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The map label for this gene is proC [H]

Identifier: 27364895

GI number: 27364895

Start: 1497166

End: 1497984

Strand: Reverse

Name: proC [H]

Synonym: VV1_1524

Alternate gene names: 27364895

Gene position: 1497984-1497166 (Counterclockwise)

Preceding gene: 27364896

Following gene: 27364894

Centisome position: 45.64

GC content: 52.63

Gene sequence:

>819_bases
ATGGAACATAAGAACATCGCTTTTATCGGTGCTGGCAATATGGTGAGAGCCATTGTCTCTGGCTTAGTGGCGAACGGTTA
CCCTGCCGATAAAATCACCGCCACCGCACCCAGCGAGACGCGTCGTTTACCCCTTGAGCAGCAGTTTGGCATTCAGACCA
CCAGCGATAATCTCATGGCAGCAACGCAAGCAGACGTGATCGTCCTTTCTGTCAAACCGCAAATGATGGAAGAAGTGTGC
AAACCGCTGCAATCCGTCGATTTCTCCAATAAGCTGGTTATTTCGATTGCCGCAGGCATCAATTGCGCACGATTAAATGA
CATGCTCGCCACTCAACTCAACTTAGTGCGCGTCATGCCCAATACCCCATCACAACTCGGGTTAGGCATGAGCGGCTTAT
ATGCGCCAGCCTCAGTGGCCGAGCAAGATCGCCACTTTGCCGAGCAGTTAATGCAAGCGGTCGGCAAAACCTGCTGGGTC
GATGAAGAATCGGGCATTAACCACGTTATTGCGGCGGCAGGCAGTGCTCCAGCGTACTTCTTCCTCTTTATGGAAGCCAT
GCAAGCTGAAGCGATGGCGCAAGGGTTTGATAAACAAACCGCTCGTTTGCTGGTTCAGCAATCCGCATTGGGGGCGGCCA
GTATGGTAGTGGAAAACCCAGACACCGAACTGGCGACTCTGCGCGAGAACGTCACCTCGAAAGGAGGGACCACCGCCGAA
GCATTGCGCACTTTCAATGAACATCAACTCTCTGATATCGTAGCCAAAGCCATGCAAGCGGCAGTGGCTCGCGCGCAAGA
GATGGAAAAACTGTTTTAA

Upstream 100 bases:

>100_bases
GGTTCAACCATGGTGCGTATTGGCACCGCCATTTTTGGCCATCGCGATTACAGCAACAAAGCGTAACTCGGCGACTTTTA
CTTACTAGCGGAACAGAAAT

Downstream 100 bases:

>100_bases
TCACCTGGCTGCTTAGCAGCTCTACGTTTTAAGGGGCATCTATGAATGCAATGAGTTTTCTGATTTCGACGCTGTTTGAT
CTCTATATCATGGTCGTGAT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MEHKNIAFIGAGNMVRAIVSGLVANGYPADKITATAPSETRRLPLEQQFGIQTTSDNLMAATQADVIVLSVKPQMMEEVC
KPLQSVDFSNKLVISIAAGINCARLNDMLATQLNLVRVMPNTPSQLGLGMSGLYAPASVAEQDRHFAEQLMQAVGKTCWV
DEESGINHVIAAAGSAPAYFFLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF

Sequences:

>Translated_272_residues
MEHKNIAFIGAGNMVRAIVSGLVANGYPADKITATAPSETRRLPLEQQFGIQTTSDNLMAATQADVIVLSVKPQMMEEVC
KPLQSVDFSNKLVISIAAGINCARLNDMLATQLNLVRVMPNTPSQLGLGMSGLYAPASVAEQDRHFAEQLMQAVGKTCWV
DEESGINHVIAAAGSAPAYFFLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF
>Mature_272_residues
MEHKNIAFIGAGNMVRAIVSGLVANGYPADKITATAPSETRRLPLEQQFGIQTTSDNLMAATQADVIVLSVKPQMMEEVC
KPLQSVDFSNKLVISIAAGINCARLNDMLATQLNLVRVMPNTPSQLGLGMSGLYAPASVAEQDRHFAEQLMQAVGKTCWV
DEESGINHVIAAAGSAPAYFFLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=273, Percent_Identity=27.4725274725275, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=29.8181818181818, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=34.4444444444444, Blast_Score=140, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=32.0754716981132, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17540664, Length=282, Percent_Identity=31.5602836879433, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=284, Percent_Identity=27.112676056338, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=32.9588014981273, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=30.7142857142857, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=32.1637426900585, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29193; Mature: 29193

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKNIAFIGAGNMVRAIVSGLVANGYPADKITATAPSETRRLPLEQQFGIQTTSDNLMA
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEECCCHHHHCCCCHHHCCCEECCCCEEE
ATQADVIVLSVKPQMMEEVCKPLQSVDFSNKLVISIAAGINCARLNDMLATQLNLVRVMP
ECCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEECC
NTPSQLGLGMSGLYAPASVAEQDRHFAEQLMQAVGKTCWVDEESGINHVIAAAGSAPAYF
CCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCEEEEECCCCHHHH
FLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHHHHHCCCCCHHH
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHKNIAFIGAGNMVRAIVSGLVANGYPADKITATAPSETRRLPLEQQFGIQTTSDNLMA
CCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEECCCHHHHCCCCHHHCCCEECCCCEEE
ATQADVIVLSVKPQMMEEVCKPLQSVDFSNKLVISIAAGINCARLNDMLATQLNLVRVMP
ECCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEECC
NTPSQLGLGMSGLYAPASVAEQDRHFAEQLMQAVGKTCWVDEESGINHVIAAAGSAPAYF
CCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCEEEEECCCCHHHH
FLFMEAMQAEAMAQGFDKQTARLLVQQSALGAASMVVENPDTELATLRENVTSKGGTTAE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHHHHHCCCCCHHH
ALRTFNEHQLSDIVAKAMQAAVARAQEMEKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]