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The map label for this gene is exo I [H]

Identifier: 27365028

GI number: 27365028

Start: 1640215

End: 1642134

Strand: Reverse

Name: exo I [H]

Synonym: VV1_1666

Alternate gene names: 27365028

Gene position: 1642134-1640215 (Counterclockwise)

Preceding gene: 27365029

Following gene: 27365027

Centisome position: 50.04

GC content: 49.17

Gene sequence:

>1920_bases
ATGGAATATCGTATCGACCTGGTTGTCCTTTCAGAACAAAAGCAAAACTGCCGTTTTGGTATGACGCTGCATAACCTCAG
TGATCAAGACTTACCCAACTGGTCTTTAACCTTTGCCTTTACTCGTTTTATTCAGCCAGGCAGCATTTCGCATGGCACCT
TAACGCAAATTGGGAGTTTCTGTCAGTTAAAACCAGATAGCTTGGTACTACCGGCCAATCATCACTTCTATTGTGAGTTC
ACCGTACTGACCAATCCATTCCGTTTTTATTCCGATGGATTGAATGAAGCTTTTGTCGAGTATCACCATGAAGGTGAGCA
GGTGCGCTCTAACGTCGATGTCACCCCGATCGTTCTTGCTTCACCCTACCGTGAACGCGAAACCATCGCTCCTACGTTAG
CCAGCGCCTATTCACTATTACCTAAAGCAAATGCGTTGCATGTTGATGCTGGGCATTTTTCTCTCACACCATCGTCAGCC
ATCACCTGCCAATCCGCATTGGCGGACTCCGCGGTGACTTGGCTCATGGACGAAATGGCGCGTTTGCATCAGTTTAAACT
TGCCACCAGCGAAGCGGGAGAAATCGTTTACCGTAGCAACCCAACACTGGATGAAGGGGCTTATCAACTCAAAATTAGCC
AAGAGCAAGTGCGCGTTGAAGCGGGCTCTAGCTCTGGCTTTGTCCACGCTACCGCAAGCCTATTACAACTGCTTGATTAC
AACTCGCTCACACAAGAGGCCCAGTTGGCTTGCTGTTCAATTTCTGACAGCCCACGTTTTCGCTATCGCGGCATGATGTT
GGATTGCTCTCGCCACTTCCACTCGGTTGAGCAAGTCAAGCGTCTAATTAATCTCCTCGCCCACTATAAGTTCAATACCT
TTCATTGGCATTTAACGGACGATGAAGGCTGGCGCGTTGAAATCAAAGCATTCCCAGCATTAACAGAGACAGGGGCTTGG
CGTGGTGTCGATGAAGCGATTGAGCCCCAATATACCCATATTTCGCAGCGTTATGGCGGGTTCTATAGCCAAGAAGAGAT
CAAAGAAGTGGTCGCCTACGCCGCGCAGCGCAGCATCATGGTCATTCCTGAAATTGACGTTCCTGGTCACTGTCGCGCAG
CGATTAAATCGCTGCCAGAAATGCTGGTAGAAGCAGAAGACGACACCGTCTATCGCAGTATTCAAAATTACTCCGATAAC
GTTCTTAATCCCGGCTTAAGCACCACCTATCAATTTTTAGATGGTGTGCTGGAAGAAATCGCCCAACTGTTCCCGGCACC
CTACGTTCATATTGGTGCCGACGAAGTACCTCACGGGGTTTGGTCAAACAGCCCAAGCTGTCAAGCCTTGATGAAGCAAC
ATGGCTATCAGGATTACAAGGAGCTGCAAGGTCACTTACTGCGTCACGCCGAGCAAAAGCTGCGCAGTCTTGGCAAGCGA
ATGTTGGGATGGGAAGAAGCACAACACGGTGACAAAGTGAGTAAGGACACCGTGATTTACTCGTGGTTAAGTGAAGAAGC
GGCGGTGAACTGCGCCCGTCAAGGCTTTGATGTGGTACTTCAACCCGCTCAAACCACTTATCTCGATATGACACAAGATT
ACGCACCGGAAGAGCCGGGGGTAGATTGGGCCAATCCACTGCCACTCGAAAAAGCCTACAACTACGAGCCGCTTGCCAAT
ATTCCGGCTGACGACCCAATTCATAAGCGAATTTGGGGAATCCAAACGGCTCTTTGGTGCGAAATCATCAATAACCCTGA
GCGAATGGACTATATGGTCTTCCCACGCATTATTGCACTCGCCGAAGCGTGTTGGACACAGAAAGAACATCGTGATTGGA
ACGACTTTTTATCAAGGCTGAAAGGTCACTTGCCGCTACTGGACAAACAGGGCATCAAGTATCGCCAGCCATGGAAATGA

Upstream 100 bases:

>100_bases
GATCGTTGAAGCTCAGTATGACGCCATAGAGGGTGCACTCATGTTTGCAGGTAAAAGCGAACATAACCTCTATGCCGTGG
CAACAAATTAGGAATCGTTT

Downstream 100 bases:

>100_bases
ACAACCGAATGAAAGCCTCGCTTTCCTAAGTTTTCACTAGCTTTAGTTTTTGACTGCCTTACCAAGCAGTTTGTTGAAAA
GGAAATGACAATGAAATACG

Product: beta-hexosaminidase

Products: NA

Alternate protein names: Beta-N-acetylhexosaminidase; N-acetyl-beta-glucosaminidase [H]

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MEYRIDLVVLSEQKQNCRFGMTLHNLSDQDLPNWSLTFAFTRFIQPGSISHGTLTQIGSFCQLKPDSLVLPANHHFYCEF
TVLTNPFRFYSDGLNEAFVEYHHEGEQVRSNVDVTPIVLASPYRERETIAPTLASAYSLLPKANALHVDAGHFSLTPSSA
ITCQSALADSAVTWLMDEMARLHQFKLATSEAGEIVYRSNPTLDEGAYQLKISQEQVRVEAGSSSGFVHATASLLQLLDY
NSLTQEAQLACCSISDSPRFRYRGMMLDCSRHFHSVEQVKRLINLLAHYKFNTFHWHLTDDEGWRVEIKAFPALTETGAW
RGVDEAIEPQYTHISQRYGGFYSQEEIKEVVAYAAQRSIMVIPEIDVPGHCRAAIKSLPEMLVEAEDDTVYRSIQNYSDN
VLNPGLSTTYQFLDGVLEEIAQLFPAPYVHIGADEVPHGVWSNSPSCQALMKQHGYQDYKELQGHLLRHAEQKLRSLGKR
MLGWEEAQHGDKVSKDTVIYSWLSEEAAVNCARQGFDVVLQPAQTTYLDMTQDYAPEEPGVDWANPLPLEKAYNYEPLAN
IPADDPIHKRIWGIQTALWCEIINNPERMDYMVFPRIIALAEACWTQKEHRDWNDFLSRLKGHLPLLDKQGIKYRQPWK

Sequences:

>Translated_639_residues
MEYRIDLVVLSEQKQNCRFGMTLHNLSDQDLPNWSLTFAFTRFIQPGSISHGTLTQIGSFCQLKPDSLVLPANHHFYCEF
TVLTNPFRFYSDGLNEAFVEYHHEGEQVRSNVDVTPIVLASPYRERETIAPTLASAYSLLPKANALHVDAGHFSLTPSSA
ITCQSALADSAVTWLMDEMARLHQFKLATSEAGEIVYRSNPTLDEGAYQLKISQEQVRVEAGSSSGFVHATASLLQLLDY
NSLTQEAQLACCSISDSPRFRYRGMMLDCSRHFHSVEQVKRLINLLAHYKFNTFHWHLTDDEGWRVEIKAFPALTETGAW
RGVDEAIEPQYTHISQRYGGFYSQEEIKEVVAYAAQRSIMVIPEIDVPGHCRAAIKSLPEMLVEAEDDTVYRSIQNYSDN
VLNPGLSTTYQFLDGVLEEIAQLFPAPYVHIGADEVPHGVWSNSPSCQALMKQHGYQDYKELQGHLLRHAEQKLRSLGKR
MLGWEEAQHGDKVSKDTVIYSWLSEEAAVNCARQGFDVVLQPAQTTYLDMTQDYAPEEPGVDWANPLPLEKAYNYEPLAN
IPADDPIHKRIWGIQTALWCEIINNPERMDYMVFPRIIALAEACWTQKEHRDWNDFLSRLKGHLPLLDKQGIKYRQPWK
>Mature_639_residues
MEYRIDLVVLSEQKQNCRFGMTLHNLSDQDLPNWSLTFAFTRFIQPGSISHGTLTQIGSFCQLKPDSLVLPANHHFYCEF
TVLTNPFRFYSDGLNEAFVEYHHEGEQVRSNVDVTPIVLASPYRERETIAPTLASAYSLLPKANALHVDAGHFSLTPSSA
ITCQSALADSAVTWLMDEMARLHQFKLATSEAGEIVYRSNPTLDEGAYQLKISQEQVRVEAGSSSGFVHATASLLQLLDY
NSLTQEAQLACCSISDSPRFRYRGMMLDCSRHFHSVEQVKRLINLLAHYKFNTFHWHLTDDEGWRVEIKAFPALTETGAW
RGVDEAIEPQYTHISQRYGGFYSQEEIKEVVAYAAQRSIMVIPEIDVPGHCRAAIKSLPEMLVEAEDDTVYRSIQNYSDN
VLNPGLSTTYQFLDGVLEEIAQLFPAPYVHIGADEVPHGVWSNSPSCQALMKQHGYQDYKELQGHLLRHAEQKLRSLGKR
MLGWEEAQHGDKVSKDTVIYSWLSEEAAVNCARQGFDVVLQPAQTTYLDMTQDYAPEEPGVDWANPLPLEKAYNYEPLAN
IPADDPIHKRIWGIQTALWCEIINNPERMDYMVFPRIIALAEACWTQKEHRDWNDFLSRLKGHLPLLDKQGIKYRQPWK

Specific function: Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc, and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc), aryl-beta-GalNAc a

COG id: COG3525

COG function: function code G; N-acetyl-beta-hexosaminidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 20 family [H]

Homologues:

Organism=Homo sapiens, GI4504373, Length=440, Percent_Identity=27.9545454545455, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI189181666, Length=445, Percent_Identity=28.314606741573, Blast_Score=166, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17569815, Length=418, Percent_Identity=27.511961722488, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI281365639, Length=461, Percent_Identity=26.0303687635575, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24657474, Length=461, Percent_Identity=26.0303687635575, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24657468, Length=461, Percent_Identity=26.0303687635575, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17647501, Length=461, Percent_Identity=26.0303687635575, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45551090, Length=456, Percent_Identity=27.8508771929825, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24653074, Length=456, Percent_Identity=27.8508771929825, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17933586, Length=467, Percent_Identity=22.2698072805139, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015882
- InterPro:   IPR001540
- InterPro:   IPR015883
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00728 Glyco_hydro_20; PF02838 Glyco_hydro_20b [H]

EC number: =3.2.1.52 [H]

Molecular weight: Translated: 72724; Mature: 72724

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRIDLVVLSEQKQNCRFGMTLHNLSDQDLPNWSLTFAFTRFIQPGSISHGTLTQIGSF
CCEEEEEEEECCCCCCCEECEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCH
CQLKPDSLVLPANHHFYCEFTVLTNPFRFYSDGLNEAFVEYHHEGEQVRSNVDVTPIVLA
HEECCCCEEECCCCEEEEEEEEECCCHHHHHCCHHHHHHHHHHCHHHHHCCCCCCEEEEE
SPYRERETIAPTLASAYSLLPKANALHVDAGHFSLTPSSAITCQSALADSAVTWLMDEMA
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
RLHQFKLATSEAGEIVYRSNPTLDEGAYQLKISQEQVRVEAGSSSGFVHATASLLQLLDY
HHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEHHHEEEECCCCCCCHHHHHHHHHHHCC
NSLTQEAQLACCSISDSPRFRYRGMMLDCSRHFHSVEQVKRLINLLAHYKFNTFHWHLTD
CCHHHHHHHEEEECCCCCCEEECCEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
DEGWRVEIKAFPALTETGAWRGVDEAIEPQYTHISQRYGGFYSQEEIKEVVAYAAQRSIM
CCCCEEEEEECCCCCCCCCCCCCCHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEE
VIPEIDVPGHCRAAIKSLPEMLVEAEDDTVYRSIQNYSDNVLNPGLSTTYQFLDGVLEEI
EEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
AQLFPAPYVHIGADEVPHGVWSNSPSCQALMKQHGYQDYKELQGHLLRHAEQKLRSLGKR
HHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLGWEEAQHGDKVSKDTVIYSWLSEEAAVNCARQGFDVVLQPAQTTYLDMTQDYAPEEPG
HHCCHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEECCCCHHEEECHHCCCCCCCC
VDWANPLPLEKAYNYEPLANIPADDPIHKRIWGIQTALWCEIINNPERMDYMVFPRIIAL
CCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AEACWTQKEHRDWNDFLSRLKGHLPLLDKQGIKYRQPWK
HHHHHCCHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEYRIDLVVLSEQKQNCRFGMTLHNLSDQDLPNWSLTFAFTRFIQPGSISHGTLTQIGSF
CCEEEEEEEECCCCCCCEECEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCH
CQLKPDSLVLPANHHFYCEFTVLTNPFRFYSDGLNEAFVEYHHEGEQVRSNVDVTPIVLA
HEECCCCEEECCCCEEEEEEEEECCCHHHHHCCHHHHHHHHHHCHHHHHCCCCCCEEEEE
SPYRERETIAPTLASAYSLLPKANALHVDAGHFSLTPSSAITCQSALADSAVTWLMDEMA
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
RLHQFKLATSEAGEIVYRSNPTLDEGAYQLKISQEQVRVEAGSSSGFVHATASLLQLLDY
HHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEHHHEEEECCCCCCCHHHHHHHHHHHCC
NSLTQEAQLACCSISDSPRFRYRGMMLDCSRHFHSVEQVKRLINLLAHYKFNTFHWHLTD
CCHHHHHHHEEEECCCCCCEEECCEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
DEGWRVEIKAFPALTETGAWRGVDEAIEPQYTHISQRYGGFYSQEEIKEVVAYAAQRSIM
CCCCEEEEEECCCCCCCCCCCCCCHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEE
VIPEIDVPGHCRAAIKSLPEMLVEAEDDTVYRSIQNYSDNVLNPGLSTTYQFLDGVLEEI
EEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
AQLFPAPYVHIGADEVPHGVWSNSPSCQALMKQHGYQDYKELQGHLLRHAEQKLRSLGKR
HHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLGWEEAQHGDKVSKDTVIYSWLSEEAAVNCARQGFDVVLQPAQTTYLDMTQDYAPEEPG
HHCCHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEECCCCHHEEECHHCCCCCCCC
VDWANPLPLEKAYNYEPLANIPADDPIHKRIWGIQTALWCEIINNPERMDYMVFPRIIAL
CCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AEACWTQKEHRDWNDFLSRLKGHLPLLDKQGIKYRQPWK
HHHHHCCHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969205 [H]