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The map label for this gene is mtaD [H]

Identifier: 27364703

GI number: 27364703

Start: 1288365

End: 1289861

Strand: Reverse

Name: mtaD [H]

Synonym: VV1_1303

Alternate gene names: 27364703

Gene position: 1289861-1288365 (Counterclockwise)

Preceding gene: 27364717

Following gene: 27364701

Centisome position: 39.3

GC content: 48.83

Gene sequence:

>1497_bases
ATGCAAACCAAAGAGCAAACGTTTGCAATTCATCATGAATCTCTTACTATCGCGGCAAACTATACCGATGCCTGTTCCAA
GGAAAATAGAATGCTGAAACGTAACGTAATTGCTGCTGCCATCGCAGGCATGAGCCTGTTTTCGTCCATGAGTTATGCCG
CACAACCTGCGGATCTTATGATCACCGATGCCATGATCCTCACCATGAACAAAGACAAAGTGGTGTATCAAAACGGCACT
GTAGTGGTAAAAGAGAACAAAATCATCGCGGTGGGTGATGCGGATGTGGCAAAGCAGTATCAAGCAAAACAAGTGCTTGA
TGTCGATGGCGATATCGTAATGCCGGGTTTAATCAACACGCACACGCATGTGTCGATGACGGTATTTCGCTCATTAGGTG
ACGATGTGCCTGACCGCCTGCATCGCTACATTTTCCCATTAGAAGCCAAACTGGTGTCACGCGATATGGTGCGCATCGGC
GCAAATTTGGGGAACGTTGAAATGCTCAAAGGCGGCGTAACGACCTACGCAGACATGTATTACTTCGAAGACGAAGTGGC
GAAAACGGTCGACCAAATTGGTATGCGTGCCGTGCTTGGCCAGAGTGTGATTCAGTTTCCTGTCGCCGATGCCAAAAACG
CAGATGAAGGCATTCAATACGCTCTGAACTTTATCGACCAATACCAAGATCACCCAAGAATTACCCCAGCGTTTGCACCG
CACGCGCCCTACACTAACACCACAGAAACGCTACAGAAAATTGCGAAGCTCTCGCTAGAAAAGAACGTGCCTGTTTTGAT
TCACTTAGCCGAATCCACCCGTGAGCAAGAAAAGATTGCTGAACGATCAAACGGTTTATCACCGGTGCAGTACATGCATC
AAATCGGCGCATTGAATGCCAACCTCGTCGGCGCTCACATGATTTTGGTCGACGACAAAGACATTGAGTTAGTGAAGCAG
GCCGATATGGGCGTGGCTCATAACATGAGTGCCAACATTAAGTCCGCCAAAGGTGTCGCCCCAGCCCTCAAGATGTACGA
CGAAAACGTGCGTATTGGTTTGGGTACCGATGGTCCAATGTCGGGCAACACGCTGAGCACCATTGATGAATTCAACCAAG
TGGCGAAAGTACACAAACTGGTCAATCACGATCGTGCAGCCATGCCACCACTCAAAGTGATCGATATGGCGACCATGGGC
GCAGCAAAAGCACTGCATATGGAAGATAAAATCGGTTCTCTTGAAGTCGGCAAACTAGCGGACATCATCGTTATCGATAC
CAAAGCGCCAAATATGGTCCCCGTTTACAACCCATACTCTGCTTTGGTTTACTCAGCCAACAGCGGCAATGTGCGCCATG
CCATTGTTGATGGCAAGCTGATCATGCAAGAGCGCCAAATCAACACGGTGAATGAGGAACAAATTCGCCAAGAAGCACTG
GCCTTTACCGACATCGTTCGCAAAACCGTGCTCGACTCGGGCGAAGAGATTCGCTAA

Upstream 100 bases:

>100_bases
ACAGCCACGCGTCGCAGTTTCAGCAAATTAACACTTATTTTTCATAGTTTTTCATCATTCTTCTGATTCGTTTACATCTC
CGTGCCAAGATCACAGAAGT

Downstream 100 bases:

>100_bases
CTCCGCGACGTTCTGCAGCAACAGTGTGCTCTATCTTTGGATAGGGCATACTGGCAACGCCAGTTAGGCTTTTTGCAGCA
AGATCAGGAGCTCTGCGTTG

Product: cytosine deaminase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MQTKEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLMITDAMILTMNKDKVVYQNGT
VVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIG
ANLGNVEMLKGGVTTYADMYYFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERSNGLSPVQYMHQIGALNANLVGAHMILVDDKDIELVKQ
ADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMG
AAKALHMEDKIGSLEVGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
AFTDIVRKTVLDSGEEIR

Sequences:

>Translated_498_residues
MQTKEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLMITDAMILTMNKDKVVYQNGT
VVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIG
ANLGNVEMLKGGVTTYADMYYFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERSNGLSPVQYMHQIGALNANLVGAHMILVDDKDIELVKQ
ADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMG
AAKALHMEDKIGSLEVGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
AFTDIVRKTVLDSGEEIR
>Mature_498_residues
MQTKEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLMITDAMILTMNKDKVVYQNGT
VVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIG
ANLGNVEMLKGGVTTYADMYYFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERSNGLSPVQYMHQIGALNANLVGAHMILVDDKDIELVKQ
ADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMG
AAKALHMEDKIGSLEVGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
AFTDIVRKTVLDSGEEIR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=379, Percent_Identity=23.7467018469657, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789249, Length=414, Percent_Identity=22.9468599033816, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319963, Length=335, Percent_Identity=26.865671641791, Blast_Score=119, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24643849, Length=435, Percent_Identity=25.0574712643678, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 54704; Mature: 54704

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLM
CCCCCCEEEEEECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
ITDAMILTMNKDKVVYQNGTVVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINT
EEEEEEEEECCCEEEEECCEEEEECCEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCC
HTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIGANLGNVEMLKGGVTTYADMY
CCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
YFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERSNGLSPVQYMHQIGALNA
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
NLVGAHMILVDDKDIELVKQADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPM
CEEEEEEEEEECCCHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCC
SGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMGAAKALHMEDKIGSLEVGKLA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHEEHHCCCCCEECCCCE
DIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
EEEEEECCCCCEEEEECCCEEEEEECCCCCEEEEEECCEEEEEHHCCCCCCHHHHHHHHH
AFTDIVRKTVLDSGEEIR
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQTKEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLM
CCCCCCEEEEEECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
ITDAMILTMNKDKVVYQNGTVVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINT
EEEEEEEEECCCEEEEECCEEEEECCEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCC
HTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIGANLGNVEMLKGGVTTYADMY
CCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
YFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERSNGLSPVQYMHQIGALNA
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
NLVGAHMILVDDKDIELVKQADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPM
CEEEEEEEEEECCCHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCC
SGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMGAAKALHMEDKIGSLEVGKLA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHEEHHCCCCCEECCCCE
DIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
EEEEEECCCCCEEEEECCCEEEEEECCCCCEEEEEECCEEEEEHHCCCCCCHHHHHHHHH
AFTDIVRKTVLDSGEEIR
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA