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The map label for this gene is der [H]

Identifier: 27363891

GI number: 27363891

Start: 419176

End: 420666

Strand: Reverse

Name: der [H]

Synonym: VV1_0423

Alternate gene names: 27363891

Gene position: 420666-419176 (Counterclockwise)

Preceding gene: 27363892

Following gene: 27363890

Centisome position: 12.82

GC content: 47.82

Gene sequence:

>1491_bases
ATGATACCTGTTGTTGCTCTAGTCGGTCGTCCAAACGTAGGTAAATCTACGTTGTTTAACCGATTGACTCGCTCTCGTGA
CGCATTGGTGGCGGACTTTCCCGGTCTGACTCGTGACCGTAAATATGGTCAAGCCAAAGTAGGTGAGCACGACTTTATTG
TGATTGATACGGGTGGTATCGATGGTTCTGAAGAAGGCGTTGAAACCAAAATGGCAGAACAGTCACTTGCTGCGATCCGC
GAAGCTGACGTTGTGTTGTTCATGGTGGATGGTCGCGCAGGATTGACGCCATCCGATGAGGCGATTGCTGCCCATTTACG
TAAAATCGAAAAAGCCACCATGCTGGTGGTAAACAAAGTGGATGGCATTGATGCGGATGCTGCCAGCGCAGACTTTTGGC
AACTGGGCGTTGATGAGATGTACCAAATTGCCGCAGCGCATGGACGTGGTGTGACTGCGCTGATTGAACGTGCACTCGAT
CCATTCTTTGACAATCTTCTCAGTGCCAACAACGAAGGTGAGATCGAAGATCTGACCGATATGGAAGATGAAGACGCAGA
ACAGCAAGAGTACTCTGAAGAAGATGCCGAAGAGTCACTGAAACGACTGCAAGACCAGCCAATTAAGCTTGCTATTATTG
GTCGTCCGAACGTGGGTAAATCAACGCTGACTAACCGTATTTTGGGTGAAGAACGCGTTGTTGTGTACGATATGCCAGGA
ACCACACGTGACTCCATTTACATTCCAATGGAACGTGATGGTCGCGAATACGTGTTGATCGACACCGCAGGTGTTCGTCG
TCGCGGTAAAGTACATGAAACGGTTGAAAAATTCTCTGTTGTTAAAACATTGAAAGCCGTTGAAGATGCCAACGTTGTAC
TGTTAGTGATTGACGCTCGTGAAAACATCTCGGATCAGGACTTGAGCTTATTGGGCTTCGCACTTAATGCGGGTCGTTCT
ATCGTGCTGGCCGTGAACAAGTGGGATGGCTTGGATAACGAAGTGAAAGAGAATGTGAAGAAAGAGCTCGATCGTCGTCT
TGGCTTCGTCGATTTTGCTCGCATCCACTTCATCTCTGCGTTGCACGGTACTGGTGTAGGCCATTTGTTTGAATCAGTAC
AAGAAGCTTACCGATCTGCAACCACTCGTGTAGGAACATCTGTACTGACGCGTATCATGAAGATGGCAACGGAAGATCAC
CAACCACCGATGGTTCGTGGCCGTCGTGTGAAACTGAAATATGCGCACGCAGGTGGTTATAACCCGCCAATCGTGGTGAT
CCATGGTAACCAAGTTCGCGAATTGCCGGATTCTTACAAACGTTATCTAATGAACTACTTCCGTAAGTCACTAGATATCA
TGGGTACGCCGATTCGTATTCAGTTCCAAAACAGTGATAACCCGTTTGAGAACCGTGTCAACAAGATGACCCTTTCTCAA
GAGCGTGCACGTAAGCGCATGATGAGCGCGGTAAAAAATCGCAAGAAATAA

Upstream 100 bases:

>100_bases
TGACAAGACGATTGTGGTTATAGGTAAAAAGCTGGTTTGAAGTGCTATCAAGCAAGTGGTTACCTATAACTACAGATCAA
AGATTATTGTAGAGGTTGTT

Downstream 100 bases:

>100_bases
TCTGAACTGTTTTTGATGCCCAAGTTTTACTTGGGCATTTTTTTATTTTCCGTTTCCCAATATGGATAACATGCCACATC
ATTCGTTGAGCGGATGATGC

Product: GTP-binding protein Der

Products: NA

Alternate protein names: GTP-binding protein EngA [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MIPVVALVGRPNVGKSTLFNRLTRSRDALVADFPGLTRDRKYGQAKVGEHDFIVIDTGGIDGSEEGVETKMAEQSLAAIR
EADVVLFMVDGRAGLTPSDEAIAAHLRKIEKATMLVVNKVDGIDADAASADFWQLGVDEMYQIAAAHGRGVTALIERALD
PFFDNLLSANNEGEIEDLTDMEDEDAEQQEYSEEDAEESLKRLQDQPIKLAIIGRPNVGKSTLTNRILGEERVVVYDMPG
TTRDSIYIPMERDGREYVLIDTAGVRRRGKVHETVEKFSVVKTLKAVEDANVVLLVIDARENISDQDLSLLGFALNAGRS
IVLAVNKWDGLDNEVKENVKKELDRRLGFVDFARIHFISALHGTGVGHLFESVQEAYRSATTRVGTSVLTRIMKMATEDH
QPPMVRGRRVKLKYAHAGGYNPPIVVIHGNQVRELPDSYKRYLMNYFRKSLDIMGTPIRIQFQNSDNPFENRVNKMTLSQ
ERARKRMMSAVKNRKK

Sequences:

>Translated_496_residues
MIPVVALVGRPNVGKSTLFNRLTRSRDALVADFPGLTRDRKYGQAKVGEHDFIVIDTGGIDGSEEGVETKMAEQSLAAIR
EADVVLFMVDGRAGLTPSDEAIAAHLRKIEKATMLVVNKVDGIDADAASADFWQLGVDEMYQIAAAHGRGVTALIERALD
PFFDNLLSANNEGEIEDLTDMEDEDAEQQEYSEEDAEESLKRLQDQPIKLAIIGRPNVGKSTLTNRILGEERVVVYDMPG
TTRDSIYIPMERDGREYVLIDTAGVRRRGKVHETVEKFSVVKTLKAVEDANVVLLVIDARENISDQDLSLLGFALNAGRS
IVLAVNKWDGLDNEVKENVKKELDRRLGFVDFARIHFISALHGTGVGHLFESVQEAYRSATTRVGTSVLTRIMKMATEDH
QPPMVRGRRVKLKYAHAGGYNPPIVVIHGNQVRELPDSYKRYLMNYFRKSLDIMGTPIRIQFQNSDNPFENRVNKMTLSQ
ERARKRMMSAVKNRKK
>Mature_496_residues
MIPVVALVGRPNVGKSTLFNRLTRSRDALVADFPGLTRDRKYGQAKVGEHDFIVIDTGGIDGSEEGVETKMAEQSLAAIR
EADVVLFMVDGRAGLTPSDEAIAAHLRKIEKATMLVVNKVDGIDADAASADFWQLGVDEMYQIAAAHGRGVTALIERALD
PFFDNLLSANNEGEIEDLTDMEDEDAEQQEYSEEDAEESLKRLQDQPIKLAIIGRPNVGKSTLTNRILGEERVVVYDMPG
TTRDSIYIPMERDGREYVLIDTAGVRRRGKVHETVEKFSVVKTLKAVEDANVVLLVIDARENISDQDLSLLGFALNAGRS
IVLAVNKWDGLDNEVKENVKKELDRRLGFVDFARIHFISALHGTGVGHLFESVQEAYRSATTRVGTSVLTRIMKMATEDH
QPPMVRGRRVKLKYAHAGGYNPPIVVIHGNQVRELPDSYKRYLMNYFRKSLDIMGTPIRIQFQNSDNPFENRVNKMTLSQ
ERARKRMMSAVKNRKK

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis [H]

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain [H]

Homologues:

Organism=Escherichia coli, GI87082120, Length=502, Percent_Identity=71.3147410358566, Blast_Score=728, Evalue=0.0,
Organism=Escherichia coli, GI1788919, Length=124, Percent_Identity=34.6774193548387, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367268, Length=144, Percent_Identity=34.0277777777778, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323665, Length=200, Percent_Identity=26, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 55470; Mature: 55470

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPVVALVGRPNVGKSTLFNRLTRSRDALVADFPGLTRDRKYGQAKVGEHDFIVIDTGGI
CCCEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC
DGSEEGVETKMAEQSLAAIREADVVLFMVDGRAGLTPSDEAIAAHLRKIEKATMLVVNKV
CCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEECC
DGIDADAASADFWQLGVDEMYQIAAAHGRGVTALIERALDPFFDNLLSANNEGEIEDLTD
CCCCCCCCCCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHCC
MEDEDAEQQEYSEEDAEESLKRLQDQPIKLAIIGRPNVGKSTLTNRILGEERVVVYDMPG
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCC
TTRDSIYIPMERDGREYVLIDTAGVRRRGKVHETVEKFSVVKTLKAVEDANVVLLVIDAR
CCCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
ENISDQDLSLLGFALNAGRSIVLAVNKWDGLDNEVKENVKKELDRRLGFVDFARIHFISA
CCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LHGTGVGHLFESVQEAYRSATTRVGTSVLTRIMKMATEDHQPPMVRGRRVKLKYAHAGGY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCC
NPPIVVIHGNQVRELPDSYKRYLMNYFRKSLDIMGTPIRIQFQNSDNPFENRVNKMTLSQ
CCCEEEEECCHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
ERARKRMMSAVKNRKK
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIPVVALVGRPNVGKSTLFNRLTRSRDALVADFPGLTRDRKYGQAKVGEHDFIVIDTGGI
CCCEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC
DGSEEGVETKMAEQSLAAIREADVVLFMVDGRAGLTPSDEAIAAHLRKIEKATMLVVNKV
CCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEECC
DGIDADAASADFWQLGVDEMYQIAAAHGRGVTALIERALDPFFDNLLSANNEGEIEDLTD
CCCCCCCCCCHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHCC
MEDEDAEQQEYSEEDAEESLKRLQDQPIKLAIIGRPNVGKSTLTNRILGEERVVVYDMPG
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCC
TTRDSIYIPMERDGREYVLIDTAGVRRRGKVHETVEKFSVVKTLKAVEDANVVLLVIDAR
CCCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
ENISDQDLSLLGFALNAGRSIVLAVNKWDGLDNEVKENVKKELDRRLGFVDFARIHFISA
CCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LHGTGVGHLFESVQEAYRSATTRVGTSVLTRIMKMATEDHQPPMVRGRRVKLKYAHAGGY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCC
NPPIVVIHGNQVRELPDSYKRYLMNYFRKSLDIMGTPIRIQFQNSDNPFENRVNKMTLSQ
CCCEEEEECCHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
ERARKRMMSAVKNRKK
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA