLRRVTAIQHGQVIFFCTASFQEREDGA
HHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEEEEECCCCEEEEEECCCHHHHCCC
EHQTNMPAVPPPEDIAPTPPLPPETLARMPPQMQTWLNLSGQFEFRRVPPNNTLDLQKHS
HHCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCHHHH
AFQHLWLRMNAPLGDRIELHQILLTYASDFQLLETATSRHGINYHTPQVQMASLDHALWF
HHHHEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHH
HRPFRIDDWLLYTLESPTAQGARGLARGQFFTRNGVLIANTAQEGLMRMTNHTTPSKD
CCCCCCCCEEEEEECCCCCHHHHHHHCCEEEECCCEEEEECHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PTHTTSNASSEWTKMLSLERLEDNLFRGQNRDIGTKYVFGGQILAQALAAAQNTIENSR
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHH
IAHSLHAYFLRTGNIQQPIIYNVERTRDGKSFSLRRVTAIQHGQVIFFCTASFQEREDGA
HHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEEEEECCCCEEEEEECCCHHHHCCC
EHQTNMPAVPPPEDIAPTPPLPPETLARMPPQMQTWLNLSGQFEFRRVPPNNTLDLQKHS
HHCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCHHHH
AFQHLWLRMNAPLGDRIELHQILLTYASDFQLLETATSRHGINYHTPQVQMASLDHALWF
HHHHEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHH
HRPFRIDDWLLYTLESPTAQGARGLARGQFFTRNGVLIANTAQEGLMRMTNHTTPSKD
CCCCCCCCEEEEEECCCCCHHHHHHHCCEEEECCCEEEEECHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]