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The map label for this gene is panC

Identifier: 27365004

GI number: 27365004

Start: 1610188

End: 1611093

Strand: Reverse

Name: panC

Synonym: VV1_1642

Alternate gene names: 27365004

Gene position: 1611093-1610188 (Counterclockwise)

Preceding gene: 27365005

Following gene: 27365000

Centisome position: 49.09

GC content: 49.23

Gene sequence:

>906_bases
ATGCAAACCTTTGCCGAAATTTCAGCCCTTCGTGAACAGATCAAAACGTTCAAACGCGAAGGACGTCGAATTGCTTTTGT
TCCAACCATGGGCAATTTACATGAAGGCCACTTAACGCTCGTGCGCAAAGCACGTGAGCACGCTGATATCGTGGTCGTCA
GTATTTTTGTCAACCCAATGCAGTTTGATCGCGCTGACGATTTAAATAATTATCCAAGAACCTTGGAAGACGATCTCAGT
AAACTCAACGGTGAAGCGGTTGAACTGGTCTTTACTCCAACACCTGAAATGATCTACCCAGAAGGCTTGGATAAGCAGAC
TCTCGTTGAAGTCCCCGGCTTATCAACCATGCTGGAAGGGGCATCGCGCCCAGGCCATTTCCGCGGCGTTGCGACAGTGG
TTACTAAGCTATTTAACATTGTTCAGCCGGATGTGGCTTGCTTTGGTGAAAAAGATTTCCAACAGCTTGCTATCATTCGC
AAAATGACCACCGATTTGGCAATGGACATTGAGATTATTGGTGTTCCTACCGTGCGTGAAATGGATGGCCTTGCCATGAG
CTCTCGCAATGGCTTATTGACCATTGATGAGCGCCAACGTGCGCCTGTCTTGGCTCGTACCATGCGTTGGATCAGCAGTG
CTATCCGTGGTGGCCGTGACGACTTTGCTTCGATCATCGAAGACGCCAGCGATCAATTGCGCGCCGCAGGCTTGCACCCA
GATGAAATTTTCATCCGTGATGCACGTACTCTACAAGTGGTCAACGCGGAGAGCACGCAAGCCGTTATTCTGATGTCCGC
TTTCTTGGGCAAAGCTCGCCTGATCGACAATCAAGTGGTTGAGTTGGTGAAAGACAGCAAAGAAGAAGTCGACAGCGCCG
AGTCAGAAAGTGAAAACAGTCACTGA

Upstream 100 bases:

>100_bases
AACAGGAGATATGCGCAAAGCCGTGGCGCTGTACATGGAACAAGTACAAGCAGGCACCTTCCCTGATGAAGCGCACACCA
TTGCTTAGAGGATAATGTAG

Downstream 100 bases:

>100_bases
TGTCTCATTACTGACCTAAACACTTCCCGTACAAAGAATAAAGGGATTGCCATCGGCAATCCCTTTTTGCTATCTGTGAA
CTGAACATTCGTTTTCGTTA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MQTFAEISALREQIKTFKREGRRIAFVPTMGNLHEGHLTLVRKAREHADIVVVSIFVNPMQFDRADDLNNYPRTLEDDLS
KLNGEAVELVFTPTPEMIYPEGLDKQTLVEVPGLSTMLEGASRPGHFRGVATVVTKLFNIVQPDVACFGEKDFQQLAIIR
KMTTDLAMDIEIIGVPTVREMDGLAMSSRNGLLTIDERQRAPVLARTMRWISSAIRGGRDDFASIIEDASDQLRAAGLHP
DEIFIRDARTLQVVNAESTQAVILMSAFLGKARLIDNQVVELVKDSKEEVDSAESESENSH

Sequences:

>Translated_301_residues
MQTFAEISALREQIKTFKREGRRIAFVPTMGNLHEGHLTLVRKAREHADIVVVSIFVNPMQFDRADDLNNYPRTLEDDLS
KLNGEAVELVFTPTPEMIYPEGLDKQTLVEVPGLSTMLEGASRPGHFRGVATVVTKLFNIVQPDVACFGEKDFQQLAIIR
KMTTDLAMDIEIIGVPTVREMDGLAMSSRNGLLTIDERQRAPVLARTMRWISSAIRGGRDDFASIIEDASDQLRAAGLHP
DEIFIRDARTLQVVNAESTQAVILMSAFLGKARLIDNQVVELVKDSKEEVDSAESESENSH
>Mature_301_residues
MQTFAEISALREQIKTFKREGRRIAFVPTMGNLHEGHLTLVRKAREHADIVVVSIFVNPMQFDRADDLNNYPRTLEDDLS
KLNGEAVELVFTPTPEMIYPEGLDKQTLVEVPGLSTMLEGASRPGHFRGVATVVTKLFNIVQPDVACFGEKDFQQLAIIR
KMTTDLAMDIEIIGVPTVREMDGLAMSSRNGLLTIDERQRAPVLARTMRWISSAIRGGRDDFASIIEDASDQLRAAGLHP
DEIFIRDARTLQVVNAESTQAVILMSAFLGKARLIDNQVVELVKDSKEEVDSAESESENSH

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=273, Percent_Identity=59.7069597069597, Blast_Score=342, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6322046, Length=307, Percent_Identity=38.7622149837134, Blast_Score=184, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_VIBVU (Q8DC12)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_760532.1
- ProteinModelPortal:   Q8DC12
- SMR:   Q8DC12
- GeneID:   1178556
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_1642
- HOGENOM:   HBG428839
- OMA:   DEAHDAK
- ProtClustDB:   PRK00380
- BioCyc:   VVUL216895:VV1_1642-MONOMER
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 33535; Mature: 33535

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTFAEISALREQIKTFKREGRRIAFVPTMGNLHEGHLTLVRKAREHADIVVVSIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCH
QFDRADDLNNYPRTLEDDLSKLNGEAVELVFTPTPEMIYPEGLDKQTLVEVPGLSTMLEG
HCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHC
ASRPGHFRGVATVVTKLFNIVQPDVACFGEKDFQQLAIIRKMTTDLAMDIEIIGVPTVRE
CCCCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCHHH
MDGLAMSSRNGLLTIDERQRAPVLARTMRWISSAIRGGRDDFASIIEDASDQLRAAGLHP
HCCCEECCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
DEIFIRDARTLQVVNAESTQAVILMSAFLGKARLIDNQVVELVKDSKEEVDSAESESENS
HHEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
H
C
>Mature Secondary Structure
MQTFAEISALREQIKTFKREGRRIAFVPTMGNLHEGHLTLVRKAREHADIVVVSIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCH
QFDRADDLNNYPRTLEDDLSKLNGEAVELVFTPTPEMIYPEGLDKQTLVEVPGLSTMLEG
HCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHC
ASRPGHFRGVATVVTKLFNIVQPDVACFGEKDFQQLAIIRKMTTDLAMDIEIIGVPTVRE
CCCCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHEEEEEECCCCHHH
MDGLAMSSRNGLLTIDERQRAPVLARTMRWISSAIRGGRDDFASIIEDASDQLRAAGLHP
HCCCEECCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
DEIFIRDARTLQVVNAESTQAVILMSAFLGKARLIDNQVVELVKDSKEEVDSAESESENS
HHEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA