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The map label for this gene is argE

Identifier: 27364764

GI number: 27364764

Start: 1351590

End: 1352726

Strand: Reverse

Name: argE

Synonym: VV1_1370

Alternate gene names: 27364764

Gene position: 1352726-1351590 (Counterclockwise)

Preceding gene: 326423828

Following gene: 326423826

Centisome position: 41.22

GC content: 50.4

Gene sequence:

>1137_bases
ATGCAATTACCGAGTTTTCTTGATGTTTACCGTGGCTTAATTTCCACCTCATCCATCAGCTCTAGCGACCCAAGTTGGGA
TCAAGGCAACCAGGCGGTGATCGAAAAGCTCTCCGATTGGTTTGCGGCATTGGGCTTTGATGTGGACGTCACCGAAGTCG
AACCGGGTAAATACAATTTATTGGCACAGAAAGGTCAGGGAGAGGGTGGCCTACTGTTGGCTGGACACAGTGATACGGTG
CCTTTTGATCAAGGCCGTTGGAGCTTTGACCCTCACCAACTCACCGAGAAAGACAACAAGTTCTATGGTTTAGGCACCGC
TGACATGAAAGGCTTTTTTGCTTTTATTTATGAAGCCGCCAAACGCATGGATTGGAAAGGACAAAATAAACCCCTTTATG
TGCTGGCGACGTGTGATGAAGAGACCACCATGCTCGGTGCGCGCCACTTTAGTGCGCATACCCCCTTTAAACCTGACTAC
TGCATCATTGGCGAGCCAACGAGTTTAGTGCCTGTTCGTGGGCACAAAGGCCATGTCGCCAATGTCGTGCGGGTCACAGG
GAAATCGGGCCACTCCTCTGATCCATCATTAGGGGTCAATGCCATCGAGATCATGCATGAAGTCCTGTTCGCGCTGATGC
AACTGCGTGATACGTTAATCAAGCAGTATCACAATCCCGGATTTGCTATCCCATCTCCCACTCTTAACCTTGGCCATATT
CATGGGGGCGATAGTGCCAACCGCATCTGCGGTTGCTGCGAGTTGCATTATGACGTAAGACCTCTTCCTGGCATTAGCCT
CGACGGTTTGGATAATCTGTTGCGTGGGGCACTCAAAGAGGTGGAAGCAAAATGGCCGGGACGGATTGAGATCGTGCCAC
TGCACGAGCCAATCCCAGGTTACGAGTGCCAACATGATCATCCATTTATTCATGGCATAGAAGAGCTCTGTGGTACACCA
TCACAAACCGTGAACTACTGTACCGAAGCGCCATTTTTGCAGCAGCTCTGCCCCACACTGGTGCTGGGTCCGGGATCTAT
CGACCAAGCTCACCAGCCAGATGAGTTCTTGGCGTTTGACTTTATCGACCCGACGATTGACGTGCTTAGTAAAGCAATGC
GCAAATACTGTTTTTAG

Upstream 100 bases:

>100_bases
TTAAAAATTACTTTATATTGATTTTTTATTCATTAAATATGAGTTAATATGTGTTTTACCTTTTTGTTACCCAACTGTCA
ACAGGGGAAGTGAATAATCT

Downstream 100 bases:

>100_bases
CTGCATGTCGGCAGAGTTGCCTTGCGCCACTCTGCCTTATAAATTGTAATAAATTTTCAATATCGTTTATTTACAAAGCA
ATACTTTGCTTTAAGTCAGA

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MQLPSFLDVYRGLISTSSISSSDPSWDQGNQAVIEKLSDWFAALGFDVDVTEVEPGKYNLLAQKGQGEGGLLLAGHSDTV
PFDQGRWSFDPHQLTEKDNKFYGLGTADMKGFFAFIYEAAKRMDWKGQNKPLYVLATCDEETTMLGARHFSAHTPFKPDY
CIIGEPTSLVPVRGHKGHVANVVRVTGKSGHSSDPSLGVNAIEIMHEVLFALMQLRDTLIKQYHNPGFAIPSPTLNLGHI
HGGDSANRICGCCELHYDVRPLPGISLDGLDNLLRGALKEVEAKWPGRIEIVPLHEPIPGYECQHDHPFIHGIEELCGTP
SQTVNYCTEAPFLQQLCPTLVLGPGSIDQAHQPDEFLAFDFIDPTIDVLSKAMRKYCF

Sequences:

>Translated_378_residues
MQLPSFLDVYRGLISTSSISSSDPSWDQGNQAVIEKLSDWFAALGFDVDVTEVEPGKYNLLAQKGQGEGGLLLAGHSDTV
PFDQGRWSFDPHQLTEKDNKFYGLGTADMKGFFAFIYEAAKRMDWKGQNKPLYVLATCDEETTMLGARHFSAHTPFKPDY
CIIGEPTSLVPVRGHKGHVANVVRVTGKSGHSSDPSLGVNAIEIMHEVLFALMQLRDTLIKQYHNPGFAIPSPTLNLGHI
HGGDSANRICGCCELHYDVRPLPGISLDGLDNLLRGALKEVEAKWPGRIEIVPLHEPIPGYECQHDHPFIHGIEELCGTP
SQTVNYCTEAPFLQQLCPTLVLGPGSIDQAHQPDEFLAFDFIDPTIDVLSKAMRKYCF
>Mature_378_residues
MQLPSFLDVYRGLISTSSISSSDPSWDQGNQAVIEKLSDWFAALGFDVDVTEVEPGKYNLLAQKGQGEGGLLLAGHSDTV
PFDQGRWSFDPHQLTEKDNKFYGLGTADMKGFFAFIYEAAKRMDWKGQNKPLYVLATCDEETTMLGARHFSAHTPFKPDY
CIIGEPTSLVPVRGHKGHVANVVRVTGKSGHSSDPSLGVNAIEIMHEVLFALMQLRDTLIKQYHNPGFAIPSPTLNLGHI
HGGDSANRICGCCELHYDVRPLPGISLDGLDNLLRGALKEVEAKWPGRIEIVPLHEPIPGYECQHDHPFIHGIEELCGTP
SQTVNYCTEAPFLQQLCPTLVLGPGSIDQAHQPDEFLAFDFIDPTIDVLSKAMRKYCF

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily

Homologues:

Organism=Escherichia coli, GI1790395, Length=380, Percent_Identity=58.421052631579, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1788816, Length=257, Percent_Identity=29.5719844357977, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789236, Length=358, Percent_Identity=24.3016759776536, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17551016, Length=302, Percent_Identity=27.1523178807947, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGE_VIBVU (Q8DCN1)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_760292.1
- ProteinModelPortal:   Q8DCN1
- GeneID:   1178291
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_1370
- HOGENOM:   HBG728841
- OMA:   DEFLAFD
- ProtClustDB:   PRK05111
- BioCyc:   VVUL216895:VV1_1370-MONOMER
- BRENDA:   3.5.1.16
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_01108
- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650
- TIGRFAMs:   TIGR01892

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20; SSF55031 Peptidase_M20_dimer

EC number: =3.5.1.16

Molecular weight: Translated: 41719; Mature: 41719

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00758 ARGE_DAPE_CPG2_1; PS00759 ARGE_DAPE_CPG2_2

Important sites: ACT_SITE 78-78 ACT_SITE 140-140

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPSFLDVYRGLISTSSISSSDPSWDQGNQAVIEKLSDWFAALGFDVDVTEVEPGKYNL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEE
LAQKGQGEGGLLLAGHSDTVPFDQGRWSFDPHQLTEKDNKFYGLGTADMKGFFAFIYEAA
EEECCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEECCCHHHHHHHHHHHHHH
KRMDWKGQNKPLYVLATCDEETTMLGARHFSAHTPFKPDYCIIGEPTSLVPVRGHKGHVA
HHCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCEEEECCCCCEEEECCCCCCEE
NVVRVTGKSGHSSDPSLGVNAIEIMHEVLFALMQLRDTLIKQYHNPGFAIPSPTLNLGHI
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECEE
HGGDSANRICGCCELHYDVRPLPGISLDGLDNLLRGALKEVEAKWPGRIEIVPLHEPIPG
ECCCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
YECQHDHPFIHGIEELCGTPSQTVNYCTEAPFLQQLCPTLVLGPGSIDQAHQPDEFLAFD
CCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHEEECCCCCCCCCCCCCEEEEE
FIDPTIDVLSKAMRKYCF
CCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLPSFLDVYRGLISTSSISSSDPSWDQGNQAVIEKLSDWFAALGFDVDVTEVEPGKYNL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEE
LAQKGQGEGGLLLAGHSDTVPFDQGRWSFDPHQLTEKDNKFYGLGTADMKGFFAFIYEAA
EEECCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEECCCHHHHHHHHHHHHHH
KRMDWKGQNKPLYVLATCDEETTMLGARHFSAHTPFKPDYCIIGEPTSLVPVRGHKGHVA
HHCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCEEEECCCCCEEEECCCCCCEE
NVVRVTGKSGHSSDPSLGVNAIEIMHEVLFALMQLRDTLIKQYHNPGFAIPSPTLNLGHI
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECEE
HGGDSANRICGCCELHYDVRPLPGISLDGLDNLLRGALKEVEAKWPGRIEIVPLHEPIPG
ECCCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
YECQHDHPFIHGIEELCGTPSQTVNYCTEAPFLQQLCPTLVLGPGSIDQAHQPDEFLAFD
CCCCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHEEECCCCCCCCCCCCCEEEEE
FIDPTIDVLSKAMRKYCF
CCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA